npc2 (npc2)


Basic Information

Item Value
gene id npc2
gene name npc2
gene type coding
species mexican tetra (Astyanax mexicanus)
category of species ornamental fish

Chromosome Information

Item Value
chromosome id NC_035905.1
NCBI id CM008308.1
chromosome length 42966623
location 18708412 ~ 18712887 (+)
genome version Astyanax_mexicanus-2.0_2017_mexican_tetra_Genome

Sequence

>XM_007252508.3
tgcctgagggcaacgCTGTGCCGTGGAGAGTTCAATAGAAACTATGTTTATTACTCTTTGGTGGAGGATAGATTTTTGAGTACCTGGCAAAAAAGTGGGCGGTTATCGGTTACGTCCCTACATAAGAGTAAATCCTATTGGCCAGCGAGCTCGAAAGATCGCTCTGCTATTGGCTGGGAGCGCTGTGTGAGTCTCGAGGGCGTCACGAGACTGCGCTGGTCATCAAAAGTAGAAGCCTGGGCTCGGCTTCGTGATTCGGAAGTGAGGAGCAGCAACACAGGCAGGGCCGGGCAGTGTGTGGTATTGAGAACTCACCTGAGCGATGGATTTCCGCCTAATCTGCGCCGTCTTGCTGCCTCTGCTCGCCTTCACTCGGGCCGAGCAGGTGAAGTTTGCTGACTGTGGTTCTGTTGAGGGAAAAGTTTCCCAGGTCGACATTAGTCCATGCCCAACACAGCCGTGTGAGCTTCACAAGGGAAAGAGCTATACTGTAAATGTGACTTTCAGCAGTGATGTTGACAGTCAGACCAGCAAAGCATTGGTTCATGGAGTGATCGCCGGTGTTCCTGTCCCCTATCCCATTCCCAATGAGGACGGCTGCAAGTCTGGAATCCAGTGCCCGATTCAGAAGCAGAAAAGCTACAGTTATATCAACGAGCTTCCAGTCAAAGCTGAGTACCCCTCAataAAATTGGTTGTTGAGTGGGAACTGAGAGATGACTCAAGCAAAGATCTGTTTTGCATCAAGTTTCCTGTTCAGATTGTGAGCTGAGTCGACACAGATGCCAACAGGGAGTCGCTTCAAAAGGGATCTCGATTACTAATGATGAGTCTTGCATTTTTCTACGAACtcacctttttaaaaatgatttagtatttttgtttgtttttctaatgaATGTTACGTCATTTTAAATTGTTAACTTCTGTAAATGTCAGTctagtcatgttttt

Function

symbol description
npc2 Enables cholesterol binding activity; cholesterol transfer activity; and enzyme binding activity. Involved in cholesterol homeostasis; cholesterol transport; and response to virus. Located in extracellular space and lysosome. Implicated in Niemann-Pick disease and Niemann-Pick disease type C2.

NR:

description
epididymal secretory protein E1 precursor

GO:

id name namespace
GO:0008203 cholesterol metabolic process biological_process
GO:0005783 endoplasmic reticulum cellular_component
GO:0005576 extracellular region cellular_component

KEGG:

id description
K13443 NPC2; Niemann-Pick C2 protein

RNA

RNA id representative length rna type GC content exon number start site end site
XM_007252508.3 True 954 mRNA 0.47 5 18708412 18712887

Neighbor

gene id symbol gene type direction distance location
eml5 eml5,si:dkey-1f12.3,LOC108435760 coding upstream 4337 18634169 ~ 18704075 (+)
LOC103031945 itpk1,itpk1b,LOC108435758,LOC107664466,LOC107561681,LOC106597151 coding upstream 75857 18580869 ~ 18632555 (+)
plk4 plk4,LOC107703461,LOC107561682,LOC107664465,LOC107718857,LOC107586821 coding upstream 128841 18568668 ~ 18579571 (+)
hspa4l hspa4l,LOC107561683,LOC107586823 coding upstream 140758 18551021 ~ 18567654 (+)
mrpl35 mrpl35 coding upstream 179723 18523754 ~ 18528689 (+)
atg2b atg2b,LOC107738272,LOC107664023 coding downstream 3651 18716538 ~ 18749129 (+)
msh4 msh4 coding downstream 37806 18750693 ~ 18764580 (+)
ktn1 ktn1 coding downstream 52766 18765653 ~ 18800218 (+)
LOC103028664 peli2,LOC103028664,LOC108435764,LOC107664501,LOC107586838,LOC107561697,LOC107668538,LOC107733323,LOC107732184,LOC108270353 coding downstream 97586 18810473 ~ 18829957 (+)
LOC103039716 LOC108425599 coding downstream 1052449 19765336 ~ 19767308 (+)
G81600 isca2 non-coding upstream 2130 18704815 ~ 18706282 (+)
G81558 chmp3,LOC107732730,LOC107586824 non-coding upstream 158205 18545469 ~ 18550207 (+)
G81539 NA non-coding upstream 207701 18447388 ~ 18500711 (+)
G81540 NA non-coding upstream 209534 18475117 ~ 18498878 (+)
G81547 NA non-coding upstream 236841 18470407 ~ 18471571 (+)
G81602 gskip,LOC107731910,LOC107561679 non-coding downstream 1318 18714205 ~ 18717199 (+)
G81701 NA non-coding downstream 152789 18865676 ~ 18865988 (+)
G81705 NA non-coding downstream 218269 18931156 ~ 18937144 (+)
G81708 NA non-coding downstream 228521 18941408 ~ 18941814 (+)
G81725 NA non-coding downstream 587471 19300358 ~ 19324568 (+)
LOC103033848 LOC108435752 other upstream 187465 18511622 ~ 18520947 (+)
LOC103035760 rtkn2,rtkn2a other upstream 238777 18460123 ~ 18469635 (+)
cmpk2 cmpk2 other upstream 671338 18027307 ~ 18037074 (+)
G80857 NA other upstream 3125081 15563987 ~ 15583331 (+)
LOC111193203 NA other upstream 3504625 15174535 ~ 15203787 (+)
G81704 NA other downstream 217351 18930238 ~ 18930754 (+)
G81761 NA other downstream 952849 19665736 ~ 19666047 (+)
G81763 NA other downstream 960240 19673127 ~ 19673638 (+)
ralgapa2 ralgapa2,LOC107687934 other downstream 2808020 21520907 ~ 21673438 (+)
G82488 NA other downstream 3644757 22357644 ~ 22358135 (+)

Expression


Co-expression Network