LOC103043023 (nkx2-1,nkx2.1,LOC107578306,LOC107582966,LOC107679765,LOC107666245)


Basic Information

Item Value
gene id LOC103043023
gene name nkx2-1,nkx2.1,LOC107578306,LOC107582966,LOC107679765,LOC107666245
gene type coding
species mexican tetra (Astyanax mexicanus)
category of species ornamental fish

Chromosome Information

Item Value
chromosome id NC_035905.1
NCBI id CM008308.1
chromosome length 42966623
location 20921537 ~ 20925668 (+)
genome version Astyanax_mexicanus-2.0_2017_mexican_tetra_Genome

Sequence

>XM_007252551.3
GGAGAGCTGCAGGCTACTTGAGCGCCGTTAACTTTACCTGAGagcctctcctcctcctccttcttctgtCGAGCGGGTTTCTTTAACACTGCGCGTCTGTGTGGAGTCGATGGGAATTTGGACAACACTCTGCGTACGCCCAATAATGTATCACACAGAAAACCGGAGAGTTAATCATTCACGCAGCCTCTTAACACGcgcatatgtatttatttatttattatcagttaGCGCTCCTTCCTCACTGCAAGGGCACTTTTGCATGTCTGAGTACGATGGGGCAATAATGTAAACACGCCTGCAATCACCACAAGCCTCTTGTGGCCATTAAAAGTCAGGAGTTCAACTCAAGCTTGcctctctgttttttcttcttctttctaaCAACTGAGTGGGTTTTCAAAGATTCAAGTCTGCGTGTGCACTTCTCATTAAGAGGGCCCCCCTCATAAACATCACTCCAACCGTCAATATTCCATCCATCACTTTGTTCCCCGACATTACCCCGAGAGCGATAAAGACATTTACACCTTGAAAGTGAAACCAGCACACCTTCACGCGCTGATGGGGTCTCGCATGTGCGCGCGTTTTGCTGGGTTGGGGGGATGGCAGGGGCAGCTCGCGACCACGTAATGGGGCTCTTTGCGTTTGGTGCACAGATGACAGCGTCGCTTTGTATTGTTGCCCTCGCTGCTGCTGATGCCCCGCCTCTGATGGTAGTCTTAAACCTGGCACCCAGCTAAAACAAACGAAAGTCAGCCTCGAGCTCCCACTCAAGCCAATTAAGGCGGACTCCAGGCTCCCTCTTACGTGTCCAGCTCGCTGCACGAAAAGCAACAGGAACCAGAGGAAGCTGGCCAGCGACGAGAAGGGACGGCTTCGCTTTTGCCTTCTAATTTCTTCCCTCGCCAGCACAAAACAATGTCGATGAGCCCCAAACATACGACTCCTTTCTCAGTGTCCGATATATTGAGTCCTCTTGAGGAGAGCTACAAAAAAGTAAGTATGGAGGGCGGCAACTTGGGTGCTTCTCTCGCCTCGTACAGACAACCGCAAGTCACGCAGGCGACCATGCAGCAGCACCACATGGGCCACAACGGGACGGTGCCCGCCGCCTACCACATGACCGCGGCTGGGGTTTCGCAGCTGTCTCATACGGCCATGGGAGGCTATTGCAACGGGAACCTGGGCAACATGAGCGAGCTGCCCCCGGCTTATCAGGACGGAATGAGGGGCAGCACGACAGCCACCAGCTGGTACGGAACAAACCCTGACCCGCGCTTTTCTACAATCTCTCGTTTCATGGGTTCCTCCTCTGGCATGAACATGGGCAGCATGAGCAGCCTGGGCTCTTTGGCGGACGTGGGCAAAGGCATGGGCTCTCTAAGCAGCGCGCCTAGGAGAAAGCGTCGCGTGCTTTTCTCGCAAGCTCAGGTCTACGAGCTGGAGCGGCGTTTCAAGCAGCAGAAGTACCTGTCCGCGCCCGAGAGGGAGCACCTGGCCAGCATGATTCACCTGACCCCAACCCAAGTCAAGATCTGGTTCCAAAATCACCGCTACAAAATGAAGCGGCAGGCCAAAGACAAAGTGTCTCAGCAGCAAATGCAGCAGGAGGGCGGCTCGTGtcagcaacagcagcaacagTCCCCTCGGAGAGTGGCAGTGCCAGTGCTAGTCAAGGACGGCAAGCCTTGCCAAGGCAGTGGCCACACGCCCAACAGCGCCGTGCAGAATCACCACCACCAGGGAGCCAACGTCATGATCATGTCCAGCAACGGCTCAATGGGGCAGCATCAGAGCCAGCAGGTGGGCAGTGCCGGACAGTCCCCAGATTTGGGGCAGCACGGCGCTAGCCCCCCGTCCCTCCAAACTCAGGTGTCCGGTCTGTCACACCTGAACTCTTCCGGTACTGAGTACGGCGCGGCCTTACCCTGTTCCGCTCTGCTTTATGGCAGGACGTGGTGACGACGGAGTggacaataaaataaagcagaCAGACAAACGGACTGACAGACAGTAACTGTGCTACCCAGTCTCGGCGTCTACCCTGAACAGGTCAACGAGAAAACTGAAATAATCAGATAGTCATGCGAACAGCGGCTGTTGCCCATTCTCATGCTTGACCCCCTAAATTTTCCTCAGACTGGTggggatacaaaaaaaaatacaggcaaCGAGCAACAATTCAGCTCTTTCAGACTGAGAAAAATGAGATGACCTTTCCAGGATGTGCGTCCAAAGATCGCGGAGTAGatggaattatttataataGCTTTTAAACGGAGACAATAAGAAACCCACATTCCCGACGGATTAAAGCAAAAAACCTTTTGTCCCCTACAGACGCCTCCTCTCAACCTGACTCTTATAGATTGCAATGTAAGCCGTAGCTTGTACATTTCTGTAAAATGGTTGAATTAAATACATAGTTTTTAGCGatatgtatattgtataaatttttATCAATATTGAGGGTTCCATGTTATTTGAGTTCCATTTGTATTTGTACGTTTCATTTCCTTGTAACTTATAGATATTTGACTTAAATGCAGTCATACaatcatattaataaattatgaaaaaaaatctaattcctAACACGCCTTTAGTATAATTGTTTGTCAGAATTTAGCCAATTATGCATAGAATTATACAGTCATAGTGTAGTTATATCATagcatattttgttttaaattttgaaaaaaaaaatgtatacatttaagGACCAGTTTTGCTGCAACATTTCTGAAATGCTCTAATTTTTCTAAAGTGTGTGTGCCCCATTTGAggacagagaaagagctagctACAAAATGTGAAGTGCGTTTATTTTTATCTCAGCCAAGAAGGTCCCTTTTTTACTGTGTGTAATAGCTCACATTCTCTCTTGCAGAAGAAAATGCCTCAGAATTGGCACCCGCATTATAAGTGCTCACTTACCCCGCAAAAAATCCGCACATTATTTCACGCTCGATACCTTCAGTTATATTTGAAAGCCTTAATCTTGTTTGTCTTTTGCAAAGGTAAACCGAAAGCAGAGCTTTTGTGAAGTCGGCGCCCTTTggggtttcttttctttttaccgCGAGCGTTTGTCTGGCCACGAGTGAGTCAGTAAAAGGTGAGGTCTCCACTCCTTTAAAAGCTGCGCACATCAAACAAACGCTCCTAAAAGCAAGCTTATCAATCAGATCCCTGACCAAACAGCAGTGCTCCCCTAAATAACAGTGTAAGACAATATACACATAGTCTATCAATACAGTGATGGGGAGAAGCTAGGGGAAAATGCAATGGCCCTCTTGTTTACGTATTGATAAAGTGTATAAACATTATGTATGTGCGCGAGCGCGTGTGTTAGTGAAGAGTAAAGGGCTATGGTAGCCTAGTTAGAAAACCACTTTGGACACACCTGTTTTTTCCTGATTGTATTTTGATGATCTAAGATTTTTCGAATaaatgtaaacatattaaa

Function

symbol description
nkx2.1 Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within hypothalamus development. Predicted to be active in nucleus. Is expressed in brain; head; swim bladder; and thyroid follicle. Human ortholog(s) of this gene implicated in choreatic disease and thyroid gland papillary carcinoma. Orthologous to human NKX2-1 (NK2 homeobox 1).
nkx2-1 Enables several functions, including DNA-binding transcription factor activity; RNA polymerase II-specific DNA-binding transcription factor binding activity; and transcription cis-regulatory region binding activity. Involved in several processes, including animal organ development; negative regulation of transforming growth factor beta receptor signaling pathway; and positive regulation of macromolecule metabolic process. Acts upstream of or within negative regulation of transcription by RNA polymerase II. Located in nucleus. Implicated in choreatic disease and thyroid gland papillary carcinoma.

NR:

description
homeobox protein Nkx-2.1

GO:

id name namespace
GO:0006355 regulation of transcription, DNA-templated biological_process
GO:0005634 nucleus cellular_component
GO:0043565 sequence-specific DNA binding molecular_function
GO:0003700 DNA-binding transcription factor activity molecular_function

KEGG:

id description
K09342 NKX2-1, TITF1; homeobox protein Nkx-2.1

RNA

RNA id representative length rna type GC content exon number start site end site
XM_007252551.3 True 3472 mRNA 0.48 2 20921537 20925668

Neighbor

gene id symbol gene type direction distance location
LOC103021743 nkx2-8,LOC108421114 coding upstream 4298 20915266 ~ 20917239 (+)
slc25a21 slc25a21,LOC107679800 coding upstream 32739 20777438 ~ 20888798 (+)
LOC103044638 LOC108425659,LOC108270359,LOC107679799,LOC107752725,LOC107666266 coding upstream 149892 20714423 ~ 20771645 (+)
tmem229b tmem229b,LOC107752730,LOC107578043,LOC107708331,LOC107679790,LOC107666241 coding upstream 456685 20447910 ~ 20464852 (+)
mta1 mta1,LOC107679789,LOC107666257 coding upstream 474731 20391370 ~ 20446806 (+)
mbip NA coding downstream 16040 20941708 ~ 20959391 (+)
cdan1 cdan1,LOC107582945 coding downstream 135027 21060695 ~ 21079622 (+)
stard9 LOC108270056,LOC107582944 coding downstream 155796 21081464 ~ 21136907 (+)
LOC103047712 sptb,LOC108425666,LOC107582900,LOC107662651,LOC107730205,LOC107602260,LOC108270244 coding downstream 216105 21141773 ~ 21189268 (+)
LOC103041063 ccdc88c,LOC107582943 coding downstream 269040 21194708 ~ 21279138 (+)
G82014 NA non-coding upstream 145060 20772756 ~ 20776477 (+)
G81983 NA non-coding upstream 377626 20543711 ~ 20543911 (+)
G81955 NA non-coding upstream 549145 20372114 ~ 20372392 (+)
G81920 NA non-coding upstream 619805 20301278 ~ 20301732 (+)
G81919 crip1,LOC103034058,LOC106611282,LOC107600860 non-coding upstream 648814 20261599 ~ 20272723 (+)
G82073 NA non-coding downstream 21928 20947596 ~ 20948442 (+)
G82089 NA non-coding downstream 93424 21019092 ~ 21019862 (+)
G82088 NA non-coding downstream 96402 21022070 ~ 21022572 (+)
G82090 NA non-coding downstream 97336 21023004 ~ 21023858 (+)
G82091 NA non-coding downstream 98467 21024135 ~ 21025804 (+)
G81763 NA other upstream 1247899 19673127 ~ 19673638 (+)
G81761 NA other upstream 1255490 19665736 ~ 19666047 (+)
G81704 NA other upstream 1990783 18930238 ~ 18930754 (+)
LOC103033848 LOC108435752 other upstream 2400590 18511622 ~ 18520947 (+)
LOC103035760 rtkn2,rtkn2a other upstream 2451902 18460123 ~ 18469635 (+)
ralgapa2 ralgapa2,LOC107687934 other downstream 595239 21520907 ~ 21673438 (+)
G82488 NA other downstream 1431976 22357644 ~ 22358135 (+)
G82609 baz1a other downstream 2304762 23230430 ~ 23231318 (+)
timm9 timm9,LOC107729247,LOC107693171,LOC107689314 other downstream 2949771 23875439 ~ 23877770 (+)
G82811 psma3,LOC107729246,LOC107725600 other downstream 2984014 23909682 ~ 23973975 (+)

Expression


Co-expression Network