tpp1 (tpp1)


Basic Information

Item Value
gene id tpp1
gene name tpp1
gene type coding
species mexican tetra (Astyanax mexicanus)
category of species ornamental fish

Chromosome Information

Item Value
chromosome id NC_035905.1
NCBI id CM008308.1
chromosome length 42966623
location 163028 ~ 173869 (+)
genome version Astyanax_mexicanus-2.0_2017_mexican_tetra_Genome

Sequence

>XM_022672523.1
CATGACGCGCTGAGAGTAGGCGGGGTTAGTTCACATTGCGgtggtgtttttgtgttgtgtttgtgtgagttagtgagttaccgagttaatgtgttagtgttttagtgttttagtgagttagtgtgtTTGGTGCTCCGGATAGTAAAGTTGGGGGAGAAAATGCGGGGACTCGCTGTGTTCTGGATCTGTGTTTATCTGGTCCGCGCGGATCGATTAGAAACGGATCAGATTTTATCTGTGCAGGAGGGCTGGATTCATGAGGGCCGAGTTTCTCCTCTGGAGGAGGTGGAGCTCACCTTCGCCCTGAAACAGCAGAACATAGAGAGACTGAAGGAGCAGCTGGAGCTGGTGTCAGACCCCGACTCTCAGCAGTATGGGAAGTTCCTGTCTCTGGAGGAAGTGTCCTCTCTGGTTGGTCCGTCTCCGCTGACGGAGAAAGTGGTGCAGAACTGGCTGCAGAGTCACGGAGTCACGAGCTGTCTCACCGTTCTCACGAGGGACTTCCTGCAGTGCTCCATGAGCGTCCAGGTGGCGGAGACGCTTCTTCCCGGTGCAGAATTTCATCGCTACAGGAGAGAAGATCAGACCCTCGTGAGGTCGTCCGCGCACTACTCCGTTCACGATGATGTCACCGAGCATCTGGATTTTGTCGGAGGCGTGCTCCGTTTTCCACCTAAAGTAAAGGAGATCAGTCGGAGCTGGGCGGGAGCGAGACGATCAGTAAAGGGATTTCACCTGGGTGTGACTCCATCAACCCTCAGGACCCGATACAACCTCACCGATACAGACATAGGAACTGCTGCTAACAACAGCCAGGCTGTGGCACAGTTCCTGGAGCAGTTCTATCACCCGGCGGACCTGGCGGAGTTCATGAGCTTATTTGCGAGAGGCTTTCAGCACCTGACGGAGGTGGAGCGGGTGGTGGGGACTCAGGGTGGGGGTAAAGCTGGTCTGGAGGCGAGTTTGGATGTGGAGTACATCATGAGCACCGGAGCAAACATCTCCACCTGGGTCTTCACCAACCCGGGACGTCACGAGACTCAGGAGCCGTTCCTGCAGTGGATGCTCCTCCTCAGTAACATGTCGTCCGTGCCGTGGGTTCACACCATCAGTTACGGAGACGACGAGGACAGCCTGTCCTCCGCTTATATGAACCGCATTAATAATGAGTTTATGAAGGCGGGAGTTCGGGGAATCTCCATGCTGTTCGCCTCCGgggACAGTGGGGCCGGATGCTGGCACAAGACTAAAGAAGAAAACGTGTTCAGGCCGAGTTTTCCTGCTTCCAGTCCGTACGTGACCACAGTGGGAGGGACTTCCTTCAAGAACCCCTTTAAAGTGACCTATGAGGTGACAGATTACATCAGTGGGGGCGGGTTCAGTAACGTGTTCCCGATGCCGGATTATCAGgTCAGTGCAGTGAAAGCGTTTCTGAAAGGGAAGCCGTCTCTTCCTCCTCAGTCCTACTTTAACTCCAGCGGGAGAGCGTACCCCGACCTCGCTGCTCTCTCAGATAATTACTGGGTCGTCACCAACCTGGTGCCCATCCCCTGGGTATCTGGAACCTCGGCTTCGACTCCAGTAGTGGGAGGAATCCTCTCTCTGATTAATGATCAGCGCTTCCTGAAAGGTCTTCCTTCCCTCGGTTTCCTCAACCCTCGTCTCTACAAACTCCAGGGAACCGGACTGTATGACGTAACGGAGGGATGTCACCTGTCCTGTCTGgatgatcaggtacagggacaAGGCTTCTGCGCTGCTCCGTCCTGGGACCCCGTGACGGGATGGGGTACGCCCAATTATCCCGCTCTACTGGCGGAGCTGGTGAAGGGTTAATCCTCTGATTAGAATCTAGTTAAATTTCATCCAGCAAACATTGCAATCATATCTCACAATGTTTAAATTTAAGATTATGGgcttttaatttgtattaaatgttactgattgttttaatgctgtttattttagttaaaagcatcttttaaggtcagATTATGATGTTTTGTTGGATTGAAAGTTCCAAACACATCAGATCCACATCtgcatgcagatttttttttgctgctaaagtttTTAAAGTACTGTTGATTAATAAAAAGCCTAAAGTTTTATAAATTCTCTATAAGGGCGTTGCTTTATACGTTTTGCATTATAGAATCattcacatttttcattttcaacaaaaacagaacaaaaacactgGAGGAGAGTAGAAGAATGTGGTAAATATGGATTTTCTGGCTGTTTGATTGGGAGGTGATGGATGTGTCGATCGGTCTTTAAGCAAATTGCACTAAAAACTGTAATGCTCTGCAAATCTGTTTTATCACCAATTAATCACTGGGGGTTTTCACTAGTTtaccagacagggattaaatcTCATCTTGAACTAAACAAGATCTAAATTGAGtttttctattaatattaaatgtactctaaggctaggcttaatccctgtgtGGAAAACCGACCCCTATTGATTTATCAATAAATTAACTTGAGTATACTTTTaacataaatgctttaaaataacatttattaaatgtataaatgcagTTCTGTCTAGATGGTGATTACCTGCCTCAGGTGTTTGGATCACTTTTTggacagaattatttttttgggCCTGAAGATCaattaaaattgtaattattGAAAAGTTTTTCACTTctagtttatacaataaaatattcctATAGAAGGAAATTATGATCcatttcatacatttacatgcattacttttgtgtgttgtgtaaaagaaaaagaaagaaatttacACCATTTTGAccgtttacacctggtcactttgtGTGATTAGAATTTAGATTTTATCCTgattatttagaattaaatctGATTAGTGTGTcagttttactttaatttgcaGCAGTTTATTCTGGATATTTGGGTTGTTAAAATGCTCAGATAAAATAGTTCATACTGCTGTAACATAacataatatgtttaaatgcgtctcagaacAATGCgtgatttgattgattgattagatTTGATCTGTTTGAAATGCAGATTAGGTGCATTATCTCTGCTTTATCTACACATATAATAATGATGTCCAATAAGAATAAGGAAGCCGTGTGTAAACAGGGGGTTTTGTTTGTGAGTTAAAGTTGAATAAGGTACTGTTTTTATGCTGTTTAGAGAGAAACGGATGAGATTAAGATCTGCAGTGCAGAATTATTGATGCCTTTCAGTAAAATTTCAAAGtgtttttcttgcttttctcAGGGGATGTAAATGAAGTGtgaattaataaaaattttGATAAAATTAA

Function

symbol description
tpp1 Predicted to enable endopeptidase activity and tripeptidyl-peptidase activity. Acts upstream of or within central nervous system development; locomotory behavior; and neurogenesis. Predicted to be located in lysosome. Is expressed in several structures, including gill; heart; liver; pleuroperitoneal region; and retinal neural layer. Used to study neuronal ceroid lipofuscinosis 2. Human ortholog(s) of this gene implicated in autosomal recessive spinocerebellar ataxia 7 and neuronal ceroid lipofuscinosis 2. Orthologous to human TPP1 (tripeptidyl peptidase 1).

NR:

description
tripeptidyl-peptidase 1

GO:

id name namespace
GO:0045453 bone resorption biological_process
GO:0007626 locomotory behavior biological_process
GO:0006508 proteolysis biological_process
GO:0043171 peptide catabolic process biological_process
GO:0007417 central nervous system development biological_process
GO:0022008 neurogenesis biological_process
GO:0005764 lysosome cellular_component
GO:0004252 serine-type endopeptidase activity molecular_function
GO:0008240 tripeptidyl-peptidase activity molecular_function

KEGG:

id description
K01279 TPP1, CLN2; tripeptidyl-peptidase I

RNA

RNA id representative length rna type GC content exon number start site end site
XM_022672523.1 True 3295 mRNA 0.44 13 163028 173869

Neighbor

gene id symbol gene type direction distance location
apob NA coding upstream 87143 52801 ~ 75885 (+)
degs2 degs2,LOC107697737,LOC107733197,LOC107674056 coding downstream 4537 178406 ~ 189134 (+)
disp2 disp2 coding downstream 147438 321307 ~ 337947 (+)
ccdc32 cunh15orf57,LOC103043985 coding downstream 178284 352153 ~ 354980 (+)
LOC103044274 LOC108425589,LOC108269650,LOC107697665,LOC107719518,LOC107563387 coding downstream 185267 359136 ~ 369003 (+)
itpka itpka coding downstream 296644 470513 ~ 495668 (+)
G76972 NA non-coding upstream 38236 123786 ~ 124792 (+)
G76970 NA non-coding upstream 44258 113419 ~ 118770 (+)
G76969 NA non-coding upstream 45576 113328 ~ 117452 (+)
G76971 NA non-coding upstream 46429 115801 ~ 116599 (+)
G76948 LOC103039036 non-coding upstream 114597 43618 ~ 48431 (+)
G76992 NA non-coding downstream 24002 197871 ~ 203592 (+)
G76995 NA non-coding downstream 48662 222531 ~ 232122 (+)
G76976 NA non-coding downstream 64396 238265 ~ 358113 (+)
G77008 NA non-coding downstream 78141 252010 ~ 252531 (+)
G77033 NA non-coding downstream 209176 383045 ~ 383284 (+)
ldah ldah other upstream 29725 84719 ~ 133303 (+)
G77059 NA other downstream 345764 519633 ~ 520590 (+)
G77154 NA other downstream 457845 631714 ~ 632372 (+)
LOC103037215 fam196ab,LOC108436749,LOC108269663,LOC107561539,LOC107733200,LOC107674119 other downstream 709428 883297 ~ 935678 (+)
G77212 NA other downstream 831260 1005129 ~ 1008842 (+)
G77410 NA other downstream 1310801 1484670 ~ 1485050 (+)

Expression


Co-expression Network