fgf8_1 (fgf8,fgf8a,LOC107673879,LOC107716294,LOC107696243,LOC108442712,LOC107585369)


Basic Information

Item Value
gene id fgf8_1
gene name fgf8,fgf8a,LOC107673879,LOC107716294,LOC107696243,LOC108442712,LOC107585369
gene type coding
species mexican tetra (Astyanax mexicanus)
category of species ornamental fish

Chromosome Information

Item Value
chromosome id NC_035921.1
NCBI id CM008324.1
chromosome length 46505145
location 16916701 ~ 16922940 (+)
genome version Astyanax_mexicanus-2.0_2017_mexican_tetra_Genome

Sequence

>NM_001291263.1
ACTCTGAGCACCACTGTTTTCCTGAAGAGAGACACCATCAGCACGGGATGCACcgtcctgctcctgctgctgcctgaCATCTAGCACGGgaacgcgcgcgcacacacatactcactcaCACGCGCAAACAGCAGAGACACATACACGCGTCCAAGGACTCCCCTCTGGAGCTTATCTACTCAGAGACTCAGCGCGGAGAGAcaccatttttatttattactgtcatttcTGATGGACATGACTTGGCTTTAACTAGCTTGTTTGCGCTGGGAGACAACATATAGCCTGCAGCCTGTACTCTATATAGAAGGCTAGTAGTTGCTTATACTGTAACTTACTGTAATGCTTGTAGGCTATAGGCTACTTTACGGacccttttttgtattttattttttgcattaagtGCACTTACAACAGTTTCTTGCTAAGaagaaacaacaacaagaagaacagaaagaaagaagagaaacagaCGGGTCTCGGTTCAcaccattttttatatatatacacatatttaaaaGGAGCTCCGTCGCCCTGCAGTTTCCCGGACACTTTTTCTCCCTATTTCTTTCTGCTGATCGGATTGTCGCCTTGTGCCTCCGCGCTTTTGGATGTCCACGCACAGACTTTCGCCGAGAGGAGCTCCCCTGTTTCCAGAGGAAGAGCTGCCGAGCTGTTATCTCTCCTTCACATCACGCGCTAATTTGGTGCGCTGAGTTTTATCTCTGCGGCCCGCTCACCTCAATCCACAATGAGACTCATCCCATCACGATTGAGTTATCTATTTCTTCACCTCTTTGCGTTTTGCTACTATGCTCAGGTAACCATTCAGTCCCCGCCTAATTTTACACAGCATGTGAATGAGCAAAGTAGGGTGACGGACCGAGTGAGCCGCAGGCTAATACGGACCTACCAGCTTTACAGCAGAACCAGCGGCAAACACGTCCAAGTCCTCGCCAACAAAAAGATCAACGCCATGGCCGATGATGGAGACGTACACGcAAAGCTGATTGTGGAGACAGACACATTCGGCAGTCGAGTCAGAATTAAAGGAGCAGAGACAGGATTCTACATCTGCATGAACAGAAGAGGAAAGCTGATTGGCAAGaaaaATGGTCAAGGGAAGGACTGCATATTCACAGAGATTGTGCTCGAGAATAACTACACGGCTCTCCAGAACGTAAAGTACGAGGGCTGGTACATGGCGTTCACACGCAAAGGAAGACCCCGCAAGGGCTCCAAAACCAGGCAACACCAGCGGGAAGTCCACTTCATGAAGCGGCTGCCCAAAGGACACCACATCGCAGAGCACAGGCCCTTTGATTTCATCAATTACCCTTTCAACAGACGGACTAAACGCACCCGTTACTCAGGAGAGCGCTGAGGAGTGAAGAAGGAGAAAAatagagacagtgagtgagcgagagacgaAACACCATCTCGTAATAATGAACAGGATCCTCTGTTCACCCTCTGGACTCATAAAAGAAATTTTGTACTGAGCATTAATATACCTAataatttagtttgttttttaaatgatttttagaaaaaaatacattaaggaaaaagacaaaaaacaaggaaaaagaGATCTATTTTTGTACTCCAGACTTTTAGTACTGAcctgtgtaaagttttaggaaAGCGAAGCACATGACTTGAGATACATGTCAGATGGGAGAGCTGACATTTTAGTAGTGTGTGGACTTCACCTCTCATCTCCTCTCTATTTGATTTTGTTTCGTTGTTTTGTTTTGACCGTTTTAGAGTAATTTATACTCTTCATATATTGCTGCTCATGGGGACTTGAAGGGCCTGAGagaatgcactgaaaaaagACGGCTGAATTCGATGACGCGTACAGCCAAGGCACCTCTCGACCACCCGGTGATAAGACACCCAGCTCATCTGATTAACCTCTCTGGTTCTTGGCTCTGGAACGCtcttgagataaaaaaaaaacacagttaaagcGAACACAGCTTTAAATCCGTTAATAAATTGTGGCAGCTACATTTTGATAATCACACGTTTCCTACCATGGTTTAAACTGTAAATTCAAGGTATATAAATGCATTGTAAGAAACGTAGGAAagccttttttgttttctgttgcattttgtctgtctgttttttatacatatataaatatattttttatttgaggatgtgtaaaataattttaaggatggaaatatttatttaaaaatgtgtaataaatttACCTTAGGATACTG
>XM_022684400.1
CCAAGGCCGTAAGCGCGAGTGGGGTTGACATTGGAGCCTGGCAGTGGGAGAAGAGGAGGGGAGAATAAGAGAGGAGGCCACAGACTCTGAGCACCACTGTTTTCCTGAAGAGAGACACCATCAGCACGGGATGCACcgtcctgctcctgctgctgcctgaCATCTAGCACGGgaacgcgcgcgcacacacatactcactcaCACGCGCAAACAGCAGAGACACATACACGCGTCCAAGGACTCCCCTCTGGAGCTTATCTACTCAGAGACTCAGCGCGGAGAGAcaccatttttatttattactgtcatttcTGATGGACATGACTTGGCTTTAACTAGCTTGTTTGCGCTGGGAGACAACATATAGCCTGCAGCCTGTACTCTATATAGAAGGCTAGTAGTTGCTTATACTGTAACTTACTGTAATGCTTGTAGGCTATAGGCTACTTTACGGacccttttttgtattttattttttgcattaagtGCACTTACAACAGTTTCTTGCTAAGaagaaacaacaacaagaagaacagaaagaaagaagagaaacagaCGGGTCTCGGTTCAcaccattttttatatatatacacatatttaaaaGGAGCTCCGTCGCCCTGCAGTTTCCCGGACACTTTTTCTCCCTATTTCTTTCTGCTGATCGGATTGTCGCCTTGTGCCTCCGCGCTTTTGGATGTCCACGCACAGACTTTCGCCGAGAGGAGCTCCCCTGTTTCCAGAGGAAGAGCTGCCGAGCTGTTATCTCTCCTTCACATCACGCGCTAATTTGGTGCGCTGAGTTTTATCTCTGCGGCCCGCTCACCTCAATCCACAATGAGACTCATCCCATCACGATTGAGTTATCTATTTCTTCACCTCTTTGCGTTTTGCTACTATGCTCAGCATGTGAATGAGCAAAGTAGGGTGACGGACCGAGTGAGCCGCAGGCTAATACGGACCTACCAGCTTTACAGCAGAACCAGCGGCAAACACGTCCAAGTCCTCGCCAACAAAAAGATCAACGCCATGGCCGATGATGGAGACGTACACGcAAAGCTGATTGTGGAGACAGACACATTCGGCAGTCGAGTCAGAATTAAAGGAGCAGAGACAGGATTCTACATCTGCATGAACAGAAGAGGAAAGCTGATTGGCAAGaaaaATGGTCAAGGGAAGGACTGCATATTCACAGAGATTGTGCTCGAGAATAACTACACGGCTCTCCAGAACGTAAAGTACGAGGGCTGGTACATGGCGTTCACACGCAAAGGAAGACCCCGCAAGGGCTCCAAAACCAGGCAACACCAGCGGGAAGTCCACTTCATGAAGCGGCTGCCCAAAGGACACCACATCGCAGAGCACAGGCCCTTTGATTTCATCAATTACCCTTTCAACAGACGGACTAAACGCACCCGTTACTCAGGAGAGCGCTGAGGAGTGAAGAAGGAGAAAAatagagacagtgagtgagcgagagacgaAACACCATCTCGTAATAATGAACAGGATCCTCTGTTCACCCTCTGGACTCATAAAAGAAATTTTGTACTGAGCATTAATATACCTAataatttagtttgttttttaaatgatttttagaaaaaaatacattaaggaaaaagacaaaaaacaaggaaaaagaGATCTATTTTTGTACTCCAGACTTTTAGTACTGAcctgtgtaaagttttaggaaAGCGAAGCACATGACTTGAGATACATGTCAGATGGGAGAGCTGACATTTTAGTAGTGTGTGGACTTCACCTCTCATCTCCTCTCTATTTGATTTTGTTTCGTTGTTTTGTTTTGACCGTTTTAGAGTAATTTATACTCTTCATATATTGCTGCTCATGGGGACTTGAAGGGCCTGAGagaatgcactgaaaaaagACGGCTGAATTCGATGACGCGTACAGCCAAGGCACCTCTCGACCACCCGGTGATAAGACACCCAGCTCATCTGATTAACCTCTCTGGTTCTTGGCTCTGGAACGCtcttgagataaaaaaaaaacacagttaaagcGAACACAGCTTTAAATCCGTTAATAAATTGTGGCAGCTACATTTTGATAATCACACGTTTCCTACCATGGTTTAAACTGTAAATTCAAGGTATATAAATGCATTGTAAGAAACGTAGGAAagccttttttgttttctgttgcattttgtctgtctgttttttatacatatataaatatattttttatttgaggatgtgtaaaataattttaaggatggaaatatttatttaaaaatgtgtaataaatttACCTTAGGATACTG

Function

symbol description
fgf8a Predicted to enable growth factor activity; type 1 fibroblast growth factor receptor binding activity; and type 2 fibroblast growth factor receptor binding activity. Involved in positive regulation of somitomeric trunk muscle development. Acts upstream of or within several processes, including animal organ development; determination of bilateral symmetry; and nervous system development. Located in extracellular space and lysosome. Is expressed in several structures, including germ ring; head; mesoderm; nervous system; and neural keel. Human ortholog(s) of this gene implicated in hypogonadotropic hypogonadism 6 with or without anosmia and prostate carcinoma in situ. Orthologous to human FGF8 (fibroblast growth factor 8).
fgf8 Enables growth factor activity; type 1 fibroblast growth factor receptor binding activity; and type 2 fibroblast growth factor receptor binding activity. Involved in several processes, including animal organ development; dopaminergic neuron differentiation; and negative regulation of cardiac muscle tissue development. Acts upstream of or within fibroblast growth factor receptor signaling pathway. Located in extracellular space. Implicated in hypogonadotropic hypogonadism 6 with or without anosmia and prostate carcinoma in situ. Biomarker of breast cancer; choriocarcinoma; embryonal carcinoma; endodermal sinus tumor; and prostatic hypertrophy.

NR:

description
fibroblast growth factor 8 (androgen-induced) precursor

GO:

id name namespace
GO:0021555 midbrain-hindbrain boundary morphogenesis biological_process
GO:0046850 regulation of bone remodeling biological_process
GO:0001756 somitogenesis biological_process
GO:0021571 rhombomere 5 development biological_process
GO:0021572 rhombomere 6 development biological_process
GO:0021588 cerebellum formation biological_process
GO:0055011 atrial cardiac muscle cell differentiation biological_process
GO:0055012 ventricular cardiac muscle cell differentiation biological_process
GO:0030177 positive regulation of Wnt signaling pathway biological_process
GO:0061195 taste bud formation biological_process
GO:0009880 embryonic pattern specification biological_process
GO:0043049 otic placode formation biological_process
GO:0051216 cartilage development biological_process
GO:0035050 embryonic heart tube development biological_process
GO:0048263 determination of dorsal identity biological_process
GO:0003208 cardiac ventricle morphogenesis biological_process
GO:0008543 fibroblast growth factor receptor signaling pathway biological_process
GO:0031076 embryonic camera-type eye development biological_process
GO:0070121 Kupffer's vesicle development biological_process
GO:0007368 determination of left/right symmetry biological_process
GO:0048339 paraxial mesoderm development biological_process
GO:0021703 locus ceruleus development biological_process
GO:0048665 neuron fate specification biological_process
GO:0060271 cilium assembly biological_process
GO:0010002 cardioblast differentiation biological_process
GO:0030878 thyroid gland development biological_process
GO:0007422 peripheral nervous system development biological_process
GO:0030901 midbrain development biological_process
GO:0060037 pharyngeal system development biological_process
GO:0030903 notochord development biological_process
GO:0030335 positive regulation of cell migration biological_process
GO:0048705 skeletal system morphogenesis biological_process
GO:0042664 negative regulation of endodermal cell fate specification biological_process
GO:0048709 oligodendrocyte differentiation biological_process
GO:0060059 embryonic retina morphogenesis in camera-type eye biological_process
GO:0005764 lysosome cellular_component
GO:0005615 extracellular space cellular_component
GO:0005104 fibroblast growth factor receptor binding molecular_function
GO:0008083 growth factor activity molecular_function

KEGG:

id description
K04358 FGF; fibroblast growth factor

RNA

RNA id representative length rna type GC content exon number start site end site
NM_001291263.1 False 2240 mRNA 0.43 5 16916784 16922940
XM_022684400.1 True 2290 mRNA 0.44 5 16916701 16922940

Neighbor

gene id symbol gene type direction distance location
LOC103035008 slc2a15a,LOC103035008,LOC108442702,LOC107716293,LOC107673883,LOC108262874,LOC107585370,LOC107708408,LOC107696166 coding upstream 36941 16852704 ~ 16879760 (+)
b3gat2 b3gat2 coding upstream 365055 16524117 ~ 16551646 (+)
LOC103032358 asrgl1,LOC103032358,LOC105911569,LOC107695955,LOC107585330,LOC108442615,LOC107673965 coding upstream 463997 16439597 ~ 16452704 (+)
mb21d1 NA coding upstream 800211 16110265 ~ 16116490 (+)
LOC103021740 LOC108442579,LOC108263602,LOC108258313,LOC108441988,LOC105023253,LOC107716315,LOC107693767 coding upstream 808135 16103228 ~ 16108566 (+)
fbxw4 fbxw4,LOC107716323,LOC107707737,LOC107694796,LOC107673945,LOC107588663 coding downstream 8158 16931098 ~ 16967406 (+)
wbp1l wbp1l coding downstream 59113 16982053 ~ 16994408 (+)
cnnm2 cnnm2,cnnm2a,LOC107673921,LOC107716327,LOC107585325,LOC107588659 coding downstream 87615 17010555 ~ 17029001 (+)
LOC103037825 ina coding downstream 129040 17051980 ~ 17056045 (+)
polr1c polr1c coding downstream 140956 17063896 ~ 17067641 (+)
LOC111196035 NA non-coding upstream 18307 16883025 ~ 16898394 (+)
G216941 smap1,LOC107588664,LOC107694205,LOC107585328 non-coding upstream 197220 16560852 ~ 16719481 (+)
G216953 NA non-coding upstream 429163 16485902 ~ 16487538 (+)
LOC103031925 NA non-coding upstream 446832 16455337 ~ 16469869 (+)
G216910 NA non-coding upstream 593400 16255488 ~ 16323301 (+)
G217109 NA non-coding downstream 86634 17009574 ~ 17009798 (+)
G217122 pcgf6 non-coding downstream 135390 17058330 ~ 17060581 (+)
G217140 NA non-coding downstream 341190 17264130 ~ 17264431 (+)
G217222 NA non-coding downstream 472099 17395039 ~ 17395249 (+)
G217313 NA non-coding downstream 853826 17776766 ~ 17777086 (+)
bcl11a bcl11a,bcl11aa,LOC107666449,LOC107601892,LOC107743494,LOC107655449,LOC107559339 other upstream 2136388 14722400 ~ 14780313 (+)
gsto1 gsto1 other upstream 2569368 14342232 ~ 14347333 (+)
spef1 spef1 other upstream 3166395 13740513 ~ 13750306 (+)
LOC103033819 LOC108426824,LOC108263419,LOC107725444 other upstream 3432330 13479176 ~ 13484371 (+)
trnay-gua_11 NA other upstream 3600539 13316075 ~ 13316162 (+)
borcs7 borcs7 other downstream 81601 17004541 ~ 17007537 (+)
LOC111195981 tacc2 other downstream 226402 17149342 ~ 17184251 (+)
pax2 pax2,pax2a,LOC107668824,LOC101463634,LOC107588637,LOC107716343,LOC107585307 other downstream 1081313 18004253 ~ 18039352 (+)
eif4ebp2 eif4ebp2,LOC107564345,LOC107716353,LOC107668794,LOC107673927 other downstream 1388953 18311893 ~ 18317228 (+)
LOC103030769 LOC103030769 other downstream 1820266 18743206 ~ 18744327 (+)

Expression


Co-expression Network