alox5 (alox5,alox5a,LOC107747471,LOC107708393,LOC107690200,LOC107582511,LOC107678516)


Basic Information

Item Value
gene id alox5
gene name alox5,alox5a,LOC107747471,LOC107708393,LOC107690200,LOC107582511,LOC107678516
gene type coding
species mexican tetra (Astyanax mexicanus)
category of species ornamental fish

Chromosome Information

Item Value
chromosome id NC_035921.1
NCBI id CM008324.1
chromosome length 46505145
location 23723299 ~ 23742646 (-)
genome version Astyanax_mexicanus-2.0_2017_mexican_tetra_Genome

Sequence

>XM_007240281.2
TGTGTGCTACAGAAGGGGAAATGCATTCTGCAAGAGGCTGCAGAGTGTACAAGTACAGAAACTGGTCTGTGAGCTTCAGTAAGAGTAGGATGCCTTGCTACACAGTGACCGTCGCTACGGGCAGCCAGTGGTTCGCTGGTACAGATGACTACATCTACCTGACTCTGGTGGGGACGGAGGGCTGCAGTGAGAGAACCCTGCTGGATAAGCCCCTCTATAATGACTTTGAGAGAGGAGCGGTGGACTCCTATGACATCACTGTGGGGGAGAACATCGGCGACATCGTACTGATCAAGATTGAGAAGAAGAAATACTGGGTGCACgatgactggtactgtaaatacaTTACAGTGAAGACCCCCTCTGGAGATTACATCGAGTTCCCCTGCTTTCGCTGGCTGGTGGACGACAAAGAGGTGATTCTTCGAGATGGCCGAGCTCGATTGCCACAGGATGACAAAACCAGGGTGGCGAAACAACACAGACGCAAGGAGCTGGAGACCAGACAAAAGACATTCAGATGGAAGGAATGGCACCCTGGCTTTCCCATGAGCATCGATGCTAAAGCCCACAAAGAACTGCCACGAGACATCCAGTTTGACAGTGAGAAAGGTGTAGATTTCATCCTCAACTACAGCAAAGCGATAGAGAATCTCTACGTTAACCAGTTCATGCACATGTTCCAGTCTTCCTGGGGggatttctctgattttgagcGGATCTTTATGAGGATCAAGAACACAATATCAGAGTACGTGATGCAGCACTGGAAGGAAGACTTCATGTTTGGATATCAGTTCTTAAACGGCTGCAATCCTGTCATGATCCAGAAGTGCACACAAATCCCAAAGAAGTTTCCTGTGACACATGAAATGGTGGCTGACTGCTTAGAAAGAGACCTCACCCTGGAAGAGGAGCTTAAAGCAGGAAACTTATACATAGCAGATTACGAGATAATGGAGGATATAACCGCGAACGCTACAGACCCATGCACTCCACAGTATTTGGCTGCACCAATTTGCTTGCTTTACAAGAACAGCCAGAACAAGATTTTGCCGATTGCCATACAGCTGAGTCAAAGCCCAGGAGAAGACAGCCCCATCTATCTCCCCAGTGATGATCAGCATGACTGGCTTTTGGCCAAAATTTGGGTGAGATCGTCCGATTTTCACGTGCACCAGACAGTGACGCATCTTCTCAGGACCCATCTGATATCAGAGGTGTTTGGCATCGCCATGTTCAGACAGCTGTCTGCTGTTCATCCAGCCTATAAGTTGCTTCTGCCACACATTCGTTTCACAATCGCCATTAACACCAAGGCACGAGAGCAGCTCATCTGTGAGAATGGACTCTTTGACAAGGCTAATGGCACAGGAGGAGGTGGCCATGTGCAACTCGTGCAGAAGGCCATGAAGACTTTTACCTACAAGTCCCTGTGCTTCCCAGAGTCTATAAAGGCTCGTGGTATGGAGAGCCAAGAAGAGCTGCCATACTACTACTACAGAGATGATGGCAACAAAGTGTGGGAGGCGATCAAAAGTTTTGTGACAGATATGATTAACATCTACTATGCCAGTGATGAGACAGTACAGGAGGATGAGGAGATACAGGCATTCGTCAAAGATGTCTGCAGCTTTGGAATGCAGGATTTTGACTACTGTGAGTTCCCTAAATCAGTGCAGACTCTGGAGCAGCTGGTGGAGTATCTGACCGTCGTAATCTTCACCGCTTCTGCTCAACATGCCGCCATCAACTTCGGACAGTATGACTGGTGTTCCTGGATTCCAAATGCTCCCCCCACCATGCGGAACCCCCCTCCCACCAAGAAGGGCCAGACAGACATGAAGCTCATAGTGGAGAGTCTGCCTGACCGTGGCCGCTCCTGCTGGCATCTTGGAGCAGTGTGGGCCCTTAGTCAGTTCCAGGAAAACGAGtTGTTCTTAGGCATGTATCCTGATGAACACTTCATAGAGAAACCTGTGAAGAAGGCTCTAGAGACTTTCCGGGAAAAACTGACTGAGGTGTCCAAATTAATCAAGAATCGCAACGAAGGAAAGAAGCTGCCCTATTACTACCTGTCCCCAGACAGAATCCCCAACAGTGTGGCGGTGTGAGCCTGCACATCTGgctgatttaaaaacagtggtGATACATTTGTTAGTTCATAATTTAGTTTAGATGCTTGGATTTCTAGTCCCTCTCATTGACGTCTTTACCGTTTCTGTTTGTTCTGTAATATAGATGAAtatgaaaacaaacacagtgaAATCCTGCATTCTGTCAATTATGCTGTGAATTGAttggtgtgtttttgttgttaaatTTTTAGCTAATGAAAATTTAAAGcgctttttttctcttgtttttgtgTCTCTTATCAAATaaagtcttacttaaaatgTCATATTATTCAAGCCACTGTGTAAACTGAAATGAGCCCAGAATTTATACAACATTCCCATCACAAGTGTCGGTGTGCCTGTATTCAACACAAACAAGAGCgatgttttatctgttttatatttttactgtgtGAATTGGCTTTGTGGAATTGATTTCATTTATAGTAAAACTAGAATCTGAATGAACTAAATGTAACCAATAT

Function

symbol description
alox5a Enables arachidonate 5-lipoxygenase activity; arachidonic acid monooxygenase activity; and leukotriene-C4 synthase activity. Acts upstream of or within arachidonic acid metabolic process. Predicted to be located in cytoplasm. Predicted to be active in nuclear envelope. Is expressed in pronephric duct. Human ortholog(s) of this gene implicated in artery disease (multiple); asthma (multiple); pancreatic cancer; and pulmonary tuberculosis. Orthologous to human ALOX5 (arachidonate 5-lipoxygenase).
alox5 Enables arachidonate 5-lipoxygenase activity and iron ion binding activity. Involved in several processes, including leukocyte chemotaxis involved in inflammatory response; leukotriene A4 biosynthetic process; and lipoxin biosynthetic process. Located in cytosol; nucleus; and perinuclear region of cytoplasm. Implicated in artery disease (multiple); asthma (multiple); pancreatic cancer; and pulmonary tuberculosis. Biomarker of several diseases, including cholangiocarcinoma; common cold; pancreatic cancer; pulmonary fibrosis; and pulmonary hypertension.

NR:

description
PREDICTED: arachidonate 5-lipoxygenase

GO:

id name namespace
GO:0055114 oxidation-reduction process biological_process
GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen molecular_function
GO:0005506 iron ion binding molecular_function

KEGG:

id description
K00461 ALOX5; arachidonate 5-lipoxygenase

RNA

RNA id representative length rna type GC content exon number start site end site
XM_007240281.2 True 2605 mRNA 0.46 14 23723299 23742646

Neighbor

gene id symbol gene type direction distance location
LOC111195939 fam21c,LOC107678570,LOC107589565 coding downstream 8941 23709285 ~ 23714358 (-)
washc2c NA coding downstream 15029 23693256 ~ 23708270 (-)
zfand4 zfand4 coding downstream 31404 23662698 ~ 23691895 (-)
LOC103037680 vdac2,LOC108444242,LOC107747461,LOC107582506 coding downstream 277174 23438656 ~ 23446125 (-)
lrmda cunh10orf11,c3h10orf11,c13h10orf11,LOC103041229,LOC107747465,LOC107678567,LOC107708444,LOC105909757 coding downstream 436850 22846282 ~ 23286449 (-)
slc25a16 slc25a16,LOC107678603,LOC107708451,LOC107747470 coding upstream 7488 23750134 ~ 23762804 (-)
LOC103041217 mat1a,LOC107582520,LOC107678534,LOC107733750,LOC107708460,LOC108263526,LOC105911600,LOC107570529 coding upstream 288228 24030874 ~ 24040368 (-)
LOC103040609 LOC103040609,LOC108441766,LOC108263463,LOC107678536,LOC107708462,LOC107570532,LOC106577244 coding upstream 337221 24079867 ~ 24091509 (-)
lzts2 lzts2,lzts2a,LOC107733684,LOC107582523,LOC107708464,LOC107690159,LOC107570533 coding upstream 395176 24137822 ~ 24255139 (-)
LOC103038918 LOC108441763,LOC108263187 coding upstream 585437 24328083 ~ 24401465 (-)
G218602 NA non-coding downstream 256255 23459492 ~ 23467044 (-)
G218527 NA non-coding downstream 880085 22843001 ~ 22843214 (-)
G218519 kcnma1 non-coding downstream 905195 22809819 ~ 22818104 (-)
G218448 anxa11,anxa11a,LOC108263209 non-coding downstream 1271363 22441756 ~ 22451936 (-)
G218441 NA non-coding downstream 1303926 22416898 ~ 22419373 (-)
G218698 NA non-coding upstream 15785 23758431 ~ 23760825 (-)
G218703 NA non-coding upstream 41172 23783818 ~ 23784105 (-)
G218697 NA non-coding upstream 42721 23785367 ~ 23786980 (-)
G218709 NA non-coding upstream 73225 23815871 ~ 23816669 (-)
G218706 NA non-coding upstream 79837 23822483 ~ 23824595 (-)
march8 march8 other downstream 66313 23454175 ~ 23656986 (-)
G218545 NA other downstream 877094 22844833 ~ 22846205 (-)
G218329 eif5,LOC107589547 other downstream 1666806 22051889 ~ 22056493 (-)
LOC103022835 NA other downstream 1678187 22038423 ~ 22045112 (-)
G218240 NA other downstream 1868158 21851372 ~ 21855141 (-)
LOC103032322 eif4e1c,if4e,LOC103032634,LOC108444323,LOC107690176,LOC107582514,LOC103032322,LOC108444348 other upstream 93133 23835779 ~ 23849800 (-)
G218720 LOC108444338,LOC104946244,LOC101064687,LOC103387332 other upstream 108317 23850963 ~ 23857507 (-)
G218781 NA other upstream 312879 24055525 ~ 24056877 (-)
LOC103045183 emx1,LOC103045183,LOC108441775,LOC108263581,LOC107567848,LOC107678523,LOC107733702,LOC107690190,LOC102233543,LOC103458176,LOC103150078,LOC107097582 other upstream 940591 24683237 ~ 24700649 (-)
LOC103046115 lrit3 other upstream 1475503 25218149 ~ 25226250 (-)

Expression


Co-expression Network