l2hgdh (l2hgdh)


Basic Information

Item Value
gene id l2hgdh
gene name l2hgdh
gene type coding
species mexican tetra (Astyanax mexicanus)
category of species ornamental fish

Chromosome Information

Item Value
chromosome id NC_035921.1
NCBI id CM008324.1
chromosome length 46505145
location 34844494 ~ 34858483 (+)
genome version Astyanax_mexicanus-2.0_2017_mexican_tetra_Genome

Sequence

>XM_007247598.3
GCAGGAGGAGAGGGGTGGTTTAGGTGGTGTAGGGTAGTAAAGGGTGGTGTAGGAGGTACAGGGGGCTATGTGGTGTTCTGTAGCGCTGATATGAGACCCTGTTCATCGCTTTTATtctctgtattttatgttttaacctCGCAGTTATGAGACCCGCTGTGTTAGTGCTTAAGCGGCTGCGCTTCACTCAGATCCGCCTGCAGCACCGCAGtgcCTGTGATGTGGCCGTAGTTGGAGGAGGGATTGTAGGTCTGGCATCAGCGAGAGAGCTCATCCTCAGACACCCCAACCTCACCTTCACCCTgctggagaaagagaaggagctTGcTCTTCATCAGACGGGTCATAACAGTGGAGTGATCCACAGTGGGATCTACTACACACCTGGATCTCTAAAAGCacgtctgtgtgtgagaggagcaTCTCTGGCCTATTCCTACTGCGACCAGAAAAACATTCCCTAcagaaaatgtggaaaaCTGATCGTGGCGGTGGAGAGGGAGGAGATCCCCCGTTTGAAGGCTCTGTATGAGCGCGGGctgaaaaataatgtaaaagaaTTATCTATAATCGATGCCCGAGCCATCCGAGAGAGAGAGCCCTACTGCAGggggATCATGGCTCTGGACTCCCCTCACACTGGGATTGTAGACTGGCGTTTGGTGTCTCTAACCTATGCAAAAGACTTTCAGGAGGCTGGTGGATCAGTAGGAACGGGCTTCGAGGCTTCAGACATTGCAATGGCAACAGAAAGTCCAGCTAGCAGCACTGAGGGTCTGAAGTTCCCACTCGTTATCAGGAGCTCGAAGGGGGAGGAGGTGAGGTGTCGGTTTGTGCTGACCTGTGGAGGTTTGTACTCTGATCGTCTCTCAGAGATTTCAGGCTGTAGTCCGGAGCCTCGTATCGTCCCCTTCAGAGGTGATTATCTCGTACTGAAACCAGAGAAGAACTACCTCATCAAGGGCAACATTTATCCTGTCCCAGATCCACGGTTTCCGTTCCTGGGCGTGCATTTTACCCCTCGTATGGACGGAAGTGTGTGGCTGGGGCCCAACGCTGTACTGGCCTTTAAACGGGAGGGATATAAACTATACGACTTCAACGCTAAAGACTTCACAGACGCGCTGTCCTTCAGaggttTACAGAAGCTGGTGCAGAAGAATTTGGTGTATGGAGTGGGGGAAATGTACAGGGGGGTGTTCCTCAGTGCACAAGTGAAGATCCTGCAGAAATACATACCGGAACTCAGCAGCAGTGATATCGTCAGGGGACCGTCTGGAGTAAGGGCGCAGGCTCTGGACCATGAGGGGAACCTGGTGGATGATTTTGTTTTTGATGGAGGTGTGGGGGAGCTGGGCAGCCGTGTGCTGCACGTCCGCAATGCACCGTCTCCCGCAGCAACCTCCTCCCTCGCCATCGCCGAGATGATCGCAGACGAACTGGAGGCGCGGTTCAAACTGTAGACACACAAccccacacacagagagacatcaGACTGAGAGAACAGACATTATTTACTACAAATATCATATAAGGGGTGATTCTGTCACAGATCTAACTCATACAGTTTTCCCCCTCTTTCACATTAATCACAGCACATCATCCAGTAGACTATCAGAACATCTGTAAACATCTGTAAACATGGAATACAGAACTGATGCACTTTAGCTGTTGACGCTTTGTGTTTAACAGCGTTTCATCTTTCAGTTCATGATctataaaacatcatcagagaCTACAAAAACAATTCTATCTGATATTACTGTGGTGGTTTGGGCCTTCAGTAAGCAGCAGTGCTAATAAATAATCACAATCCCAAAGCCTCACCAAGTTCAGTACATAAACCACAATGCCTTTAAACATGCAGCATTACATTGCAAAAAttacttgttttcttgtttgtttatttattggctGCTGCATGGGAAATAATTACTAAACTCTCGGGACACATTAGatcattaattatatttaatatttggttgTGTAACTGAATGTGGAGCAGGACCAATATTGGATGTCCTGATTTCTTTTTCTGATATCTTTTGTTATTTGAATTTTGCACATCAATAAGAGATTTTAAGgctctgtttgttagtttgggaattatttagcattattttcttttaaacataaaataatacaaaaatatttttgtaatgatGTGGGAGTTTTTCCAAGTGGAATGTAATAACTGTtgtggtgctgttt

Function

symbol description
l2hgdh Predicted to enable (S)-2-hydroxy-acid oxidase activity and 2-hydroxyglutarate dehydrogenase activity. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in 2-hydroxyglutaric aciduria; L-2-hydroxyglutaric aciduria; cerebellar ataxia; hereditary spastic paraplegia; and visual epilepsy. Orthologous to human L2HGDH (L-2-hydroxyglutarate dehydrogenase).

NR:

description
L-2-hydroxyglutarate dehydrogenase, mitochondrial

GO:

id name namespace
GO:0055114 oxidation-reduction process biological_process
GO:0016491 oxidoreductase activity molecular_function

KEGG:

id description
K00109 L2HGDH; 2-hydroxyglutarate dehydrogenase

RNA

RNA id representative length rna type GC content exon number start site end site
XM_007247598.3 True 2211 mRNA 0.46 10 34844494 34858483

Neighbor

gene id symbol gene type direction distance location
LOC103021397 NA coding upstream 15037 34794083 ~ 34829457 (+)
LOC103021727 vip,LOC107585469,LOC108262931,LOC107655780 coding upstream 1385712 33454776 ~ 33458782 (+)
acoxl acoxl coding upstream 1633757 33109959 ~ 33210737 (+)
fbln7 fbln7,LOC107679196,LOC107754577,LOC107688955,LOC107733340,LOC107585467 coding upstream 1870926 32946416 ~ 32973568 (+)
LOC111196032 NA coding upstream 1922916 32911781 ~ 32921578 (+)
sos2 sos2,LOC107654947 coding downstream 4655 34863138 ~ 34892584 (+)
cdkn3 cdkn3 coding downstream 67801 34926284 ~ 34932635 (+)
LOC103035732 LOC103035732,LOC108411054,LOC106924735,LOC102214456,LOC105891002,LOC101468242 coding downstream 110741 34969224 ~ 34979881 (+)
LOC103035102 LOC103035102,LOC108411051,LOC794838,LOC107705434,LOC107654921,LOC107553207,LOC105890990,LOC107602927 coding downstream 143722 35002205 ~ 35014129 (+)
pacs2 pacs2 coding downstream 178149 35036632 ~ 35108241 (+)
G221422 NA non-coding upstream 7142 34836961 ~ 34837352 (+)
G221419 NA non-coding upstream 8634 34830093 ~ 34835860 (+)
G221377 NA non-coding upstream 827351 34013515 ~ 34017143 (+)
G221369 NA non-coding upstream 901943 33942227 ~ 33942551 (+)
G221361 fgfr2 non-coding upstream 986960 33854494 ~ 33857534 (+)
G221438 NA non-coding downstream 36978 34895461 ~ 34898316 (+)
G221420 NA non-coding downstream 46295 34904778 ~ 34905637 (+)
G221441 LOC108411061 non-coding downstream 48290 34906773 ~ 34907405 (+)
G221445 NA non-coding downstream 60088 34918571 ~ 34918853 (+)
G221446 NA non-coding downstream 62854 34921337 ~ 34921649 (+)
G221390 ate1 other upstream 661257 34162581 ~ 34183237 (+)
G221292 NA other upstream 1399773 33444117 ~ 33444721 (+)
bcl2l11 bcl2l11 other upstream 1611703 33213628 ~ 33232791 (+)
LOC103038412 LOC108430255,LOC107679129,LOC107585442,LOC107688640 other upstream 2167209 32613474 ~ 32677285 (+)
LOC103027057 fbxo11a,msh6,LOC108413220,LOC107725019,LOC107588452,LOC107679165,LOC107733352,LOC108430631 other upstream 2265942 32502774 ~ 32578552 (+)
synj2bp synj2bp,LOC108411060 other downstream 128516 34986999 ~ 34997044 (+)
srsf5 srsf5,srsf5a,LOC107553206,LOC107736490,LOC108411053,LOC107602962 other downstream 159959 35018442 ~ 35025598 (+)
LOC103031497 NA other downstream 349948 35208431 ~ 35218378 (+)
gclc gclc,LOC107597697,LOC107664701,LOC107712340,LOC107688787 other downstream 1011535 35870018 ~ 35888815 (+)
G221728 fbxo9 other downstream 1111506 35969989 ~ 35972354 (+)

Expression


Co-expression Network