th (th,LOC108274586)


Basic Information

Item Value
gene id th
gene name th,LOC108274586
gene type coding
species mexican tetra (Astyanax mexicanus)
category of species ornamental fish

Chromosome Information

Item Value
chromosome id NC_035904.1
NCBI id CM008307.1
chromosome length 27092187
location 11105654 ~ 11116630 (+)
genome version Astyanax_mexicanus-2.0_2017_mexican_tetra_Genome

Sequence

>XM_007228063.3
GAAATTAgctgtacttttaaatataaGAGTATTACCATTGTTGATTTCCATAAAGAACCATATTTGtatgtgaagaaccttttaaaacTCAAAAGAACCAAAACCATCAATTCGTTCACCAGTTTGAATGTTTTTCTTCCACTTTATGgaagcaaatgttttttttttttctatagcaTCACTCAAATTAACATTTGTTACCAATTGAACCCCAATATAAGGTTAACTAACGAATCTCTGGCCAaccaaatatacatttaaactaattaaaaaccaATGCTCATAAAACCAGTTGGCTTTAAAGAAGAGCAGGGGTGGGGGAGTTTCAGAAACGCTGGACGGCGAGAATTAGAGGCTGTTTGACGTCAGTAAAGAGAAATTGTCTCTATAAATACTGTGAGTGATAGAAAAAGCCCAGCGCAGCCAACAAACCCAACAAAGCCAGCACTTTCCACCCAGAAGGAGCAGCAGGACGTCTCGGACATCTGAAGCAAAAGATCGCCAAGAGAAGAGCATCAACAGCTGAGTTATGCCCAATTCAACCAGCTCCACATCATCCACCAAAAGCATGAGGAGAGCCGCGTCCGAGCTGGAGCGCTCTGACTCCATCACGTCTCCGCGGTTCGTGGGGAGGCGGCAGAGCTTGATCGAGGACGCGCGGAAAGAGCGCgaggcggcggcggcggcggcggcagcagcgGCGGAGGCGGCGGAGACCAACGAGCACATCGTGTTCGAGGAGGAGGATGGAAAAGCCCTGCTCAATCTCTTCTTCACCCTGAGGAGCTCCAAGAGCCCTGCCCTTTCCCGCACACTCAAAGTGTTCGAGACATTTGAAGCCAAGATGCATCACCTTGAGACCAGACCGAGTCGGAAGCCTAAAGATGGTCTGGAGGATTTAGAATACTTTGTGCGGTGTGAAGTGCATCTCTCAGACGTTAGCACTCTCGTCAGCTCCCTGAAGAGGATCGCAGAGGATGTCAGAACCACTAAAGAGGTTAAATTTCACTGGTTTCCAAAGAAAATAGCTGAACTGGATAGATGTCATCACTTGGTCACTAAATTTGATCCAGATTTGGACCAGGATCATCCCGGCTTCACAGACCCAGTGTACAGAAAACGAAGAAAGCAGATTGGTGACATTGCCTTCAAATACAGGCATGGAGAGTCAATCCCCAGAGTGGAGTACACAGAGGAGGAAATTGGAACATGGAGGGAGGTCTACAGTACCCTTAGGGACCTGTACACCACTCATGCATGCAGTGAGTATCTAGATGCATTGAAGCTGCTGGAGAAGCACTGCACGTACAGCCCTAACAACATCCCTCAGCTGGAGGACGTCTCaaattttttaaaagAGCGTACTGGGTTTCTGCTGAGGCCAGTGGCAGGTCTTCTGTCAGCACGAGATTTTTTGGCCAGTCTGGCATTCCGCGTGTTCCAGTGTACACAGTACATCCGCCATGCTTCCGCACCCATGCACTCTCCAGAACCAGACTGTGTGCATGAGCTCCTTGGACATGTCCCGATGCTAGCTGATAAAACATTTGCTCAGTTTTCCCAGAGCATTGGTCTTGCCTCTCTCGGTGCATCAGAAGAAGACATTGAGAAACTGTCAACCcttTACTGGTTCACAGTGGAGTTTGGGCTGTGTAAGCAGGGAGACACATTGAAAGCTTATGGTGCAGGCCTTCTGTCTTCCTACGGCGAGCTAGTGCATGCGCTGTCAGATGAGCCAGAGATCCGTGAATTTGATCCAGAGACTGTAGCTGTGCAGCCGTACCAAGACCAGGAATACCAGTCTGTCTACTTCGTGTCTGAGAGCTTCGCTGATGCTAAAGAAAAACTGAGAGGATATTCTACGGGCATCAAGAGGCCGTTTTCAGTCAGGTTCGACCCGTTCACAAGCAGCATAGAAGTGCTGGACAACCCCCTAAAGATCAGAGGAGGACTGGAATTAGTCAAAGAAGACCTGAAGGTCTTGACAGACGCCTTAAATGTGCTGGCATGAGCTTACCCGGCCCTGCCACCTGCCCTGCCACCCTGTCCCTCACTGCTTACTATGTGCCATTTTCTATATGTTGTGTTTCTTGTACTGTTTTGCTGCTGCTGAAGTTGTTGCTTTTAAAAAGCTGGGTGGCAACCACGAGACCTCACGTTAGAGTTTGTTTCCAAAGATTTATTGGGTCACTTGGTGACTCTATTTCAGTTTCTGTCAGAAATgtgtggtatttttttttttttgaagagatTTATCCACTGAGTCAAAgccaaattatatttattaaaaataaataaaatactatgtaataaaattactatttatttagtatatacaAATAGGTGTGTCTGTTTAAACCAGTAGTTCTCAGTAGTTATCTATGTACCACTGGTGGAACTTAAAGCATCCCACTATGGTTCCGAGAAGACCTCAGAAAATTGACTACATGCACAGAAATGTTAACATCCATGTTCAAAGATTTATTCTGTAATTGTTATGATTTTAGATATGTTTATGTTCAGTGCTTTACCCAGTAAATACTGTGCGTAAGCTCACTCTTTAGTGCACACTTTACTCTCATAGCCACAGGGATATAATTATTATCAACAGTTTTATAGGACCTACAACAAAACCCTCTGTAGTTTCTGCATTAGGGTTATTAGCTGAACGGTTAACATACGATTCAAAGgaaggttatttttttttgctaaacacACAGTAGCATGGATTATGGTTGATACCTGTGATCCAAGtctgagaaacactgatttaaacaACCCTGGAGCCTCAGCCTCTTCCAATTATGAATGTATATATAgtttcaataatatatatatatatacatatatcatgGCATAAGTGTTAATAATGTGAAGTATGCTCTTGCAATCGGTGATCATTTTTCATTACCATGCACCGCCACACAGTACGCTGTGTGCTTCTAAGTTTTTCCAAGTGTGAATTTATCtctaaatagctaaaataaaacaatgaaataaattactttttactttcagtattgGTCATGCTTTGGCTATTATTTGATGTGGAAAGTACTGTGCTTCGTGCATTGTGGTGGCCGACTCAAACGCATCGTTTCAGCTGTGCTTGCCTTTGAGGCAATCAAGTGCTGctaatataaaatcaacatgatggaaaataaaccattttaaagtga

Function

symbol description
th Enables tyrosine 3-monooxygenase activity. Acts upstream of or within dopamine biosynthetic process and spinal cord motor neuron differentiation. Predicted to be located in perinuclear region of cytoplasm. Predicted to be active in axon; cytoplasm; and perikaryon. Is expressed in several structures, including chromaffin cell; digestive system; head; nervous system; and posterior presumptive neural plate. Human ortholog(s) of this gene implicated in Parkinson's disease; Parkinsonism; hypertension; and obesity. Orthologous to human TH (tyrosine hydroxylase).

NR:

description
tyrosine 3-monooxygenase

GO:

id name namespace
GO:0042416 dopamine biosynthetic process biological_process
GO:0042136 neurotransmitter biosynthetic process biological_process
GO:0009072 aromatic amino acid family metabolic process biological_process
GO:0055114 oxidation-reduction process biological_process
GO:0005506 iron ion binding molecular_function
GO:0004511 tyrosine 3-monooxygenase activity molecular_function

KEGG:

id description
K00501 TH; tyrosine 3-monooxygenase

RNA

RNA id representative length rna type GC content exon number start site end site
XM_007228063.3 True 3179 mRNA 0.43 13 11105654 11116630

Neighbor

gene id symbol gene type direction distance location
LOC103022764 uevld,LOC108275186 coding upstream 57256 11037500 ~ 11048398 (+)
spty2d1 spty2d1 coding upstream 70826 11029486 ~ 11034828 (+)
igsf22 igsf22 coding upstream 105063 10975721 ~ 11000591 (+)
tsg101 tsg101,tsg101a coding upstream 883827 10212563 ~ 10221827 (+)
LOC103047796 NA coding upstream 893158 10207709 ~ 10212496 (+)
LOC103024122 LOC108439251,LOC100136550,LOC100304637,LOC107675272 coding downstream 6549 11123179 ~ 11132277 (+)
LOC103028645 LOC108428835 coding downstream 446702 11563332 ~ 11634593 (+)
LOC103029705 mob2,LOC108411394,LOC108274974 coding downstream 549185 11665815 ~ 11733195 (+)
LOC103038976 LOC108428833 coding downstream 809357 11925987 ~ 11938380 (+)
myod1 myod1,myod coding downstream 822894 11939524 ~ 11941817 (+)
G72766 NA non-coding upstream 90047 11008549 ~ 11015607 (+)
G72753 NA non-coding upstream 303882 10799546 ~ 10801772 (+)
G72752 NA non-coding upstream 306809 10797992 ~ 10798845 (+)
LOC111193092 NA non-coding upstream 1006509 10097259 ~ 10099145 (+)
G72617 NA non-coding upstream 1046768 10058685 ~ 10058886 (+)
G72871 NA non-coding downstream 68036 11184666 ~ 11184981 (+)
G72875 NA non-coding downstream 106144 11222774 ~ 11223004 (+)
G72876 NA non-coding downstream 108164 11224794 ~ 11226186 (+)
G72882 NA non-coding downstream 404382 11521012 ~ 11522661 (+)
G72893 NA non-coding downstream 450947 11567577 ~ 11625496 (+)
LOC103022150 brsk2a,brsk2b,LOC107707552,LOC107675281,LOC107600443 other upstream 478690 10272919 ~ 10626964 (+)
G72621 NA other upstream 1023514 10078579 ~ 10082140 (+)
LOC103043718 LOC103043718,LOC108442465 other upstream 1135612 9968506 ~ 9970042 (+)
G72281 LOC107754548,LOC108274935,LOC107754545,LOC107754498 other upstream 1956235 9142899 ~ 9149419 (+)
LOC103030246 pcdh2ab8,pcdh2ab10,pcdh2ab12,LOC108430950,LOC101884096,LOC108274577,LOC107588388,LOC108430926,LOC108430925,LOC108430922,LOC108275110,LOC108430948,LOC108275111,LOC107588302,LOC107660888,LOC107754492,LOC107655665 other upstream 2069628 8869128 ~ 9036026 (+)
LOC103043719 NA other downstream 1754854 12871484 ~ 12897931 (+)
G73533 NA other downstream 3532199 14648829 ~ 14649551 (+)
rpgrip1l rpgrip1l other downstream 3774904 14891534 ~ 14921003 (+)
svip svip other downstream 4455672 15572302 ~ 15577533 (+)
G74169 NA other downstream 5170046 16286676 ~ 16288329 (+)

Expression


Co-expression Network