tph1 (tph1,tph1a,LOC107673292,LOC107564603,LOC107670227)


Basic Information

Item Value
gene id tph1
gene name tph1,tph1a,LOC107673292,LOC107564603,LOC107670227
gene type coding
species mexican tetra (Astyanax mexicanus)
category of species ornamental fish

Chromosome Information

Item Value
chromosome id NC_035904.1
NCBI id CM008307.1
chromosome length 27092187
location 23703925 ~ 23710875 (+)
genome version Astyanax_mexicanus-2.0_2017_mexican_tetra_Genome

Sequence

>XM_007235176.3
AAGCGCCCTGCCTCGGTGTATTATTCCATCACGGGCAAACTGAGACCGGGCAAAAGGGTTGATCATAATCAGACCTCGGGCGAATAAATAGCAGCCTTGACGAGCTAAAAATGTACTCAAGCAAAAGCGAGGGTCCACGCAGAGGGAGGTCCTTCGACTCCATGAACATCGGCCTCACTCTGGAAGGGAAGCAACTTAACAATGAGATGAACAAATCTGCATACCCTAAGATAGATGAAAACAAAGACAACAAAAGCGAATCTGCAGAGAAGGGTCGTGCAGCTATTGTCTTCTCCCTGAAGAATGAGGTCGGTGGGCTTGTCAAAGCACTAAAGCTATTCCAGGAAAACCACGTCAACCTCGTGCACATTGAGTCGAGGAAATCGCGGAGGCGAAACTCGGAGTTTGAGATCTTGGTGGACTGCGACAGCAACCACGAGCAGCTCAACGAGATCATCCAACTGCTGCGCAAACACGTAAACGTGCTGGACACTGAGACGTCAATCAAGAGCCTCCCAGAAGAAGACGAGATGGATAATGTACCCTGGTTCCCCAAGAAGATCGCCGATCTGGATAAATGCGCTAATCGTGTACTGATGTATGGATCAGACCTGGATGCAGACCACCCGGGCTTTAAAGACAATGTTTACCGGAAAAGGAGAAAGTATTTTGCAGATTTGGCCATGAGTTACAAGCATGGAGACCCCATCCCCCGTATTGAGTTCACGGAAGAAGAGGTGAAGACGTGGGGTGTTGTGTTCCGAGAGCTAAATAAACTGTATCCCACTCATGCCTGCCGAGAACACCTGAAGAACCTACCTCTGCTCACCAAGTACTGTGGATATCGTGAGGACAACATTCCTCAGCTAGAAGACGTCTCACGCTTCTTAAGAGAGCGTACCGGTTTCAACATAAGACCTGTGGCAGGATACCTCTCCCCCAGAGACTTCCTGGCAGGCTTGGCCTTCCGTGTTTTCCACTGCACACAGTATGTCCGGCACAGCTCGGACCCTCTGTACACACCTGAACCAGACACATGTCACGAGTTACTGGGTCACGTACCTCTTTTGGCTGAGCCCAGTTTCGCTCAGTTCAGCCAGGAGATTGGACTTGCTTCACTGGGAGCATCTGATGAGGCAGTTCAGAAACTTGCCACTTGTTACTTCTTCACTGTGGAGTTCGGGCTGTGTAAGCAGGAGGGGAAACTGAGAGCATATGGAGCAGGTCTGCTGTCCTCCATCAGTGAACTGAGGCACGCTCTGTCGGGGAATGCCCGGATCATGCCCTTCGACCCCAAAGTTACATGCAAACAAGAGTGCATCATCACAACTTTTCAGGACGTGTACTTCGTGTCAGACAGCTTTGAGGAGGCCAAAGTCAAAATGAGGGAGTTTGCAAAGACAATCAAGCGGCCATTCACAGTGCGTTACAACCCCTACACACAGAGCGTGGACGTCCTAAAGGACACAACTAGCATCAACAGTGTGGTGGAGGAGCTGAGACATGAGCTGGACATTGTGGGAGATGCGCTGAACAGACTCAACAAACATCTAGGCGTCTGAATGACTTACAGTGATCTTACAAATCGTCTTATATACACCGCTTTTTCCATCAAAGAGCAAAACCACAGAACTGTTTCCAGTTTCCACCAAATCCACAATAGTGCATCTAATGACAATATCTCACTCATTGTTCAAATCCATTTCAAATTATGTTAATCATCATTTCTGTTTTAGTACCATGGAGCTTTAAAAACTTGCAGTGGtactaatttaattaacttattCATCTATTGTCTTTTACACAATACTTGTGGACATTATATTTGCTTTAAATGTCATTGTGATAAAGTAATACTCTCTGCCatcaatatattgtttttgtgaTTTCAGCTTTTTTGTGTAGAAGTCATTAAaatcatcttggcatcataaGGCACTTTATCATATAATTTGATATTTATTATGGGCTTGTACCTTAAAGCTTTAGTATCACTAGTTTTCTATCTCTATCCACATTATTAGGGGAAAAGGACAAGCACTTGTAATGTTTTGTCTCAGTGTGAACCTAATTCtatcatatttttatgtttatatttattattagctGTGTCTCATGTCCTGTATGCTCTCTTTGTTTTATCTTCATAAAATCAgagcttttattcattttttcatttgtcACTGGGTATGCAAGGGTCATTTTACACATCAGACATCTAAGACTTTGGTCTAATCAATATAGATGCTCCTATTCTCAAACAGTTCATTTACAACAGATTTACACTATGATTTACACTTCAGGTTTCAA
>XM_007235177.3
ctctctctctctctctctcactctgttaaATCGAGACAGCGTTGTGCTCTGACCCGTTGCGATCGACCCTGAGCCGTGAGTGCGCCTCTGACCCGAGTGACCCGCGGGCCGCTCTCAATGCACCGATGCTGTTAGGGATCCTTCAGGCGGGAGGACGCGGCCGGCGGCAGCTGCTCTGCCCCGCAGTCGCGCTACGAGCAATGATGAACAAATCTGCATACCCTAAGATAGATGAAAACAAAGACAACAAAAGCGAATCTGCAGAGAAGGGTCGTGCAGCTATTGTCTTCTCCCTGAAGAATGAGGTCGGTGGGCTTGTCAAAGCACTAAAGCTATTCCAGGAAAACCACGTCAACCTCGTGCACATTGAGTCGAGGAAATCGCGGAGGCGAAACTCGGAGTTTGAGATCTTGGTGGACTGCGACAGCAACCACGAGCAGCTCAACGAGATCATCCAACTGCTGCGCAAACACGTAAACGTGCTGGACACTGAGACGTCAATCAAGAGCCTCCCAGAAGAAGACGAGATGGATAATGTACCCTGGTTCCCCAAGAAGATCGCCGATCTGGATAAATGCGCTAATCGTGTACTGATGTATGGATCAGACCTGGATGCAGACCACCCGGGCTTTAAAGACAATGTTTACCGGAAAAGGAGAAAGTATTTTGCAGATTTGGCCATGAGTTACAAGCATGGAGACCCCATCCCCCGTATTGAGTTCACGGAAGAAGAGGTGAAGACGTGGGGTGTTGTGTTCCGAGAGCTAAATAAACTGTATCCCACTCATGCCTGCCGAGAACACCTGAAGAACCTACCTCTGCTCACCAAGTACTGTGGATATCGTGAGGACAACATTCCTCAGCTAGAAGACGTCTCACGCTTCTTAAGAGAGCGTACCGGTTTCAACATAAGACCTGTGGCAGGATACCTCTCCCCCAGAGACTTCCTGGCAGGCTTGGCCTTCCGTGTTTTCCACTGCACACAGTATGTCCGGCACAGCTCGGACCCTCTGTACACACCTGAACCAGACACATGTCACGAGTTACTGGGTCACGTACCTCTTTTGGCTGAGCCCAGTTTCGCTCAGTTCAGCCAGGAGATTGGACTTGCTTCACTGGGAGCATCTGATGAGGCAGTTCAGAAACTTGCCACTTGTTACTTCTTCACTGTGGAGTTCGGGCTGTGTAAGCAGGAGGGGAAACTGAGAGCATATGGAGCAGGTCTGCTGTCCTCCATCAGTGAACTGAGGCACGCTCTGTCGGGGAATGCCCGGATCATGCCCTTCGACCCCAAAGTTACATGCAAACAAGAGTGCATCATCACAACTTTTCAGGACGTGTACTTCGTGTCAGACAGCTTTGAGGAGGCCAAAGTCAAAATGAGGGAGTTTGCAAAGACAATCAAGCGGCCATTCACAGTGCGTTACAACCCCTACACACAGAGCGTGGACGTCCTAAAGGACACAACTAGCATCAACAGTGTGGTGGAGGAGCTGAGACATGAGCTGGACATTGTGGGAGATGCGCTGAACAGACTCAACAAACATCTAGGCGTCTGAATGACTTACAGTGATCTTACAAATCGTCTTATATACACCGCTTTTTCCATCAAAGAGCAAAACCACAGAACTGTTTCCAGTTTCCACCAAATCCACAATAGTGCATCTAATGACAATATCTCACTCATTGTTCAAATCCATTTCAAATTATGTTAATCATCATTTCTGTTTTAGTACCATGGAGCTTTAAAAACTTGCAGTGGtactaatttaattaacttattCATCTATTGTCTTTTACACAATACTTGTGGACATTATATTTGCTTTAAATGTCATTGTGATAAAGTAATACTCTCTGCCatcaatatattgtttttgtgaTTTCAGCTTTTTTGTGTAGAAGTCATTAAaatcatcttggcatcataaGGCACTTTATCATATAATTTGATATTTATTATGGGCTTGTACCTTAAAGCTTTAGTATCACTAGTTTTCTATCTCTATCCACATTATTAGGGGAAAAGGACAAGCACTTGTAATGTTTTGTCTCAGTGTGAACCTAATTCtatcatatttttatgtttatatttattattagctGTGTCTCATGTCCTGTATGCTCTCTTTGTTTTATCTTCATAAAATCAgagcttttattcattttttcatttgtcACTGGGTATGCAAGGGTCATTTTACACATCAGACATCTAAGACTTTGGTCTAATCAATATAGATGCTCCTATTCTCAAACAGTTCATTTACAACAGATTTACACTATGATTTACACTTCAGGTTTCAA
>XM_007235178.3
AAGCGCCCTGCCTCGGTGTATTATTCCATCACGGGCAAACTGAGACCGGGCAAAAGGGTTGATCATAATCAGACCTCGGGCGAATAAATAGCAGCCTTGACGAGCTAAAAATGTACTCAAGCAAAAGCGAGGGTCCACGCAGAGGGAGGTCCTTCGACTCCATGAACATCGGCCTCACTCTGGAAGGGAAGCAACTTAACAATGAGATGAACAAATCTGCATACCCTAAGATAGATGAAAACAAAGACAACAAAAGCGAATCTGCAGAGAAGGGTCGTGCAGCTATTGTCTTCTCCCTGAAGAATGAGGAAAACCACGTCAACCTCGTGCACATTGAGTCGAGGAAATCGCGGAGGCGAAACTCGGAGTTTGAGATCTTGGTGGACTGCGACAGCAACCACGAGCAGCTCAACGAGATCATCCAACTGCTGCGCAAACACGTAAACGTGCTGGACACTGAGACGTCAATCAAGAGCCTCCCAGAAGAAGACGAGATGGATAATGTACCCTGGTTCCCCAAGAAGATCGCCGATCTGGATAAATGCGCTAATCGTGTACTGATGTATGGATCAGACCTGGATGCAGACCACCCGGGCTTTAAAGACAATGTTTACCGGAAAAGGAGAAAGTATTTTGCAGATTTGGCCATGAGTTACAAGCATGGAGACCCCATCCCCCGTATTGAGTTCACGGAAGAAGAGGTGAAGACGTGGGGTGTTGTGTTCCGAGAGCTAAATAAACTGTATCCCACTCATGCCTGCCGAGAACACCTGAAGAACCTACCTCTGCTCACCAAGTACTGTGGATATCGTGAGGACAACATTCCTCAGCTAGAAGACGTCTCACGCTTCTTAAGAGAGCGTACCGGTTTCAACATAAGACCTGTGGCAGGATACCTCTCCCCCAGAGACTTCCTGGCAGGCTTGGCCTTCCGTGTTTTCCACTGCACACAGTATGTCCGGCACAGCTCGGACCCTCTGTACACACCTGAACCAGACACATGTCACGAGTTACTGGGTCACGTACCTCTTTTGGCTGAGCCCAGTTTCGCTCAGTTCAGCCAGGAGATTGGACTTGCTTCACTGGGAGCATCTGATGAGGCAGTTCAGAAACTTGCCACTTGTTACTTCTTCACTGTGGAGTTCGGGCTGTGTAAGCAGGAGGGGAAACTGAGAGCATATGGAGCAGGTCTGCTGTCCTCCATCAGTGAACTGAGGCACGCTCTGTCGGGGAATGCCCGGATCATGCCCTTCGACCCCAAAGTTACATGCAAACAAGAGTGCATCATCACAACTTTTCAGGACGTGTACTTCGTGTCAGACAGCTTTGAGGAGGCCAAAGTCAAAATGAGGGAGTTTGCAAAGACAATCAAGCGGCCATTCACAGTGCGTTACAACCCCTACACACAGAGCGTGGACGTCCTAAAGGACACAACTAGCATCAACAGTGTGGTGGAGGAGCTGAGACATGAGCTGGACATTGTGGGAGATGCGCTGAACAGACTCAACAAACATCTAGGCGTCTGAATGACTTACAGTGATCTTACAAATCGTCTTATATACACCGCTTTTTCCATCAAAGAGCAAAACCACAGAACTGTTTCCAGTTTCCACCAAATCCACAATAGTGCATCTAATGACAATATCTCACTCATTGTTCAAATCCATTTCAAATTATGTTAATCATCATTTCTGTTTTAGTACCATGGAGCTTTAAAAACTTGCAGTGGtactaatttaattaacttattCATCTATTGTCTTTTACACAATACTTGTGGACATTATATTTGCTTTAAATGTCATTGTGATAAAGTAATACTCTCTGCCatcaatatattgtttttgtgaTTTCAGCTTTTTTGTGTAGAAGTCATTAAaatcatcttggcatcataaGGCACTTTATCATATAATTTGATATTTATTATGGGCTTGTACCTTAAAGCTTTAGTATCACTAGTTTTCTATCTCTATCCACATTATTAGGGGAAAAGGACAAGCACTTGTAATGTTTTGTCTCAGTGTGAACCTAATTCtatcatatttttatgtttatatttattattagctGTGTCTCATGTCCTGTATGCTCTCTTTGTTTTATCTTCATAAAATCAgagcttttattcattttttcatttgtcACTGGGTATGCAAGGGTCATTTTACACATCAGACATCTAAGACTTTGGTCTAATCAATATAGATGCTCCTATTCTCAAACAGTTCATTTACAACAGATTTACACTATGATTTACACTTCAGGTTTCAA

Function

symbol description
tph1a Predicted to enable tryptophan 5-monooxygenase activity. Acts upstream of or within regulation of hematopoietic stem cell differentiation. Predicted to be active in neuron projection. Is expressed in nervous system; neural tube; and ovary. Human ortholog(s) of this gene implicated in several diseases, including alcohol use disorder; attention deficit hyperactivity disorder; borderline personality disorder; mental depression (multiple); and scoliosis. Orthologous to human TPH1 (tryptophan hydroxylase 1).
tph1 Predicted to enable tryptophan 5-monooxygenase activity. Predicted to be involved in platelet degranulation; regulation of hemostasis; and serotonin biosynthetic process. Predicted to act upstream of or within bone remodeling; mammary gland alveolus development; and positive regulation of fat cell differentiation. Predicted to be located in cytoplasm. Predicted to be active in neuron projection. Implicated in several diseases, including alcohol use disorder; attention deficit hyperactivity disorder; borderline personality disorder; mental depression (multiple); and scoliosis.

NR:

description
tryptophan 5-hydroxylase 1 isoform X1

GO:

id name namespace
GO:0042427 serotonin biosynthetic process biological_process
GO:0009072 aromatic amino acid family metabolic process biological_process
GO:0055114 oxidation-reduction process biological_process
GO:0005506 iron ion binding molecular_function
GO:0004510 tryptophan 5-monooxygenase activity molecular_function
GO:0016597 amino acid binding molecular_function

KEGG:

id description
K00502 TPH1_2; tryptophan 5-monooxygenase

RNA

RNA id representative length rna type GC content exon number start site end site
XM_007235176.3 True 2310 mRNA 0.44 11 23703925 23710875
XM_007235177.3 False 2307 mRNA 0.45 11 23705140 23710875
XM_007235178.3 False 2274 mRNA 0.44 11 23703925 23710875

Neighbor

gene id symbol gene type direction distance location
saal1 NA coding upstream 16529 23679217 ~ 23687396 (+)
fam96a fam96a,LOC107673635 coding upstream 278620 23418666 ~ 23425305 (+)
rsl24d1 rsl24d1,LOC107694994 coding upstream 879509 22821117 ~ 22824416 (+)
LOC103027184 LOC108428395,LOC108275251,LOC103155695,LOC105938547,LOC106919346,LOC107706850,LOC103466445,LOC107552424 coding upstream 1037116 22637160 ~ 22666809 (+)
LOC103021604 LOC103021604,LOC108428402 coding upstream 1732689 21956572 ~ 21971236 (+)
sergef NA coding downstream 1655 23712530 ~ 23742791 (+)
LOC103043661 NA coding downstream 21187 23732062 ~ 23736230 (+)
dhtkd1 dhtkd1,LOC107559980,LOC107673284 coding downstream 75390 23786265 ~ 23802931 (+)
LOC103041809 camk1d,camk1db,LOC103041809,LOC108275359,LOC107569715,LOC107670218,LOC107740872 coding downstream 93687 23804562 ~ 23827333 (+)
LOC103041200 hal,LOC103041200,LOC108275357,LOC107740873,LOC107670217,LOC107720790,LOC107673290 coding downstream 125443 23836318 ~ 23856218 (+)
G75889 NA non-coding upstream 410783 23292836 ~ 23293142 (+)
G75882 NA non-coding upstream 428912 23274570 ~ 23275013 (+)
G75881 NA non-coding upstream 437606 23265930 ~ 23266319 (+)
G75874 NA non-coding upstream 489176 23214403 ~ 23214749 (+)
G75807 NA non-coding upstream 622254 23025275 ~ 23081671 (+)
G75957 NA non-coding downstream 71157 23782032 ~ 23782993 (+)
G75988 NA non-coding downstream 266190 23977065 ~ 23977422 (+)
G76060 LOC103039440,LOC108432681,LOC105892437,LOC107673304,LOC107740884,LOC107569705,LOC102199411,LOC100711429 non-coding downstream 329499 24040374 ~ 24041616 (+)
G76197 NA non-coding downstream 568619 24279494 ~ 24280790 (+)
G76202 NA non-coding downstream 578517 24289392 ~ 24291726 (+)
G75938 LOC105900730,LOC105912833 other upstream 216055 23487530 ~ 23487870 (+)
LOC103047784 LOC108428360,LOC108274708 other upstream 888403 22781735 ~ 22815522 (+)
LOC103028957 rfx7,LOC108428391,LOC108275305,LOC107695007,LOC107563886,LOC100538179,LOC107741823,LOC100694937 other upstream 922966 22754973 ~ 22780959 (+)
mov10l1 NA other upstream 2439149 21250467 ~ 21264776 (+)
G75391 pus7 other upstream 2607019 21088622 ~ 21096906 (+)
G75974 NA other downstream 204916 23915791 ~ 23917603 (+)
LOC103038709 LOC103038709,LOC108432651 other downstream 321217 24032092 ~ 24037861 (+)
LOC103035272 LOC108432640,LOC107569703,LOC107720762,LOC107670190,LOC107740887 other downstream 342186 24053061 ~ 24082844 (+)
G76192 NA other downstream 547634 24258509 ~ 24260506 (+)
LOC111193110 NA other downstream 1162525 24873400 ~ 24898537 (+)

Expression


Co-expression Network