egr2 (egr2,egr2b,LOC107596611,LOC107596614,LOC107653961,LOC107739063,LOC107745678)


Basic Information

Item Value
gene id egr2
gene name egr2,egr2b,LOC107596611,LOC107596614,LOC107653961,LOC107739063,LOC107745678
gene type coding
species mexican tetra (Astyanax mexicanus)
category of species ornamental fish

Chromosome Information

Item Value
chromosome id NC_035900.1
NCBI id CM008303.1
chromosome length 25652880
location 16463328 ~ 16484145 (-)
genome version Astyanax_mexicanus-2.0_2017_mexican_tetra_Genome

Sequence

>XM_007255117.3
CTCCATCTATGGGCAGTGACGTAACGGGACTCGGAAAGCGCCGCATAAATACAAAGTCGCGAGTAGCCCGTGCGATCACACGCtcatgcttacacacacactctacatctCGCGCAACACATTTACTCACACACTGATCTCAGTCAGTCTGACAGGCAGAGAGTTTGATAggtgagtttaaaaaaaaggctgtgAGAGAAAAGCTAGAGAAACAGAACAGCAGCTCTGCGTGGatgtggaggagtgtgtgtgtgaggtgagaGTGGGTGGTAGTAGTGATGGTGGTGGGAGGGTAAAGACCCCAACACTCACATACTACTCCTTACTATTActatagcagacaaacacagagagcgagagagagagagacatcagcagcaaacaacaacaaagaaaaGGAAAACTCTCCGCgtgcttttttattaataaataaaaaagcatatacAACTCCGCTCGGTTCTTCGTGCGCGCGTGAACCATGACGGCGAAGACCCTGGAGAAAAGCCCCGTGTTCGTGCACCCGCTGGCCGAGAGCATCTACTCTGTGGATGAGCTCAGCGCCCCCCTCAGCGTCTTCCCCGGCGGAGACGCGCCGGTACACTACGAGCACATGAGTGCAGATGGCTTGATCAACGGTGATATGAGTGCAGAGAAGCGGTCCCTAGACTTGTCCTACGCCAGCAGCTTCGCTCAGCCGGCAGCTCCCCGTAACCAGACCCTTACCTACATGGGCAAGTTCTCCATCGAACCGCAGTACCCGGCCAACTGGAACCCAGAAGGGGTGATCAACATTGTCAGCGCGGGTTTCCTGGGCATGACCCAGCCTTCCTCTGCCTCCTCCTCTCCATCCTCCTCTGTGTCTCCGGGCCACTTCTCTAGCACCCTCAGCTGCACGGCAGCACAGACTCAGGCAGACATGGACCACATCTATTCCCCTCCACCACCTTATTCAGGTTGTGGCGAAATGTACCAGGACCCGTCAGCATTCCTCTCAACATCAGCGTGCCCCATCTCCTCATACCCTCCGCCATCTTACTCCTCACCCAAAGCCACAGCAGACGGCCCCGGCGTCTTTCCCATCATCCCGGACTATGCCAGCTTCTTCCAGCCGACATGCCAGAGAGATATTCCGTCCATTCCAGAAAGGAAGCCCTTCTCCTGCCCCCTGGACTCTTTCCGGGTGGCTCCACCACTCACCCCACTCAACACAATCCGGAACTTTACCCTGGGTGCACCCCCTGTACCCGAGGGTCCCCGGCTCCCTGCAGCAGCATACGGTCCCCAGAACCTTCCGCTGAGGCCGATCCTGCGGCCCCGGAAGTACCCAAACCGCCCCAGCAAGACTCCAGTGCACGAGAGGCCATACCCATGCCCGGCAGAGGGCTGCGACAGACGCTTCTCTCGCTCTGATGAACTCACACGCCACATTCGCATCCACACCGGCCACAAGCCCTTCCAGTGCCGGATATGCATGCGCAACTTCAGCCGCAGTGACCACTTGACCACACACATTCGCACACACACAGGCGAGAAGCCCTTTGCCTGCGATTTCTGTGGACGAAAGTTTGCCCGCAGCGATGAGCGGAAGAGGCACACCAAGATCCACTTGAGACAGAAGGAGAGGAAGTCGTCTGCTGCCCCCTCAAACTCTGAGCGCTCCATTGGCATCGGATCCTCAGCGGTCTGCTCATCCAGCTCGGGCCACTAAGTTCCCCTAGTTAGTTCTGTGGTTTCCAGACCCGGGTACTTAGAGTAACCCTGTCTCTGCATAGATTGGTGTTTCTTCCCTGCTCTCCCTGCACAATTTATCTGACTAATCAGCTAATTAACAAGCCTTTCCTGAGTTTAAGTGGGGGTATCAGAGCAAGGAAAGCAAATGTCAAATGTGCAGATCTGAACAGGACACCAAGGCAAGGTTTGGGGTCAACTGCCCTACATTACTAGCAGGGGAGCATGCAACACTAGGCAATATCCACGATCCAAACTTGCTGTGAAGCCAGGGGGGACCAGTTGAACACAGAAAAGCCAAAGGACATAAATGAGGGACATTGACGACAAGTACAATTCCTCAACCGGCACGTTCCTTTGACTGCTTCTTCTATCCCCCTTAGTATCGGTCGCATGTTGACTGACAAAATCGCACTTTGTTTATGATATTTAGGTCaaataatttaatgaaatatAACTTGCAGCAGCATGTGGGACTGTGTGTTCTAAAGTGCACGTTTGGTTGAGAGAGGACTTTGTGGAGGTCATTCCAACGTGACAGCTTCAAACTTGCAATAATGCAGACACTTGTGAACTTGTCACAACCGTGTTTTCTCGGCAAGCTGAAACTAACAGATTTATCGTGCCTTTGTATTGTGTCTTTTTGTAAATAGCCGCATACCTGAAGAGGCTTTGAAATAAAATTGTACAGTGGTCCTTTAATAAGAAAGTTtttgagataaaaaaatatatatttttgtataaactttgttttgtgTCGCAAGTGTTTCCATTgtggtaaaaaaacaacaggaatGTAAATAACTGGACTTATATATGTGAAGCTTGTTTTTGTAGATGTTTTCACTGATATGTTGTGTTGGGAATGAGCTAACTAATGCAGGTCCGTGACTTGCTGGCCTAACTTTCTGTCATTgtgaaagaaataataaataaaacttgaaTTAAGATA
>XM_015607335.2
tgtgcgagagtgtgttGTTATTGGAGCAATGTAATGCTCTTGGAGGAGCCCACTCATGTGATGGAGATTCACAAAGAGCCACTTCTCTCCAAGCCCTCATAATATGGCTTGATCAACGGTGATATGAGTGCAGAGAAGCGGTCCCTAGACTTGTCCTACGCCAGCAGCTTCGCTCAGCCGGCAGCTCCCCGTAACCAGACCCTTACCTACATGGGCAAGTTCTCCATCGAACCGCAGTACCCGGCCAACTGGAACCCAGAAGGGGTGATCAACATTGTCAGCGCGGGTTTCCTGGGCATGACCCAGCCTTCCTCTGCCTCCTCCTCTCCATCCTCCTCTGTGTCTCCGGGCCACTTCTCTAGCACCCTCAGCTGCACGGCAGCACAGACTCAGGCAGACATGGACCACATCTATTCCCCTCCACCACCTTATTCAGGTTGTGGCGAAATGTACCAGGACCCGTCAGCATTCCTCTCAACATCAGCGTGCCCCATCTCCTCATACCCTCCGCCATCTTACTCCTCACCCAAAGCCACAGCAGACGGCCCCGGCGTCTTTCCCATCATCCCGGACTATGCCAGCTTCTTCCAGCCGACATGCCAGAGAGATATTCCGTCCATTCCAGAAAGGAAGCCCTTCTCCTGCCCCCTGGACTCTTTCCGGGTGGCTCCACCACTCACCCCACTCAACACAATCCGGAACTTTACCCTGGGTGCACCCCCTGTACCCGAGGGTCCCCGGCTCCCTGCAGCAGCATACGGTCCCCAGAACCTTCCGCTGAGGCCGATCCTGCGGCCCCGGAAGTACCCAAACCGCCCCAGCAAGACTCCAGTGCACGAGAGGCCATACCCATGCCCGGCAGAGGGCTGCGACAGACGCTTCTCTCGCTCTGATGAACTCACACGCCACATTCGCATCCACACCGGCCACAAGCCCTTCCAGTGCCGGATATGCATGCGCAACTTCAGCCGCAGTGACCACTTGACCACACACATTCGCACACACACAGGCGAGAAGCCCTTTGCCTGCGATTTCTGTGGACGAAAGTTTGCCCGCAGCGATGAGCGGAAGAGGCACACCAAGATCCACTTGAGACAGAAGGAGAGGAAGTCGTCTGCTGCCCCCTCAAACTCTGAGCGCTCCATTGGCATCGGATCCTCAGCGGTCTGCTCATCCAGCTCGGGCCACTAAGTTCCCCTAGTTAGTTCTGTGGTTTCCAGACCCGGGTACTTAGAGTAACCCTGTCTCTGCATAGATTGGTGTTTCTTCCCTGCTCTCCCTGCACAATTTATCTGACTAATCAGCTAATTAACAAGCCTTTCCTGAGTTTAAGTGGGGGTATCAGAGCAAGGAAAGCAAATGTCAAATGTGCAGATCTGAACAGGACACCAAGGCAAGGTTTGGGGTCAACTGCCCTACATTACTAGCAGGGGAGCATGCAACACTAGGCAATATCCACGATCCAAACTTGCTGTGAAGCCAGGGGGGACCAGTTGAACACAGAAAAGCCAAAGGACATAAATGAGGGACATTGACGACAAGTACAATTCCTCAACCGGCACGTTCCTTTGACTGCTTCTTCTATCCCCCTTAGTATCGGTCGCATGTTGACTGACAAAATCGCACTTTGTTTATGATATTTAGGTCaaataatttaatgaaatatAACTTGCAGCAGCATGTGGGACTGTGTGTTCTAAAGTGCACGTTTGGTTGAGAGAGGACTTTGTGGAGGTCATTCCAACGTGACAGCTTCAAACTTGCAATAATGCAGACACTTGTGAACTTGTCACAACCGTGTTTTCTCGGCAAGCTGAAACTAACAGATTTATCGTGCCTTTGTATTGTGTCTTTTTGTAAATAGCCGCATACCTGAAGAGGCTTTGAAATAAAATTGTACAGTGGTCCTTTAATAAGAAAGTTtttgagataaaaaaatatatatttttgtataaactttgttttgtgTCGCAAGTGTTTCCATTgtggtaaaaaaacaacaggaatGTAAATAACTGGACTTATATATGTGAAGCTTGTTTTTGTAGATGTTTTCACTGATATGTTGTGTTGGGAATGAGCTAACTAATGCAGGTCCGTGACTTGCTGGCCTAACTTTCTGTCATTgtgaaagaaataataaataaaacttgaaTTAAGATA

Function

symbol description
egr2b Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within embryonic organ development and nervous system development. Predicted to be located in nucleus. Is expressed in several structures, including nervous system; neural crest; neural keel; neural plate; and neural rod. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease type 1D; Charcot-Marie-Tooth disease type 3; Charcot-Marie-Tooth disease type 4E; and motor peripheral neuropathy. Orthologous to human EGR2 (early growth response 2).
egr2 Enables DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and ubiquitin protein ligase binding activity. Involved in positive regulation of transcription by RNA polymerase II. Located in nucleoplasm. Implicated in Charcot-Marie-Tooth disease type 1D; Charcot-Marie-Tooth disease type 3; Charcot-Marie-Tooth disease type 4E; and motor peripheral neuropathy.

NR:

description
PREDICTED: E3 SUMO-protein ligase EGR2

GO:

id name namespace
GO:0048168 regulation of neuronal synaptic plasticity biological_process
GO:0006355 regulation of transcription, DNA-templated biological_process
GO:0071320 cellular response to cAMP biological_process
GO:0021575 hindbrain morphogenesis biological_process
GO:0071371 cellular response to gonadotropin stimulus biological_process
GO:0043066 negative regulation of apoptotic process biological_process
GO:0021654 rhombomere boundary formation biological_process
GO:0035914 skeletal muscle cell differentiation biological_process
GO:0048932 myelination of posterior lateral line nerve axons biological_process
GO:0005634 nucleus cellular_component
GO:0005737 cytoplasm cellular_component
GO:0046872 metal ion binding molecular_function
GO:0003677 DNA binding molecular_function
GO:0003700 DNA-binding transcription factor activity molecular_function

KEGG:

id description
K12496 EGR2; early growth response protein 2

RNA

RNA id representative length rna type GC content exon number start site end site
XM_007255117.3 True 2680 mRNA 0.50 2 16463328 16467148
XM_015607335.2 False 2163 mRNA 0.50 2 16463328 16484145

Neighbor

gene id symbol gene type direction distance location
LOC103021447 tmem26 coding downstream 254414 16196413 ~ 16208914 (-)
ank3 ank3b,ank3,LOC107654059,LOC107695539 coding downstream 437206 15874359 ~ 16026122 (-)
LOC103023209 NA coding downstream 611651 15841393 ~ 15851677 (-)
LOC103033657 NA coding downstream 684481 15772958 ~ 15778847 (-)
LOC103024156 NA coding downstream 693859 15746284 ~ 15769469 (-)
jmjd1c jmjd1c,jmjd1cb,LOC108412835 coding upstream 54036 16538181 ~ 16713489 (-)
LOC103044660 LOC103044660,LOC108412396,LOC107653962,LOC108273895,LOC107745679,LOC107593523,LOC107596578 coding upstream 306482 16790627 ~ 16793507 (-)
exoc6 exoc6,LOC107654070 coding upstream 314372 16798517 ~ 16866094 (-)
LOC103037732 NA coding upstream 390877 16875022 ~ 16893517 (-)
LOC103032763 snu13,nh2l1,snu13b,LOC105898651,LOC105031476,LOC105910236 coding upstream 581258 17065403 ~ 17067982 (-)
G36836 NA non-coding downstream 57845 16405253 ~ 16405483 (-)
G36807 NA non-coding downstream 216557 16246540 ~ 16246771 (-)
G36806 NA non-coding downstream 216798 16246079 ~ 16246530 (-)
G36805 NA non-coding downstream 219995 16243077 ~ 16243333 (-)
G36800 NA non-coding downstream 248499 16213800 ~ 16214829 (-)
G36845 NA non-coding upstream 2890 16487035 ~ 16488592 (-)
G36882 NA non-coding upstream 154447 16638592 ~ 16644565 (-)
G36922 reep3 non-coding upstream 258687 16742832 ~ 16752168 (-)
G37185 sun1 non-coding upstream 516227 17000372 ~ 17015898 (-)
G37189 NA non-coding upstream 536576 17020721 ~ 17020928 (-)
LOC103023526 ndua4,ndufa4,LOC103023526,LOC108443163,LOC107745684,LOC107684782,LOC107569184 other downstream 622812 15837105 ~ 15840516 (-)
G36677 NA other downstream 688735 15747400 ~ 15774593 (-)
c4h10orf88 LOC103041415 other downstream 1666116 14785952 ~ 14797212 (-)
p4ha1 p4ha1,p4ha1a,LOC107753313,LOC108273903,LOC107560551,LOC107684765 other downstream 2963151 13475166 ~ 13500177 (-)
lsm5 lsm5,LOC107653262,LOC107727957,LOC107674592 other downstream 3151803 13307088 ~ 13311525 (-)
LOC103043629 LOC108412394 other upstream 429425 16913570 ~ 16915285 (-)
G37183 NA other upstream 531983 17016128 ~ 17018918 (-)
crym rac1,RAC1,rac1a,crym,LOC105898786,LOC108412270,LOC108437155,LOC107569188 other upstream 563462 17047607 ~ 17062947 (-)
LOC103030148 csdc2,LOC105919973,LOC102235694 other upstream 695202 17179347 ~ 17184427 (-)
LOC103024241 maff,LOC107690056,LOC107692071,LOC107554043,LOC107584105,LOC107734233 other upstream 890039 17374184 ~ 17381733 (-)

Expression


Co-expression Network