LOC103024286 (timp2,timp2a,LOC103024286,LOC108274067,LOC107755484,LOC107684079,LOC107565802)


Basic Information

Item Value
gene id LOC103024286
gene name timp2,timp2a,LOC103024286,LOC108274067,LOC107755484,LOC107684079,LOC107565802
gene type coding
species mexican tetra (Astyanax mexicanus)
category of species ornamental fish

Chromosome Information

Item Value
chromosome id NC_035900.1
NCBI id CM008303.1
chromosome length 25652880
location 4799103 ~ 4819304 (+)
genome version Astyanax_mexicanus-2.0_2017_mexican_tetra_Genome

Sequence

>XM_007259188.3
TGCAGGGCAGTGTGGAGGAGCTAAATGCATGAGGCTAGCCTGTGCTCTGTAAAACAGACCCATACAAGGCGCTGCGCGGATCCAGAGCGGCTACAGTCGAGCACAGAGCAGCACAGGGCAGCTTTTGTTAGCGCAGCTCTGTTCAGTTgatcgcctctctctctctctctgtgtgttgaggttCTCGGGGAGAGCTGAGAGCTCCGGACGGGctggtgtgaggagtgtgtgtgtgagagagacccGCACACTGCAGGAGCTCCGTGTTTGGGTTGAGTCTCTGTGGTGAAGCAGCGGTAGCGGCAGAGCGGGGAGATGCGGGGTGTGAGCGGCTGGGTGTGCGCGCTGCTGGGGCTGCTGCTGGTCGGGGTGCAGGACAGGGCAGACGCCTGCAGCTGCTCTCCGGTTCATCCTCAGCAGGCGTTCTGTAACGCGGATGTCGTAATTAGGGCTAAGGTGGTAGGAGGGAAGGAAGTGGATGCTGGGAATGATATTTATGGCAACCCTATCAAGAGGATCCAGTATGACATCAAACAGATCAAGATGTTTAAAGGACCAGACCGTCACATTGATGTGATCTTTACTGCACCTTCATCTGCTGTGTGTGGGATAACTCTGGACACCAATGGAAAGAAGGAGTATCTCATTTCAGGCAAGGCAGATGGCAATGGAAAAATGCACGTAACCCTGTGTGATCTCAATATACCCTGGGAGTCCATGAGTGCCACCCAGAAGAAGAGCCTGAGCCAGCGCTACCAGATGGGCTGTGACTGCAAGATTACCCGCTGTGCGGCCTTCCCGTGTGAGGTCAGTACCCCGGAGGAGTGCTTGTGGACAGACTGGGTGACAGAGAAGATCATCCACGGACGCCAGTCTGACCACTACGCCTGTATCAAGAGAGGAGATGGTTCATGTGCCTGGTATCGTGGAAGTGCTCCACCCAAGAAAGAGTTCCTGGACAGCGAGGACCCATAATCCAGCCCCAcacctctctccacctctctgaCGTTccttaaaatacaatatactaAAGATCCAAAATAaggcagaacaaatgaaaagaaaaaaactgcacCAAATTGAAATGCTAAAGTACAGATTAGCTTACAGTCTTCATTAGATAACGTAACTAGTGGAGTAGATAATACTAGTGAAAACTGGTCAAATACTGATGTGATTTATTCTTCAAGGCTTTAATTCAAAACCCACCAACCATTATATATGAGGGACAATCCTAATTCGTGAGCACTTTCTGCCCCTGACAGCGCTTAATCTTTATCACCTTAAACGACTGAAATTGCGCATCAGTCTTATAAAAGCTCATTCCACatctttaattgtttaattctgTGTCCAAACCCCTAATATAGTGACGGCTGAAATATTACTCTTGCTTAGTGTAGTTTCCTAAAGCAATGCCAATTGGTCCAGTTAGATAAATGGTGAGGCAGGACTTCCCAGATAGTTCAAAGATGAACTGAGACCAAACGAAGAGAGTTAAAACAGGCAGATGCATGAGCTTCTAGGAAAAGGAAAATTAGAGACCAAAGTCAGTGTCACTCCGTGTTGATTTATGTGGGACAAAGCTTCAGTTTGCTGCTGACCAAATTCCAGAATGTGTAACTTTAGTACATGGGTAcaagtttgtttttcttttttttctccacagacGTGGATCCTCTTTGCTTTTAGACACAAAAATCTATGGGACCTTTTAGCCCCTGATtggaaaaagaagaaggaaCAATAAGGCAATACCTTTACAACACTTAAACTCTTTTTGGCAGGATAGTTTAGGTCCTTCCTAATTTGGAATAAGGTATTGTGTAATGGAAAAGGAGTCTGCTTGCCTTGTGTCCTTGTTTCTTTTTCAAGTGCTTCTTCTACTAACCGATTCTCTCCCTGCCTCTGTACTCCTTTAACCCTTTATCTCCCTTAACTACATGTATACATTTGTCTGTGCTTTTTTGTACGTTAGATATTTGCCTTTTTTCAAAAGTCATTTCTCTGAAATCAGTCTTCATCCTGATTGAACTTTGCACTTTGTGGGAATCGCTACAGGAGGATTGAATCCTCTTATCAGGATTTGTAACTCTTCTcttcttccttccttcattTAATGCCTATGAGCTTATTTACCAGCTGTTTTGTGACGTCACTCCTATAGGGCTTAGGCTAGTGAGGGCCCTATATCTGCTATTTCATCTTCTCTGTGTATGTTTGATGGTTGATGTGCCACACGGACGTGTTTCATGGGACtccaagagaaagaaagaaagcctACGTAAGACATTAGTTGCCATGGTAATGGGAAGACCCCAGCTTTATTCCTCCACACTTACAAGGCTGATTGGATTAACATAGAAAAGGCACAGTTATATATCTTTCataagagagagaacaagagagggGCAGAGAGAAAAGCCAGGTTTCTTCCCTCCGTGAGGTcgataaactgtgtttattgGCAGTCTGGGAGGAAGGCATGCTGAATTATGTTGTTGCAACTGTCCCCTGATTGGACACTGCCAAGTCATGTGACTGATGGAGAGTAAGGTGTGAGGGTAGTAGTTGCTAGGCATTTTGTCAGGGTGAACCATGGTGCCACAATGCGgtcagaatgagagagagaaagggagggaagAAGACAGAAAGGGGACCAAACAGTGGAAGACAAACACTGGTGGGTTGGGGGGGCAGTTGATTGTCGGTAGATTTTAATATTCCTGCATTTTAACGAGAGCTAGGCCTGTCACTATAACTATTTTTTATTGGACGATATCTTGCCCATAGGAATAattgtgatttattttgttgtcattttaagacaatttaactattttaaagaacaatacactttttaaaatacccATTAAAAAATATGGGTAAAGTTCATTCATGTCAACAGGcaagcagaaaaaaattatgtagGGCTGCagaaatgattgaggtcatgccCATATATTGTCTGATAAGTTGctaatgtaattatcgtgacaggcctaacaaATGCTGTTTTGTGTACGGAgctttaaaattagtttttaaggTACTTTCAAAGCTGTACAAAATCAATACAGTAATCTATGCCAAGCAGAACGCTGCATTAATATGAGCATTAATCGATGATGGCTTTTCTGTTGTGGCCTAACTAACCAGCTAACTTCATGGCTGAAGCAGAgttgaagaagtaaagcgtatATAAAGCTGTCTAAACAGCTTACAGTATTCAGAGGCGTGCTTTAAATTAAAACCTTTCTCTGTAATCGTCTTACCTTTTTAAAACTTGCCATAAACGAGCGCGTAAATCTACAAAGGGTAAACGTTGGCAATATTTAATATGCATCCTGCTATATCTACTTAACTGCTTTGTATTAAGTGTAATGGAATATAAATggcataatttaaatgtttgttgttGCCATGTTTCTACATTTTTACTGTGTCATTACCTTTGATTTATATGATGTGTTATTTTTACCAgtcttttgtctttctcttgAAGATTTGCTGAAAGTACAGAAATGTGAGAGCTCTTGTGTGAGTGTGAACCACATGAGAGCCGAGGTATGATGAGAACCAGACTATGCATGTCTTTGATGCTTTGATGTGTAATTCCTATGTGGATGTTCACTCGATGggcaaatatacagtattatcaaataaatgagaaaaagtTAAAGAACA

Function

symbol description
timp2a Predicted to enable metalloendopeptidase inhibitor activity and protease binding activity. Predicted to be involved in negative regulation of proteolysis; response to cytokine; and response to hormone. Predicted to act upstream of or within negative regulation of peptidase activity. Located in extracellular space. Is expressed in several structures, including brain; heart; liver; post-vent region; and trunk. Human ortholog(s) of this gene implicated in Moyamoya disease. Orthologous to human TIMP2 (TIMP metallopeptidase inhibitor 2).
timp2 Enables peptidase inhibitor activity; protease binding activity; and zinc ion binding activity. Involved in negative regulation of metallopeptidase activity. Located in collagen-containing extracellular matrix. Implicated in Moyamoya disease. Biomarker of several diseases, including Duchenne muscular dystrophy; aortic disease (multiple); carcinoma (multiple); neurodegenerative disease (multiple); and preretinal fibrosis.

NR:

description
metalloproteinase inhibitor 2-like

GO:

id name namespace
GO:0010951 negative regulation of endopeptidase activity biological_process
GO:0005576 extracellular region cellular_component
GO:0008191 metalloendopeptidase inhibitor activity molecular_function

KEGG:

id description
K22583 TIMP2; metalloproteinase inhibitor 2

RNA

RNA id representative length rna type GC content exon number start site end site
XM_007259188.3 True 3687 mRNA 0.43 5 4799103 4819304

Neighbor

gene id symbol gene type direction distance location
LOC103022011 gfra1,gfra1b,LOC107755550,LOC107702444,LOC107581544,LOC107707958 coding upstream 228254 4526945 ~ 4570849 (+)
bms1 bms1,LOC107689949,LOC107675025,LOC107566656 coding upstream 666132 4108457 ~ 4132971 (+)
LOC103043774 NA coding upstream 693350 4103372 ~ 4105753 (+)
LOC103037237 adgra1a,LOC108426471,LOC107754080,LOC107675035,LOC107565950,LOC107693584,LOC107563791 coding upstream 728371 4039157 ~ 4070732 (+)
LOC103037557 gabrz,LOC108426470,LOC108273489,LOC107675029,LOC107754081,LOC107565977,LOC107677887,LOC107563789,LOC107743757 coding upstream 795838 3958779 ~ 4003265 (+)
LOC103024595 arl3,LOC102778022,LOC103367836,LOC107684078,LOC103145158,LOC102201386 coding downstream 9734 4829038 ~ 4832548 (+)
twnk cunh10orf2,peo1,LOC107755431,LOC107690904,LOC107565785 coding downstream 112111 4931415 ~ 4937026 (+)
galk1 galk1 coding downstream 119695 4938999 ~ 4943449 (+)
llgl2 llgl2,LOC107690902,LOC107684069,LOC107755492,LOC107722216 coding downstream 124566 4943870 ~ 4966430 (+)
chac2 chac2,LOC107749368,LOC107686371 coding downstream 148270 4967574 ~ 4971335 (+)
G34394 NA non-coding upstream 23762 4775021 ~ 4775341 (+)
G34393 NA non-coding upstream 24251 4773886 ~ 4774852 (+)
LOC111192352 NA non-coding upstream 90130 4704913 ~ 4708973 (+)
G34345 NA non-coding upstream 215126 4583718 ~ 4583977 (+)
G34288 NA non-coding upstream 660950 4137755 ~ 4138153 (+)
G34396 sfxn2 non-coding downstream 5039 4824343 ~ 4827906 (+)
G34410 mfsd13a non-coding downstream 51060 4870364 ~ 4871420 (+)
G34409 mfsd13a,LOC107755491,LOC107565800,LOC107690908 non-coding downstream 55834 4875138 ~ 4875554 (+)
G34485 NA non-coding downstream 152481 4971785 ~ 4973087 (+)
G34489 NA non-coding downstream 159443 4978747 ~ 4979412 (+)
G34309 NA other upstream 621020 4171051 ~ 4178083 (+)
tbkbp1 tbkbp1,LOC107565677,LOC107754096,LOC107677885,LOC107743771 other upstream 1139971 3564030 ~ 3659132 (+)
amz2 amz2 other upstream 2742140 2050742 ~ 2056963 (+)
LOC111192342 dnah9 other upstream 3411084 1369173 ~ 1388019 (+)
trnal-aag NA other upstream 3806585 992312 ~ 992518 (+)
LOC103025551 sema4g other downstream 63252 4882556 ~ 4924766 (+)
dnmbp dnmbp,LOC107722208,LOC107684043 other downstream 873218 5692522 ~ 5756116 (+)
LOC103045604 LOC108426437,LOC107683136 other downstream 1427342 6246646 ~ 6258050 (+)
slc38a10 slc38a10,LOC102792191,LOC107749860 other downstream 1682841 6502145 ~ 6541460 (+)
LOC103029551 qki2,LOC103029551,LOC108426533,LOC107684089,LOC108274051,LOC107749853,LOC107755469 other downstream 1773303 6592607 ~ 6663607 (+)

Expression


Co-expression Network