dll4 (dll4,LOC107562694,LOC107721368,LOC107602157,LOC107668208,LOC107739369)


Basic Information

Item Value
gene id dll4
gene name dll4,LOC107562694,LOC107721368,LOC107602157,LOC107668208,LOC107739369
gene type coding
species mexican tetra (Astyanax mexicanus)
category of species ornamental fish

Chromosome Information

Item Value
chromosome id NC_035899.1
NCBI id CM008302.1
chromosome length 74127438
location 56839749 ~ 56852430 (-)
genome version Astyanax_mexicanus-2.0_2017_mexican_tetra_Genome

Sequence

>XM_007231505.3
GAGAAACAAGTCTTCATTCACGACTTAAGAAGACGGGCGTTAGGAGAAACACCCCCACCCCAaacgcgcgcgcgcacacacacatacacacaaacgcacgcacgcgcacgcacgcacacacatatatacatagccTACaaacgcgcgcgcacacacatacacaatcacACTGGACAACCCCTTATGCACGCAACGAAACGACAGCCTGAGGCATCGAGGTGACCACAGTGGAGGGAATAGGGGACATGCACGGTGGTCGGAGTGGATAGAAGAGTGGATACTCGTCTGCTGCTGGCTGAGCTTCACCTTTTGGGATAAAGCTGGGGGGGATTTTGAGATTTTGACCCCCttctgttgttttctttttttttctttgacgtTTCTCGCAACGGACACGCGCGCAGAGGCGCAGGACCGGAGGAGCGCGCGCGCAAAGGAATATACGCCTTGTctcctttttgtcttttttatattatttattttttgaattgTTGCGACCTGCAGACACGCTTGTGGAGTAGGAGCTCGTACGGAATAGACTACTTACTGAAGCCGCGGGTGAAGCAGTTgcacccccctccctccctccctcctccccgGGAGCACTGAGCAGCAGCATGGCAGCTCGGCTCACCTTCCTCCTCTCAATGCTCTCCTCGCTCATAACGCAGATGTTGGGATCCGGCGTGTTCGAACTGGACCTTCACGAGTTCAAAAATTTCAAGGGGCTGCTGGCCAACGGAGAGCCGTGCCGGCCCGAGTGCAGGACTTTCTTTCGAGTTTGCCTCAAAAACTACCAGGCGGTGGTCTCTCCGGGAGACTGCATCTTCGGCACCGCCGTCACCCCGGTGCTGGGCTCCAACTCGTTCAGGGCGGAGGGTGCACCTCTCAGCACCCCAGTTCGACTGCCCTTCAGCTTTGGATGGCCGGGATCCTTTTCTTTGATTATTGAAGCCTGGTATTCACCTGTAGactCAAACAACTCTGACTTAAAGATTAGTACTTTTGCCATCCAAAGACAGTTGGACGTAGGGGCTGAGTGGTCTCAGGATGTCCAAAGTGGGCAGCAGACAGAGCTGAGGTATTCTTACCGGTTCATCTGCAATGAAAATTACTACGGCGAcagttgttccaaaatatgcGCACCCAGGGATGACCGATTTGGCCACTACACCTGCAATCCAGATGGGCAGTTGTCCTGTCTCCCTGGCTGGAAAGGGGAATACTGCGAAGAACCTATCTGCCTTAAGGGGTGCAGCGAGGCCAACGGCAATTGCTCCAAGCCcggagagtgtgtCTGTAGAGAGGGTTGGCAGGGCACCTTCTGTACTGAGTGTAAGAAGCACCCAGTGTGCAAGCATGGCACTTGCAACCAGCCTTGGCAGTGCAACTGCAAGGAGGGCTGGGGTGGACTCTTCTGTGACCAAGATCTGAACTTCTGCACCCACCACAAGCCGTGTAAGAATGGAGCCACGTGCATGAACACAGGCCAGGGCAGCTACACGTGCACGTGCATGCCAGGCTACACTGGGGTCAACTGTGAGCTGGAGGTGCGGCAGTGTGACAGCAACCCCTGCAGGAACAGAGGCCACTGTACGGAGCTGGATAATGGCTATATGTGCACCTGCCTGCCTGGCTTTGAGGGCTCTCACTGTGAACACAGCCTGCTCACCTGTGCAGATATGCCATGCTTCCAAGGCGGCAAGTGCCACGAAAAGGACAATGGCCGCAGCTACTCATGTGACTGCCCCAGAGGTTACACAGGCCTCAACTGTGAGAAGAGGGTGGACAAATGCACGACCCTGCCATGTGCCAACGGTGGTGCGTGTGTTGTTCTGGGAGGCGTACGCATGTGCAGCTGCCGCGCCGGCTTCACGGGTCAGCGCTGTGAGATCAACATCAACGACTGTGCATCCAACCCCTGTGCCAACGGGGGCACCTGCCACGACCGGATCAGCGACTACATCTGCTCCTGCCCCCCAGGGTACGGAGGCCGCAACTGCAACCTGCTGACCACTGCCTGCCCCGCTCAGCTCTGCCTCAACGGGGGCTCATGTGCCACCATCCCCGGAGGACCTCCAGCCTGCTTCTGCCCCAGCGGCTTCACCGGACCCCGCTGCGAGTACTTCGCACTCACCCTGCCCTCCCTCCCAGCAACCGAGCCCAAGGACAGCTTCCAGTGGGCCGCCGTGTCCCTGGCTGTGGGGCTGGTGGCCCTGTTGGTCCTTCTCTGCATGGTGGGCATTGCACTGCGCCACATTCACAGACAGGCCAATGCCGAAAGAACTCAGGCAGATGCAATGAACAACCTGTCCGATACGCAGAGAGACAATTTAATACCTACGTCCCAGTTAAAGAACACCAATAAAAAGGTGGGCCTAGAAGTGGACTGTGGACCAGAGAAGTCCAATTACATACACAAGAATTACCACTTGGACTACAACTCGTCAAAAGATTTCAAAGAGGCTCCTTCGCAAGAGGATAAAAGTCACAAATATGAAAAGTGTTTAGAAGACAAAATACCATTGAGTAGAATGTACAGCGAAAAGCCGGAGTGTAGGATATCAACAATATGTTCCCCGAGAGACTCCATGTACCAATCTGTGTTTGTAATAGCGGAGGAGAGGAGTGAATGCGTCATAGCAACTGAGGTATAAATGACAGGAGGATGTATACGAAGCGGAGAGATGGGGAGGACACAATCAAAGCAGAATATCCTGgattgtttacaaaaaaactgAAGAGACTGGAGATGATTATTTGTGGTGTCCACTGCTGCTCTGAGAAACTTGAGGAactgaagagagaaagagcggaACTCTGCTCACTGAACGCAATAGATTAGTTCCTGTTGAAGGAGTGTTTGTGTACAAACGTGTACAGTCCTGGACGTTTTTCTCATCCCTTCTGCTACGGTATGGTTTTTCCCTCACAAACTGTAAGGAGGAAAGAAAAGGACTTACACTGcaagaggaaaaaaatgtttttggcaGAGAGAAGTGGTCTCCCCCCACATTGAGtgagtgtttctctctctctctctttccttctctttctctctctctctctgtctgtctgtctgtctgtctctcactctcgtgTGGTAATCACGGACACATCATCTGCCAACAAATCACTAAGAAGGTGCCAGGAACTTCCAAACCTTCAACCAGCATTGCCAGCTATGCAAGAACGGAGAGGGGGGAACCAATCAGAGCCCAATCCCACTCACCCCAATCATGAGAAGAGATATGaatgtctgaaaaaaacaacatgtacAAATGTCAATCATATCAAAAAGTGACTGTTGTTCTCCGTGCTAAGATTGTATGCAGCCCAAATTCACAAAAAAGCCTTAAAAGAATGGGAAAGGATGCTAATTTTGTGCCCCGGGTCGTCTTGGATTGCCTGAAACGAGGGAAACATTCCTTTTTAATCAACGGGGATTCTGACGACAGCAGGATTGTTATACATCGAGCTGCACAAAAAGGATCCAAGAGGACATAAAGTGTCATTTATGTCTTTTATGCAACATGGCCCAACATGTACAAGACCAgagaatgacaaaaaaaaaacagagaaaaaaagtgaCTGCACACCACTGACTGCCTATAATTAGTTTTTGAGAccaataatgtaattttaaaataaaaaagattatttcCAGAGTTAATTTAATTGACACACTGctctttatatgttttatactattattttgtatataatgCATATTTATAAGAACCAAACAtctgaagaataaaaaaatgttaattcctTCTGTA

Function

symbol description
dll4 Predicted to enable Notch binding activity. Acts upstream of or within several processes, including negative regulation of blood vessel endothelial cell migration; vasculature development; and ventral spinal cord interneuron differentiation. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including atrioventricular canal endocardium; brain; endothelial cell; vasculature; and xanthophore. Human ortholog(s) of this gene implicated in Adams-Oliver syndrome. Orthologous to human DLL4 (delta like canonical Notch ligand 4).

NR:

description
PREDICTED: delta-like protein 4

GO:

id name namespace
GO:0060854 branching involved in lymph vessel morphogenesis biological_process
GO:0060855 venous endothelial cell migration involved in lymph vessel development biological_process
GO:0030947 regulation of vascular endothelial growth factor receptor signaling pathway biological_process
GO:0007219 Notch signaling pathway biological_process
GO:0045765 regulation of angiogenesis biological_process
GO:0002040 sprouting angiogenesis biological_process
GO:0001569 branching involved in blood vessel morphogenesis biological_process
GO:0060840 artery development biological_process
GO:0060841 venous blood vessel development biological_process
GO:0043537 negative regulation of blood vessel endothelial cell migration biological_process
GO:0016021 integral component of membrane cellular_component
GO:0005509 calcium ion binding molecular_function

KEGG:

id description
K06051 DLL; delta

RNA

RNA id representative length rna type GC content exon number start site end site
XM_007231505.3 True 3782 mRNA 0.50 11 56839749 56852430

Neighbor

gene id symbol gene type direction distance location
chac1 chac1,LOC107721326,LOC107739370,LOC107659180,LOC107668209 coding downstream 16698 56820485 ~ 56823051 (-)
rhov rhov,LOC107602886,LOC107659156,LOC107668201,LOC107562688,LOC107721274 coding downstream 80983 56755389 ~ 56758766 (-)
zfyve1 zfyve1,LOC107721321 coding downstream 115975 56712617 ~ 56723774 (-)
LOC103033540 fntb,LOC108424508,LOC107668263,LOC107756604,LOC107721314,LOC107671778,LOC103359368 coding downstream 549911 56274486 ~ 56289838 (-)
LOC103029201 LOC103029201 coding downstream 587172 56240971 ~ 56252577 (-)
LOC111189704 NA coding upstream 366480 57218910 ~ 57226087 (-)
vrtn vrtn coding upstream 527383 57379813 ~ 57384666 (-)
zbtb1 zbtb1,LOC107711663,LOC107668253,LOC107721384,LOC107602161,LOC107562689 coding upstream 572875 57425305 ~ 57431655 (-)
LOC103044876 NA coding upstream 588241 57440671 ~ 57446335 (-)
LOC103044195 NA coding upstream 598495 57450925 ~ 57490723 (-)
G28813 NA non-coding downstream 14748 56824696 ~ 56825001 (-)
LOC111189610 NA non-coding downstream 225682 56588694 ~ 56614067 (-)
G28728 LOC108415780 non-coding downstream 330061 56487213 ~ 56509688 (-)
G28657 srsf5,LOC103029514,LOC107756601,LOC107549086,LOC107602033,LOC107721313 non-coding downstream 600026 56232707 ~ 56239723 (-)
G28661 NA non-coding downstream 611895 56214544 ~ 56227854 (-)
G28823 NA non-coding upstream 158047 57010477 ~ 57010707 (-)
G28938 NA non-coding upstream 911071 57763501 ~ 57764257 (-)
G28959 prph2l,LOC108424527,LOC107711660,LOC107665408,LOC107569893,LOC107721267,LOC108258119,LOC107602225 non-coding upstream 945661 57798091 ~ 57798381 (-)
G28960 prph2l,LOC108424527,LOC107569893,LOC107711660,LOC107665408,LOC107602225,LOC107721267 non-coding upstream 946632 57799062 ~ 57800871 (-)
LOC111189782 NA non-coding upstream 997304 57849734 ~ 57853758 (-)
LOC103031416 dpf3,LOC108424513,LOC107659173,LOC107721322,LOC107668213,LOC108257599,LOC107562702,LOC107602065 other downstream 144914 56640351 ~ 56694835 (-)
G28536 NA other downstream 1023151 55815872 ~ 55816598 (-)
gtf2h5 gtf2h5,tf2h5,LOC107721375,LOC107659223 other downstream 1198374 55634532 ~ 55641375 (-)
G28501 nrbp1,LOC103372645,LOC105015343,LOC106537236,LOC102314540 other downstream 1232863 55602870 ~ 55606886 (-)
LOC111189318 NA other downstream 1337989 55499900 ~ 55501760 (-)
ppp4r4 ppp4r4,LOC107711657 other upstream 959832 57812262 ~ 57841318 (-)
LOC103041090 LOC103041090,LOC108424449 other upstream 1139211 57991641 ~ 57995476 (-)
LOC111189852 LOC108411318,LOC108257913,LOC107721335,LOC102302990,LOC102081001 other upstream 1306777 58159207 ~ 58174704 (-)
G29317 eif5,LOC103022293,LOC107561927,LOC107746071,LOC108435020,LOC107589079,LOC107701513,LOC107582488 other upstream 2080533 58932963 ~ 58934789 (-)
LOC103023855 xkr6b,xkr6,LOC103023855,LOC108435015,LOC107746102,LOC107701509,LOC108258067,LOC107589046,LOC107723320,LOC107684793 other upstream 2146111 58998541 ~ 59085886 (-)

Expression


Co-expression Network