sh3rf1 (sh3rf1,LOC107683940,LOC107739375,LOC107597452,LOC107755262)


Basic Information

Item Value
gene id sh3rf1
gene name sh3rf1,LOC107683940,LOC107739375,LOC107597452,LOC107755262
gene type coding
species mexican tetra (Astyanax mexicanus)
category of species ornamental fish

Chromosome Information

Item Value
chromosome id NC_035899.1
NCBI id CM008302.1
chromosome length 74127438
location 67352889 ~ 67415892 (-)
genome version Astyanax_mexicanus-2.0_2017_mexican_tetra_Genome

Sequence

>XM_007255228.3
GTCGTCGCGGGGTCTGGATCCTCCTGCTTGTTCCTCGGTCAGTAGAGGAGTCTCGCTGAGTTGGCTCGCGTCTCCGGGTGGAAGACAACAGGAAAACGGGCTGTTTTTGATGGTAAAGACTCAGAGGAGAGCCTGTGAAGTGAGTTTGTGTCTCAGAGCAGGGAACGGAGATTTCGTGGACGCTTTTCTGAGCCACTTTCCCTCAGTTCTGAAGGAACTAGTGCAGGAACAGTTTTgtgggagaggaggaggagaaggaggagcagCGAGCTGCGGACGGGAGGAGGCCGTGTTCAAGTGGCTGCTGGTGATGTGACCATGAGCGCGGCATGGGAGTGACGTGACAAAAGGGGTGGATCTGTCTCTggctctgtctttctctctctctccctctcgcacACGCACGCATACACATGATGTCTCTCTTTGCTCCGAGAGACAGAACTGAGTGAGcaagtgagtgagcgagtgaaCACGTGGAGAGGGACAGCCTGGGAGTCGCGATGGACGAGTCGGCTCTTCTGGACCTCCTGGAGTGCCCAGTATGCTTGGAGCGGCTAGATGCCACGGCCAAGGTGCTGCCGTGCCAGCATACGTTTTGCCGCCGCTGCCTGCTGGGCATTGTGGGCTCGCGCGGGGAGCTCCGCTGTCCAGAGTGCCGCACACTTGTGGAGAGCGGCGTGGATGAGTTGCCTAGCAACATTTTGCTGGTACGTCTGCTGGATGGCATCAAGCAGCGGCCCAGGCGGGCGGGGGCAGGACCGGTGGCAGCGGCAGCAGCTGTGACCAACGGCTCAGCGGGTGGGGGAGTGAGAAACCAGGGGGCCGGCGGAGGAGGACAGAGGGATCAGACAAACCCAGGAGTGCAGCCCCAAAGAGTCCAGACCAAGAGCACTCCAGTCAGAGGGGTGCCTCAGCTCCCTTGTGCCAAGGCCTTATACAACTATGACGGCAAAGAACCAGGTGACCTCAAGTTCACTAAGGGTGACATCATTATCCTGCGCCGGCAGGTGGATGAAAACTGGTACCATGGAGAAATGGGCGGGGTCCACGGATTCTTCCCAACCAGCTTTGTGCAGGTGATCAAACCTCTGCCCCAGCCTCCCCCACAGTGCAAAGCTCTGTACGACTTTGAACTGAAAGACAAGGAGGCAGACAAGGACTGCCTGCCCTTCTCAAAGGATGACATTTTGACAGTGATTCGGCGGGTTGACCAGAACTGGGCTGAAGGAATGCTGGGAGATAAGATTGGCATCTTTCCTATATCATATGTAGAGttTAACACAGCAGCGCGGCTGCTTATTGAGCTGGACAAGGTGCCAGACAGTGGCAGCGATTCCGGTGAAGGAGCTTCTTCGTCTGCGTCGGGACCACAGGCTAATGGTGTGCAGAAGACTGCAGGAGAGAAGAAGAACAGCAAAAAGCGCCACTCGTTTACGTCTCTGACCATGTCCCATAAGCCATGCCTGGCTCCGCCGCCACAGAGGCACTCCATGGAGATTAGTGGCCCTGTGCTCATCAGCTCCTCCAATCCTACAGCAGCAGCTCGCATCGGGGAGCTCAGTGGAGGATTGTCCTCCAGTGCCCCGTCCCAAGTTCACATTTGCACGTCAGGCCTCATTGTCACTCCTCCTCCGAGCAGCCCTGTAACTACGGCAACCGTCTTCACTTTCCCCCCAGAGACCAGCTACGCCTCAATCCCAGTGGATGTGCTGCCTCCTCCTCCACCGCCTCCCCCACAGTCTTCTGCTGTCGGCGCTGCCTCTGGATTGGCCGCTGGACAGAGGCCTTCCCCCACAGCGAGTGACCAGAGTGGGCGCCAGAGGCCGACAGTGTATGTGGCAATGTTCCCATACACTCCCCGTAAGGAGGATGAGCTAGAGCTAAGGAAAGGAGAGATGTTCCTGGTACTGGAACGCTGTCAGGATGGCTGGTTTAAGGGAACATCCATGCACACCGGCAAGATCGGAGTGTTTCCTGGCAACTACATGAGTCCTGTCAGCAGGACGGCAGCAAGCAGCAGTCAGCCTAAAGTACCCCTAACACTGTGCTCTCAAGCCGGGCGCAGCGTCACCATCGTTAGCCCCTCCTCTGCCCAACTCGGACCTTCCCAGAGTGGCATAGACCCCAGCAAGTCCATTCCAATTTGTACAGGTCCTGCTCCTTCTAGCCCTCTACCGGCAGCCATAGTGACTGCGGCTCACATGCCTCCTGGTCAGCATCCTAAAGTGCTGATGCATGTGACTTCACAGATGACTGTCAATCAAGCTCGGAATGCTGTAAGGACAGGAGTCTGTCACAACCAAGATCGCCCTACTGCTGCTGTAACACCCATCCAGTCCCAGAATCCCTTGCCTTTCCTTCCTCACTTGGCAGTGTGTCCACAGCTTTCACCCAGCCCCGGATCAGTCCCCACCTCTAACCCTGCCTCACGAATGGGTGTGGCTATGGGCTGTGCTGCCGCCTCCCTCACCCCACCCAACGTCAGTGCTGCTTCACTGGAGGTTGATACCTTGAGACCCGCTGCCATGGTAGCACTCCCAGTTGCCCCTGGTAATGCCAAACCCATGGGTGCCACAGCAGCAAATCAGACGGCTGCCTGTAGACTGGACAAGGACTGCAAGAGGGAGAAGAAAGGTCTGCTGAAACTGCTTTCGAACAAAAAGAAGCTGCGGCCCTCTCCCCCATCCTCCCCAACGCTGGAGGCCGAACAGGCAGCTACTGCAGACGTGACACAGGGTGCCATGGGGCCTGAATTGCCCATTCCTGCCTCTGCAGTGGGGGCCAGTGGAAGCCAAGCTAGAACTGGGTCCTGTCCAGTAGAGTCTGAGACATCTTTGTCatgttcatcatcatcatcgaaCACTGATGCAGCACACCGCAGGAGTGGATCCCAGGACAACCCTGCCCCCATTGCACCACCGCCACGGCAAGCATGCTCCTCCCTCCTATCCATGCAGCATGACGGCCGGCCAATTGTGTGCGAGAGGTACCGTGTGGTAGTGTCATACCCTCCACAGAGCGaggctgagctggagctgaaagAGGGAGACATAGTGTTTGTGCACAAGAAGCGTGAGGACGGCTGGTTCAAAGGAACTCTCCAGAGGAACGGTCGGACGGGCCTCTTTCCCGGCAGCTTTGTTGACAGCATCTGACTTGTGTGAACATGTTTTGTCATGAAGCAAAATAACACCAACAAACTGTTATCATGTTAGCAACTGCCACCTGCGCTGTAACCTGGAAAGCACCAGACATACGAAGCGATGGACTGAAGAGATGGAGGACTCTGCATCTGCATCAAGCACAATTCAGTGTTGGTGTTCCAACATCCCGGACGCCAGGAGGCTTCAGTGGTCTCCTGGAGCTGAACACAGACTTGCATCTCACACAGAGACTCACAAAACCAGCCCCCAGTTGGGTCAGTCAGCACATAGTCAAGCACATGTATAAAACCTTTTTATCCCGCGCACACCACATGTGACGGAGCTGGCTTAAGCCTGTAGCCTTTAGCCTATAGCACAGGAGTCGGAGCGTAGTAGAGCTAGTCATGTGATGATTTgttaatttatgtatttgaaACGTTTCAAAAAGGTTTAAATGTGTGCCTTGTACTGTCTCTCACTTTATTGTATATAAGCAAACAAAGCTGATCTATGAATCGCAAAACAGTATGAACCGAGCGAGGCTGGAAAATATGAACTTaacttatttctttttatatttagttatggTACTGATGGGTGGCTGTTGTGGGAGGAGCTATGTGAACTGAAGCAAAAGTTATTCGTGTGCCCCACTGCTTGCTCATTGGTGGAGGCTGTTTGTCATCATTGTTCACCTCTTGCTTCAGCAGTATGGATGCGGTTGCCTAGTTACACTACTGTTGATTGTCTTAGTTTTAGAGTTAGAGTTCTGATCCCGATTTACTACTGATTTAAATATTGATTGTTAATTAGAATCTTAACAGTATATCTATGCCAATATTGTACttatcctcctgttttttttgtcattacagAAAGAATCTTCTCAGTAGATTGAATTTGATCATTATTAATCATTGGCACGTATGGCCTCACCCTGGACAAAGTAGTCACATGTATAATTACTTCTTTTAGTACGTGGTTAAGCCTCTGGCGGCCTTAGTACTCAGTGATATCAGCATCAGCAGTGTCATGTGAAGAATACATCAGTCTCTGATACAGTTCCTTTCCACTATTCCACTGGTTCCCTGAACTGGGTGCACCTTCTGAGTTAACGTACAGTAATATGTGCAGTACTATCTGCTGCTCACATTGAGAGAAGTGAGAGAATCAAAGTCTGTCTAGGTCTGCTGTACAAGTCTCACAAAGAAACCCCTACAGTCGTCATCCCCGAGTGTTATAGTGTTAGAGGAGTGGGCGAAAATGATCAGGAAAAAAATTCTACCATTGGACACTAGGACAAGAAGACATGTAACAATGTGTTACAAAACATAGcgaatatatttaatatttttaattcggGGAAAATGCAAAATGTGGCTGTATATTTGGCTCAGTCTGTCTAGCAAAGTAAAGTTAACATTAAGTTAGAAAGCATAAAAATTCTTGGCACTCCTGCATGATGACCGATTGTAGTACATGTGGCCGTAGGGGGCGGCAGCAGCAAGGGCACATTTTAATGATTCTGCTgtagattatttttattcaatgaTTATAGGGATAATGTTTTTAGTCTTATATTTTTCTTAAGAAAACAAATGTTCCGCAACGCATCAGAATGgtagtgtaataaatgtatcaCTCAGATTATA
>XM_007255229.3
GTCGTCGCGGGGTCTGGATCCTCCTGCTTGTTCCTCGGTCAGTAGAGGAGTCTCGCTGAGTTGGCTCGCGTCTCCGGGTGGAAGACAACAGGAAAACGGGCTGTTTTTGATGGTAAAGACTCAGAGGAGAGCCTGTGAAGTGAGTTTGTGTCTCAGAGCAGGGAACGGAGATTTCGTGGACGCTTTTCTGAGCCACTTTCCCTCAGTTCTGAAGGAACTAGTGCAGGAACAGTTTTgtgggagaggaggaggagaaggaggagcagCGAGCTGCGGACGGGAGGAGGCCGTGTTCAAGTGGCTGCTGGTGATGTGACCATGAGCGCGGCATGGGAGTGACGTGACAAAAGGGGTGGATCTGTCTCTggctctgtctttctctctctctccctctcgcacACGCACGCATACACATGATGTCTCTCTTTGCTCCGAGAGACAGAACTGAGTGAGcaagtgagtgagcgagtgaaCACGTGGAGAGGGACAGCCTGGGAGTCGCGATGGACGAGTCGGCTCTTCTGGACCTCCTGGAGTGCCCAGTATGCTTGGAGCGGCTAGATGCCACGGCCAAGGTGCTGCCGTGCCAGCATACGTTTTGCCGCCGCTGCCTGCTGGGCATTGTGGGCTCGCGCGGGGAGCTCCGCTGTCCAGAGTGCCGCACACTTGTGGAGAGCGGCGTGGATGAGTTGCCTAGCAACATTTTGCTGGTACGTCTGCTGGATGGCATCAAGCAGCGGCCCAGGCGGGCGGGGGCAGGACCGGTGGCAGCGGCAGCAGCTGTGACCAACGGCTCAGCGGGTGGGGGAGTGAGAAACCAGGGGGCCGGCGGAGGAGGACAGAGGGATCAGACAAACCCAGGAGTGCAGCCCCAAAGAGTCCAGACCAAGAGCACTCCAGTCAGAGGGGTGCCTCAGCTCCCTTGTGCCAAGGCCTTATACAACTATGACGGCAAAGAACCAGGTGACCTCAAGTTCACTAAGGGTGACATCATTATCCTGCGCCGGCAGGTGGATGAAAACTGGTACCATGGAGAAATGGGCGGGGTCCACGGATTCTTCCCAACCAGCTTTGTGCAGGTGATCAAACCTCTGCCCCAGCCTCCCCCACAGTGCAAAGCTCTGTACGACTTTGAACTGAAAGACAAGGAGGCAGACAAGGACTGCCTGCCCTTCTCAAAGGATGACATTTTGACAGTGATTCGGCGGGTTGACCAGAACTGGGCTGAAGGAATGCTGGGAGATAAGATTGGCATCTTTCCTATATCATATGTAGAGttTAACACAGCAGCGCGGCTGCTTATTGAGCTGGACAAGGTGCCAGACAGTGGCAGCGATTCCGGTGAAGGAGCTTCTTCGTCTGCGTCGGGACCACAGGCTAATGGTGTGCAGAAGACTGCAGGAGAGAAGAAGAACAGCAAAAAGCGCCACTCGTTTACGTCTCTGACCATGTCCCATAAGCCATGCCTGGCTCCGCCGCCACAGAGGCACTCCATGGAGATTAGTGGCCCTGTGCTCATCAGCTCCTCCAATCCTACAGCAGCAGCTCGCATCGGGGAGCTCAGTGGAGGATTGTCCTCCAGTGCCCCGTCCCAAGATGTGCTGCCTCCTCCTCCACCGCCTCCCCCACAGTCTTCTGCTGTCGGCGCTGCCTCTGGATTGGCCGCTGGACAGAGGCCTTCCCCCACAGCGAGTGACCAGAGTGGGCGCCAGAGGCCGACAGTGTATGTGGCAATGTTCCCATACACTCCCCGTAAGGAGGATGAGCTAGAGCTAAGGAAAGGAGAGATGTTCCTGGTACTGGAACGCTGTCAGGATGGCTGGTTTAAGGGAACATCCATGCACACCGGCAAGATCGGAGTGTTTCCTGGCAACTACATGAGTCCTGTCAGCAGGACGGCAGCAAGCAGCAGTCAGCCTAAAGTACCCCTAACACTGTGCTCTCAAGCCGGGCGCAGCGTCACCATCGTTAGCCCCTCCTCTGCCCAACTCGGACCTTCCCAGAGTGGCATAGACCCCAGCAAGTCCATTCCAATTTGTACAGGTCCTGCTCCTTCTAGCCCTCTACCGGCAGCCATAGTGACTGCGGCTCACATGCCTCCTGGTCAGCATCCTAAAGTGCTGATGCATGTGACTTCACAGATGACTGTCAATCAAGCTCGGAATGCTGTAAGGACAGGAGTCTGTCACAACCAAGATCGCCCTACTGCTGCTGTAACACCCATCCAGTCCCAGAATCCCTTGCCTTTCCTTCCTCACTTGGCAGTGTGTCCACAGCTTTCACCCAGCCCCGGATCAGTCCCCACCTCTAACCCTGCCTCACGAATGGGTGTGGCTATGGGCTGTGCTGCCGCCTCCCTCACCCCACCCAACGTCAGTGCTGCTTCACTGGAGGTTGATACCTTGAGACCCGCTGCCATGGTAGCACTCCCAGTTGCCCCTGGTAATGCCAAACCCATGGGTGCCACAGCAGCAAATCAGACGGCTGCCTGTAGACTGGACAAGGACTGCAAGAGGGAGAAGAAAGGTCTGCTGAAACTGCTTTCGAACAAAAAGAAGCTGCGGCCCTCTCCCCCATCCTCCCCAACGCTGGAGGCCGAACAGGCAGCTACTGCAGACGTGACACAGGGTGCCATGGGGCCTGAATTGCCCATTCCTGCCTCTGCAGTGGGGGCCAGTGGAAGCCAAGCTAGAACTGGGTCCTGTCCAGTAGAGTCTGAGACATCTTTGTCatgttcatcatcatcatcgaaCACTGATGCAGCACACCGCAGGAGTGGATCCCAGGACAACCCTGCCCCCATTGCACCACCGCCACGGCAAGCATGCTCCTCCCTCCTATCCATGCAGCATGACGGCCGGCCAATTGTGTGCGAGAGGTACCGTGTGGTAGTGTCATACCCTCCACAGAGCGaggctgagctggagctgaaagAGGGAGACATAGTGTTTGTGCACAAGAAGCGTGAGGACGGCTGGTTCAAAGGAACTCTCCAGAGGAACGGTCGGACGGGCCTCTTTCCCGGCAGCTTTGTTGACAGCATCTGACTTGTGTGAACATGTTTTGTCATGAAGCAAAATAACACCAACAAACTGTTATCATGTTAGCAACTGCCACCTGCGCTGTAACCTGGAAAGCACCAGACATACGAAGCGATGGACTGAAGAGATGGAGGACTCTGCATCTGCATCAAGCACAATTCAGTGTTGGTGTTCCAACATCCCGGACGCCAGGAGGCTTCAGTGGTCTCCTGGAGCTGAACACAGACTTGCATCTCACACAGAGACTCACAAAACCAGCCCCCAGTTGGGTCAGTCAGCACATAGTCAAGCACATGTATAAAACCTTTTTATCCCGCGCACACCACATGTGACGGAGCTGGCTTAAGCCTGTAGCCTTTAGCCTATAGCACAGGAGTCGGAGCGTAGTAGAGCTAGTCATGTGATGATTTgttaatttatgtatttgaaACGTTTCAAAAAGGTTTAAATGTGTGCCTTGTACTGTCTCTCACTTTATTGTATATAAGCAAACAAAGCTGATCTATGAATCGCAAAACAGTATGAACCGAGCGAGGCTGGAAAATATGAACTTaacttatttctttttatatttagttatggTACTGATGGGTGGCTGTTGTGGGAGGAGCTATGTGAACTGAAGCAAAAGTTATTCGTGTGCCCCACTGCTTGCTCATTGGTGGAGGCTGTTTGTCATCATTGTTCACCTCTTGCTTCAGCAGTATGGATGCGGTTGCCTAGTTACACTACTGTTGATTGTCTTAGTTTTAGAGTTAGAGTTCTGATCCCGATTTACTACTGATTTAAATATTGATTGTTAATTAGAATCTTAACAGTATATCTATGCCAATATTGTACttatcctcctgttttttttgtcattacagAAAGAATCTTCTCAGTAGATTGAATTTGATCATTATTAATCATTGGCACGTATGGCCTCACCCTGGACAAAGTAGTCACATGTATAATTACTTCTTTTAGTACGTGGTTAAGCCTCTGGCGGCCTTAGTACTCAGTGATATCAGCATCAGCAGTGTCATGTGAAGAATACATCAGTCTCTGATACAGTTCCTTTCCACTATTCCACTGGTTCCCTGAACTGGGTGCACCTTCTGAGTTAACGTACAGTAATATGTGCAGTACTATCTGCTGCTCACATTGAGAGAAGTGAGAGAATCAAAGTCTGTCTAGGTCTGCTGTACAAGTCTCACAAAGAAACCCCTACAGTCGTCATCCCCGAGTGTTATAGTGTTAGAGGAGTGGGCGAAAATGATCAGGAAAAAAATTCTACCATTGGACACTAGGACAAGAAGACATGTAACAATGTGTTACAAAACATAGcgaatatatttaatatttttaattcggGGAAAATGCAAAATGTGGCTGTATATTTGGCTCAGTCTGTCTAGCAAAGTAAAGTTAACATTAAGTTAGAAAGCATAAAAATTCTTGGCACTCCTGCATGATGACCGATTGTAGTACATGTGGCCGTAGGGGGCGGCAGCAGCAAGGGCACATTTTAATGATTCTGCTgtagattatttttattcaatgaTTATAGGGATAATGTTTTTAGTCTTATATTTTTCTTAAGAAAACAAATGTTCCGCAACGCATCAGAATGgtagtgtaataaatgtatcaCTCAGATTATA

Function

symbol description
sh3rf1 Predicted to enable MAP-kinase scaffold activity and ubiquitin protein ligase activity. Predicted to be involved in several processes, including positive regulation of JNK cascade; protein autoubiquitination; and regulation of alpha-beta T cell activation. Predicted to be located in lamellipodium. Orthologous to several human genes including SH3RF1 (SH3 domain containing ring finger 1).

NR:

description
E3 ubiquitin-protein ligase SH3RF1-like isoform X3

GO:

id name namespace
GO:0016567 protein ubiquitination biological_process
GO:0048471 perinuclear region of cytoplasm cellular_component
GO:0005794 Golgi apparatus cellular_component
GO:0030027 lamellipodium cellular_component
GO:0008270 zinc ion binding molecular_function
GO:0016874 ligase activity molecular_function

KEGG: NA

RNA

RNA id representative length rna type GC content exon number start site end site
XM_007255228.3 True 4798 mRNA 0.51 12 67352889 67415892
XM_007255229.3 False 4687 mRNA 0.51 11 67352889 67415892

Neighbor

gene id symbol gene type direction distance location
LOC103032908 LOC108427497,LOC100690439 coding downstream 37138 67214548 ~ 67315751 (-)
LOC103026745 LOC108427498 coding downstream 184813 67156457 ~ 67168076 (-)
LOC103026240 LOC103026240,LOC108427476,LOC105895132,LOC108274573 coding downstream 201463 67128169 ~ 67151426 (-)
LOC103025634 NA coding downstream 264738 67086434 ~ 67088151 (-)
senp6 senp6 coding downstream 273447 67053665 ~ 67079442 (-)
nek1 NA coding upstream 19077 67434969 ~ 67479787 (-)
LOC103030302 ivns1abp,ivns1abpa,LOC108256770,LOC107732388,LOC107726450,LOC107553504 coding upstream 169219 67585111 ~ 67606176 (-)
trnai-aau NA coding upstream 241573 67657465 ~ 67657537 (-)
trnai-aau_1 NA coding upstream 241734 67657626 ~ 67657698 (-)
trnai-aau_2 NA coding upstream 242289 67658181 ~ 67658253 (-)
G31385 NA non-coding downstream 36716 67315844 ~ 67316173 (-)
G31352 NA non-coding downstream 148640 67203958 ~ 67204249 (-)
G31329 NA non-coding downstream 229949 67122629 ~ 67122940 (-)
G31303 NA non-coding downstream 255347 67089429 ~ 67097542 (-)
G31316 NA non-coding downstream 294455 67058059 ~ 67058434 (-)
G31480 NA non-coding upstream 238258 67654150 ~ 67654617 (-)
G31482 NA non-coding upstream 241683 67657575 ~ 67659085 (-)
LOC111191948 NA non-coding upstream 269474 67685366 ~ 67686312 (-)
G31546 hmcn1,LOC106560561 non-coding upstream 417531 67833423 ~ 67835048 (-)
G31523 hmcn1,LOC107599116 non-coding upstream 427392 67843284 ~ 67889027 (-)
LOC103031958 myo6 other downstream 308571 66862465 ~ 67044318 (-)
trnad-guc_8 NA other downstream 2255216 65097602 ~ 65097673 (-)
trnad-guc_7 NA other downstream 2259740 65093078 ~ 65093149 (-)
LOC103036530 cyp2p7,cyp2j20,LOC108415355 other downstream 2553713 64774684 ~ 64799176 (-)
scfd2 scfd2 other downstream 3589216 63528281 ~ 63763673 (-)
G31424 NA other upstream 7980 67423872 ~ 67432424 (-)
G31437 NA other upstream 87857 67503749 ~ 67528337 (-)
arpc5 arpc5,arpc5b,LOC103045524,LOC107599090,LOC107698380,LOC107732423,LOC104921830 other upstream 439714 67855606 ~ 67885433 (-)
LOC103046133 LOC108439589 other upstream 516668 67932560 ~ 67940713 (-)
G31622 NA other upstream 675328 68091220 ~ 68091581 (-)

Expression


Co-expression Network