kdr (kdr)


Basic Information

Item Value
gene id kdr
gene name kdr
gene type coding
species mexican tetra (Astyanax mexicanus)
category of species ornamental fish

Chromosome Information

Item Value
chromosome id NC_035899.1
NCBI id CM008302.1
chromosome length 74127438
location 64335713 ~ 64370564 (-)
genome version Astyanax_mexicanus-2.0_2017_mexican_tetra_Genome

Sequence

>XM_022664454.1
CTCTGTGCTGCtccctcagtgtgtgtgtggagcgcGCGGGTCTCCTGCAGTGCGCGGGGCATCGCTGAGTGGATTATCTCCGGGTTCCGCTACAGgactgtgtgagagagtgtggacagcagtgtgtgtgagagagtgtgtgtgtgagtgtggagcTGTGGGTCCTGATGCGCAGCTGAGGATAGCCGTCCTGTGGGAACTTCTAAGAGGGGTTTGATGCGGGGACAGTCCGGCAGGGTGGTCGCACCATGGCAAAGCCATTTTCACTTCTCTCTCTGGTGGGCATTATTTCTGCAGTCAGCTGGGTGACAGCTATGGAGCTCAGGTTTGTGCCTGACCCTCCAATCTTAAGCATCTCaaataaaacactcaaaatCAATGCTTCTGACACGCTGGAGATAACCTGCAGGGGCCGCCAGATCCTGGAGTGGTACACACCTCATAACCGCACTGGGTCTGAAAGCAGACTCAATGTATCCGACTGCAGCGGAGATGGACTTTTCTGTAGTAAACTTACACTGACCGCAGCCTTGGCTAATGAGACAGGAGAGTATCGCTGCTCCTACAGAAACCTGGCCGTGGAGGATAGGAAGACCTCGCTGGGGGTGTACGTCTTTGTGCAAGACTATCGTGTGCCGTTTGTCCGCTCGGCTCAGGAATATGACGTGGTCTTTCTTCGGGAAGGTGAACAGGTGGTCATCCCCTGCCTTGGTTCCGTAGAAGACCTTAACGTCACTCTGTACACGAAGTATCCAGTAAAGGAACTGGCCACTGATGGAAAAGATGTGCTCTGGGACAGCAGGAGAGGCTTTATCCTTCCTAGTCATGTGATCAGCTATGCTGGCGTGGTCTTCTGTCAAACGCGAATCCAGAACGAAACCTTTCAGTCTTCACTCTACATTGTGGCTGTTGTGGGATATAAGATCTATGACCTCACTGTGAGTCCTGCTCACGAGAAGCTGGCCGTCGGGGAGAGACTGGTGCTCAACTGTACCGCTCGCACTGAGCTCAACGTGGCTATTGACTTTCAGTGGTCCTTACCTCAGGACAGGAGAAATACCAACCGTTCTACACCAACAAATTATGAGACCAAGTCCTACAAGAAGAAGCTGTGGAACTCTCTGGAACTGTCCAACTTACTGATTATGGAGAATGTGACGAATGATAACATGGGGGAGTATATTTGCACAGCTTCCAGTGGTCAGATGGTCAGAACTGCTCAGGCAGCTCTTATAGTGTACGAGAAGCCCTTCATATCACTGAATGAACAGTGGGTTCGTGTTGTGGACACAAACACAGGCCAGCGGGAAACAAAGATCCCTGTGAAATATGATGCTTATCCAGAACCTAATGTGAAGTGGTTGAAGAATGGCCTTGCCATTTCTAATGAAGAGTACAGGATGAAGCCAGCCAAAGACTCTCTCACTATATTTGAGGTCACAGAAAGAGATGCTGGGAATTACACCGTGGTCATGACCAATAAGATCACTAAAGAAACACAGAAGCAGACATTTCAGCTACTGGTGAACGcTCACCCTAAGATCTTTGAGAAGGAGGTGCCGTTGGATCGTAACATTCACATGTTTGGCAGCAGCCCCACCCTCACCTGCACTGCGTCCGGCGGCTCCAGCCCTGTCACTATCCAGTGGCAGTGGATGCCCAGCGAGGACTGTCCGTCACGATTTCAGCCCAGGTCAGACcagagtgcagtgtgtgagggGAAGTGGAGAGAAATTTCCAACAACACAGGAAAGAATCGCATTGGCCAGCTGATCACTTTCACTGACAGCTCACTCAAGACAATCAGCACACTGAAGATCCAGAAGGCTGTGGCTCATGCCCTGTACAGGTGTGTTGCTGCCAATAAAGTAGGAGTGGAGGAAAGAATCATTGTTTTTCAAGTGACACGTTTCCTCAATCTCTGTGTGTTCCCATCCAGCAAACCTATAGAGCAGGAGGATGTGCTGCTGCGCTGTGTGGTCGACCGCATGCTCTACTCCAGTTTGAGTTGGTACCGGGTGCTTAATGTGTCCAATCCAGACAGCTTACCCGCCACTGTACCCTGCGGCACTCTTGCCCTGAGCCCTCTCACACAGCCCAACGCCACCATCATGGCCCTGCATGGGAACAACGCCACTCTGGACCTGTCGCTGCCCAGAGCTTCCCGAAAGGATCAGGGCCTGTATGCCTGTCGGGTGGAGAACGCTGACAGCAGTGAGAGAACCTGCCTGCTACACTACCTGAAGCTCAGAGctctggaGTTGCCATGGATTGTGAGCAACCTAACAAATCAGCGGGTTAATGTGAGCGACTCTGCTATACTGATGTGTGAAGTCAAAGGAACTCCAAACCCCACCGTTATCTGGACCAAAGACAACCAGACGGTCACTAAGGGATCAgGAGTCATTCTGACCAACTCAAACCGTGTTTTGACCATCCAGAGGGTGAAGAAAGAGGACAGTGGTCTGTACACATGCACAGCCTGCAACAAACAGGGCTGTGACTTTGCCCAGGCCAAGCTTACAGTGGAGGGTGCAGAGGAGAAGATGAATGTGGAGCTCATTGTGCCGATTGGTGCTGTGGTCATTGCCATGTTCTTCTGGCTTCTCATTGTCTTTGTCATACGCAACAGGAAACGGCCTGCTGATGGAGAAATGAAAACAGGCTACCTGTCAATCATCCTGGACTCTGAAGACATGCCTATGGATGAGCACTGTGAGAGACTCACCTATGACGCCAGCAAGTGGGAGTTCCCCCGAGAACGACTCAAACTAGGGGAGCCTCTGGGTAGAGGAGCGTTTGGTCAGGTTGTGGAGGCGGCAGCGTTTGGTATTGAGAAAGCTACCACCTGCACTACAGTAGCAGTGAAGATGCTTAAGGaGGGTGCTACCACCAGTGAGTACCGTGCCTTGATGTCTGAACTGAAGATTCTCATCCATATTGGCCACCATCTCAATGTGGTCAACCTGCTCGGTGCCTGCACCAAGCCAGGAGGTCCATTGATGGTGGTAGTAGAGTACTGTAAGCACGGTAACCTCTCCAGCTATCTGAAGAGCAAGCGTGGCGAGTACAGCCCCTATAAGAGGAGCAGGCCACGGCTGGTGCAGGACAATGCAGGACTAGAGGAGGATCTGAATGAAGGGGATCTGGGTTTGGGTACCACCACCCGACTGGACATCTGCACTGGAACAGCTGTGTGCTCTGGGCTGAGAGGGGATTGCCTCTTAACCCCCTCACAGGATGAGCAAGAGAGTTCAGACTGGGATCATCTGACCATGGAGGACCTCATCAGCTACAGCTTCCAGGTGGCCAAGGGCATGGAATTCCTTTCCTCACGAAAGTGTATTCATCGTGATCTGGCAGCCAGGAACATTCTGCTTTCTGAGAACAACATTGTGAAGATCTGTGACTTTGGCCTGGCTAGAGACGTGTACAAAGATCCAGACTACGTCCGCAAAGGAGATGCTCGTCTTCCTCTGAAGTGGATGGCTCCAGAGACCATTTTTGACCGTGTGTACACCACCCAAAGTGATGTGTGGTCCTTCGGAGTGCTGCTCTGGGAGATATTCTCTCTGGGTGCGTCTCCTTATCCTGGAGTGAACATTGATGAATCGTTCTGCAGGAGGCTGAAGGAGGGCACTAGGATGAGACCACCAGACTACGCTACCCCTGAGATCTATCAGACAATGCTGGACTGCTGGCTGGATCGGCCCACAGACAGACCCACTTTCACAGAGCTAGTGGAACATCTGGGTAATCTACTGCAGGCCAGCGCCCAACAGGATGGTAAAGATTACATCCCGCTGACGGTGGGAGAGGCGGAGTCAGGTATCGGACATCTCAGACTGACATCATATAAACAAGGACCTCGAGCTGACAGCTCAGGGAACCAGCTCAACTATGATAATGCTCCACCACTGGGATATGGTCAGCAGCTGGAGATATGCAGTCATCAGATATTTGAGGACATTCCTCTGGAACGAAGTGCTGTGATGGATGGTCAGATGGACTGTGGCGTGGGTTTATCACGTGAGCAGATGAACCATCAAGTTCACAGAACAGCAACATTCAGCCCTCTCCTGCGATGTAAGAGTAAGGAATCTCTAGCCTCCGAATCGTCCAATCAGACGAGTGGCTACCAGTCAGGTTACCACTCAGACGACGCTGAGGCACCTGTGTATGCCAACGAAGAGATGATCCTGAAGAGGGACATTCTAAAGAAGCCTCCGCTCCCCAAGAGAGATGACAAGTACAGCGCCGAGGTCCGTTACAGCACTCCCCCTGTCTAACAGAGACCACATGGGACCCTGGGACTTTAAAGCCAAGCCTGTCTTTATTGTGACCATAAAGTTTGGACATTTGACCTGGAATAGCAGATTTAGCCTTTTCATTTGGAGAAGAAGTAATTCACTGAatttaacacaataaaatatgGATAATTTTCACACATTGACCAAATAATATGTGATGCCGACACAGTTCTGAAGTAAACAGATACATATAATTGTATTGATTAAATGTACACTATACTTGTACACGATTCTAACTAGAAAATGAACTGCGTCACTGTCCTCAGTGTAGGGCAGGGGCATTATGTGGGTGTTATCTATAATGTTCTGCTTATGATAGGTTGGCATATAGCCATGATTTCAGAAATGTCTTCTTAAGGTTATATGAGCGGACCCAAAAACTGGTGCCGGCAACAAGAGGTGACTAAACATTTCTTATCTTGCGTTCTTCCTCTGAGATCATTTCCTTTGCAGGCCCTACCCTTCTCATACTGTCAGTCAGCAGCActgtgcatttatttaatattatttaatcagGTACATGCATTACAATCTGTAAGGCTTCCTCTGATCAACACTTACAGTAACATATTTCACCCTCAGATCACTGTGTAttgcacatacagtacagtatcagCTCCACATCAGTATAGACCAGTTCACCATTGTGCCTTATTTGTCTTTATTCGTTGATCCATTCCTCCCCATTTTAAGAAATACaggtaatttattgtgttggcGCCGATAAGCTGTATGTGTTAGTTTTCATTCCTTTTAAGAAAGCTTTGGAAATGTAATCACTGTTTACACAGACCACAGAACAAATCTAGCCTTATAGCGAGACCACTCCCACTTCCTGAGTAGGACCACACCCACTTTCTTCCAGACAGGAAATAGCAACTGCAGTGCGAGACAATCAAGTGAGCgaatgtagtgtttttttctgtttttatcttttgtaTTGTCTTAAACTGAAGTTCAGCCAGACTCTTTCAATTCCAAGCAGCAGAAAGGGCTCTGTGACGGCCGTGTCTCGATTGTACAGTTTATAAAGTGAGGACTTAATAAAGTCCGTCAGTTATTTACTAAACTTGTCCTAAATGTAActagttttataaaataaacattcagcaaaattaatatta

Function

symbol description
kdr Predicted to enable transmembrane receptor protein tyrosine kinase activity. Acts upstream of or within angiogenesis. Predicted to be located in endoplasmic reticulum. Predicted to be part of receptor complex. Predicted to be integral component of plasma membrane. Is expressed in several structures, including axis; endocardium; intermediate cell mass of mesoderm; tail bud; and vasculature. Human ortholog(s) of this gene implicated in several diseases, including adhesions of uterus; artery disease (multiple); gastrointestinal system cancer (multiple); macular degeneration (multiple); and pancreatic cancer (multiple). Orthologous to human KDR (kinase insert domain receptor).

NR:

description
vascular endothelial growth factor receptor 2 isoform X1

GO:

id name namespace
GO:0030154 cell differentiation biological_process
GO:0001525 angiogenesis biological_process
GO:0006468 protein phosphorylation biological_process
GO:0048010 vascular endothelial growth factor receptor signaling pathway biological_process
GO:0005769 early endosome cellular_component
GO:0005887 integral component of plasma membrane cellular_component
GO:0005634 nucleus cellular_component
GO:0030054 cell junction cellular_component
GO:0005524 ATP binding molecular_function
GO:0019838 growth factor binding molecular_function
GO:0005021 vascular endothelial growth factor-activated receptor activity molecular_function

KEGG:

id description
K05098 KDR, VEGFR2, CD309; kinase insert domain protein receptor

RNA

RNA id representative length rna type GC content exon number start site end site
XM_022664454.1 True 5434 mRNA 0.49 30 64335713 64370564

Neighbor

gene id symbol gene type direction distance location
lnx1 lnx1,LOC107683953,LOC107665364 coding downstream 428048 63823872 ~ 63907665 (-)
sgcb sgcb,LOC107597442,LOC107665396,LOC107718388,LOC107601954,LOC107683993,LOC107755229 coding downstream 971302 63357911 ~ 63364411 (-)
lrrc66 NA coding downstream 979424 63335850 ~ 63356289 (-)
LOC103038514 LOC108414611 coding downstream 1216217 63114090 ~ 63119496 (-)
trappc8 trappc8 coding downstream 1270481 63014238 ~ 63065232 (-)
clock clock,clocka coding upstream 56540 64427104 ~ 64500676 (-)
nmu nmu coding upstream 136395 64506959 ~ 64526668 (-)
cep135 cep135 coding upstream 235807 64606371 ~ 64626394 (-)
aasdh NA coding upstream 302951 64673515 ~ 64694914 (-)
ppat ppat,LOC107737308,LOC107683925,LOC107556156,LOC107721366,LOC107665312 coding upstream 331936 64702500 ~ 64719032 (-)
G30554 NA non-coding downstream 66059 64266410 ~ 64269654 (-)
G30502 NA non-coding downstream 191426 64141052 ~ 64144287 (-)
G30489 NA non-coding downstream 221206 64111726 ~ 64114507 (-)
G30477 NA non-coding downstream 282461 64052561 ~ 64053252 (-)
G30474 NA non-coding downstream 356350 63979064 ~ 63979363 (-)
G30581 NA non-coding upstream 93675 64464239 ~ 64465591 (-)
G30597 NA non-coding upstream 157221 64527785 ~ 64528040 (-)
LOC111191943 NA non-coding upstream 197012 64567576 ~ 64571280 (-)
G30608 LOC107721360,LOC107665383,LOC107683916,LOC107556159 non-coding upstream 209810 64580374 ~ 64582695 (-)
G30598 exoc1 non-coding upstream 216889 64587453 ~ 64590755 (-)
scfd2 scfd2 other downstream 572040 63528281 ~ 63763673 (-)
usp46 usp46 other downstream 850692 63433792 ~ 63485021 (-)
G30376 NA other downstream 1000867 63330044 ~ 63334846 (-)
fryl fryl,LOC107683942,LOC107665346 other downstream 1047605 63136951 ~ 63288108 (-)
LOC103043586 mark3b,LOC108412004,LOC107697167,LOC108258043 other downstream 2444984 61831841 ~ 61890729 (-)
LOC103036530 cyp2p7,cyp2j20,LOC108415355 other upstream 404120 64774684 ~ 64799176 (-)
trnad-guc_7 NA other upstream 722514 65093078 ~ 65093149 (-)
trnad-guc_8 NA other upstream 727038 65097602 ~ 65097673 (-)
LOC103031958 myo6 other upstream 2491901 66862465 ~ 67044318 (-)
G31424 NA other upstream 3053308 67423872 ~ 67432424 (-)

Expression


Co-expression Network