ireb2 (ireb2)


Basic Information

Item Value
gene id ireb2
gene name ireb2
gene type coding
species mexican tetra (Astyanax mexicanus)
category of species ornamental fish

Chromosome Information

Item Value
chromosome id NC_035903.1
NCBI id CM008306.1
chromosome length 40813162
location 25531046 ~ 25547668 (+)
genome version Astyanax_mexicanus-2.0_2017_mexican_tetra_Genome

Sequence

>XM_007228554.3
CTCCTGTCGCTAATTGGCTGGATGTGGGGGAGGCGTTACCACACTCCTCTCGAGCAGAGTCGTGTTAATCTCAGAAGTCATCATGGCGCTCACTTCCTCACAGCAAGAGCACCCATTTGCCCATTTGATTGACACACTACAAACTGAGAAAAATGAAGCCCAGAAATATTTCAATCCTCAGAAACTTGGGGATCCCAAATATGAGAGACTGCCGCTTTCTATTCGTGTGCTGCTAGAGTCTGCCATCCGGAAGTGTGATGGCTTTTATGTGAAGCAGGAAGATGTGGACAATATTCTGAACTGGGAAGAACGACAGAATGAGGCAGAAATCCCGTTCTTCCCTGCACGAGTCCTGCTGCAGGACTTCACGGGCATTCCAGCCATGGTGGACCTGGCAGCCATGAGAGATGCTGTGGCAAAGAACGGAATCGACCCCAACCTCATCAACCCCAAATGTCCTACTGACCTTATAGTAGATCACTCACTACAAATCGACTTTAGCAAATGtGCCATCCAAAATGCCCCTAATCCTGGCGGAGGTGATGGACAAGGGACAGGTCCACGCTTGGGCCCTGCACGGTCTTCTCCCAGAAACAGCCAGTGTGGAGGTCAGAGAGGAAGTTGCAGCAAAGGCTCCTGCAGTGATGCTCCCTCCAGTGCCAGCAGAGCACCTTCGGTACAGATAGAAAATACGCCACTTCTCTGCCCCTTCCATCTGCAGCCTGTCTCAGAGCAAGATACAGCCGTCAGGAACCAGGAGATGGAACTCATACGAAACAAAGAAAGACTTCAGTTTTTTAAGTGGTGTTCTAAAGCATTTAAGAACGTGACCGTGGTTCCTCCAGACATTGGTTCTGTGCACCAGGTCAATCTGGAGTACCTGTCTCAAGTAGTTCAGGAGATTGGGGGCTTTGTCTATCCAGACACAGTTGTAGGCACAGACTCCCACACGACTATGATTAACGGCCTTGGTATACTCGGCTGGGgtgTAGGAGGAATAGAGTCTGAGGCAGTAATGCTGGGTCAACCTGTATCTCTGACCTTGCCACATGTTGTGGGGTGCAGGCTGGTGGGATCCATCAGCACACTGGCTACATCTATAGACATAGTTCTCGGTATCACAAAGCACTTACGTCAAGCCAGTGTCGGTGGGAAGTTTGTGGAGTTTTTTGGACCAGGAGTTTCTCAGCTCTCTGCCGCAGACAGAACCACCATTGCTAACATGTGCCCTGAATACAATGCTACTGTTAGCTTTTTCCCTGTGGACGACACCACTCTCAAGCACTTTAAACAGACCAactttacagaagagaaacTTGAAGTTATGGAGCGATACCTTAAAGCTGTTAAGCTGTTCCGGAGCTCCGATGATCAGACAGAAGATCCACAATATTCTGAGGTTATTGAAATCAACCTAGCTTCAATTGTGCCCTGTGTAAGTGGACCCAAACGGCCGCAGGATCGAGTACCTGTACCCTGTATGAAGGAGGACTTTCTCAACTGTCTCAATGAGAAGGTGGGTTTTAAAGGGTTCCACATTCCAAAAGAGAAGCAGTGCATTACAGTGCCGTTTCTACATGAGGGTACCGAGTACTTTCTGTCTCACGGATCAGTTGTCATCGCCGCCGTTATCAGTTGCACTAATAATTGCAACCCTTCTGTCATGCTCACTGCAGGCCTTTTAGCAAAGAAAGCTGTGGAGGCTGGTCTTACGGTAAAGCCTTACATCAGGACCAGCCTAGCTCCAGGCAGTGGCATGGTTACACACTACCTCAACGCCAGTGGAGTGCTGCCTTACCTAAGCCAGCTTggGTTTGAGGTGATTGGTTATGGATGTGCCACTTGTGTAGGAAACACAGCACCTTTACCTGAGTCTGTGGTAGATGCTATTAAACAGGGTGATCTGGTTGCATGTGGAGTGTTGTCTGGTAACAGGCATTTTGAAGGACGCCTTTGTGACTGTGTTCGTGCCAATTATCTAGCTTCACCTCCCCTAGTGGTTGCCTATGCCATCACGGGCACAGTTGGAATTGACTTTGAGAAAGAGCCTATTGGCTTCAACCCAGAAGGCAAAGAGGTGTATCTTAAAGATGTGTGGCCATCTAAAGAAGAAGTTCAGGATGTAGAAGAACACACAGTTGTTGCCTCTGTATTTAGAGAGCTTAGGAGTCGGATGCAGAAAGGAAGCACGTATTGGAGTAACCTGGATGCACCAGATGCTCTGCTTTTCCCTTGGGATCCCAAATCTACATACATCCGTTGCCCCCCTTTCTTCAGCAAACTTTCTAAAGAAATGCCAACTCCTGTGTCCATCGATAATGCTCATGCTCTTCTATTTTTGGGGGACAAAGTCACCACTGATCACATCTCTCCTGCCGGTAGTATTGCACGTGTCAGCGCAGCTGCAAGATACCTACAAAGTAAACGCCTCACCCCTAGAGAGTTTAACTCTTATGGAGCACGGAGAGGAAATGATGCTGTAATGACTAGAGGAACTTTTGCTAGCATTAAACTCCAGAACCGTTTTATTGGCAAAACTGGCCCCAAGACGCTTCACATTCCTTCTGGACAGACGTTGGATGTGTTTGAGGCAGCGGAGCGGTACCAAAGAGACGGAGTTCCCCTCATCATTTTGGCAGGGAAGGAGTATGGCTCTGGCAATTCCCGGGACTGGGCGGCTAAAGGACCTTACCTACTGGGAGTTCGGGCAGTGATTGCAGAGAGTTTTGAGAAAATGCATAAGAACCACCTGGTAGGGATGGGTATTGCTCCTCTACAGTTCCTGCCTGGACAGAATGCTGACTCACTGGAGCTCTGTGGAAAAGAGAGATTTTCTATTTCAATACCAGAGGAGTTCACTCCTCAACAAGAATTAACCGTAATGacAAGCACAGGAAAGTGTTTCCGTGTGGTGGCTCTGTTTGAGAATGAGATGGACGTTGCGTTTTATAGACATGGAGGTATCCTGAAATATGTGGCTCGGGGTATGCTCCAGTAACATCTGTGGCCTGCTTCTTCTTGTCTCTAGACTCTGATCCTGGGTCAGTCTTGGAAGTACTGAGTACTCCACCGACAGGGCTATTGATGGCCTAGCAATTGCTCTGAACTCCAGTCAGTGATTTTCAGGCCATGGACTCTGCTGTGCCTGTTTTCTGCTGTTTCCTCTGTCACACCTAGGGCATCTGCTGAAGGATGCATCTCTCttgcacttaaaaataaataaataaataaataaataaaggtctGTGCATGGGTCTCTAAAATGTCTGTAGAAATGGACATTTTTGTTTGCAGTGCCTGCTCAGCTCGTAAGTGGACGAAATTTCAGTCAAGGTTGAAGATTGTGGTGCTAGGCTCCTGCACAGGCTACTCAATGTGCTTACTTTCGCCGGTGCTTctcaaactcaaactgcatTCTGGTCTTTTACTTCTGCTGTAGTGCTTACAGGCAGATAGATGgagcttcttttctttttcagttttttttttaattatttgtgtttAGAAAATTATTCAGTTAAAAGTGTACGAAGTCAAACGAAATGCCTGTTCACCTTACTTATTCCagctttttttatgttgtgatatatatatatattttttttcttataaatgTTACCTCACATATTGCCATCATTCTGAGGAAGAGAAAaatcattgtttattttttatccaatcGAGCTCAGAAATCTTTACGTTAACAGTTTACATATATCTCTGACCCTTGAGTGTTTTGAGTGCTTGTGTGGACAGTGACAATGACTGGATGTAGATAATTGCAATAAACCTGATGTCATTTGTTGTTCATTTAGCTGGCA

Function

symbol description
ireb2 Predicted to enable 4 iron, 4 sulfur cluster binding activity; aconitate hydratase activity; and iron-responsive element binding activity. Predicted to be involved in citrate metabolic process and tricarboxylic acid cycle. Predicted to act upstream of or within cellular iron ion homeostasis and negative regulation of translation. Predicted to be located in cytoplasm. Predicted to be active in cytosol and mitochondrion. Is expressed in blood and presumptive blood. Human ortholog(s) of this gene implicated in Alzheimer's disease. Orthologous to human IREB2 (iron responsive element binding protein 2).

NR:

description
iron-responsive element-binding protein 2 isoform X2

GO:

id name namespace
GO:0008152 metabolic process biological_process
GO:0051539 4 iron, 4 sulfur cluster binding molecular_function

KEGG:

id description
K22416 IREB2; iron-responsive element-binding protein 2

RNA

RNA id representative length rna type GC content exon number start site end site
XM_007228554.3 True 3818 mRNA 0.46 22 25531046 25547668

Neighbor

gene id symbol gene type direction distance location
wdr61 wdr61 coding upstream 15698 25508880 ~ 25515348 (+)
sin3a sin3a coding upstream 81790 25426737 ~ 25449256 (+)
ptpn9 ptpn9,ptpn9a,LOC107727494,LOC107673262,LOC107560010 coding upstream 107382 25394435 ~ 25423664 (+)
snupn snupn,LOC107673280,LOC107738646 coding upstream 143926 25378437 ~ 25387120 (+)
LOC103033942 LOC103033942,LOC108442313 coding upstream 971424 24555601 ~ 24559622 (+)
LOC103026250 gnai1,LOC107590838,LOC108279833,LOC107386448,LOC100706147,LOC107680033,LOC106609493 coding downstream 30218 25577886 ~ 25609148 (+)
LOC103027045 magi2 coding downstream 156609 25704277 ~ 26025417 (+)
nup107 nup107,LOC107710680,LOC107590859 coding downstream 495579 26043247 ~ 26069392 (+)
slc35e3 slc35e3,LOC107737854,LOC107710682 coding downstream 524917 26072585 ~ 26081131 (+)
mdm2 mdm2,LOC107577534,LOC106599688 coding downstream 557089 26104757 ~ 26118299 (+)
G66739 NA non-coding upstream 11499 25478860 ~ 25519547 (+)
G66718 snx33,LOC107680142,LOC107560006,LOC107673279 non-coding upstream 190590 25335335 ~ 25340456 (+)
G66714 NA non-coding upstream 196604 25328781 ~ 25334442 (+)
G66712 NA non-coding upstream 224063 25306619 ~ 25306983 (+)
G66710 NA non-coding upstream 271473 25258379 ~ 25259573 (+)
G66748 NA non-coding downstream 12826 25560494 ~ 25561181 (+)
G66755 NA non-coding downstream 23170 25570838 ~ 25572159 (+)
G66756 NA non-coding downstream 28187 25575855 ~ 25576194 (+)
G66833 NA non-coding downstream 65218 25612886 ~ 25614889 (+)
G66837 NA non-coding downstream 85125 25632793 ~ 25633083 (+)
cspg4 cspg4 other upstream 230171 25189185 ~ 25300875 (+)
lingo1 lingo1,LOC107673268,LOC107727415,LOC107562294,LOC107680146,LOC107560004 other upstream 846466 24599166 ~ 24684580 (+)
osgep apex1,osgep,LOC107658891,LOC107656416,LOC107579619,LOC102796710,LOC103033632 other upstream 978706 24518622 ~ 24552340 (+)
rpap3 rpap3 other upstream 1148024 24367492 ~ 24383022 (+)
LOC103027234 timp3,LOC108412896,LOC106609153,LOC103152565 other upstream 1810952 23698152 ~ 23720094 (+)
LOC111192916 NA other downstream 532784 26080452 ~ 26092119 (+)
oaz2 oaz2,LOC108432726 other downstream 2601592 28149260 ~ 28220857 (+)
G67459 NA other downstream 4009468 29557136 ~ 29558666 (+)
G67453 cat,LOC102775586,LOC102293936 other downstream 4038308 29585976 ~ 29592287 (+)
LOC111193014 NA other downstream 4739867 30287535 ~ 30289624 (+)

Expression


Co-expression Network