mdm2 (mdm2,LOC107577534,LOC106599688)


Basic Information

Item Value
gene id mdm2
gene name mdm2,LOC107577534,LOC106599688
gene type coding
species mexican tetra (Astyanax mexicanus)
category of species ornamental fish

Chromosome Information

Item Value
chromosome id NC_035903.1
NCBI id CM008306.1
chromosome length 40813162
location 26104757 ~ 26118299 (+)
genome version Astyanax_mexicanus-2.0_2017_mexican_tetra_Genome

Sequence

>XM_007241018.3
TCAGCAGCCGGCCCACAGCAAGCTCCCACTTCCACTGAGCTCACTACAGCACTTTATGTACAGATGGAGAGTGTATAGTATATTAACtctaacttaaaatatatttattcagATTATAGATATGGCTACAGAGAGCTGTCTGAGTAGCTCCCAGATCAACAAGATTGACAATGAAAAACTGGTAAGACCAAAAGTGCAATTGCAAACCCTGTTAAAAGATGTAGGTGCAGACAAGGACGTCTTTACCATGAAGGAGGTGATGTTTTACCTGGGTAAGTACATCATGAGCAAGGAGCTTTACgacaagcagcagcagcacatcgTCCACTGCGGGAACGACGCACTCGGTGAAGTGCTGGGTGTGACCAGCTTTTCTGTCAAAGAACCACGTGCTTTATTTGCAATGATTTCGAAAAACCTCATAGCAGTGAAAAACCCagaGTCCCAGTCATCCTTAACAGAGCCCAGGAGTCGAACTGAACCAGACAGGGGGCAAGAGGAGACAAACTCTGATTCATCTACctcagtgcagcagcagcagcagcgcaggAGACGGAGAAGCAGTGATACtgCGAGTTTCTCTGTGGAGGAGGAAAGCAGCGAGCCCAGGAAGAGGCACAAGTCAGACAGCTTCTCCCTGACATTTGACGACAGCCTGTCGTGGTGCGTGATCGGAGGACTGCGCAGAGAGAGCGGGAGCAGCGAGTCTTCAGACTCACGCAGCATATCGGATGTAGGTATAGCTCGAAGTGAGGACAGTGAAGAAAGTGAGGATTCAGACTCTGATAACTTCAGTGTGGAGTTTGAGGTGGAGTCCATCGATTCGGATGCGTACAGCGAGAATGATGACGACTCTGTACCAGGGGAAGACGAGGTGTACGAGGTTACTATTTTTGCAGAAGATGAAGATTCCTTTGATGAAGATTTGGAGATCAGTGAGGCCGACTACTGGAAGTGCTCAGAGTGTGAAGAGCTGAACCCCCCGCTACCTCGACACTGCAAGAGCTGCTGGAAGGTACGGCCGGATTGGCTGCCAGAAAACGATTCATGTCTGGAGAACCCCAGCGATGAAACCCAAGCCAGTGCTGCAGCCGCTGACAGCACCTGCCTTGGTTTGACAGTCGGCTCCGCCTTAGAGTCCAAACCTCTGCCCTCAAATCCTCCCAGCCCCACCCCCGATTCTGATGAAGGAATGGACGTACCGGATGGCAAGGTTTCCCGGTCACTGAATGCCAGCAGAGACGAATCTAAGGCTGCCACAGCTGCTGCCACCGCCGCCGTCGCTTCTGGCCCAGACTCTCAGGGCCTGAGCCTGTCCTCCTCTCAGCCCTCCACTTCCTCCTCACAGGGTAACAACAGCCAGGAAGACACTCCCGAGCTGGAGCGCTTCAACAGCATGGAGGCCTGCCTCCCTGCCACCTGCCTGGAGCCCTGTGTCATCTGCCAGAGCCGGCCCAAGAACGGCTGCATCGTCCACGGCCGCACCGGACATCTTATGGCCTGCTACACCTGCGCCAAGAAGCTGAAGAACCGCAACAAGCTGTGTCCTGTTTGCCGGGAGCCCATTCAGTCTGTCGTGCTGACCTATGTGAGCTGATGGAggacaaaaacaaataataaaattacctCAATTTTTCTCACCCGCCTTATTCTAAAATACCCTTAAAGcaaatacaattaaaacatgAATGTTGTGTTAAATTATACAGTTTTCGTtggatttaaaatatttttgtggtAACAATTAATGGCATAAGAAttgtgtataaatattcatatatttctgtgtaaatataaatactttcAGTTAAACAATCTTTTGTaggtataataattattaatattattttagcgTGCAGTCCAGTTAAGATTGTACagataataatttatatttagtgAATATTTTTCATGTTAATCTAATCTTTATGTCCCGGCTTTAACGTTAAAACcacttcttttgttttttacgCACATACACCATTTGATtgactccactgatcatatacgacacattgtagttctataatttcAAACTGCctttctgcatattttattattctccttTTACTCTGGTGTTGTGCTTGTAAAACAGGCAcagtagtgctgctggagtttttaaacatcttaaaGTCCTGGTGGACTGAAAATAGGCCACCAACAGCGTTCAgtaacagtattttaaaaactgtctgTTCTGATTAGTGTCACTTCAGTGCTCAGAATAACCCGCCACCCAAATTATAGCTGCTGCTGTGTGCTTGTCTATCCTGTGAGGTCCTGTgtattgaagaacagagaaAAGGAGGATGATAGTaaagtatgcagaaaaacagatacaggacttgtctgtaattatagaactacaaaactgtatgatcagtggagctgaaaaaaaggCATGATGAGGTGAggaacaaggaggtggtcataatgttatgacagatttttgtgttattttttgatGCTCTGAAGTACTGAAGTTATTAAATGCCTCTGATGTTCTCTTTTGCACTGTTGTGCTGCACAGACTGCTACTCACTCCTTAATGTCTCTACGTTTGCTGGAATAAATGACTGATtgcttatgta
>XM_007241019.3
TCGCGATTCGTTAGTTTTCAAATCTTCAAAATTTCCAACGGTCCAGCAGGAGGCGCTGAAACAGCCGCGCGCTGCAGGTCCGCTACAGAAGCTGCTGCAGATTATAGATATGGCTACAGAGAGCTGTCTGAGTAGCTCCCAGATCAACAAGATTGACAATGAAAAACTGGTAAGACCAAAAGTGCAATTGCAAACCCTGTTAAAAGATGTAGGTGCAGACAAGGACGTCTTTACCATGAAGGAGGTGATGTTTTACCTGGGTAAGTACATCATGAGCAAGGAGCTTTACgacaagcagcagcagcacatcgTCCACTGCGGGAACGACGCACTCGGTGAAGTGCTGGGTGTGACCAGCTTTTCTGTCAAAGAACCACGTGCTTTATTTGCAATGATTTCGAAAAACCTCATAGCAGTGAAAAACCCagaGTCCCAGTCATCCTTAACAGAGCCCAGGAGTCGAACTGAACCAGACAGGGGGCAAGAGGAGACAAACTCTGATTCATCTACctcagtgcagcagcagcagcagcgcaggAGACGGAGAAGCAGTGATACtgCGAGTTTCTCTGTGGAGGAGGAAAGCAGCGAGCCCAGGAAGAGGCACAAGTCAGACAGCTTCTCCCTGACATTTGACGACAGCCTGTCGTGGTGCGTGATCGGAGGACTGCGCAGAGAGAGCGGGAGCAGCGAGTCTTCAGACTCACGCAGCATATCGGATGTAGGTATAGCTCGAAGTGAGGACAGTGAAGAAAGTGAGGATTCAGACTCTGATAACTTCAGTGTGGAGTTTGAGGTGGAGTCCATCGATTCGGATGCGTACAGCGAGAATGATGACGACTCTGTACCAGGGGAAGACGAGGTGTACGAGGTTACTATTTTTGCAGAAGATGAAGATTCCTTTGATGAAGATTTGGAGATCAGTGAGGCCGACTACTGGAAGTGCTCAGAGTGTGAAGAGCTGAACCCCCCGCTACCTCGACACTGCAAGAGCTGCTGGAAGGTACGGCCGGATTGGCTGCCAGAAAACGATTCATGTCTGGAGAACCCCAGCGATGAAACCCAAGCCAGTGCTGCAGCCGCTGACAGCACCTGCCTTGGTTTGACAGTCGGCTCCGCCTTAGAGTCCAAACCTCTGCCCTCAAATCCTCCCAGCCCCACCCCCGATTCTGATGAAGGAATGGACGTACCGGATGGCAAGGTTTCCCGGTCACTGAATGCCAGCAGAGACGAATCTAAGGCTGCCACAGCTGCTGCCACCGCCGCCGTCGCTTCTGGCCCAGACTCTCAGGGCCTGAGCCTGTCCTCCTCTCAGCCCTCCACTTCCTCCTCACAGGGTAACAACAGCCAGGAAGACACTCCCGAGCTGGAGCGCTTCAACAGCATGGAGGCCTGCCTCCCTGCCACCTGCCTGGAGCCCTGTGTCATCTGCCAGAGCCGGCCCAAGAACGGCTGCATCGTCCACGGCCGCACCGGACATCTTATGGCCTGCTACACCTGCGCCAAGAAGCTGAAGAACCGCAACAAGCTGTGTCCTGTTTGCCGGGAGCCCATTCAGTCTGTCGTGCTGACCTATGTGAGCTGATGGAggacaaaaacaaataataaaattacctCAATTTTTCTCACCCGCCTTATTCTAAAATACCCTTAAAGcaaatacaattaaaacatgAATGTTGTGTTAAATTATACAGTTTTCGTtggatttaaaatatttttgtggtAACAATTAATGGCATAAGAAttgtgtataaatattcatatatttctgtgtaaatataaatactttcAGTTAAACAATCTTTTGTaggtataataattattaatattattttagcgTGCAGTCCAGTTAAGATTGTACagataataatttatatttagtgAATATTTTTCATGTTAATCTAATCTTTATGTCCCGGCTTTAACGTTAAAACcacttcttttgttttttacgCACATACACCATTTGATtgactccactgatcatatacgacacattgtagttctataatttcAAACTGCctttctgcatattttattattctccttTTACTCTGGTGTTGTGCTTGTAAAACAGGCAcagtagtgctgctggagtttttaaacatcttaaaGTCCTGGTGGACTGAAAATAGGCCACCAACAGCGTTCAgtaacagtattttaaaaactgtctgTTCTGATTAGTGTCACTTCAGTGCTCAGAATAACCCGCCACCCAAATTATAGCTGCTGCTGTGTGCTTGTCTATCCTGTGAGGTCCTGTgtattgaagaacagagaaAAGGAGGATGATAGTaaagtatgcagaaaaacagatacaggacttgtctgtaattatagaactacaaaactgtatgatcagtggagctgaaaaaaaggCATGATGAGGTGAggaacaaggaggtggtcataatgttatgacagatttttgtgttattttttgatGCTCTGAAGTACTGAAGTTATTAAATGCCTCTGATGTTCTCTTTTGCACTGTTGTGCTGCACAGACTGCTACTCACTCCTTAATGTCTCTACGTTTGCTGGAATAAATGACTGATtgcttatgta

Function

symbol description
mdm2 Predicted to enable p53 binding activity and ubiquitin protein ligase activity. Acts upstream of or within several processes, including negative regulation of apoptotic process; pronephric glomerulus morphogenesis; and response to X-ray. Predicted to be located in cytoplasm. Predicted to be active in nucleus. Is expressed in several structures, including blood; digestive system; mesoderm; peripheral olfactory organ; and yolk syncytial layer. Human ortholog(s) of this gene implicated in chronic myeloid leukemia; endocrine gland cancer (multiple); glioblastoma; ichthyosis; and sarcoma. Orthologous to human MDM2 (MDM2 proto-oncogene).

NR:

description
PREDICTED: E3 ubiquitin-protein ligase Mdm2 isoform X2

GO:

id name namespace
GO:0043066 negative regulation of apoptotic process biological_process
GO:0010165 response to X-ray biological_process
GO:0044238 primary metabolic process biological_process
GO:0071157 negative regulation of cell cycle arrest biological_process
GO:0044260 cellular macromolecule metabolic process biological_process
GO:0031981 nuclear lumen cellular_component
GO:0046872 metal ion binding molecular_function

KEGG:

id description
K06643 MDM2; E3 ubiquitin-protein ligase Mdm2

RNA

RNA id representative length rna type GC content exon number start site end site
XM_007241018.3 True 2588 mRNA 0.45 11 26107372 26118299
XM_007241019.3 False 2576 mRNA 0.46 11 26104757 26118299

Neighbor

gene id symbol gene type direction distance location
slc35e3 slc35e3,LOC107737854,LOC107710682 coding upstream 23626 26072585 ~ 26081131 (+)
nup107 nup107,LOC107710680,LOC107590859 coding upstream 35365 26043247 ~ 26069392 (+)
LOC103027045 magi2 coding upstream 79340 25704277 ~ 26025417 (+)
LOC103026250 gnai1,LOC107590838,LOC108279833,LOC107386448,LOC100706147,LOC107680033,LOC106609493 coding upstream 495609 25577886 ~ 25609148 (+)
ireb2 ireb2 coding upstream 557089 25531046 ~ 25547668 (+)
LOC111192885 NA coding downstream 1378496 27496795 ~ 27497727 (+)
LOC103045890 LOC108432719 coding downstream 1842418 27960717 ~ 27981189 (+)
tmem138 tmem138,LOC105904230,LOC107561148,LOC107551428,LOC107655161 coding downstream 1907578 28025877 ~ 28031998 (+)
ptn ptn,LOC106609498 coding downstream 2235763 28354062 ~ 28457012 (+)
rtcb rtcb coding downstream 3044379 29162678 ~ 29174983 (+)
LOC111192883 NA non-coding upstream 11652 26092200 ~ 26093105 (+)
G66844 NA non-coding upstream 33602 26025980 ~ 26071155 (+)
G66854 NA non-coding upstream 333996 25737387 ~ 25770761 (+)
G66851 NA non-coding upstream 388519 25715976 ~ 25716238 (+)
G66842 NA non-coding upstream 415522 25688404 ~ 25689235 (+)
G66982 NA non-coding downstream 35116 26153415 ~ 26153644 (+)
G66987 NA non-coding downstream 79122 26197421 ~ 26198071 (+)
G67028 NA non-coding downstream 338756 26457055 ~ 26461093 (+)
G67059 NA non-coding downstream 678173 26796472 ~ 26797829 (+)
G67060 NA non-coding downstream 680170 26798469 ~ 26798977 (+)
LOC111192916 NA other upstream 12638 26080452 ~ 26092119 (+)
cspg4 cspg4 other upstream 803882 25189185 ~ 25300875 (+)
lingo1 lingo1,LOC107673268,LOC107727415,LOC107562294,LOC107680146,LOC107560004 other upstream 1420177 24599166 ~ 24684580 (+)
osgep apex1,osgep,LOC107658891,LOC107656416,LOC107579619,LOC102796710,LOC103033632 other upstream 1552417 24518622 ~ 24552340 (+)
rpap3 rpap3 other upstream 1721735 24367492 ~ 24383022 (+)
oaz2 oaz2,LOC108432726 other downstream 2030961 28149260 ~ 28220857 (+)
G67459 NA other downstream 3438837 29557136 ~ 29558666 (+)
G67453 cat,LOC102775586,LOC102293936 other downstream 3467677 29585976 ~ 29592287 (+)
LOC111193014 NA other downstream 4169236 30287535 ~ 30289624 (+)
G67690 atp6v1f,LOC101079638,LOC106511462,LOC104938441 other downstream 4480302 30598601 ~ 30600595 (+)

Expression


Co-expression Network