crbn (crbn,LOC107711034,LOC107748399)


Basic Information

Item Value
gene id crbn
gene name crbn,LOC107711034,LOC107748399
gene type coding
species mexican tetra (Astyanax mexicanus)
category of species ornamental fish

Chromosome Information

Item Value
chromosome id NC_035909.1
NCBI id CM008312.1
chromosome length 44161018
location 36039192 ~ 36046913 (+)
genome version Astyanax_mexicanus-2.0_2017_mexican_tetra_Genome

Sequence

>XM_007254266.3
AGTGTAAACAGACGGCGATGGCTGCTGAGAGGGGCGGAGGCGACAACAACATCCACGACGACATGGGCAACCAGCTGCAGCTCGTACCTGAAaatgaggaggaggaagaagatgaCATGGAAACTGAAGACCGTGATAGTGAAGATGCAGAAAAGCCAAGCATTATCAACTTTGACCCAAGTTTGCCGACATCACATGCTTACCTGGGCTCAGACATGGAGGAGTTCCACGGCCGGACTCTTCATGATGAGGACAGTGTGCAAAACTTGCCTGTTCTCCCGCATGCGGCTCTCATGCTGATCCCAGGTCAGACACTGCCATTGCAGCTTTTTCGACCACAGGAGGTCAGCATGTTCCGCAACCTTGTCAGTCATGACCGCACATTTGCTGTGCTTGCACACAGTCCTGATGCAAGTGGGGGAGAGCTAAAAGCAGAGTTTGGGACAACAGCAGAGATTTATGCCTTTCGTGAGGAGCAGGAGTACGGCATTGAGACGGTGAAAATCAAAGCTATTGGGCGGCAGCGCTTCAGAGTGCATGACATTCGCACACAGGCAGACGGGATTCGTCAGGCGAAGGTGCAAATTTTGCCAGAGAGAATTCTGCTTGACCCCTTGAGTGCCGTTCAGCTCTTGTCCCACGTACGCACACATTCACCTCCTACCAAGCAAACACAACCACAGAGCCAAGTGCAACGTTGCCAGGCCTACAGACGGAGAAAGTTATATCCTGCAAGTATGACCCCATGGCCTCCTTGGGTGTATGCCCTTTATGACTCTgagactctaatgAGCAGAGTAAAGCGGCAGCTCCATGAGTGGGACGAGAACCTCAAGGATGAATCGCTGCCTACAAATGCTATAgATTTTTCATACAGAGTGGCTGCCTGTTTGCCAATAGATGATGCTCTTAGACTGCAGTTGCTTAAGATCGGCAGTGCTATACAGAGACTACGCTGTGAGCTGGACATTATGGACAGGTGCACATCCCTATGCTGCAAACAGTGCCAAGACACAGAGATTACAACCAAGAACGAAATATTCAGTCTGTCGCTTTATGGGCCAATGGCGGCTTATGTGAATCCACATGGTTACGTTCATGAGACACTGACTGTTTATAAGGCTAGCAACCTCAATCTGGTTGGAAGACCATCCACACTGCATAGCTGGTTCCCAGGGTATGCATGGACGATTGCGCAGTGCCGGACGTGTGGATCTCACATGGGCTGGAAGTTCTCTGCAGTAAAGAAGGATCTGAGCCCACCACGCTTTTGGGGTCTGACTCGCTCTGCTCTTCTGCCCACAATCCCTCAAGGCGAGGAGGGAGTGGAGGGCTCACGCCTGCTCTGCCTGTGACCTCAGCATGACCCGCGACTCTTCAACTCGCAGCACATAAAACATCCACCACTTTAATCCTTCTCCACTTCACCCTGAAACATCACACTCCAGaccataaagagagagagagagagggtgagaccCAGAAAGACATAGTTAGGGGGGGAAaggagacagtgagacagaaaagtggacagagagggagaaaaaactGGCTTGTAAATTAGTTTCTCTTGAAGAAGTAAATCAGACAGGCCTCAAGGGTCAAAGTGAACCCTGTCAGTTTAAATATGTGGCTTTTACAATCAAATTTTGTTCTGCTGATCATGTATGTTGTTGTAACAGTTCAGCCTTGCATTTGACAACATACACTTATTTCAAGCCcacaatcttttttttcattaagcTAATAAAACGGTCTCCTATTTAAACATGGACATTATGAAAGGGTTAACACATGGTGTTTCTTAATATTATGTTAATATAAACAAACCAACTTCGAAGAGAAGGGACTATTTTGTGCATATTCCTTATCGTACAAAGAAAGATGGTTCCACTgagttagttaaaaaaaaagtcaatcaGTGTGGCATAATGAGCCTGTGTGGTGCTGGATGCCACAGTAACTACTAATAGGGATGATTTATAAAGTAACAGAGTTACTCTTATCATCATTAAGTCATATCAGGGGCATAACTCTGctactgtatttttgtatttcttctCAGCCCCCTTTCCCTTTTTGTCTATGACAATGCTATTGGATGTAGGTGTGTTTAGACACTGAAAGGATTTTGTTAGCAGGTGTTTTGGTAGACAGGTCTGTAAGTAGACTGCAGCCCTTTCTGGAGAAACCTCTATTATAAATGCAGTGTTAGGAAACGGAGTGCATATACACATACTTTAAATACATCCAGGACATCTTGTGCATACCTCAGCAGTCTCACATATCCATAATGTTAAAATGAGATATACAAAATACACTTGACAAGCCACTGACTTGCATATCTGTAACCATAATATTCAAGGGATTCAGGATCCAAAAAGGTGTTCAGTTCTACTAAATATgctaataaaatcatttttggaACGTC

Function

symbol description
crbn Predicted to enable metal ion binding activity. Involved in fin development; limb development; and otic vesicle development. Acts upstream of with a positive effect on cell population proliferation. Acts upstream of or within embryonic pectoral fin morphogenesis and otic vesicle morphogenesis. Part of ubiquitin ligase complex. Is expressed in several structures, including cranial vasculature; nervous system; notochord; otic vesicle; and radial glial cell. Human ortholog(s) of this gene implicated in autosomal recessive non-syndromic intellectual disability. Orthologous to human CRBN (cereblon).

NR:

description
protein cereblon

GO:

id name namespace
GO:0071600 otic vesicle morphogenesis biological_process
GO:0060173 limb development biological_process
GO:0016567 protein ubiquitination biological_process
GO:0035118 embryonic pectoral fin morphogenesis biological_process
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process biological_process
GO:0005634 nucleus cellular_component
GO:0031464 Cul4A-RING E3 ubiquitin ligase complex cellular_component
GO:0005737 cytoplasm cellular_component
GO:0004176 ATP-dependent peptidase activity molecular_function

KEGG:

id description
K11793 CRBN; cereblon

RNA

RNA id representative length rna type GC content exon number start site end site
XM_007254266.3 True 2431 mRNA 0.45 11 36039192 36046913

Neighbor

gene id symbol gene type direction distance location
tspo tspo,LOC107721166,LOC107568174,LOC107667354,LOC107584504 coding upstream 83650 35952041 ~ 35955542 (+)
ppil1 ppil1,LOC107667353 coding upstream 133174 35901223 ~ 35906018 (+)
LOC103033861 NA coding upstream 169760 35864138 ~ 35869432 (+)
LOC103035259 LOC103035259 coding upstream 177761 35858681 ~ 35861431 (+)
c13h1orf159 cunh1orf159,LOC103036790 coding upstream 185101 35849749 ~ 35854091 (+)
LOC103026553 vhl coding downstream 984 36047897 ~ 36050402 (+)
tatdn2 NA coding downstream 3597 36050510 ~ 36056356 (+)
ccdc174 NA coding downstream 14552 36061465 ~ 36066292 (+)
LOC103028900 LOC108439894 coding downstream 20064 36066977 ~ 36075546 (+)
col7a1 col7a1 coding downstream 83071 36129984 ~ 36195424 (+)
G116105 LOC103030273,LOC108440644,LOC107712078,LOC107721176,LOC107673500 non-coding upstream 39136 35990033 ~ 36000056 (+)
G116050 NA non-coding upstream 105986 35930924 ~ 35933206 (+)
LOC111193772 NA non-coding upstream 139799 35894947 ~ 35899393 (+)
G116020 NA non-coding upstream 176369 35862214 ~ 35862823 (+)
G115915 eif4enif1 non-coding upstream 362351 35676178 ~ 35676841 (+)
G116138 NA non-coding downstream 142861 36189774 ~ 36223578 (+)
G116155 NA non-coding downstream 259437 36306350 ~ 36306762 (+)
G116255 NA non-coding downstream 369895 36416808 ~ 36462597 (+)
LOC111193778 NA non-coding downstream 454320 36501233 ~ 36503562 (+)
G116349 LOC108440912,LOC108439999 non-coding downstream 685235 36732148 ~ 36742014 (+)
G116103 prkcda,LOC103030273,LOC108440644,LOC107582675,LOC107667398,LOC107721176,LOC107673500,LOC107712078,LOC108271968 other upstream 51132 35982119 ~ 35988060 (+)
tomm6 NA other upstream 71314 35958543 ~ 35967878 (+)
G115931 NA other upstream 304833 35730379 ~ 35734359 (+)
G115917 NA other upstream 363157 35642874 ~ 35676035 (+)
LOC103045376 LOC103045376,LOC107721197,LOC107584442,LOC107673487,LOC107712108,LOC107667402 other upstream 479466 35553601 ~ 35559726 (+)
LOC103024058 LOC103024058,LOC108440764,LOC107748389,LOC107711047,LOC107673509,LOC107585116,LOC106583201 other downstream 296072 36342985 ~ 36359777 (+)
LOC103044253 LOC108440873 other downstream 610479 36657392 ~ 36713884 (+)
LOC103045245 vdrb,LOC108272216,LOC107585146,LOC107673565,LOC107711077,LOC108441087 other downstream 1053101 37100014 ~ 37121327 (+)
gabra5 gabra5,LOC107711088,LOC107673539,LOC107585151,LOC107685289 other downstream 1477938 37524851 ~ 37612322 (+)
LOC103036266 LOC108441345 other downstream 2343364 38390277 ~ 38394530 (+)

Expression


Co-expression Network