LOC103026553 (vhl)


Basic Information

Item Value
gene id LOC103026553
gene name vhl
gene type coding
species mexican tetra (Astyanax mexicanus)
category of species ornamental fish

Chromosome Information

Item Value
chromosome id NC_035909.1
NCBI id CM008312.1
chromosome length 44161018
location 36047897 ~ 36050402 (+)
genome version Astyanax_mexicanus-2.0_2017_mexican_tetra_Genome

Sequence

>XM_007254267.3
ttggGTTACCCACCTCTACTTTCTCTATATGAAGATGTGTAATTTCAGCAGAAGGCCAGTCGGGGGCGATATTAAACAGCGACGACACGTTTTCTTCGTCGGCGTTGGGTGGATCACGTAATCAAAACAAACCTGAGGCACGTACTAGGCGTAGACCCCCGTCTGTAATTCAGCTCACTTTGATATGTGATTGTTTTAGCttagtttttacatttattttatgctcatttttgtgataataagtaaaacattttcttcGTTTCTTGGCTGATTTAACCGCTGTGCCTCTGTTGTTGGGAAAGCTGCGCTAAAGGTAGTTGTTAGTTGTTAGTAGTTAGTTGTTAGTAAGTTAGTAAGTCCGGCAGGTAACTAGGTGAGTTAGCCTAGCTAGGTTACCTGTGTGCAGGTAACCATGCCACAGGAACCCGTGGAGGGGCAGCAGCAGCTCCCGCTGGTCCGCTCCTTGATCAGTCGTCTCCAGGCTCATGTGGTGTTCTGTAACCGGTCTCCTCGAACCGTTAAACTCGTTTGGATCAACTTTCGCGGAGAGCCGCAGTCGTACGGGGAGCTGCGGCCCCTCACCGGAAAGCGAATAACTACTTATGTGGGACACCCATGGATGTTTCGTGATGCTGAATCTGATGATCCATTATTGGTGAATAACAAGGAGATGTACCTACCCAGTGCACTGGAAAATGGTCAAGTGTCCATGGCCAACATCACACTACCAGtgttttcACTGCGAGAGCGATGTTTGCAGGTGGTGAGGCAGCTGGTGCGTAGTGAAAATTTTCAGCGCTTAGAAATTGCTCGCTGTCTACAGGAAGAACTTGCTCAGAGACCGAATATCCAGGCTGACCTGCGGCGTATCAGCCAGCGAGTGGAGCAGAGACTACTTCAGAACAGAGAGACACAAAACAACTGAATACACACATTGTGTTGTTGATTCGAAGACCTTCTTAATTTTTGTGAATTCAACAGACATTCTGTTTTTTCCTACCGAGGAACAGACAACTTGATATTTTATTGGAGCTGCTTTAGACAATCTGTGCCTTTGCTGCAGAGCACCTGTGCCCACTTGCCTTTGCACATATCTATCCccacttttacacattttaaataaaaagcatgAATTTTTCTCATCA
>XM_022675749.1
tggGTTACCCACCTCTACTTTCTCTATATGAAGATGTGTAATTTCAGCAGAAGGCCAGTCGGGGGCGATATTAAACAGCGACGACACGTTTTCTTCGTCGGCGTTGGGTGGATCACGTAATCAAAACAAACCTGAGGCACGTACTAGGCGTAGACCCCCGTCTGTAATTCAGCTCACTTTGATATGTGATTGTTTTAGCttagtttttacatttattttattcttcGTTTCTTGGCTGATTTAACCGCTGTGCCTCTGTTGTTGGGAAAGCTGCGCTAAAGGTAGTTGTTAGTTGTTAGTAGTTAGTTGTTAGTAAGTTAGTAAGTCCGGCAGGTAACTAGGTGAGTTAGCCTAGCTAGGTTACCTGTGTGCAGGTAACCATGCCACAGGAACCCGTGGAGGGGCAGCAGCAGCTCCCGCTGGTCCGCTCCTTGATCAGTCGTCTCCAGGCTCATGTGGTGTTCTGTAACCGGTCTCCTCGAACCGTTAAACTCGTTTGGATCAACTTTCGCGGAGAGCCGCAGTCGTACGGGGAGCTGCGGCCCCTCACCGGAAAGCGAATAACTACTTATGTGGGACACCCATGGATGTTTCGTGATGCTGAATCTGATGATCCATTATTGGTGAATAACAAGGAGATGTACCTACCCAGTGCACTGGAAAATGGTCAAGTGTCCATGGCCAACATCACACTACCAGtgttttcACTGCGAGAGCGATGTTTGCAGGTGGTGAGGCAGCTGGTGCGTAGTGAAAATTTTCAGCGCTTAGAAATTGCTCGCTGTCTACAGGAAGAACTTGCTCAGAGACCGAATATCCAGGCTGACCTGCGGCGTATCAGCCAGCGAGTGGAGCAGAGACTACTTCAGAACAGAGAGACACAAAACAACTGAATACACACATTGTGTTGTTGATTCGAAGACCTTCTTAATTTTTGTGAATTCAACAGACATTCTGTTTTTTCCTACCGAGGAACAGACAACTTGATATTTTATTGGAGCTGCTTTAGACAATCTGTGCCTTTGCTGCAGAGCACCTGTGCCCACTTGCCTTTGCACATATCTATCCccacttttacacattttaaataaaaagcatgAATTTTTCTCATCA

Function

symbol description
vhl Acts upstream of or within several processes, including hemopoiesis; pronephric duct development; and regulation of vascular endothelial growth factor receptor signaling pathway. Predicted to be part of VCB complex. Predicted to be active in nucleus. Is expressed in several structures, including lateral mesoderm; liver; nervous system; otic vesicle; and pleuroperitoneal region. Used to study clear cell renal cell carcinoma; familial erythrocytosis 2; and von Hippel-Lindau disease. Human ortholog(s) of this gene implicated in several diseases, including pancreatic cancer (multiple); pheochromocytoma; polycythemia (multiple); renal cell carcinoma; and von Hippel-Lindau disease. Orthologous to human VHL (von Hippel-Lindau tumor suppressor).

NR:

description
von Hippel-Lindau disease tumor suppressor

GO:

id name namespace
GO:0030947 regulation of vascular endothelial growth factor receptor signaling pathway biological_process
GO:0045765 regulation of angiogenesis biological_process
GO:0030218 erythrocyte differentiation biological_process
GO:0016567 protein ubiquitination biological_process
GO:0005634 nucleus cellular_component

KEGG:

id description
K03871 VHL; von Hippel-Lindau disease tumor supressor

RNA

RNA id representative length rna type GC content exon number start site end site
XM_007254267.3 True 1145 mRNA 0.46 3 36047897 36050402
XM_022675749.1 False 1113 mRNA 0.46 4 36047898 36050402

Neighbor

gene id symbol gene type direction distance location
crbn crbn,LOC107711034,LOC107748399 coding upstream 984 36039192 ~ 36046913 (+)
tspo tspo,LOC107721166,LOC107568174,LOC107667354,LOC107584504 coding upstream 92355 35952041 ~ 35955542 (+)
ppil1 ppil1,LOC107667353 coding upstream 141879 35901223 ~ 35906018 (+)
LOC103033861 NA coding upstream 178465 35864138 ~ 35869432 (+)
LOC103035259 LOC103035259 coding upstream 186466 35858681 ~ 35861431 (+)
tatdn2 NA coding downstream 108 36050510 ~ 36056356 (+)
ccdc174 NA coding downstream 11063 36061465 ~ 36066292 (+)
LOC103028900 LOC108439894 coding downstream 16575 36066977 ~ 36075546 (+)
col7a1 col7a1 coding downstream 79582 36129984 ~ 36195424 (+)
LOC111193774 col7a1 coding downstream 155270 36205672 ~ 36218972 (+)
G116105 LOC103030273,LOC108440644,LOC107712078,LOC107721176,LOC107673500 non-coding upstream 47841 35990033 ~ 36000056 (+)
G116050 NA non-coding upstream 114691 35930924 ~ 35933206 (+)
LOC111193772 NA non-coding upstream 148504 35894947 ~ 35899393 (+)
G116020 NA non-coding upstream 185074 35862214 ~ 35862823 (+)
G115915 eif4enif1 non-coding upstream 371056 35676178 ~ 35676841 (+)
G116138 NA non-coding downstream 139372 36189774 ~ 36223578 (+)
G116155 NA non-coding downstream 255948 36306350 ~ 36306762 (+)
G116255 NA non-coding downstream 366406 36416808 ~ 36462597 (+)
LOC111193778 NA non-coding downstream 450831 36501233 ~ 36503562 (+)
G116349 LOC108440912,LOC108439999 non-coding downstream 681746 36732148 ~ 36742014 (+)
G116103 prkcda,LOC103030273,LOC108440644,LOC107582675,LOC107667398,LOC107721176,LOC107673500,LOC107712078,LOC108271968 other upstream 59837 35982119 ~ 35988060 (+)
tomm6 NA other upstream 80019 35958543 ~ 35967878 (+)
G115931 NA other upstream 313538 35730379 ~ 35734359 (+)
G115917 NA other upstream 371862 35642874 ~ 35676035 (+)
LOC103045376 LOC103045376,LOC107721197,LOC107584442,LOC107673487,LOC107712108,LOC107667402 other upstream 488171 35553601 ~ 35559726 (+)
LOC103024058 LOC103024058,LOC108440764,LOC107748389,LOC107711047,LOC107673509,LOC107585116,LOC106583201 other downstream 292583 36342985 ~ 36359777 (+)
LOC103044253 LOC108440873 other downstream 606990 36657392 ~ 36713884 (+)
LOC103045245 vdrb,LOC108272216,LOC107585146,LOC107673565,LOC107711077,LOC108441087 other downstream 1049612 37100014 ~ 37121327 (+)
gabra5 gabra5,LOC107711088,LOC107673539,LOC107585151,LOC107685289 other downstream 1474449 37524851 ~ 37612322 (+)
LOC103036266 LOC108441345 other downstream 2339875 38390277 ~ 38394530 (+)

Expression


Co-expression Network