LOC103027811 (smad3,smad3a,LOC108430827,LOC103353199,LOC107740443,LOC107553101)


Basic Information

Item Value
gene id LOC103027811
gene name smad3,smad3a,LOC108430827,LOC103353199,LOC107740443,LOC107553101
gene type coding
species mexican tetra (Astyanax mexicanus)
category of species ornamental fish

Chromosome Information

Item Value
chromosome id NW_019172830.1
NCBI id APWO02000048.1
chromosome length 5891159
location 5327517 ~ 5373340 (+)
genome version Astyanax_mexicanus-2.0_2017_mexican_tetra_Genome

Sequence

>XM_022665238.1
ATGTCAATTTTGCCGTTTACTCCCCCCATAGTGAAGAGACTGCTGGGCTGGAAGAAGGGAGAGCAGAACGGACAGGAGGAGAAATGGTGTGAGAAGGCTGTGAAGAGCCTGGTGAAGAAGCTGAAGAAGACAGGACAGCTGGATGAGCTGGAGAAAGCCATCACAACTCAGATAGTCAACACCAAATGCATTACTATACCACGGTCGCTGGATGGACGTTTGCAGGTGTCTCATCGGAAAGGTCTTCCCCACGTGATTTACTGCCGATTGTGGCGCTGGCCAGACCTGCAGTCCCACCACGAGCTGAGAGCAGTGGAGCTGTGTGAATACGCCTTCCACATGAAGAAGGACGAAGTATGCGTGAACCCGTACCACTACCAGCGCGTGGAGACGCCAGTTCTGCCACCAGTGCTGGTACCTCGTCACACAGAGATCCCCAGTGAATTTCCTCCTCTAGACGATTACAGCCACTCCATCCCCGAAAACACCAACTTCCCCGCGGGCATCGAGCCTCAGAGCAACTATATACCAGagacGCCTCCTCCAGGTTACCTCAGTGAGGATGGGGAGACCAGCGACCATCAGATGAACCATAGCATGGACACAGGCTCTCCAAACTTGTCTCCAAGTCCTGTATCTCCAGCAAACAACAACTTAGACCTGCAGCCTGTGACGTACTGTGAGCCAGCGTTCTGGTGTTCAATATCGTATTATGAGCTGAATCAGCGAGTCGGGGAAATCTTCCACGCGTCCCAGCCTTCCCTCACAGTCGACGGCTTCACCGACCCGTCCAACTCAGAGCGCTTCTGCCTGGGCCTGCTGTCCAACGTCAACCGCAACGCTGCAGTGGAGCTCACCCGCAGACACATCGgtAGAGGTGTGCGTTTATACTACATCGGAGGCGAGGTGTTTGCAGAGTGTCTCAGCGACAGTGCCATCTTTGTTCAGAGTCCCAACTGTAACCAGCGCTACGGCTGGCACCCGGCCACCGTCTGCAAGATTCCTCCAGGCTGTAATCTGAAGATCTTTAATAATCAGGAGTTCGCCGCTCTTTTGGCTCAGTCTGTGAACCAAGGCTTCGAGGCCGTGTACCAGCTGACCAGGATGTGCACCATCCGCATGAGCTTCGTTAAGGGCTGGGGAGCAGAGTACAGGCGGCAGACAGTGACCAGCACCCCCTGCTGGATAGAGCTTCACCTGAATGGACCCCTGCAGTGGCTGGACAAGGTCCTGACCCAAATGGGTTCCCCATCCATCCGATGCTCCAGTGTGTCCTAGGAAATACCCAGAACCAACAACTATCACAATAAACATGAACAACAGGGAGAACCAGACCAAAACCAGAACCGAAACCCAGAAGAGCTTCTTATGGGAAGTGGTGGGTGACGACCCAGAAACCCATCAGCCAA

Function

symbol description
smad3a Enables sequence-specific DNA binding activity. Acts upstream of or within mesoderm development; primitive hemopoiesis; and regulation of transcription, DNA-templated. Predicted to be located in cytoplasm and nucleus. Predicted to be part of heteromeric SMAD protein complex. Is expressed in immature eye; integument; somite; and tail bud. Human ortholog(s) of this gene implicated in Loeys-Dietz syndrome 3; Lynch syndrome; and pancreatic cancer. Orthologous to human SMAD3 (SMAD family member 3).
smad3 Enables several functions, including DNA-binding transcription factor binding activity; SMAD binding activity; and enzyme binding activity. Contributes to DNA-binding transcription factor activity. Involved in several processes, including cell surface receptor signaling pathway; positive regulation of nitrogen compound metabolic process; and regulation of gene expression. Located in chromatin; cytosol; and nucleus. Part of heteromeric SMAD protein complex and receptor complex. Implicated in Loeys-Dietz syndrome 3; Lynch syndrome; and pancreatic cancer. Biomarker of cervical squamous cell carcinoma; endometrial cancer; and prostate cancer.

NR:

description
PREDICTED: mothers against decapentaplegic homolog 3

GO:

id name namespace
GO:0007179 transforming growth factor beta receptor signaling pathway biological_process
GO:0006355 regulation of transcription, DNA-templated biological_process
GO:0005634 nucleus cellular_component
GO:0005667 transcription regulator complex cellular_component
GO:0043565 sequence-specific DNA binding molecular_function
GO:0005515 protein binding molecular_function
GO:0003700 DNA-binding transcription factor activity molecular_function

KEGG:

id description
K23605 SMAD3; mothers against decapentaplegic homolog 3

RNA

RNA id representative length rna type GC content exon number start site end site
XM_022665238.1 True 1409 mRNA 0.54 9 5327517 5373340

Neighbor

gene id symbol gene type direction distance location
LOC103028443 crybgx,LOC103028443,LOC105906490,LOC103368872,LOC108259467,LOC102304589,LOC102204928 coding upstream 121951 5198798 ~ 5205566 (+)
dis3l dis3l,LOC107740444,LOC107663953,LOC107664394,LOC107755103 coding upstream 160219 5146969 ~ 5167298 (+)
muc15 NA coding upstream 182633 5131893 ~ 5144884 (+)
LOC103030650 nr1h3,LOC107689968,LOC107664377,LOC107755109 coding upstream 432830 4862196 ~ 4894687 (+)
tshz3 tshz3,tshz3b,LOC108429148,LOC107570485,LOC107556246,LOC107696607 coding upstream 1582391 3657859 ~ 3745126 (+)
map2k5 map2k5 coding downstream 68200 5441540 ~ 5533366 (+)
LOC103026906 pias1a,pias1b,LOC108430823,LOC108259600,LOC107553093 coding downstream 190919 5564259 ~ 5652806 (+)
LOC103026610 LOC103026610,LOC108430825 coding downstream 286258 5659598 ~ 5660875 (+)
LOC103042267 LOC108430822 coding downstream 316446 5689786 ~ 5814523 (+)
LOC111191167 NA non-coding upstream 76105 5251022 ~ 5251412 (+)
G299918 NA non-coding upstream 77905 5249218 ~ 5249612 (+)
G299912 NA non-coding upstream 79423 5210722 ~ 5248094 (+)
G299901 NA non-coding upstream 117984 5125958 ~ 5209533 (+)
G299896 NA non-coding upstream 259895 5066097 ~ 5067622 (+)
G299934 NA non-coding downstream 102720 5476060 ~ 5508588 (+)
G299932 NA non-coding downstream 148172 5521512 ~ 5535585 (+)
G299938 NA non-coding downstream 149895 5523235 ~ 5524082 (+)
G299946 NA non-coding downstream 204723 5578063 ~ 5579719 (+)
G299948 NA non-coding downstream 241679 5615019 ~ 5615717 (+)
LOC111191166 NA other upstream 71206 5253574 ~ 5256311 (+)
G299903 NA other upstream 157409 5168626 ~ 5170108 (+)
madd madd,LOC107755105 other upstream 300096 4902634 ~ 5027421 (+)
LOC103025330 si:ch211-186j3.6,LOC108442966,LOC108259100,LOC106562040,LOC105022727,LOC107696606,LOC107572394,LOC107712488,LOC107680491,LOC107565684 other upstream 2399655 2398717 ~ 2927862 (+)
G299477 NA other upstream 3123262 2187333 ~ 2204255 (+)
LOC111191164 NA other downstream 170472 5543812 ~ 5548569 (+)
LOC111191158 skor1a,LOC108430798,LOC108259147,LOC107563488,LOC107663943,LOC107553092 other downstream 177753 5551093 ~ 5556428 (+)

Expression


Co-expression Network