smad6 (smad6,smad6b,LOC107583766,LOC107672304,LOC107596967,LOC107738716,LOC107686299)


Basic Information

Item Value
gene id smad6
gene name smad6,smad6b,LOC107583766,LOC107672304,LOC107596967,LOC107738716,LOC107686299
gene type misc
species mexican tetra (Astyanax mexicanus)
category of species ornamental fish

Chromosome Information

Item Value
chromosome id NC_035914.1
NCBI id CM008317.1
chromosome length 41377133
location 17327100 ~ 17372206 (+)
genome version Astyanax_mexicanus-2.0_2017_mexican_tetra_Genome

Sequence

>TU215532
GACGGAGACTGCAGAGCCGTCACGTGCTGCTTGTTTAAAGAGCGCTCggtcagtagtagtagtggaggaggaggagcaagCGGAGGAGACTGGGACGGAGGGGATAACGGCGGCGGAGAACGGGACTCCGGCAGCGCGAGCCCGGGCGGCTCCAGCTCGTGCCGCCTCGCCGAGGCCAACAAGGCGCCCGAGCACGAGCTCAAGAGCGCCACGTACGCGCTGCTCAAGCGGCTGAAGGAGAAGACGCTGCACGCGCTGCTCGAGGCCGTGGAGTCCGGCGGCGGCGTGCCCAGCGAGTGCGTGTTGGTGGCGCGCGCCGAGCTGCGCGCTCCCGGACACGccgcgccgccgccgccgcagcTGCTGCTGTGCAGACTGTACCGCTGGGCAGACGTGCAGCACGCGGCGCAGCTCAAAGCGCTCTGCGAGTGCAAGAGCTTCGGCGCGCAGGACGGGCCACTGGTGTGCTGCAACCCCTACCATTACAGCAGGCTCTGTGGGCCAGAGTCGCCTCCTCCTCCGTACTCAAGGCTTTCCCCTAGTGACGAACACAAGCCACTGGATCTGTCAGATTCCACACTGTCTTACACTGAAACGGAGGCTGCCAGCTCGCCAAACATCACCCAAGGGGAATTCTCAGATGCCAGTCTGTCACCGGACGCCCCCAAACAGACGCACTGGTGCAGCGTGGCGTACTGGGAGCACCGCACGCGGGTGGGCCGCCTCTACCCGGTGTACGAGCCCTCCGTCAGCATCTTCTACGACCTACCTCAAGGCACAGGTTTCTGCCTGGGCCAGCTGAGCGGCGAACGGCGCAGCGGAACCGCCCAGCGCACCCGCGGCAAGATCGGGTACGGCCTGCTGCTCAGCAAGGAGCCCGACGGCGTTTGGGCCTACAACCGCAGCCAGCACCCGATCTTCGTCAACTCGCCCACACTGGAGGCCGGACCAGCCACGCGCGGCCTGCTGGTGGTGCGCAAGGTCATGCCTGGCTACTCCATTAAGGTGTTTGACTATGAGCGTTCGGCGCTGCTGCTGCGGCAGGGGGCGGAGCCGGCGCTCCCGGACGGCCCGTATGACCCCAACAGTGTCCGCATCAGCTTCGCCAAGGGCTGGGGCCCCTGCTACTCGCGCCAGTTCATCACCTCCTGCCCGTGCTGGCTCGAAATCCTCCTCAACAACcacagataacacacacacacacaaacggaCAGACTCGGACTTTGGACTCGAGAGACGCGCCGAGAGACCCTACGGACCCCCACAAACTATCCCAAATATCATCTACTTAGATTTaatataaagttttatatattatatgaaatatatattatacttgtAAATACTGGAGTCATTTTtacaatgtaattatttatgtaTGGTGCAATGTGTACAAGtggaaaaaacaggaaatgcac
>TU215533
TTGCAGTTTGAGCAGGTCTGTGCGCCGGATCAGGAGCTGTGCTTGAATGTAGTTCTCACGGATTTGCTGCTTTTTGTTTTGGTGCTGGCTGCTTCTTCACACTACTTCACtcacagataaacacacacgcGCACGAGCGGATACCTCTGGACCTTTGAACCGGAGTGGACACCGAGCAGAACCGGGATTGTtctctttttgcatttttttgctgttttttgtgttgtgcATGTCTGTGGATTTTACCCCTCGGTGGAGCGTGTTCTTCTAGTTCTTCTTTTTAATTCATGTCTGTGCAGAGTGGATGTGAGCTGTGGGCTGGCGGCTCTGGGAGCGGGCGAGTTCTGCGTCCCGGCGCGTCCGGCTTTTTGATCTGACGCACGCGGGGCGCTGTGAGTCCCGCTAGCTGCTAAACTGTGTCTGCTAGCTGAGAACCCAGAAACTAGTCTGAAACGAGTCTGCAGCCTATAAAATAACGCTAAACTAGCTTTTTCCAGCAGCCCACAGTGTCTGTGTATCACGCGAGCTCGCAGCTGAATGCATTTTGATTTCTGCGAGGTTGTctcgtgcagcagcagcagctcggttGTAAATGCGAGCCACCGCGGCGCCTTCCAAACTCATGTTGTGGAGGTTTTGCCCCCAGCAGCCCGCACGGCGCTCAACAGCAGCGACCGTGGATGAGGCTCCTACACGGGTTTGAAGCGTGACCGGGGGACACGAGAGAGCAGAGGAGCGGAGGAAGAATtagaaaaaaggaaggaaaacgaagaaaaagagtgaaaaagaagAGCCGGAgcacgaggaggaggaggaggagaaggagataAGAGCGTGCGGTCAGGAGGGGGCTCGAAGTTGTCGTATGTTCAGGACGAAACGCTCAGGTCTCGTGCGGCGACTCTGGCGAAGCCGTTTGGTTCCGGATAGAGACGGAGGCGACGG
>XM_007249251.3
TAGGCAGCCAATGGCTCCACCGCTCTCCTCGGGGGCCCCGCGTGCGTgcgtatgtgtatgtgtgtgtgtctctgtgtgtatgtgtgtgtgtcagcgggagaggaaaaaaaggaaaagggagagagagaaacgggagaaaggcagagaagtgGGTTGCAGTTTGAGCAGGTCTGTGCGCCGGATCAGGAGCTGTGCTTGAATGTAGTTCTCACGGATTTGCTGCTTTTTGTTTTGGTGCTGGCTGCTTCTTCACACTACTTCACtcacagataaacacacacgcGCACGAGCGGATACCTCTGGACCTTTGAACCGGAGTGGACACCGAGCAGAACCGGGATTGTtctctttttgcatttttttgctgttttttgtgttgtgcATGTCTGTGGATTTTACCCCTCGGTGGAGCGTGTTCTTCTAGTTCTTCTTTTTAATTCATGTCTGTGCAGAGTGGATGTGAGCTGTGGGCTGGCGGCTCTGGGAGCGGGCGAGTTCTGCGTCCCGGCGCGTCCGGCTTTTTGATCTGACGCACGCGGGGCGCTGTGAGTCCCGCTAGCTGCTAAACTGTGTCTGCTAGCTGAGAACCCAGAAACTAGTCTGAAACGAGTCTGCAGCCTATAAAATAACGCTAAACTAGCTTTTTCCAGCAGCCCACAGTGTCTGTGTATCACGCGAGCTCGCAGCTGAATGCATTTTGATTTCTGCGAGGTTGTctcgtgcagcagcagcagctcggttGTAAATGCGAGCCACCGCGGCGCCTTCCAAACTCATGTTGTGGAGGTTTTGCCCCCAGCAGCCCGCACGGCGCTCAACAGCAGCGACCGTGGATGAGGCTCCTACACGGGTTTGAAGCGTGACCGGGGGACACGAGAGAGCAGAGGAGCGGAGGAAGAATtagaaaaaaggaaggaaaacgaagaaaaagagtgaaaaagaagAGCCGGAgcacgaggaggaggaggaggagaaggagataAGAGCGTGCGGTCAGGAGGGGGCTCGAAGTTGTCGTATGTTCAGGACGAAACGCTCAGGTCTCGTGCGGCGACTCTGGCGAAGCCGTTTGGTTCCGGATAGAGACGGAGGCGACGGGGATGGCAGGAGGGGGGGCGGCGGCGGAGGGGAAGGAGGCGAGGGCGAGGGGGGCTCACGGACCGGCGAGCGACGCGCGGACGACGTCGCCAAGACGGAGACGGGAGTTTTGTTGAGCGGGTGCGGGAGCGCGGTGGACGGTGGCGGTGGAGGCGGGGGGGACGAAGCCGGGGACGGAGACTGCAGAGCCGTCACGTGCTGCTTGTTTAAAGAGCGCTCggtcagtagtagtagtggaggaggaggagcaagCGGAGGAGACTGGGACGGAGGGGATAACGGCGGCGGAGAACGGGACTCCGGCAGCGCGAGCCCGGGCGGCTCCAGCTCGTGCCGCCTCGCCGAGGCCAACAAGGCGCCCGAGCACGAGCTCAAGAGCGCCACGTACGCGCTGCTCAAGCGGCTGAAGGAGAAGACGCTGCACGCGCTGCTCGAGGCCGTGGAGTCCGGCGGCGGCGTGCCCAGCGAGTGCGTGTTGGTGGCGCGCGCCGAGCTGCGCGCTCCCGGACACGccgcgccgccgccgccgcagcTGCTGCTGTGCAGACTGTACCGCTGGGCAGACGTGCAGCACGCGGCGCAGCTCAAAGCGCTCTGCGAGTGCAAGAGCTTCGGCGCGCAGGACGGGCCACTGGTGTGCTGCAACCCCTACCATTACAGCAGGCTCTGTGGGCCAGAGTCGCCTCCTCCTCCGTACTCAAGGCTTTCCCCTAGTGACGAACACAAGCCACTGGATCTGTCAGATTCCACACTGTCTTACACTGAAACGGAGGCTGCCAGCTCGCCAAACATCACCCAAGGGGAATTCTCAGATGCCAGTCTGTCACCGGACGCCCCCAAACAGACGCACTGGTGCAGCGTGGCGTACTGGGAGCACCGCACGCGGGTGGGCCGCCTCTACCCGGTGTACGAGCCCTCCGTCAGCATCTTCTACGACCTACCTCAAGGCACAGGTTTCTGCCTGGGCCAGCTGAGCGGCGAACGGCGCAGCGGAACCGCCCAGCGCACCCGCGGCAAGATCGGGTACGGCCTGCTGCTCAGCAAGGAGCCCGACGGCGTTTGGGCCTACAACCGCAGCCAGCACCCGATCTTCGTCAACTCGCCCACACTGGAGGCCGGACCAGCCACGCGCGGCCTGCTGGTGGTGCGCAAGGTCATGCCTGGCTACTCCATTAAGGTGTTTGACTATGAGCGTTCGGCGCTGCTGCTGCGGCAGGGGGCGGAGCCGGCGCTCCCGGACGGCCCGTATGACCCCAACAGTGTCCGCATCAGCTTCGCCAAGGGCTGGGGCCCCTGCTACTCGCGCCAGTTCATCACCTCCTGCCCGTGCTGGCTCGAAATCCTCCTCAACAACcacagataacacacacacacacaaacggaCAGACTCGGACTTTGGACTCGAGAGACGCGCCGAGAGACCCTACGGACCCCCACAAACTATCCCAAATATCATCTACTTAGATTTaatataaagttttatatattatatgaaatatatattatacttgtAAATACTGGAGTCATTTTtacaatgtaattatttatgtaTGGTGCAATGTGTACAAGtggaaaaaacaggaaatgcactttggcttatatatattatatatataaatatctataaagATAAAGAATCTTTCAATACCAATTTGAAAAATTATACAGCAAAAATAGGATCAGCCTGGTTTTGGTGTATAGTTTTcatgtattattaatatccAGACAAAAAGCTAACACCATTCACACATTGATAATAAAGTATTCGCATTATA

Function

symbol description
smad6b Predicted to enable I-SMAD binding activity and transcription regulator inhibitor activity. Predicted to be involved in several processes, including cell differentiation; regulation of transcription by RNA polymerase II; and transmembrane receptor protein serine/threonine kinase signaling pathway. Predicted to act upstream of or within regulation of transcription, DNA-templated. Predicted to be located in cytoplasm and nucleus. Predicted to be part of heteromeric SMAD protein complex. Is expressed in several structures, including cardiovascular system; head; notochord; optic vesicle; and periderm. Human ortholog(s) of this gene implicated in aortic valve disease 2; craniosynostosis; and radioulnar synostosis. Orthologous to human SMAD6 (SMAD family member 6).
smad6 Enables several functions, including SMAD binding activity; signaling receptor binding activity; and transcription regulator inhibitor activity. Involved in several processes, including negative regulation of osteoblast differentiation; negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway; and zygotic specification of dorsal/ventral axis. Located in Golgi apparatus; cytosol; and nuclear body. Part of protein-containing complex. Implicated in aortic valve disease 2; craniosynostosis; and radioulnar synostosis.

NR:

description
mothers against decapentaplegic homolog 6

GO:

id name namespace
GO:0007179 transforming growth factor beta receptor signaling pathway biological_process
GO:0006355 regulation of transcription, DNA-templated biological_process
GO:0005634 nucleus cellular_component
GO:0005667 transcription regulator complex cellular_component
GO:0003700 DNA-binding transcription factor activity molecular_function

KEGG:

id description
K04677 SMAD6; mothers against decapentaplegic homolog 6

RNA

RNA id representative length rna type GC content exon number start site end site
TU215532 False 1418 lncRNA 0.61 4 17328370 17372021
TU215533 False 945 lncRNA 0.54 1 17327253 17328197
XM_007249251.3 True 2873 mRNA 0.57 4 17327100 17372206

Neighbor

gene id symbol gene type direction distance location
LOC107197433 NA coding upstream 25418 17295207 ~ 17301682 (+)
rab11a rab11a,LOC105007892,LOC106591986,LOC100698633,LOC106588008,LOC103378951,LOC106562755 coding upstream 395738 16921369 ~ 16931362 (+)
slc24a1 slc24a1,LOC107738725,LOC107596980,LOC107742879,LOC107686291 coding upstream 442945 16859892 ~ 16884155 (+)
hacd3 hacd3,LOC107738726,LOC107686290,LOC107672296,LOC107596982,LOC107583769,LOC107742880 coding upstream 474641 16842661 ~ 16852459 (+)
pllp pllp coding upstream 554100 16764032 ~ 16773000 (+)
LOC103027004 smad3,LOC108424035,LOC105892538,LOC103353199,LOC107740443 coding downstream 53012 17425218 ~ 17447793 (+)
iqch NA coding downstream 85809 17458015 ~ 17492931 (+)
c18h15orf61 cunh15orf61,c4h15orf61,LOC103025902,LOC107738714,LOC107583911,LOC107718314,LOC107686305,LOC107596966 coding downstream 121587 17493793 ~ 17498771 (+)
LOC103029280 skor1 coding downstream 191669 17563875 ~ 17571917 (+)
LOC103025173 pias1b,LOC108424062,LOC108264782,LOC107596961,LOC107738708 coding downstream 205186 17577392 ~ 17604549 (+)
G158991 NA non-coding upstream 43218 17283467 ~ 17283882 (+)
G158882 rpl4 non-coding upstream 149908 17173067 ~ 17177192 (+)
G158891 NA non-coding upstream 168649 17157142 ~ 17158451 (+)
G158881 NA non-coding upstream 242839 17083953 ~ 17084261 (+)
G158878 NA non-coding upstream 243362 17079112 ~ 17083738 (+)
G159014 NA non-coding downstream 76626 17448832 ~ 17451332 (+)
G159017 aagab non-coding downstream 83109 17455315 ~ 17456977 (+)
G159028 NA non-coding downstream 223853 17596059 ~ 17599354 (+)
G159115 NA non-coding downstream 497801 17870007 ~ 17870468 (+)
G159120 kif23,LOC107686310 non-coding downstream 554782 17926988 ~ 17938088 (+)
zwilch zwilch other upstream 137849 17177675 ~ 17189251 (+)
map2k1 map2k1,LOC107596971,LOC107583767,LOC107686295 other upstream 154872 17101612 ~ 17172228 (+)
LOC103031606 arih1,LOC108423892,LOC107742882,LOC107672283,LOC107549652,LOC105892496 other upstream 528700 16779506 ~ 16798400 (+)
st3gal2 st3gal2,LOC107686287,LOC106573711 other upstream 601891 16654136 ~ 16725209 (+)
siah1 siah1,LOC107549647,LOC107742888,LOC106573709 other upstream 755642 16542878 ~ 16571458 (+)
rapsn rapsn other downstream 598890 17971096 ~ 17985904 (+)
necab2 necab2,LOC107694920,LOC107672281,LOC106573751 other downstream 1153322 18525528 ~ 18576437 (+)
G159666 NA other downstream 2813310 20185516 ~ 20186919 (+)
G159728 NA other downstream 3364392 20736598 ~ 20737049 (+)
G159748 chd2,LOC107715217,LOC107601632,LOC107549011,LOC107715589,LOC107690375 other downstream 3637096 21009302 ~ 21011794 (+)

Expression


Co-expression Network