cftr (cftr,LOC107738689,LOC107583749,LOC107596947,LOC107708216)


Basic Information

Item Value
gene id cftr
gene name cftr,LOC107738689,LOC107583749,LOC107596947,LOC107708216
gene type coding
species mexican tetra (Astyanax mexicanus)
category of species ornamental fish

Chromosome Information

Item Value
chromosome id NC_035914.1
NCBI id CM008317.1
chromosome length 41377133
location 18134717 ~ 18164724 (+)
genome version Astyanax_mexicanus-2.0_2017_mexican_tetra_Genome

Sequence

>XM_007255961.3
CAGTATAAGGAAATCCATGTGTCGGTTAATGTCGGTGTTGATGATGTCTGTATGTGGGGAATGAGTGCAGGGCGCTTCCTGCACTGAGTGTGAGTTAGGTACAGTGGTGTGAATATGTGGTGACTGTGGGCTCTGAATGACCGAGTCTCGCGCAGATCTCCTCCTCCGCCTCCGCGcgcctgtttgtgtgtttggatATCGTGTCTCCTCGCCGCGCCGCACGTGAGCTGATTGTGTTTAAAAGGCAGAGCGCGCGAGAGCGGCGTGCCCACAGGGGAGCTCGCGCAGTGCAGCGCGGACAGAGTGCGGTGCTGCTCGCGCGCGGATCACAGGGGGGCTCGCGACGTCCACGCGCACACACCAAGTACACGGACAGCGCTGTGAGACGGTGTGGGGAAGGGGGGGGTTTCTTAACGGGGAGAAATACGGAGAACCCCTTACCCcttaagtgtgtgagtgtgagtgtgtgtggaggacaGCAGCCCTATTGAAGGGACAGCAGATGTGAGCGGAGAGCTGCTTCCCGCGCCCGGGCTCGGCGAGCATGAACAAGTCACCTGTGGATGAGGCCAGTTTCCTCTCCAGATACTTCTTCTGGTGGACAAACCCTATTATGCGAAAGGGTTTCAGGGAGAAACTGAGGCCAACAGATGTGTATCAAACGCCATCACAAGACACAGCTGATGTACTTGCAGAACGGCTTGAGAAGGAATGGGACAGAGAAGTTATCTCCGCGAAGAAGAAGCCCAGTCTCCTCCGAGCACTTTCCCGATGCTTTATTCGGCCCTTTCTGTTCTTTGGAGTTCTCCTCTATTTGGGGGAAGCCACAAAATCtgtacagcctcagctcctgggACGAATAATTGCTTCATTCGACCCCTTCCACGAGCCAGAACGAGAGCAGGGCTACTTCCTGGCCTTCGGCCTGGGCCTTCTCTTTATTGCTCGCTTCCTACTACTGCAGCCAGCCATGTTTGGGCTGCACCACGTGGGCATGCAGATCCGCATCGCCCTCTTTAGCTTAATCTACAAAAAGACGCTGAAACTGTCCAGTCGAGTTTTGGACAAGATCAGCACAGGACAGCTAGTCAGCTTGATGTCAGCTAACCTGGGCAAGTTTGATCAGAGTCTGGGCATGGCCCACTACGTCTGGATTTCTCCTTTGcagtgtatactgtgtgtgggACTAATCTGGGAGCTTATTGATATTAACAGCCTCTGTGCCCTCGCTGCCATCTCCTTACTGGGAGTCATTCAGGCCTGTCTGTCCCATAAAATGGGCCCCTACAAagcaAAAAGGATACTGCTGACCAACAAGCGTCTAGCTCTGACCTCGGAGATCATGGAGAATCTACACTCAGTGAAAGCCTATGGCTGGGAGGACATCATGGAGACCATCATCAAGAACATCAGACAAGATGAGGTCAAGCTGACCAGGAAGATTGGCTCTCTGCGCTACTTTTACAGTGCTGCCTACTTCTTCTCTGCCATCTGGGTGATCACTGCAGCAGTGGTGCCCCAAGCCCTCACCACCGGCATCACTGTGCGGCGCGTCTTCACCACGCTGTCTTACTGCATGGTGCTGCGCATGACTGTCACCCGCCAGCTGCCTGCCTCTATCCAGATGTGGTATGATACCATTCGGCTCATCTGGAAAATTgagGACTTTCTCAGCAAAGAAGAATACAAAATGTTGGCGTATGACCTCAGCATCACAGACATGACTCTAGAAAACGTCACAGCTTCCTGGGATGAGGGAATAGGGGAActatttgagaagattaaacaGGAGAATAAAGGAAATGGTTATCAGAATGGAGACGGGCTCTTCTTCACCAACCTCTACGTAACACCTGTTCTTAGGAATATCAGCTTGCACTTACACAAAGGTGAAATGTTGGCTGTGGCTGGCTCCACAGGATCTGGAAAGAGCTCTCTGTTAATGACAATCTTGGGTGAGCTGGTCCCCTCCTCTGGAAAAATCTGCCACAGTGGCCGGGTCTCCTTCTCCTCTCAGACTGCCTGGACGTTGCCTGGCACCATTCGAGACAACATCCTGTTTGGTCTGACCTATGACGAATTCCGCTATACCAGTGTGGTCAAAGCATGTCAGCTAGAGGAGGACCTGGCTACTCTTCCTGAGAATGACAGAACACTTTTGGCAGAGGGTGGAATAAACCTCAGTGGCGGTCAGAAGGCACGGGTGGCCCTGGCAAGGGCAGTGTACAGAGATGCTGATACCTACCTGCTGGATGCACCTTTCACTCATCTGGATATCGCAACAGAGAAAGAAATATTTGACAAGTGTGTGTGCAGACTCATGGCCTCCAAGACACGGATATTGGTCACCAACAAAATCGAGCACCTGAAACGGGCCAACAAGATTCTGCTGCTCCACAACGGCGAGTCTTTCTTCTACGGCACCTTCTCAGAGCTGCAGTCCCAGCGCCCTGACTTCAGCTCCCTGCTGCTCGGCCTGGAGGCCTATGACAACGTCAATGCAGAGCGTCGCTGCTCCATCCTTACTGAGACCCTTCGCAGAATCTCTGTGGATGAGAGTTCAGGGATTCGCCCCGATCGTTCTTCTTACAGACAGGTGGCTCCACCAGCCTACAAAGATGAACGTAAATCATCTGTGATCATCAGTCCGCTTATGGCTGACCGCAAGTCTTCCTTCACCCCTACTGGACTCGAGGAGGAAGTGAGGCGTCCACTGTCTGACCGCAGAATCTCTCTAGTGCCTGAGAATGAGCTGGTGGATGACTGCTTCATGGGGAACGATACATACCATAATCACGGCGTGCACCTGGCAGGCCAGAGGAGACAGTCAGTCCTAGCCTTTATGACAAATGCACAGGGCCAGGGTAGACGGGATCAGCTCCAGTCTTCCTTCCGCCGCCGCCTGTCCATAGTGCCCCAGAGCGAACTTGCCTCGGAGGTGGACATCTACGCCCGCCGACTGTCCAAGGACAGCATGTATGATATTACTGGAGACTTGGATGAGGAGAACATTGAGGCGTGCCTTGCAGACGAACAAATTGAAAACGTCTTTGAAACCACAAAATGGAACACATATGTCCGATATGTGACATCCAACAAAAGTCTAATTTATGTTCTAATCTTTATTCTCGCCATCTATGCTGTAGAGGTGGCAGGATCTGTTGCTGGGATTTTTTTGATAACCGATGAGGTCTGGAAAGAAGAGAATCAGATGTTCGCCCTGAACACCACAAACACTGAAAAAGCCAACGTATCCCTGGCAAGCTCACAGTATGCTGTCATCGTTCGCCCCACCAGCAGCTACTATATCATCTACATCTATGTGGCCACTTCAGAGAGCATATTAGCTCTGGGCTTTTTCAGAGGGCTTCCCCTGGTCCACACCATGATCACCATCTCCAAGAAACTGCACCAGAAAATGTTGAGTTCTGTGCTGAGGGCACCTATGTCCATTTTGAACACCATGAAGACAGGTTCTATCATGAACAGATTCACAAAAGACATGGCCATCATAGATGACATGTTGCCTCTGCTAATGTTCGACCTTGTCCAGctgaCCCTGGTGGTGATTGGATGCATTCTGGTGGTGTCCATCATGCGGCCCTACATATTTCTTGCAGCTACACCCTTGGCCCTCATCTTTATTGTGATGAGGAAGTACTTCTTGCGAACGGGGCAGCAGCTGAAACAAATGGAGACAGAAGCCCGGAGTCCCATCTTTTCTCATCTCATCATTTCCCTGAAGGGCCTGTGGACGATCCGGGCGTTCGACCGGCAGGCGTATTTTGAAACCCTGTTCCACAAAGCCCTGAATACTCACACAGCGGTCTGGTTCCTCTACCTCTCCACCTTGCGCTGGTTCCTATTCCGTGCTGACATCATCTACGTCTTCTTCTTCACCCTTGCTGCCTGGATTGCTGTTGGAACCAACCAGGATAAACCAGGGGAGATTGGTATCATAGTAGCCCTGGCAATGCTCATTCTGGGTACCTTTCAGTGGTGTGTCGTCACCAGCATTGCAGTGGATGGAATGATGCGGTCTGTGGAGCGTGTCTTCAAGTTCATCGACTTGCCGTCCGAGGAGCCCAAACCAAAGCTAGGCCAAAGAAACGTCTCAGACCTGGTCATCGAGAACCCAGACACTTCCAACGAGGCTGCCTGGCCCAGCCACGGTCAGATGGACGTGCAGAATTTGACGGTCAAATACACAGAGTCTGGGCACGCCGTGCTCAAGAACCTCTCCTTCGCCGTGGAGGGTGGACAGAAGgtgGGAATACTGGGCAGAACAGGTTCTGGGAAGAGCACGCTGCTTAGCGCACTCCTGCGACTGGCCTACACAGATGGAGAAATGTCCATCGATGGCGTGTCCTTTAACAGCATGCCCCTGCAGAAGTGGCGCAAGGCTTTTGGTGTGGTGCCTCAGAAAGTTTTTATCTTCACTGGTTCGTTCCGTATGAACTTGGACCCCTATGGTTGCCACAGTGACGAGGAGTTGTGGAGCGTTGTTGAGGAGGTGGGCCTTAAGTCAGTAATTGAGCAGTTTCCTGATAAGTTAGACTTTCAGCTGGAGTATGGGGGCCACGTGCTGAGCTACGGACACAAGCAGCTGATGTGTCTGGCCCGGTCTATCCTCAGCAGGGCTCGTATCCTGCTGCTTGATGAACCCAGTGCCCATCTCGACCCACTGACAGTGAAGGTACTGAAGAAGACGCTGAGGCAGTCCTTCTCCACCTGCACCATCTTAATGTGTGAACACAAGGTGGAACCACTGCTCGAGTGCCAGTGTTTCCTGATGATGGAGCAGGGTAAAGTGAAGACCTACGACTCGATCCAGAGACTCCTGAATGAGACCAGCCAGCTGAAGCAGGCCATGAGTCCAGCTGAGCGCCTCAAACTCTTCCCCCGGCGCAACTCCAGCATGCATGTAGCTCAGCCCAAACTCAGCTCCGTCACACTCACCCTGCAGGAGGAAGCAGAGGACGACATCCAGGACACTCGCCTCTGAGACCCCTCACCTCCGAGACCCCTAAAGACACTAAACAGAGACTCCTTCATGAGGTCAGTGAGGGGAGTCGCATCTCATTCTGTCCAGGAGGAAGACTTTTCACATTGTGGACAGAGTTATTAACGAAGCGGGACTTATGAACTTGTTTAAGATGGTGGTACAGTGGACACGTGAAGCATTGGAACTGTTTTTATATATGCTGTTAATGTAACTTATGGTACTTAAGGATTTTTAGAAGGGGCCACACCAAGACCCTTCAGTTCAGCTGTAAACCTCCCTCTTAACTTATTGAGCCGATGTAGGACCACGCGTCTTCCTATAATAGCTCTTCTGTAAATCACATAACTGGAAAGGCAGtcattttccttttattttttatttagatattttaagaAACTATGCACAAACTGAATTTATGTAataattgtgtgtttttgttttgcttagGTGTAAATAGATGAACAATGTTTCTGTAAACATTggatatttttatataacaaCTACTCTCTCATTATTGTTTGTTCAAAGCCAAAGATGGATACAGCGCACAACATTCTGTCCATTGACTGCATATTTCTGCTCCCTggttcgtttttttttaatgggaaaaaaaaaaaaaacaaaacaaa

Function

symbol description
cftr Enables ATP binding activity; ATP hydrolysis activity; and chloride channel activity. Acts upstream of or within several processes, including Kupffer's vesicle development; germ cell migration; and regulation of neutrophil chemotaxis. Located in apical plasma membrane. Is integral component of membrane. Is expressed in several structures, including Kupffer's vesicle; digestive system; forerunner cell group; head; and pleuroperitoneal region. Used to study cystic fibrosis and diabetes mellitus. Human ortholog(s) of this gene implicated in several diseases, including alcoholic pancreatitis; allergic bronchopulmonary aspergillosis; bronchial disease (multiple); congenital bilateral absence of vas deferens (multiple); and lung disease (multiple). Orthologous to human CFTR (CF transmembrane conductance regulator).

NR:

description
cystic fibrosis transmembrane conductance regulator

GO:

id name namespace
GO:0042742 defense response to bacterium biological_process
GO:0090022 regulation of neutrophil chemotaxis biological_process
GO:0055085 transmembrane transport biological_process
GO:0070121 Kupffer's vesicle development biological_process
GO:0002679 respiratory burst involved in defense response biological_process
GO:0006811 ion transport biological_process
GO:0016021 integral component of membrane cellular_component
GO:0005524 ATP binding molecular_function
GO:0005254 chloride channel activity molecular_function
GO:0042626 ATPase-coupled transmembrane transporter activity molecular_function

KEGG:

id description
K05031 CFTR, ABCC7; cystic fibrosis transmembrane conductance regulator

RNA

RNA id representative length rna type GC content exon number start site end site
XM_007255961.3 True 5634 mRNA 0.51 27 18134717 18164724

Neighbor

gene id symbol gene type direction distance location
LOC107197792 LOC107197792 coding upstream 99021 18030488 ~ 18035696 (+)
wee2 wee2 coding upstream 104712 18023904 ~ 18030005 (+)
agk agk coding upstream 124163 18004007 ~ 18010554 (+)
LOC103029004 NA coding upstream 140347 17985993 ~ 17994370 (+)
kbtbd4 kbtbd4,LOC107708223,LOC107738697,LOC107596956,LOC107672308 coding upstream 165781 17964383 ~ 17968936 (+)
LOC103028633 NA coding downstream 96441 18261165 ~ 18265803 (+)
arpin arpin coding downstream 250803 18415527 ~ 18435115 (+)
kmt5b kmt5b,LOC107738677,LOC107694947,LOC107596936,LOC107583742,LOC108264420,LOC107726382,LOC107672243 coding downstream 297374 18462098 ~ 18468279 (+)
chka chka,LOC108424340,LOC107738676,LOC107726368,LOC107694945,LOC107583738 coding downstream 308212 18472936 ~ 18491526 (+)
LOC111194773 LOC106934266,LOC108233135 coding downstream 331370 18496094 ~ 18500819 (+)
G159184 asz1 non-coding upstream 6288 18114005 ~ 18128429 (+)
G159182 NA non-coding upstream 25178 18108163 ~ 18109539 (+)
G159129 NA non-coding upstream 137989 17995698 ~ 17996728 (+)
G159122 NA non-coding upstream 188034 17942316 ~ 17946683 (+)
G159120 kif23,LOC107686310 non-coding upstream 196629 17926988 ~ 17938088 (+)
G159272 NA non-coding downstream 246588 18411312 ~ 18411936 (+)
LOC111194744 NA non-coding downstream 248637 18413361 ~ 18413950 (+)
G159274 NA non-coding downstream 263431 18428155 ~ 18428426 (+)
G159298 NA non-coding downstream 343687 18508411 ~ 18508695 (+)
G159344 NA non-coding downstream 448440 18613164 ~ 18615494 (+)
rapsn rapsn other upstream 148813 17971096 ~ 17985904 (+)
smad6 smad6,smad6b,LOC107583766,LOC107672304,LOC107596967,LOC107738716,LOC107686299 other upstream 762511 17327100 ~ 17372206 (+)
zwilch zwilch other upstream 945466 17177675 ~ 17189251 (+)
map2k1 map2k1,LOC107596971,LOC107583767,LOC107686295 other upstream 962489 17101612 ~ 17172228 (+)
LOC103031606 arih1,LOC108423892,LOC107742882,LOC107672283,LOC107549652,LOC105892496 other upstream 1336317 16779506 ~ 16798400 (+)
necab2 necab2,LOC107694920,LOC107672281,LOC106573751 other downstream 360804 18525528 ~ 18576437 (+)
G159666 NA other downstream 2020792 20185516 ~ 20186919 (+)
G159728 NA other downstream 2571874 20736598 ~ 20737049 (+)
G159748 chd2,LOC107715217,LOC107601632,LOC107549011,LOC107715589,LOC107690375 other downstream 2844578 21009302 ~ 21011794 (+)
fam174b NA other downstream 2895932 21060656 ~ 21074573 (+)

Expression


Co-expression Network