gdnf (gdnf,LOC107653769,LOC107752627,LOC107692037,LOC107569368,LOC107727951)



Basic Information


Item Value
gene id gdnf
gene name gdnf,LOC107653769,LOC107752627,LOC107692037,LOC107569368,LOC107727951
gene type misc
species mexican tetra (Astyanax mexicanus)
category of species ornamental fish

Chromosome Information


Item Value
chromosome id NC_035916.1
NCBI id CM008319.1
chromosome length 36262418
location 4118034 ~ 4130482 (+)
genome version Astyanax_mexicanus-2.0_2017_mexican_tetra_Genome

Sequence


>TU234481
TCCAAACAAGTCAGTCAGGGGTTCCAACAGCGCTGCATGAGAGGATATGCTACGCCAAGGCTATGCTACGCTAGGGCTAAGTCTCCCACTACCTGATGATGCCTTGTGTTTGTTTCTGAGGTCATTAAGGCCACCTCAGCAGCTTGTTGGCCAAGTTTAAGCCCCCCCTGATCTGGGTTTAGAAAACGATCCTCAAACATTTGAACTTAAGCTGCTCCGCTAGTCGTGGCACCCTGGTGTTTAAGACCATTTAAACAAGATCTGCTTCTGTCTTCCTCAGCTGAATTGGAGTAAACCTCCTAAACAGAAGGAGACAAAAACAGTTGGCGAGGACAGGCACGGCACGAGCTCTAGAGCTCCAGAACTCTAGTAAACATACAACCAGAAAAGCAGGACTTCAGAAACAGCTGGCGATGCTTACGTCACCGCCGTTCTGAGAGCAGATTTTGGTCTCagccacacagaaagaccccgGGGAAACGCCTCAACGATTCCGTGGATTACGGAGCAAAATCTGGCCTCATACAACAGGCATGGAGCTAGCTTTACTCGATAATCCCTCCTATATATACAGCGCACAGTACAAAATCCAAAAAATCCTCACAATTCAGACGTTCTGGTGGGTATTTAGGCCAAACTCCCCTCTTAAATTGCTAAGTTAGCTCCATATTTAATGTACTGTAGCTCAACTGTCCCCAACAGGCTCCTCATCCATCGCAAAATAATTCACGAATATGTTTCCATATACCGTGTTCTGTACTCTTCTGTCCTCATGattaagatgatgatgatgatgaagatggtttGCTGTACTGTTAAGTGTTCTGTTGTGACTAAAAGAGtctataaacacacaccaaattaaaaaatgttaaaaaattaaaacaattagaaTGATAtgtgattaatatatatatatat
>TU234482
CGACCTGGTTAAAGGTCAGGGCCGCGGGTGCCTTCTCAAAGAAATCCACCTCAATGTGACGGACCTCGGGTTGGGCTACCGGACCAAAGAGGAATTGATATTCAGGTACTGCAGCGGTCCCTGCTTCGATTCAGAGACCAACTACGACAAGATCCTGAACAACCTCACCCACAACAAGAAGCTGGACAAAGAGTCGCCTTCGAGAACTTGCTGTCGGCCAATCGCGTTCGACGACGACCTCTCGTTCTTGGACGACGACTTGGAGTACCACACTCTCAAGAAGCATTCCGCCAAGAAGTGTGCCTGTGTCTGACTTGCGAGGTcatgcgaaaaaaaaaaagagggagaaaaagacaCTTGGACAAAAAGCAGGAGTCTCGCACTTCACAGGGCTCAAGGCCAGTGCGAAGACTAATGCTGCTTCTCGGAGGGAAAGTGCAGGGCTTGAGTGTGTCATAGCTTATTTTCCCCAGACACTCAAAAAGAACAGCCCGAGAAAAGCTAGCGGCGCACGTCAGATATGGTGGAAATCTTTCGACCCGCAGGACTGAGGTTTAACAGCGAAAGCTTCGggaaaaaaagtactttataGCTGAGGAGCAACGACTAAGTATTCACTTTG
>XM_007244797.3
TCTCCCGGACGCCACTCTAATAACGCAGCGTGGATCTTTCACCGAGCCTCGCGCCACTGGgaatttgtgtgtttgtgtccggACTGCAGGTCTGCATGGGTCCGAGCTAAGCTCCTTCCATAGGAACGGAGTCTAAAATGAAGTTATGGGATGTTCTAGCCACGTGTTTGTTGCTCCTGAGCTCTGCGTCCGCCCGTCCTCTGTTCCACAAACTGCAGCCGTCGAAGAGAGCCTCACTGCCACAGCATTACACTGAGCCCCTCGCTGGGGACCCCGTCATAGACTCCCGACCTGAAGCCGGCAGTCTGAAACAAGCTTTCATGGAAGAACAAAATGATATCAACGGCCTCTACCCAGAGCAGTTTGACGATGTGATGGACTTCATCGAGGCGACCATTGGTAGACTACGGAGGTCTCCGGAGGCGGACAATGGCTTGGTGGGCAAGAAGGACAGGGGGAGACAGAGAGGAGCAGCAAACACCGACAGAGGAGGTCGGGGgcgaggagaaaaaaagaagggtCGAGGACGGACTGGAGGCAGAGGGGGCAAAGGGAGTCGGGACGACCTGGTTAAAGGTCAGGGCCGCGGGTGCCTTCTCAAAGAAATCCACCTCAATGTGACGGACCTCGGGTTGGGCTACCGGACCAAAGAGGAATTGATATTCAGGTACTGCAGCGGTCCCTGCTTCGATTCAGAGACCAACTACGACAAGATCCTGAACAACCTCACCCACAACAAGAAGCTGGACAAAGAGTCGCCTTCGAGAACTTGCTGTCGGCCAATCGCGTTCGACGACGACCTCTCGTTCTTGGACGACGACTTGGAGTACCACACTCTCAAGAAGCATTCCGCCAAGAAGTGTGCCTGTGTCTGACTTGCGAGGTcatgcgaaaaaaaaaaagagggagaaaaagacaCTTGGACAAAAAGCAGGAGTCTCGCACTTCACAGGGCTCAAGGCCAGTGCGAAGACTAATGCTGCTTCTCGGAGGGAAAGTGCAGGGCTTGAGTGTGTCATAGCTTATTTTCCCCAGACACTCAAAAAGAACAGCCCGAGAAAAGCTAGCGGCGCACGTCAGATATGGTGGAAATCTTTCGACCCGCAGGACTGAGGTTTAACAGCGAAAGCTTCGggaaaaaaagtactttataGCTGAGGAGCAACGACTAAGTATTCACTTTGTTACCAAACAAAACCAGAGCATTTCCTTATAAGTGCGGCTTAAAGTGTTTAATgctatttaaatagcaacaataACATACTTCATCAATAAGTCACACACAAATCACATCCTGACAGCTGTACCATTGAAGTATACACAAACTGTAATTTAGGACCTGTGCGTGGTAGCCCTTGGGATGGGTGCTATGGAGTTAGCGCACTGGAGAGGTTGTGGacagcaacgattttatggatTTTTCCATTAGCTGCAGAGCGCGGTGACATTTACTTACTCAGAAAAACCTGAGAGCGCCCTTCTCACGGTGCGGACTGACCGACCCCACAGCCACACAGTCATGATGGACTCGGACTCATcccaaaaaatgtttaatattcagaaagttatctatatagtatatatgaAATGCGTATTTATTGAAATCTAATTAacttattgttatttattgcgATCCATTGtattagagtgttttttttttcgtattattatttatttgcggagcttttttttttctcctccatcTTGGACGGTGCCAAAGTTGGAGCACGTGTTTCTAAGGAAAAGCAGATGACGTGATAATCTAGCCTCAAGGTTTTAGCTGTACAGTGATCACTCACTCGTTATAGGAGCCGTTGTTAGAACCCTGCCTCACACCTCGTTTCTGGATAAAACAAATGGTACATTCAGACCTCATTACACTAACCAAACAATTACCAGATGATTTAACTTAAGGACGAGTGGACCAACGATTCTGTGGAAGGGGAgggaaaataaaacagaaaaagttaCAGGAAAACAGACAgctttttgtttagtaaattgCATGTATgatacactatatgttcaaatgtttatggacaccgtatttaatgaatgcatttggGTGGTTCAATTTGCACCCTTGCTTGCTGCTAACAGAGATTTGGAAAGTGTCTCTGTAGAAGACAAACATATACTTATTAAAACCATCCCTCCTAATGCTGGGCGTTGTCTACTGGAGGAATATACGATATACAATAAACCTCCAGCACTGatttgtgaaaaagtgaattGGGGTATTGGTAACGAGGTGGAATGGTGGGGTCGTCAACCAATACAAATTCTCAAAGCAATGCAATCCATCAGATTCCCTGAACAGAACAAACAGGTACTCtaacaacaaaagcagaataaactctgcTGAGCTTTTTAATTCCCTTGCTTTTGGtagaaaaaatgaagataaaaaACTGGCGTCCAAatgcttttgtccatatagtgtaacaCAATATTCACAATATTCCAAAGTTTCCTGTAATCTTGTGTTGCTTAGGAAAACGAATCATGTAAATGGGTTAGACGAGGAGGAGGGGAAGGCAAGGCCTGTGGCAGACCAGTCAATGTTTACTCAACGCGAGCAGTTTAAGCAAAATGTTAACATTGGCTCTCCAACTGCTCTACACCAATTATCTGTTTGCGAGAGAAAATACAGCTCCTgccctgtgtgtttattttcaaCCAAAATAAATCCACTACCGAGGAGGAGGTTTCTAGCATAGCTACACCGTGCCCCATGGAGACCCAGAATCACAAATAGAAAACATCCTTCCAAACAAGTCAGTCAGGGGTTCCAACAGCGCTGCATGAGAGGATATGCTACGCCAAGGCTATGCTACGCTAGGGCTAAGTCTCCCACTACCTGATGATGCCTTGTGTTTGTTTCTGAGGTCATTAAGGCCACCTCAGCAGCTTGTTGGCCAAGTTTAAGCCCCCCCTGATCTGGGTTTAGAAAACGATCCTCAAACATTTGAACTTAAGCTGCTCCGCTAGTCGTGGCACCCTGGTGTTTAAGACCATTTAAACAAGATCTGCTTCTGTCTTCCTCAGCTGAATTGGAGTAAACCTCCTAAACAGAAGGAGACAAAAACAGTTGGCGAGGACAGGCACGGCACGAGCTCTAGAGCTCCAGAACTCTAGTAAACATACAACCAGAAAAGCAGGACTTCAGAAACAGCTGGCGATGCTTACGTCACCGCCGTTCTGAGAGCAGATTTTGGTCTCagccacacagaaagaccccgGGGAAACGCCTCAACGATTCCGTGGATTACGGAGCAAAATCTGGCCTCATACAACAGGCATGGAGCTAGCTTTACTCGATAATCCCTCCTATATATACAGCGCACAGTACAAAATCCAAAAAATCCTCACAATTCAGACGTTCTGGTGGGTATTTAGGCCAAACTCCCCTCTTAAATTGCTAAGTTAGCTCCATATTTAATGTACTGTAGCTCAACTGTCCCCAACAGGCTCCTCATCCATCGCAAAATAATTCACGAATATGTTTCCATATACCGTGTTCTGTACTCTTCTGTCCTCATGattaagatgatgatgatgatgaagatggtttGCTGTACTGTTAAGTGTTCTGTTGTGACTAAAGTTTGTGGATGCTTTTCAGGTGCTCTTAAGGTTGCTGGAAGTTTCAGAGAGtctataaacacacaccaaattaaaaaatgttaaaaaattaaaacaattagaaTGATAtgtgattaa

Function


symbol description
gdnf Enables protein homodimerization activity. Involved in several processes, including negative regulation of apoptotic process; positive regulation of morphogenesis of an epithelium; and regulation of RNA metabolic process. Acts upstream of or within several processes, including neural crest cell migration; neuron projection development; and positive regulation of cell population proliferation. Located in Golgi apparatus and extracellular region. Implicated in Hirschsprung's disease; Parkinsonism; congenital central hypoventilation syndrome; epilepsy; and pheochromocytoma. Biomarker of acoustic neuroma; autoimmune disease (multiple); neurodegenerative disease (multiple); pancreatic cancer; and vasculitis (multiple).

NR:

description
glial cell line-derived neurotrophic factor

GO:

id name namespace
GO:0021784 postganglionic parasympathetic fiber development biological_process
GO:0048484 enteric nervous system development biological_process
GO:0048485 sympathetic nervous system development biological_process
GO:0072107 positive regulation of ureteric bud formation biological_process
GO:0001755 neural crest cell migration biological_process
GO:0030432 peristalsis biological_process
GO:0048255 mRNA stabilization biological_process
GO:0051584 regulation of dopamine uptake involved in synaptic transmission biological_process
GO:0032770 positive regulation of monooxygenase activity biological_process
GO:0045944 positive regulation of transcription by RNA polymerase II biological_process
GO:0090190 positive regulation of branching involved in ureteric bud morphogenesis biological_process
GO:0001656 metanephros development biological_process
GO:0031175 neuron projection development biological_process
GO:0043524 negative regulation of neuron apoptotic process biological_process
GO:0005576 extracellular region cellular_component
GO:0042803 protein homodimerization activity molecular_function
GO:0008083 growth factor activity molecular_function

KEGG:

id description
K05452 GDNF; glial cell derived neurotrophic factor

RNA


RNA id representative length rna type GC content exon number start site end site
TU234481 False 921 lncRNA 0.43 2 4129515 4130482
TU234482 False 622 lncRNA 0.50 1 4127309 4127930
XM_007244797.3 True 3723 mRNA 0.45 3 4118034 4130469

Neighbor


gene id symbol gene type direction distance location
LOC103029394 smad4a,LOC108435141,LOC107559658,LOC107668639,LOC107741365,LOC104924734,LOC107373891 coding upstream 928334 3178378 ~ 3189700 (+)
LOC103031084 NA coding upstream 944478 3170196 ~ 3173556 (+)
LOC111195007 LOC108435126 coding upstream 961919 3142848 ~ 3156115 (+)
LOC103030033 NA coding upstream 986398 3125086 ~ 3131636 (+)
LOC103031401 LOC108435143,LOC108276558 coding upstream 993782 3098197 ~ 3124252 (+)
LOC103042678 NA coding downstream 111686 4242168 ~ 4244029 (+)
LOC111195096 NA coding downstream 202391 4332873 ~ 4337695 (+)
ranbp3l NA coding downstream 224452 4354934 ~ 4379352 (+)
LOC103029159 NA coding downstream 252649 4383131 ~ 4389029 (+)
LOC103026990 ucp3,LOC103026990,LOC108433282,LOC108277383,LOC107578242,LOC105890488,LOC107743402 coding downstream 307558 4438040 ~ 4444030 (+)
G173182 NA non-coding upstream 71690 4046083 ~ 4046344 (+)
G173121 NA non-coding upstream 76074 4008213 ~ 4041960 (+)
G173119 pdlim5b,LOC108435134,LOC108277016 non-coding upstream 112377 3958740 ~ 4005657 (+)
G173090 NA non-coding upstream 255840 3861105 ~ 3862194 (+)
G173079 NA non-coding upstream 738876 3378879 ~ 3379158 (+)
G173232 NA non-coding downstream 118390 4248872 ~ 4249963 (+)
G173259 NA non-coding downstream 183362 4313844 ~ 4316472 (+)
G173268 NA non-coding downstream 262592 4393074 ~ 4400580 (+)
G173270 NA non-coding downstream 271554 4402036 ~ 4476650 (+)
G173272 rsf1b.1,LOC108277234,LOC107697440 non-coding downstream 278470 4408952 ~ 4410779 (+)
G173111 LOC108435134,LOC108277016 other upstream 186043 3908942 ~ 3931991 (+)
G173094 NA other upstream 374829 3740302 ~ 3743205 (+)
unc5c unc5c,LOC108435138,LOC108277026,LOC105911728,LOC106564027,LOC105025160,LOC106568183 other upstream 378298 3465133 ~ 3739736 (+)
LOC103031931 LOC103031931,LOC108435131,LOC104953549 other upstream 1391958 2718609 ~ 2726076 (+)
G172770 h2afvb,h2afva,LOC107386217,LOC105007341,LOC107668744,LOC107599604,LOC103039302 other upstream 2120672 1994708 ~ 1997362 (+)
G173397 NA other downstream 613087 4743569 ~ 4744249 (+)
ptbp3 ptbp3,LOC106592370 other downstream 670147 4800629 ~ 4904202 (+)
nrarp nrarp,nrarpa other downstream 973245 5103727 ~ 5152836 (+)
G173501 NA other downstream 1053009 5183491 ~ 5183777 (+)
LOC103041160 NA other downstream 2405845 6536327 ~ 6541379 (+)

Expression



Co-expression Network