LOC111191028 (grb2b,grb2,LOC108432081,LOC107719324,LOC108256494,LOC107672691,LOC107672145,LOC107723603)


Basic Information

Item Value
gene id LOC111191028
gene name grb2b,grb2,LOC108432081,LOC107719324,LOC108256494,LOC107672691,LOC107672145,LOC107723603
gene type misc
species mexican tetra (Astyanax mexicanus)
category of species ornamental fish

Chromosome Information

Item Value
chromosome id NW_019172828.1
NCBI id APWO02000046.1
chromosome length 5964967
location 3042432 ~ 3148603 (+)
genome version Astyanax_mexicanus-2.0_2017_mexican_tetra_Genome

Sequence

>TU408592
ATAAAGCATACACTTACTTTAAGCAAAACTTACATcacaataacagtaaaaatatacatttaaaaatacaaaaaaatgtgttttaccaAAAGTAATGTGATATTTGGCCACGCCCACCACTAATACCTTACAGTATTAGACCGACCTCTCTTTAgtggtttttaaaaaatatatatctgccATTTCTTTCATGTGAATCATGTGAATACCCACATTTAACATACAACAGAAGAACACATCTTCCTGCACATGTTAAAAAACTAACAGGTCAATCCAGAACAAATCTGTGGTATTTATGCTGCGTTCCATTTAAACTCAAGTGTCAAgcaatgaagtacaaatactactTCATTATCtgacttaagtagaaatgttggttatctatactttattgGAGTAATTCTAATTTTTCTgacgactttttacttctatttcttacatttccacacagttatctgaactttctacttcttacattttaataaaaatagcctAAAaatactcctatttcatttcagttcGTTTTTATTCctgcttctcatcgttcaataaaacccccatccagataaatctctccatccagatagagtgatgagatctgattgtgattggatgtagagaagtataaatatataccattctgactccctattggtttatactgtgatccatcacatctgcaccccccccccccacacacacacacacacacactcacacacacacacacactcaccaacCCTAAACCCTCTGATCCTGCCCCGAACCCTCAGCCTACACCCTGAGATCTCCACCGCGAAAACGGAGAGACAGAAAtcttggagagagagagagcgagagatagatagagaagaAGAAAGTGTAGAGAACGGACGTCTCTGCAGGGCGTCTGGGCGAGATCAGCGCTGATTCCTGAGAATATCTGCAGCACCACGAACGCTTCAGGGtggaagcagagagagagcaacacagACCACAGAATcagaaatattataataaataaaa
>XM_022664959.1
gAGGCAAACAAGCGTCTGGCTGAGGCTCCAGCAGAAGCAACGGGCTTTCCGTGGGCAGCGTACGGGGGAAACACGGCGCCGTAGCGGCTTTATACTGCTTAAAGTGGGATTTACCGGGGAGTGGTAGCGAATAGAGACCTCCAGCCAGGGCCAGCGGCTGTGATCTGTATGCGAGGATCGAGACAGAGGATCAGAGGCTGGAGGGCTGATTCAGAGCCGCCagttccagcagcagcagcagcagcagtgtctgTCCTGGATCTACCTACCCTCGTGCTCTCAACACCACTTGTGACATCTTTTGTCTTCAACCAAACATCAGCCAGGCAGAGGGGAACAAACTCTGCCAAAGAAATACAAGAACAGACATTTTCTGCTGTagatatatagtttatagtctCTTGGAGGTGTCCGTCCCGCTGAATCATGGAGGCCATTGCCAAGTATGATTTCAAAGCGACTGCAGATGATGAGCTAAGTTTTAAACGAGGAGAAGTCCTTAAGGTATTAAATGAAGAATGTGACCAGAACTGGTATAAAGCAGAGCTGAACGGAAAAGACGGTTTCATCCCTAAGAACTACATAGAAATGAAAGCACATCCGTGGTTTTTCGGGAGGATTCCTCGAGCCAGAGCGGAGGAACTACTGAACAAACAGAGGCACGACGGAGCTTTCCTTattagagagagcgagagcgcaCCCGGAGACTTCTCCCTGTCCGTCAAgttcGGTAATGACGTGCAGCACTTTAAAGTGTTGCGTGACGGAGCAGGGAAGTACTTCCTGTGGGTGGTAAAGTTTAACTCTCTGAATGAGCTGGTGGATTATCATCGCTCCACCTCCGTCTCACGAAACCAACAGATCTTTTTACGAGACATCGAGCAGGTTACTCAGCACCCGACATATGTGCAGGCCCTGTTCGACTTCGACCCTCAGGAGGACGGTGAGCTGGGATTCCGGCGTGGAGATTTCATCCAGGTCCTAGACAACTCCGACCCCAACTGGTGGAAGGGAGCGTGCCACGGCCAGACGGGCATGTTCCCCCGCAATTACGTCACGCCCGTCAGTCGGAACATGTAGAACGGATCAAATAAAAGTCCCTCTcttcctgtacacacacacacacacatctacacacacacacacacacacacacacacacacacacataatctatacacacactcaccaacCCTAAACCCTCTGATCCTGCCCCGAACCCTCAGCCTACACCCTGAGATCTCCACCGCGAAAACGGAGAGACAGAAAtcttggagagagagagagcgagagatagatagagaagaAGAAAGTGTAGAGAACGGACGTCTCTGCAGGGCGTCTGGGCGAGATCAGCGCTGATTCCTGAGAATATCTGCAGCACCACGAACGCTTCAGGGtggaagcagagagagagcaacacagACCACAGAATcagaaatattataataaataaaaaaaaacaaaaaaacatcacaaataTGATAAcaattatgatgatgatgatgataattatgattatgatgattCTGTCTTAGATTCGTTCACCTTGCTGCTTTTGCCTCCcctttagttttcttttttttttttcgtctgaAGTAAAAGCATTtgtgcatttattattattaggttttttttttttttccttttttttttttcttttgttttttgtttgtttttggctgcatgttttaatcacaattttgcATAACAAAATTCTAAGgctgttttaagtttttaaaaaatatattaaacataaaaaaaaa

Function

symbol description
grb2b Predicted to be located in Golgi apparatus; endosome; and nucleus. Is expressed in central nervous system and trigeminal placode. Human ortholog(s) of this gene implicated in breast cancer; prostate adenocarcinoma; and prostate cancer. Orthologous to human GRB2 (growth factor receptor bound protein 2).
grb2 Enables several functions, including SH3 domain binding activity; insulin receptor substrate binding activity; and signaling receptor binding activity. Involved in several processes, including cellular response to ionizing radiation; signal transduction in response to DNA damage; and transmembrane receptor protein tyrosine kinase signaling pathway. Acts upstream of or within actin cytoskeleton reorganization. Located in endosome; nucleolus; and nucleoplasm. Part of COP9 signalosome and Grb2-EGFR complex. Implicated in breast cancer; prostate adenocarcinoma; and prostate cancer. Biomarker of endometrial carcinoma.

NR:

description
PREDICTED: growth factor receptor-bound protein 2

GO: NA

KEGG:

id description
K04364 GRB2; growth factor receptor-bound protein 2

RNA

RNA id representative length rna type GC content exon number start site end site
TU408592 False 1005 lncRNA 0.38 3 3042432 3148295
XM_022664959.1 True 1766 mRNA 0.46 6 3069637 3148603

Neighbor

gene id symbol gene type direction distance location
LOC111191042 LOC108432083 coding upstream 117247 2768664 ~ 2925185 (+)
LOC111191060 ntn1,LOC107583316,LOC107728387,LOC107672692,LOC107719327,LOC107703884,LOC107563365 coding upstream 353642 2549150 ~ 2688790 (+)
LOC111191061 NA coding upstream 364155 2674748 ~ 2678277 (+)
LOC103028117 crhr1,LOC108413653,LOC107662410,LOC108261365 coding upstream 920938 1844980 ~ 2121494 (+)
LOC103044572 NA coding upstream 1691512 1334340 ~ 1350920 (+)
LOC103026062 LOC108432079 coding downstream 16446 3165049 ~ 3216189 (+)
LOC103025752 kpna2,LOC108432045,LOC108261381 coding downstream 71326 3219929 ~ 3227171 (+)
LOC103025443 smurf2,LOC108432078,LOC108254810,LOC107748797,LOC107695141,LOC105891874 coding downstream 79855 3228458 ~ 3326996 (+)
LOC103024726 LOC103024726,LOC108432077,LOC108257112,LOC107583258,LOC107748799,LOC103360002,LOC105013158 coding downstream 184276 3332879 ~ 3342234 (+)
LOC111191052 NA coding downstream 197842 3346445 ~ 3357240 (+)
G297128 NA non-coding upstream 6818 3034512 ~ 3035614 (+)
G297126 NA non-coding upstream 21275 3020513 ~ 3021157 (+)
G297116 NA non-coding upstream 62061 2980093 ~ 2980371 (+)
G297063 NA non-coding upstream 110515 2929187 ~ 2931917 (+)
G297070 NA non-coding upstream 138897 2903076 ~ 2903535 (+)
G297190 NA non-coding downstream 69068 3217671 ~ 3218609 (+)
G297203 NA non-coding downstream 157566 3306169 ~ 3312518 (+)
G297214 NA non-coding downstream 197491 3346094 ~ 3375734 (+)
G297217 NA non-coding downstream 200139 3348742 ~ 3410812 (+)
G297218 NA non-coding downstream 262653 3411256 ~ 3412085 (+)
G296790 tcap,LOC108413611 other upstream 1680497 1359112 ~ 1361935 (+)
LOC103044283 LOC103044283,LOC108412482 other upstream 1752012 1287516 ~ 1290420 (+)
G296679 tlk2,LOC108413572,LOC107660745 other upstream 1841644 1191763 ~ 1200788 (+)
mien1 mien1,sepw2a,LOC107566883 other upstream 2208374 826378 ~ 834058 (+)
LOC103026352 ndufa4l,LOC103026352,LOC108413413,LOC108260900,LOC107684646,LOC107590798,LOC103357383,LOC107582867 other upstream 3001541 36833 ~ 40891 (+)
LOC103030733 NA other downstream 401724 3550327 ~ 3640614 (+)
LOC103041102 LOC108440983,LOC108258030,LOC107718582,LOC107661664,LOC107715658,LOC107695723,LOC107550253 other downstream 1104413 4253016 ~ 4299447 (+)
znf653 znf653,LOC106601361,LOC107553636,LOC104961106,LOC103393609 other downstream 1271394 4419997 ~ 4434071 (+)
LOC111191039 NA other downstream 1502040 4650643 ~ 4675621 (+)
LOC103033323 NA other downstream 2553909 5702512 ~ 5711874 (+)

Expression


Co-expression Network