lhx2 (lhx2,lhx2b)



Basic Information


Item Value
gene id lhx2
gene name lhx2,lhx2b
gene type coding
species mexican tetra (Astyanax mexicanus)
category of species ornamental fish

Chromosome Information


Item Value
chromosome id NC_035902.1
NCBI id CM008305.1
chromosome length 52532229
location 35594983 ~ 35605830 (+)
genome version Astyanax_mexicanus-2.0_2017_mexican_tetra_Genome

Sequence


>XM_007229122.3
GAGAACTGGGGGGAAAAGGGGCGCTGACTGGGGGATTAGAGCCTACAAAAGCCGAAGTGCGCTCAACTCCTCCTCCCCAATTACTCACACTGCGCTCCGAGCTCGGGGAGAGGGCGCGCGGCCCTGAAGACACGGGAAAAAGAGAAATCACGGCAGTGGAAATTCGGTATTGGACGTTGTTTTGCTCTTTCGGTCGTATCGATGCGCGAGCAGTGCTTGTGCTTATTACTTGCACCTTTTTTTGAGCTGACACGGAGAgattcaacaaaaaaaactattctacACCGGCTCCGggattatatatgattttttcccAGCGACATAAAAATGGATTTCTGATCAATCAGGTGCGTGAGGCACTTTAATCGAGCAACGAAtgaatttatttctaaaaaaaataaaataaagaagaacgaaagaaggaaggaaaaaaacagcaacacacTGCTGGTCGTTATAAGCTCGTGCTGACAGATGCTCCTCCAACATGTGGTAAAGGAAGATCGCtcctgattttattattttacgcGTCTGTAGAAGTAGAAACAGTGCCTTGTTTCCGAAGCTCTCAAAATCCAAGGAACGCGCAAATATCGGCGTGCGCGCGCGCCATGTGCCATGTATGTGCTGCTAAAGCCTGGAGCGCCTGAAGACGTCCACCACCAGCAGCCTGCGGGGAGAGTGCGGGGAAGCGGCGGGAAGTGCGCGCTGGAGGCTGGGCTGCACTGAGCAGGAGCCGTGGGTCGTATGAACTGCACCGGGCCGGGACTGCGCCTCACGGAAATCTCGGCCCGCAGCACGAAAGCGAGCACGTGCTGCTCGTTCTCCACGATGCTTTTCCACGGCGTGCCCGGCGCCGACATGCGCGGGGTCGTGGAGGAGATGGAGCGAAGGGGCAAGAGCGACTCGGCGCCCATCAGCTCCGCCATCGACATGGGGGAAACAGAGACGAGTGCGCCGTCCATGAGCGGTGAGCGCGTGGCGTTGTGCGCGGGCTGCGGCGGCAGGATCTCTGACCGATACTACCTGCTGGCCGTGGACAAGCAGTGGCACATGCGCTGTCTGAAGTGCTGCGAGTGCAAACTCAACCTGGAGTCCGAGCTCACCTGTTTCAGCAAGGACGGTAGCATCTACTGCAAAGAGGACTATTACAGGAGGTTTTCGGTGCAGAGATGCGCGCGCTGTCACCTGGGCATCTCGGCTTCTGAGATGGTGATGCGCGCGAGGGATTTGGTGTACCACTTGAACTGTTTCACGTGCACGACGTGTAGCAAAATGCTGACCACGGGCGACCACTTCGGCATGAAGGACAGCCTGGTGTACTGCCGCCTGCACTTCGAGACGCTCGTGCAGGGTGACTACGGCGCGCCGTTCGGGCACGCGGACGTGGCGCATGGTAAAGGCGCGGTGCCCGCGGGCCCGCTGGGACTGGCCTACTACAACGGGGTGGGCACCGTGCAGAAGGGCCGACCGAGGAAGAGGAAAAGTCCGGGGCCGGGGGCTGATCTAGCGGCTTATAATGCAGCGCTTAGCTGTAATGAAAACGATGGTGATCCTATGGACAGAGACTCTCAGTACAGTTCTGGCCAGAAGACCAAGCGCATGAGAACCTCCTTCAAGCACCATCAGCTCCGAACCATGAAGTCCTATTTCGCCATCAACCACAACCCTGATGCCAAGGACCTGAAACAGCTGGCCCAGAAAACGGGGCTCACCAAGCGAGTACTTCAGGTTTGGTTCCAGAACGCCAGGGCCAAGTTCCGGCGGAACCTCTTGCGTCAGGAGAACACGGGCGTGGACAAGGCTTCGGATGGGTCCAACTTGCCCGGAGGAACCCCGTCCGGACCGGCCTCGGAGATCTCCAACGCGTCCATGAGCCCGTCGAGCACTCCAACCACACTGACAGACCTTACCAACCCCACCATGCCCACCGTCACTTCCGTACTGACCTCTGTGCCTGGTAGCCTGGACGTCCACGAGTGCCGGAGCCCCTCACAGACCACCCTCACCAGCCTCTTCTGATGCTAGTTCACCCAGGCCCTCGGTGACCTTCACCCTTATCGTCCAACTGCAGGGCGAAGGGCGAATGGACCTTACAGACACTAGACTGCTCATCTTCTCGGCTTGAGTCACTGAAGAGCCGAAATGCATCGTTTTCCTATTTTATGTTGTTGAGGATCCAGCGCTGGATGACCTTGCTTTGAGATCGGAACCACGAGCATCGTCCTTGCGTCCTTGCACTGACATCACTGACGTCACTGGTATTTCCCATAAAACAGAAACAATCCACCGTCCACATCCACGTCATGCAGCTGGAACGTGTGCAGCTGGTCACttgcacaaaataaaaaaattaaataaaacaaaacctcACTGCAACTGCaaaactgcaactgcaaaaCTGCAACAACAGTCACAAACCTCCGTAGACGGGCGACGTACGATAGATGGCGAAGCCCAAACTTAAACTTAGCTTACGCTCGGTCCAAACACAAACCAGAGACGAtgaaaatttaaacaaaacaaaaaaaagacttttaaaggGGGacgagaaaatgaaaaattaaaaaatgaactgagctaaaaaagaaaagaaaagaaaagagaaagctTTCATTTGACCGTGAGCCTCTTTTAGAGTATTGCATACGTGCGTGAGTGAGTGCGTACGTACGGGCAGGTGGGCATGCCTCACTGAAGGATCTGTTgatgtcttttcttttttttgatgtTGTTGCTTTTTTGTCTTTGAAGGAATTGAGGAAGAAGGCttcatttgcatttttattttcattttttgtttctcCCCCTGACTATGTTTACAGCgcgagagaaaagaggagaggagagaagcgCTCTCAGCTTATGGGAATTCATCCTCACTTCAACCTATTATTTATGTAACTGCACCGGGGTCAAAGTGAGGAAACTGGATTATAATGTGAATAATTGTGAGATGAAAAAAGAGAACACAGCGAAACTTAGCCTGACTGTCACGTGCCTTATCCTGCGATTTACTCCACCggtacacaacacacaaacacacaccttttACTCATCGCTGATGCATTCAAACGTGTGTATTATTATAGCCcgat

Function


symbol description
lhx2b Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Acts upstream of or within several processes, including camera-type eye development; nervous system development; and optomotor response. Predicted to be active in nucleus. Is expressed in several structures, including brain; forebrain neural keel; forebrain neural rod; optic vesicle; and retina. Used to study congenital nystagmus and pathologic nystagmus. Orthologous to human LHX2 (LIM homeobox 2).
lhx2 Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in neuron differentiation; positive regulation of transcription, DNA-templated; and regulation of transcription by RNA polymerase II. Predicted to act upstream of or within several processes, including hair follicle development; maintenance of epithelial cell apical/basal polarity; and nervous system development. Predicted to be part of chromatin. Predicted to be active in nucleus.

NR:

description
LIM/homeobox protein Lhx2

GO:

id name namespace
GO:0021794 thalamus development biological_process
GO:0021537 telencephalon development biological_process
GO:0021554 optic nerve development biological_process
GO:0006355 regulation of transcription, DNA-templated biological_process
GO:0043010 camera-type eye development biological_process
GO:0031290 retinal ganglion cell axon guidance biological_process
GO:0071632 optomotor response biological_process
GO:0005634 nucleus cellular_component
GO:0043565 sequence-specific DNA binding molecular_function
GO:0003700 DNA-binding transcription factor activity molecular_function
GO:0008270 zinc ion binding molecular_function

KEGG:

id description
K09373 LHX2_9; LIM homeobox protein 2/9

RNA


RNA id representative length rna type GC content exon number start site end site
XM_007229122.3 True 3098 mRNA 0.52 5 35594983 35605830

Neighbor


gene id symbol gene type direction distance location
LOC103030350 NA coding upstream 157556 35405454 ~ 35437427 (+)
LOC103030661 LOC108430371 coding upstream 204811 35371911 ~ 35390172 (+)
LOC103038477 fam102aa,LOC108430372,LOC107752986,LOC107671017,LOC107699668,LOC105891604,LOC107754406 coding upstream 229778 35341479 ~ 35365205 (+)
naif1 naif1 coding upstream 254913 35337272 ~ 35340070 (+)
LOC103031612 NA coding upstream 283496 35308625 ~ 35311487 (+)
LOC103029489 NA coding downstream 113119 35718949 ~ 35724427 (+)
ctu1 ctu1 coding downstream 121517 35727347 ~ 35734257 (+)
pxn pxnb,LOC107754409,LOC107552183 coding downstream 130757 35736587 ~ 35770038 (+)
gcn1 gcn1,LOC107552181 coding downstream 168235 35774065 ~ 35810149 (+)
rab35 rab35,LOC108430363,LOC107699662,LOC107671023 coding downstream 205610 35811440 ~ 35822755 (+)
G56672 NA non-coding upstream 10882 35583886 ~ 35584101 (+)
G56669 NA non-coding upstream 17161 35577522 ~ 35577822 (+)
G56658 NA non-coding upstream 41231 35553381 ~ 35553752 (+)
G56655 NA non-coding upstream 50993 35543697 ~ 35543990 (+)
G56649 NA non-coding upstream 64749 35529904 ~ 35530234 (+)
G56673 NA non-coding downstream 1993 35607823 ~ 35608182 (+)
G56707 NA non-coding downstream 204548 35810378 ~ 35836710 (+)
G56712 NA non-coding downstream 221346 35827176 ~ 35912416 (+)
G56732 unc45b,LOC106585035 non-coding downstream 392355 35998185 ~ 36001333 (+)
G56753 NA non-coding downstream 523226 36129056 ~ 36151490 (+)
G56504 NA other upstream 136106 35420718 ~ 35458877 (+)
LOC103032256 dynll1,LOC103397138,LOC107554284,LOC107559583,LOC100698873 other upstream 310712 35276079 ~ 35284271 (+)
ikbkb ikbkb,vdac3,LOC107560056,LOC107671013,LOC107754399 other upstream 322455 35226485 ~ 35272528 (+)
LOC103047498 NA other upstream 605698 34961800 ~ 34989285 (+)
G56414 tcf7l1,LOC107721095,LOC107556226 other upstream 843420 34713218 ~ 34751563 (+)
G56701 pola2,LOC107710902,LOC107657899 other downstream 350274 35956104 ~ 35964510 (+)
G57066 NA other downstream 1399443 37005273 ~ 37005798 (+)
agtpbp1 agtpbp1 other downstream 3503414 39109244 ~ 39153476 (+)
frmd3 frmd3,LOC107678471 other downstream 3686241 39292071 ~ 39370585 (+)
LOC103039219 iqsec2,LOC107747221,LOC107683900,LOC107702804,LOC108265842 other downstream 4361260 39967090 ~ 40090271 (+)

Expression



Co-expression Network