mfn2 (mfn2,LOC107748965,LOC107710790,LOC107602467,LOC107678429)


Basic Information

Item Value
gene id mfn2
gene name mfn2,LOC107748965,LOC107710790,LOC107602467,LOC107678429
gene type coding
species mexican tetra (Astyanax mexicanus)
category of species ornamental fish

Chromosome Information

Item Value
chromosome id NC_035902.1
NCBI id CM008305.1
chromosome length 52532229
location 41247386 ~ 41278478 (-)
genome version Astyanax_mexicanus-2.0_2017_mexican_tetra_Genome

Sequence

>XM_007247914.3
AGGGAAGAAAGCAATGTTATTGGGACGCGGCCTTTCTGCCTCCTCTTCTCAGAGCTGTGTCGCATTCGGATGATGTGAGGTTAATGCACTTGTAGAAGGAGACCGACCAGTTAACATTGTTACATAATAAAACTACAGCTGGATTCATAGAGTAAACAGTAcgattttaatcatttttggcTGCATTAGAGGCAGTAAGGTGTATTAAATTACCTGGGTATAATTAACTAGCAGAGCTAGCTGTGTCCTGACCGCTCTTCCCTTCTTTCTGGGAGCGCTGACGGAAAGACCAAACTGgacaagctaagctaagctaacctagctagccaCCTAACGTTTACTATCTTTATTACGCTAAATTTCTTAAAACTTACGTACAGTTTCGTGGATAATCTTGGAAATAAAACTAGCAACTGGCTGTTTATTCGAGGACAGTGGAACCAACATGCTTGAGGACTTGTTATAACCACGCCTTTCTTGTGCAATGTCTCTGGTTTTCCCCCGACCCAACACCAGTGCGATCGGCAAAAAGGACAAGCGACACATGGCTGAGGTGAATGCCTCTCCACTCAAGCACTTTGTCACCGCCAAGAAGAAAATCAACGGCATCTTTGAGCAGCTTGGCGCGTATATCAAAGAAAGCTCGGCCTTTCTGGAAGAGACATACAGCAATGAGGAACTGGATCCAGTCACGACAGAGGAGCAGGTGGCAGAGGTGCGGGGTTACCTGTCCAAGGTAGCAGGGATTGGTGAAGTCTTGTCCCGCAGACACATGAAAGTGGTCTTTTTTGGCAGGACTAGCAATGGCAAAAGCTCTGTCATCAACGCCATGCTGTGGGACAAAGTCTTACCATCAGGTATTGGACACACCACAAACTGCTTCCTGCGAGTAGAAGGAACTGATGGCAATGAGGCCTTCCTGCTTACAGAAGGTTCAGAGGAAAGAAAGAACGTTAAGACGGTGAACCAACTGGCCCATGCTCTACATCAAGATGAGGACCTGGATGCAGGCAGCCTGGTGTGTGTCATGTGGCCTAAAGCGAAGTGTGCTCTGCTGCGTGACGACTTAGTACTGGTGGACAGCCCTGGCATTGATGTCACCACAGAATTGGATAGCTGGATTGACAAGTTTTGCCTGGATGCTGACGTTTTCGTGCTGGTGGCCAATTCAGAGTCTACTTTGATGCAAACAgaGAAATCCTTCTTTCATAAAGTGAACGAGCGTCTCTCAAGCCCCAACATTTTCATCCTGAATAACCGCTGGGATGCTTCAGCCAGTGAGCCTGAGTACATGGAGGAGGTCAGGCGGCAGCACATGGACCGCTGCAGCAGTTTCCTGGTGGATGAGCTGGGGGTGGTGGACAGAGCACAGGCCAGTGATCGCATCTTCTTCGTCTCTGCTAAAGAGGTCCTGCAGGCACGTGTTCAGAAGGCCCAAGGAATGCCTGAAGCAGGTGGTGCCCTGGCTGAAGGCTTTCAAGCCAGAATGTTTGAGTTTCAGAATTTTGAGAGGCGTTTTGAGgagTGTATATCTCAATCAGCAGTGAAGACAAAGTTTGAGCAGCACACTGTTAGGGCCAAGCAGATTTCAGAAGCACTTCGACTGATTATGGATTCTGTGCACGTGGCTGCCCAAGAGCAAAGGATACACTGCATGGAGACAAAGGAGGAACGGGAGGACAGGCTGGACTTCATTGATAAGCAGCTGGACCTACTCACCCTGGACTGTAAGAGCAAGATCAGAAAAATCACTGAGGAGGTGGAGAAACAGGTGTCAAACGCAATGGCTGAAGAGATAAGGAGGCTTCATGTGCTGGTGGACGAGTTCCACCTTGATTTCCATCCCTCACAAGTGGTTCTGAAGGTGTACAAGAATGAGCTGCACAGGCACATAGAGGAGGGCCTGGGAAGGAACATGTCTGAGAGGTGTTCCAATGCAATCACAAGTGCTCTTcagaacacacagacagaaatgaTAGATGGTTTGAAGCCCTTGCTTCCCCTTTCTGTGAGAGAACAAGTGGATAAGATGGTGCCCAGACAGTGCTTCAGTCTCAGCTATGACCTTAACTGTGACAAGCTGTGCAGCGACTTCCAGGAAGACATCAACTTCCACTTCTCACTTGGCTGGACCATGCTGGTCAACCGATTCCTCGGACCCAAGAATACCCGCCGTGCCCTCATGGGTTACAACGACCAGGTCCCCAGGCCCATGGCCATTACCCCAGTCAGCACTTCCATGCCCCCTTTCCAGCAGGGTTCTATGACTCAAGAAGAGCTTATGGTCTCAATGGTGACAGGGCTTGCCTCTCTCACCTCACGGACATCCATGGGCATCATAGTCGTCGGAGGCGTGATCTGGAAAGCAGTGGGCTGGAGGCTGATTGCTTTGTCTGTGGGGCTCTATGGGCTGCTCTATGTGTATGAGAGGCTCACGTGGACCACCAGGGCTAAAGAGCGAGCCTTCAAGAGACAGTTTGTGGACTACGCCAGCGAAAAGCTTCAGCTCATTGTCAGCTACACTGGCTCCAACTGCAGCCACCAAGTCCAGCAGGAGCTGTCAGGCACCTTTGCCCAACTGTGTCAGCAGGTGGATGTGACACGGCAGCAGCTGGAGGATGAGATTCAGGACATGAACCGCAAGATTGAACAATTAGACACACTACAGAGCAAAGCCAAGCTGctcagGAATAAAGCCGGCTGGCTGGACAGTGAGCTGAACATGTACCAACAGTACCTTCAGCAGGGTCGATAAAGGTTTAGCGTTTAAATTGCCGAACaaacaagaccaagaccaacAATAAAAGTGCAAACTAATACATGCAGCATAAGTTATTCTACTATTCAT

Function

symbol description
mfn2 Predicted to enable GTPase activity. Acts upstream of or within several processes, including axonal transport of mitochondrion; axonogenesis; and neuromuscular junction development. Predicted to be located in mitochondrial outer membrane. Predicted to be integral component of membrane. Predicted to be intrinsic component of mitochondrial outer membrane. Is expressed in several structures, including heart; muscle; nervous system; otic vesicle; and ventral mesenchyme. Used to study Charcot-Marie-Tooth disease type 2. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease; Charcot-Marie-Tooth disease type 2A2A; Charcot-Marie-Tooth disease type 2A2B; and Charcot-Marie-Tooth disease type 6. Orthologous to human MFN2 (mitofusin 2).

NR:

description
unnamed protein product

GO:

id name namespace
GO:0007528 neuromuscular junction development biological_process
GO:0019896 axonal transport of mitochondrion biological_process
GO:0006184 obsolete GTP catabolic process biological_process
GO:0048662 negative regulation of smooth muscle cell proliferation biological_process
GO:0007409 axonogenesis biological_process
GO:0008053 mitochondrial fusion biological_process
GO:0016021 integral component of membrane cellular_component
GO:0005741 mitochondrial outer membrane cellular_component
GO:0003924 GTPase activity molecular_function
GO:0005525 GTP binding molecular_function

KEGG:

id description
K06030 MFN2, FZO1; mitofusin 2

RNA

RNA id representative length rna type GC content exon number start site end site
XM_007247914.3 True 2848 mRNA 0.49 19 41247386 41278478

Neighbor

gene id symbol gene type direction distance location
prdm16 prdm16 coding downstream 175147 40763855 ~ 41072239 (-)
tp73 tp73 coding downstream 520907 40666471 ~ 40726479 (-)
rer1 rer1,LOC107678415,LOC107710784,LOC107698848,LOC107595758 coding downstream 584815 40652574 ~ 40662571 (-)
LOC103024844 NA coding downstream 608613 40632068 ~ 40638773 (-)
LOC103026801 LOC103026801,LOC108414620,LOC107756851,LOC107702881,LOC107573971,LOC107691553,LOC107566963,LOC108265407 coding downstream 619735 40619650 ~ 40627651 (-)
plod1 plod1,plod1a,LOC107698842 coding upstream 2683 41281161 ~ 41296693 (-)
clcn6 clcn6 coding upstream 126893 41405371 ~ 41436478 (-)
LOC103033502 NA coding upstream 179518 41457996 ~ 41493671 (-)
LOC103034037 NA coding upstream 215126 41493604 ~ 41513087 (-)
pex10 pex10 coding upstream 238487 41516965 ~ 41527890 (-)
G57920 NA non-coding downstream 485214 40761495 ~ 40762172 (-)
G57925 wrap73,LOC107678416,LOC107748967,LOC107710786,LOC107595759 non-coding downstream 498847 40741514 ~ 40748539 (-)
G57916 NA non-coding downstream 582622 40664520 ~ 40664764 (-)
G57788 NA non-coding downstream 956200 40290977 ~ 40291186 (-)
G57782 NA non-coding downstream 991570 40255567 ~ 40255816 (-)
G58031 mthfr,LOC107687111 non-coding upstream 170735 41449213 ~ 41452982 (-)
G58145 NA non-coding upstream 574111 41852589 ~ 41944829 (-)
G58152 NA non-coding upstream 597785 41876263 ~ 41934574 (-)
G58149 plch2 non-coding upstream 621632 41900110 ~ 41903678 (-)
G58159 NA non-coding upstream 632305 41910783 ~ 41911110 (-)
tprg1l tprg1l,LOC107710788,LOC107678419,LOC107698845,LOC106513028 other downstream 491372 40748741 ~ 40756014 (-)
LOC103037008 LOC108442081,LOC105022382,LOC106567250 other downstream 1068245 40165400 ~ 40179141 (-)
G57727 kdm5c,LOC107550909,LOC107747206,LOC107570512 other downstream 1128291 40117789 ~ 40119095 (-)
LOC103030299 fkbp1aa,fkb1b,fkbp1a,LOC103030299,LOC107553142,LOC107574256,LOC107752559,LOC107707744 other downstream 1684465 39521544 ~ 39562921 (-)
LOC111192682 NA other downstream 2941920 38261117 ~ 38305466 (-)
G58022 LOC103032860,LOC108432146 other upstream 117608 41396086 ~ 41398478 (-)
G58435 aaas other upstream 1824392 43102870 ~ 43107623 (-)
G58537 NA other upstream 2403846 43682324 ~ 43682684 (-)
G58649 NA other upstream 3089422 44367900 ~ 44368368 (-)
G58678 NA other upstream 3195681 44474159 ~ 44477666 (-)

Expression


Co-expression Network