mthfr (mthfr,LOC107602465,LOC107687111,LOC107691055)


Basic Information

Item Value
gene id mthfr
gene name mthfr,LOC107602465,LOC107687111,LOC107691055
gene type coding
species mexican tetra (Astyanax mexicanus)
category of species ornamental fish

Chromosome Information

Item Value
chromosome id NC_035902.1
NCBI id CM008305.1
chromosome length 52532229
location 41440699 ~ 41452963 (+)
genome version Astyanax_mexicanus-2.0_2017_mexican_tetra_Genome

Sequence

>XM_007247925.3
TCCGCTACTATAACCCATATTCTTCCCTTTATTCCGCCCGTTCGTCGGATGCTGAGCCGCTCGGGGACGCGCCTCGCCTCGGTTGTGTTGTTGTGGTTATCGGGGGGAACTGTGAGGTACCATGGTTAACCAGCGACTGGACACCGGCTGGCAGCCGTGTAAGAGCGACTCCAGTGGTGGAAGCAACAGTGGAGAGAGTTCTAAAGAGAGCTCAAGATGTTCCACCCCAGTGCTGGACACGGACCGCACTGACCGACTGCGGGACAAGATGAGGAGGAGAATTGAGTCTGGGGACCACTGGTTCTCCCTCGAGTTTTTTCCTCCCCGCACAGCTGGAGGCGCGGTTAATCTCATATCTAGGTTTGACCGCATGGGATCTGGCGGACCACTCTTCATCGATGTAACATGGCATCCAGCAGGAGACCCCGGCTCAGATAAGGAGACCTCCTCAATGATGATAGCCAGCACAGCAGTCAACTACTGCGGCCTGGAGAGCATCCTGCACCTGACCTGCTGCAAACAGACGAAAGAGATAATCACAGCTCACCTCAACAAAGCCAAGCGCCTGGGCCTAAAGAACATCATGGCATTAAGGGGAGATCCAATTGGAGCTGACTGGGAGGAAGAAGAGGGAGGATTCAACTATGCTACAGACCTGGTGAAGCACATTCGCCATGAATTCGATGACTACTTTGACATCTGTGTTGCTGGCTACCCAACTGGGCATCCGGAGGCTGAGAGCTATGAAGATGACCTGAAGCACTTGAAAGAGAAAGTGGATGCAGGAGCACACTTCATCGTGACTCAGCTCTTTTTCAGAGCGGAGACATTCCTTAAATTCGTCAAGGACTGCAGAGCCATCGGCATCACCTGTCCTATTGTGCCTGGAATCTTCCCCATACAGGGTTACCACTCCCTGCGGCAGCTGGTCAAGCTGTCCAAACTGGAGGTGCCAGAGGAGATCATGCAGGTAATCGAGCCCATCAAGGACAACGATGCTGCCATCCGGAACTACGGCATCCAGCAGGCTGTGGAGATGTGCAGGGTTCTGCTGGCCAGCGGGGACGTGTCTGGGCTGCACTTCTACACACTCAACAGAGAGGTTGCCACCATGGAAGTGCTCAGACAGCTGGGCTTGTGGGCAGAAGACCCTCGcCGGCCTTTGCCATGGGCTGTCAGCGCTCATCCTAAACGAAAGGTTGAAGATGTTCGGCCGATCTTCTGGGCTTCAAGGCCTAAAAGCTACATCTACAGAACTCAAGACTGGGATGATTTCCCCAATGGAAGATGgGGAAACTCCTCATCCCCAGCTTTTGGCGAGCTGACAGATTATTATTTGTTCTACCTGAAGAGCAAGTCTTCCAAAGAGGCCTTATTGAAGATGTGGGAAGAGGAGCTAACCAGTGAGGACAGTGTGTATCAAGTCTTCACTAACTACATCACAGCAGAGCCCAACAAGAGTGGACACAAGGTGATGTGTCTTCCATGGAACGATGACCCTTTAGCTCCAGAGACAAACATGCTGAAGGAGGAACTGGAGAAGGTGAATCGCAGGGGAGTTCTCACCATCAACTCTCAGCCCAACATCAATGGCAAGCCTTCTTCTGACCCAATTGTGGGGTGGGGCCCACCGGGCGGATATGTCTTTCAAAAGTCATACCTGGAATTCTTCACATCAAGTGAAAATGTTAACGCACTTCTCCAAGTACTGAAGAAATATGAACCACGTGTGAACTACCACATTGTCAATGTGAAGGGCAAGAATATTACAAACGCCCATGATATGCAACCCAATGCTGTAACGTGGGGGATTTTCCCAGGCAAAGAGATTGTTCAGCCCACGGTGGTGGATCCAGTCAGCTTTATGTACTGGAAGGACGAGGCGTTCGCACTGTGGATCGAGCAGTGGGGGAAGCTTTACGAGGACGAGTCTCCTTCACGAATGATTATCCAGTACATCCACGACAATTACTTCCTGGTCAACCTAGTGGACAATGACTTCCCTCTAGATAGCTGCTTATGGCAGGTCATCGACGACATGTTCGAACTGCTGGACGCACCTCCAGAACCTCTGGATCAAGAAAACCTACAGTAGCTTCAAAAACCACACACCTTTggtctgctgctgctttattCTAGGACTTATTATAAAGACACAAACAGAGACATATcactattaattttttttttattattgtaatatcaGCTATTTATACTCTCACTCGTCTGAGTTGTTACATAAAATGCTACATAAAAATGCTGATGAATTTTCAGAACAGTTTACAGAATCGAAAGCTTCTAACTTATGATTATTGCAAATCAAGGGCAAGAGCACTTTTAACACATTATTAGACAAATATACAGATATTATAGGGAATCATAGTACATTATCATGTACAGTCTAATTCCTGGAATCAATGGCACAAGGATTTGCAAGGATTActatttctacatttttatgtaattttttaagctgatgtttttaaagctatttataaacagtattttggCTGTTGCGCGAGTCCGAAGTCCGAGGatgtcaagtttttttggggggactTTCTGCTTTTTATCTCGCCAGCtacatcacacaaacacacgcacacacacccacacaaaacTGCAACCTtgcagagttaaaaaaaaaaaaaaagaccggTCAGAAGCTTAACGCACAAATATTTACTAGTGAAGTCATCCAAGGCCAAAGATGGTGACGGAGATTTTTGATTACTATTGTAATCTGAAGAAGGTTGTTTTATCATTGCCTTGGGTCATATTTCCGTCAGTGTAatgtttttccattttccatgtttttttttttttttccattttttttgttcatatctGCCCCCAAAGTCTGAATTAATTAATCTTTActcttatttcatttttttttcttctcatttttgCATCATGTAATGAAAGGTGGATGGATTATACTATCAAATTGggggcaaaaaaataaataaatctgaaaattaatttagcctcaaatggttaaaaaaaaaaaaaaaaaaa

Function

symbol description
mthfr Predicted to enable FAD binding activity and methylenetetrahydrofolate reductase (NAD(P)H) activity. Predicted to be involved in methionine biosynthetic process and tetrahydrofolate interconversion. Predicted to act upstream of or within methionine metabolic process. Predicted to be active in cytosol. Is expressed in anterior neural tube; optic cup; and somite. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); carcinoma (multiple); cardiovascular system disease (multiple); hematologic cancer (multiple); and kidney failure (multiple). Orthologous to human MTHFR (methylenetetrahydrofolate reductase).

NR:

description
PREDICTED: methylenetetrahydrofolate reductase

GO:

id name namespace
GO:0055114 oxidation-reduction process biological_process
GO:0006555 methionine metabolic process biological_process
GO:0035999 tetrahydrofolate interconversion biological_process
GO:0004489 methylenetetrahydrofolate reductase (NAD(P)H) activity molecular_function

KEGG:

id description
K25004 MTHFR; methylenetetrahydrofolate reductase (NADPH)

RNA

RNA id representative length rna type GC content exon number start site end site
XM_007247925.3 True 3021 mRNA 0.46 12 41440699 41452963

Neighbor

gene id symbol gene type direction distance location
LOC103032860 LOC103032860,LOC108432146 coding upstream 42594 41396141 ~ 41398105 (+)
nppa NA coding upstream 50203 41389619 ~ 41390496 (+)
LOC103039684 LOC108432092,LOC107710771,LOC106926566,LOC107691064,LOC102306682 coding upstream 105117 41318725 ~ 41335582 (+)
kiaa2013 kiaa2013,si:dkeyp-104h9.5,LOC107678452,LOC107698843,LOC107595762,LOC107602448 coding upstream 125491 41305310 ~ 41315208 (+)
wrap73 wrap73,LOC107678416,LOC107748967,LOC107710786,LOC107595759 coding upstream 691960 40720804 ~ 40748739 (+)
plch2 plch2,LOC107691057,LOC107602463 coding downstream 332677 41785640 ~ 41903713 (+)
LOC103035003 LOC108432140 coding downstream 457785 41910748 ~ 41934572 (+)
dpp9 dpp9 coding downstream 495056 41948019 ~ 41977048 (+)
LOC103027292 NA coding downstream 589364 42042327 ~ 42059412 (+)
LOC103027595 NA coding downstream 609335 42062298 ~ 42067929 (+)
G57987 NA non-coding upstream 144025 41294584 ~ 41296674 (+)
G57972 mfn2,LOC107748965,LOC107710790,LOC107698839,LOC107678429,LOC107602467 non-coding upstream 185260 41252811 ~ 41255439 (+)
G57967 NA non-coding upstream 193158 41245137 ~ 41247541 (+)
G57965 NA non-coding upstream 202030 41238321 ~ 41238669 (+)
G57880 NA non-coding upstream 365323 41072386 ~ 41075376 (+)
G58054 NA non-coding downstream 125358 41578321 ~ 41579048 (+)
G58074 NA non-coding downstream 238158 41691121 ~ 41691388 (+)
G58096 NA non-coding downstream 305320 41758283 ~ 41763578 (+)
G58114 NA non-coding downstream 557083 42010046 ~ 42030054 (+)
G58177 NA non-coding downstream 597178 42050141 ~ 42051109 (+)
G58025 NA other upstream 1788 41438027 ~ 41438911 (+)
LOC103032352 LOC103032352,LOC108432100 other upstream 63254 41374689 ~ 41377445 (+)
G57856 tp73 other upstream 760144 40675040 ~ 40680555 (+)
LOC103039219 iqsec2,LOC107747221,LOC107683900,LOC107702804,LOC108265842 other upstream 1350428 39967090 ~ 40090271 (+)
G57664 NA other upstream 1394232 40044653 ~ 40046467 (+)
ndufa7 ndufa7 other downstream 582876 42035839 ~ 42053889 (+)
G58211 acot7 other downstream 755758 42208721 ~ 42281970 (+)
LOC103040535 arhgef16,ybx1,LOC107595774 other downstream 1081938 42534901 ~ 42576703 (+)
G58256 ppih other downstream 1124229 42577192 ~ 42626114 (+)
G58529 NA other downstream 2207819 43660782 ~ 43661647 (+)

Expression


Co-expression Network