XLOC_008188 (rest)


Basic Information

Item Value
gene id XLOC_008188
gene name rest
gene type coding
species zebrafish (Danio rerio)
category of species model fish

Chromosome Information

Item Value
chromosome id NC_007125.7
NCBI id CM002898.2
chromosome length 52660232
location 52418247 ~ 52433292 (-)
genome version GRCz11_2017_zebrafish_Genome

Sequence

>TCONS_00015931
GCCGCGAGATGCGCGATGTGCTGGAATGCGTGAGTGGCGCTTCCTCGAGCGAAAGACGGAGAGTTTGGACCGAAGTTTACTTTGAGAAACACACCGCCCGAAGACGAGTCCACCGCCGtggtcCAGCATGTCTCAGCCGGTGTTTCCCACTGCCTCTGGGATCTTCCTGCCGGATCTGCACCATGACGAGGTGTCTGCTCCTCAGCTGGTGATGCTGGCGAATGTGGTGGTGTCCGCGGAGGCGTCTGCATCAGAATACAGCACTGAGGGGAAGCAGATGATGGAGCTCCAGACCGTGGCCTGCAGCAGCTACTCCGACAGCGAAGAAGACGACGACGCCGTCGTGAGATACAGCATGGACACCTCTGAAGATCTCTACACACAACAAGCATCACATATACAGCCAGAGCCAGTGCTGGAGGAGATAGAAATCGTGCGAGTTGGACGTCCACCAAACCAGACGGAAAGCACCGAAAATGCTGCATCGGCAGAACAAAAGCGAACGACGCTCGCCATCCTGGAATCcagcaaaaagaagaaaaaaccttTCTTCTGCAAACCCTGCCAGTATCAGGGTGAGAACGAGCAGGAGTTTATAGTGCACATACGCACGCACGGAGCCAAGAAGATGCTGGTGGTGAACGGTGGAGATTCTGATGAGGATCTGAGCGCTGATGCAGGACCGCAGACCTCCGTACCCAACGCTGAGAGCGCAGAGAGCAACTCTAAAGGCGTGATCCGCTGCGAGCGCTGCGGCTACAACACAAACCGCTTCGACCACTACATGGCGCACCTCAAACACCACACTAAAGAGGGCGAGGACCAGCGGGTGTTCAAGTGCACCATCTGCGCGTACACCACCATCAGTCAGTACCACTGGAAGAAACACCTGAGGAACCACTTTCCCAGCAAGCTCTTCACCTGCAGCCAGTGCTCATACTTTTCTGACCGCAAAAACAACTACATTCAGCACATCCGGACTCACACTGGTGAGCGTCCATTCCAGTGCATTTACTGCGAGTACTCCAGTTCCCAAAAAACCCATCTGACAAGACACATGCGAACGCATTCAGGTGAAAGGCCTTTCAAATGCGATAACTGCAGCTACCTGGCAGCCAATCAGCATGAGGTGACCCGCCACGCCCGCCAGGTGCACAACGGACCCAAACCACTCAGCTGCCCCTACTGCCAGTACAAGACTGCCGACCGCAGCAACTTCAAGAAGCACGTGGAGCTGCACGTCAACCCGCGCCAGTTCCTCTGCCCCGTCTGCAAGTACGCCGCATCCAAGAAGTGCAACCTGCAGTATCACATCAAGTCCAGACACCCGGGGTGCAAAGATATCTCCATGGACGTGTCGAAGGTGAGACTGCGGGTCAAACGGAGTGACGGAGACGACGCTTCACCCAATAAGCTGACCGCAGAACAGGCCAAAATAATGGAGGAACTGGAGGACGCTGGCCCGATCAACCTGTCCATTAAAAAACCCAGTAAGCTCAATGCAGTAGTGGAGACTGAGAAGAGCTCGAAGAAAAACATGGATGGGAAGGCaaaccagccgcaacccaacgaGAAGAAGAGCCTGTCGAAAAACGAGCCAAAGGAGAAAACCGCTAAGAAGCTGAAAGGAAAGACTGCTGTGAAAGACACTGAAGAGACACAAACCGAAGATACACgggttaataataaaaaggagaCCAAGAAGGCGGAGAAATCTGCGGAGAAAGCCTTGAAAAGCCGTCAGAAGAAGGAGAAGCCTGTGAAGGACTCCAGCGTTCAGCAGCAGAGCGATGACTGTGAGCAAACGCAACACACACCACAGCAGAACGAGACACAGGAAAACAGGCCTGAGAAGGAAAACAGATCATTGACTGAGATCGATAATGCAAAGGATTGTGGGAAAGTGCAAACCAAGAAACCATGCAAGAAGCAAACGAAGACTTTAAAGGTCTGCGGTGAAACCCAGAACGTGGAAGAGGAGGAGATAATGAGGCAGAAAGCAGGCAAAAGAAAAGCAGACAATCCAGCAGAACCAAAGCAGCGGATCAAACGGACCAAGAAGAAGGATTCGGGAAAACCAACAACAAGTGAAGCAAATCAAACCAATCCTGAAGTCATGGAGAGCGAAAGCTCTGAAGCAAATAATGCAAGCAAACCCGACGACAGTATTGATGAATCTCAAAATCCTCCTGTAGCTGAATCACGGCCTGATGTGGAACCACAGAGCGTTCCTGACTGTCCGATTGAGAAAGCTCCAGCTGTAGAGGAAGTCCAGCGCCCTCTGGAGGTGGAGATCAGCACTGCAGCGCCAGATGCTCCAGAAGTGGACAGTGGAAATGAAATGCCATCTCCGACCGACAGCGACGGTGCTCCGGGATTCACCCCGACTCTACCACTGCAGCACAAGCCTGCAGATGCTGAAGATGACGAGGGCATCCACAGTAATGATGGAGGAAGTGACATCAGCGACAGCGCCTCTGAAGGAAGCTACGACTCTGGGCTGATGGCGGGCGCAGAGAAACTGCCAGAGACTCCGACTGAGGAGAGAGACGCTTCTGCAGCCCGACTGCTCAGCCACACCTGCATCTTCTGCGACCGCAGCTTCGCTCTGGAGATGGACTACCGGAAACACCTGAACCGACATTTAGTCAATGTGTACTACCTAGAAGGGGCGGCACAGGGGGGCAAATGAGATGCAACCGAACTGGGTCAGATGTAAAACAAACATGGGGCTGTTGCTAGATCCGCAGCAGGACatcagtttttaaaaatgcatcgcTGTTCTCTCTTGAATCAAATCTGAGTTTAGCTTTTTAGCAGTAGATGGCGCTGTAGGATAGTTTGAACAGCAGTTGATGCTCTACACCTGCATTTCAGAACATTCAAATGTTAAAAACTAAACTAGAATGCCGTCTGCTGTCAAGCACTAGCCTAATGCACAATCTGCtgctcaaaactagcctagagggacATCTGTTAAAACGAGTATAGACTGCCATCTGgtgtttaaaactagtctagatcGCCGTCTgatgttagaaactagcctagagtgacgttgttaaaaactagagtgccatctgctgttcagacgttgctctaggctagttttgatgTTAAATATAGCCTAGAGCaccttctgctgttaaacactagcctagagctctgtctgctgttcaaaactggTCTAGAGTGCCGTCTGGTGTTTaacactagtctagagtgccatctggtGTTTAAtactagtctagagtgccatctggtGTTTAACACTAGTCTAGAGTGCTATCtggtgtttaaaactagcctagagtgaaaTTTTGCTAAAAGCTAGCCTATAGCGCTGTCTGCTAAAACTaccctagagtgccatctggtgTTTAAAAATAGTCTTGAGTGTCATCTGGTGTTTAAAACTGGTCTACAGCACCATCAggtgtttaaaactagcctagagtgtcatctgcggttcaatactagcctagagcgctgtctggtGGTTAAAAgtagtctagagtgccatctggtgtttaaaactagcctagagcgccgtttgTTGTTCAAAACTACCTTAGAGTGCCGTCTGCTAAACATGCCTAGTTTACTACCTGAGGTTATAAATTAGCCTTTAGCTCTatgttgttcaaaactagcctagaacaccatatactgttaaaactagcctagagcgacgtctgctgttaaaactagtctagtgtgccatctgctgttcaaaaccagTCGAGAGCACCATCTGCTAAAACTTGCCTAGTTTGCCACCTACTGTATGAATAAGCCTAGAGCGCTATGTTGTTAAAAACAGGCCTAAAACTCCAAATgctgttaaactagcctagagtgccatctgctgttcaaaactagcctagggtgccatctgctgttcaaaattatcctagagcaccatgtgtttaaactagcctagagcgccatctgctgttcaaaactagcctagagcgccatctgctgttcaaaactagcctagagcgccatctgctgttcaaaactagcctagagcgccatctgctgttcaaaactagcctagagtaccatGTGTttaaactagcttagagcaccatctgctgttcaaaactagccaagagcgccatgtgtttaaactagcctagagcgccatctgctgttcaaaactagcctggagcgccatctgctgttcaaaactagcctagagtaccatgtgtttaaactagcctagagctccgtctgctgttcaaaactagcctagagcgacatctgctgttcaaaactagcctagagcaccatgtgttttaactagcctagagcgccacctgctgttcaaaactagcctagagtgacatctgctgttcaaaacttgCCGAGAccaccacctgctgttaaaaactagactattTCAATAACGTCactctagtctagagcaccgtctgcggttcaaaactagtctaaaacaacatgttaaaaactagtctagagcaacatgttgttaaaaactagtctagagtgccatctgcattTCAAATCTactctagagtgccatctgctgttcaaaactagactagtttAACAACATGTCATTCTaggctagagcgccatctgctgttcaaaactagcctaaagctcTATCTGatgttcaaaactagtctagagcaacatgttgttaaaaactagtctagagtgccatctgcattTCAGATCTactctagagcgccatctgctaaaactagcctagagtgtcaactgctgttcaaaactagactagtttAACAACATGTCACTCTAGGCTAGAGCGCTATCTgcagttcaaaactagtctagagcaacatgttgttaaaaactaatctagagtgccatctgcattTCAAATGTactctagagcgccatctgctaaaactagcctagagcgccatctgctaaaactagcctagagtgtcatctgctgtttaaaagcaGCTTAGAGCTCCATTTACTGttcaaaattagcctagagcacaatCTGTTAACACGATTCTAGAGTGCCAGCTGCTGTTCAAAACTactctagagcgccatctgctaaaactagcctagagcattatCTGGTGTTAAACACTatcctagagcgccctctgctgtttaaaactgaaCTCAGAGTTGATTCAGGAGAGAAAATTGATGCCTTTTGGAAAATCTACACAGGATTATTTCTGGATGACTCAGCTCCAGTTATTGTCTGTGGATCTGGCAGACGCACTCATCAGTGCTGTGCTGTTTTTAATCGCACAATAATGATCCAACACTGAACATCAAACATGACTCAGATCAAAGATTGATTGATTTAGTGTCAGTAATAATGAAATCTAGTGCTAGAGTCCTGAACAGCAGACCACAGTTTAGAAAGCACTTGACTAACCATAATCTAACCCTTCTCTTAAAGACACAGCTCACACAATAATCAACATCTCCTCACTCAAATTCTCAGAAAGTATTTAATGAATATGAACACCAAGAGCAgaatccagcattcttcagaatatcttattgtGAAAGACTCGAGGGTCAGTCAATAGAGAAACACATGAATGTTTTAGTGAACTGCCCCTTCCCATGGTGTCACACAGATTTCTGTAGACAGGCCTGCTGCAGCCGGAGCGTGTCGTGTGTAATGGAGGATGTTTTTTACTCTCTGTACAGATCAATTTCTCTCTTCCTCTTTAAATGTCTTTTATATATTTCAGTTTCATGCTCAATCCAAAGATTCTGTTGCTTTTGTCTGTGTATTatcactgtatatattattttcttcCTCTTCAGTGCCTCCGACAATCAATTTGAGCATTTTACTCACATCTGATGGACCCACGAGTGAAAGAGCGGCTTGTTTCCTCCATATCGAGCTCTTCTGCTTCTATAATTGATCATCTGCATTGAAAATCAGTTTCTCCAAAGTTGATCTGATGCTATTCCAGTGACTTTCAGCATGAGTGTGAAAGTGCCACGACCCTTAATGTCTAATATGATCAGAGAATACTGTAAAGAGAAGGTTGCCTGTAGTATGTTGTGCAATATTGACTTTTGGATCTCTTAACCAAAGCCGGATGTGGATGGTGGAGTTTGAGCTCTGCTCACGGTTGCATTCTTCATGTAAATGGAGGACTTTTGTATGTTGAATTAGCACTGCTCTTCTGTCTCGTTTGTTCTGCTCTTCTTCTATAGGAATAGCATATTGCATATTCACAATGTGGATCAATGTAGTCAGTGCGTCTTCATTTCTTATTAAAAGTAGTCAAATGATATCAGTCAGAATGTT

Function

symbol description
rest Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Acts upstream of or within several processes, including negative regulation of neuron maturation; negative regulation of smoothened signaling pathway; and nervous system development. Predicted to be located in cytoplasm. Predicted to be active in nucleus. Is expressed in ectoderm; endoderm; fin; head mesenchyme; and nervous system. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 27; gingival fibromatosis 5; and nephroblastoma. Orthologous to human REST (RE1 silencing transcription factor).

GO:

id name namespace
GO:0021785 branchiomotor neuron axon guidance biological_process
GO:0010629 negative regulation of gene expression biological_process
GO:0006357 regulation of transcription by RNA polymerase II biological_process
GO:0001764 neuron migration biological_process
GO:0000381 regulation of alternative mRNA splicing, via spliceosome biological_process
GO:0021610 facial nerve morphogenesis biological_process
GO:0042551 neuron maturation biological_process
GO:0045879 negative regulation of smoothened signaling pathway biological_process
GO:0007626 locomotory behavior biological_process
GO:0045892 negative regulation of transcription, DNA-templated biological_process
GO:0097475 motor neuron migration biological_process
GO:0014043 negative regulation of neuron maturation biological_process
GO:0045666 positive regulation of neuron differentiation biological_process
GO:0045667 regulation of osteoblast differentiation biological_process
GO:0001666 response to hypoxia biological_process
GO:0021754 facial nucleus development biological_process
GO:0060831 smoothened signaling pathway involved in dorsal/ventral neural tube patterning biological_process
GO:0005634 nucleus cellular_component
GO:0005737 cytoplasm cellular_component
GO:0046872 metal ion binding molecular_function
GO:0003676 nucleic acid binding molecular_function
GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding molecular_function
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific molecular_function

KEGG:

id description
ko04550 Signaling pathways regulating pluripotency of stem cells
ko05016 Huntington disease
ko03000 Transcription factors

ZFIN:

id description
ZDB-GENE-080415-1 Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Acts upstream of or within several processes, including negative regulation of neuron maturation; negative regulation of smoothened signaling pathway; and nervous system development. Predicted to be located in cytoplasm. Predicted to be active in nucleus. Is expressed in ectoderm; endoderm; fin; head mesenchyme; and nervous system. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 27; gingival fibromatosis 5; and nephroblastoma. Orthologous to human REST (RE1 silencing transcription factor).

Ensembl:

ensembl_id ENSDARG00000103046

RNA

RNA id representative length rna type GC content exon number start site end site
TCONS_00015931 True 6301 mRNA 0.47 4 52418247 52433292

Neighbor

gene id symbol gene type direction distance location
XLOC_008187 polr2b coding downstream 9430 52377557 ~ 52408817 (-)
XLOC_008186 NA coding downstream 226555 52189877 ~ 52191692 (-)
XLOC_008185 CABZ01075745.1 coding downstream 368973 52049158 ~ 52049274 (-)
XLOC_008184 NA coding downstream 514609 51903159 ~ 51903638 (-)
XLOC_008183 cplx2 coding downstream 563200 51829317 ~ 51855047 (-)
XLOC_008189 exosc3 coding upstream 43228 52476520 ~ 52480661 (-)
XLOC_008190 GPR151 coding upstream 86912 52520204 ~ 52521460 (-)
XLOC_008191 ppp2r2ca coding upstream 89425 52522717 ~ 52552875 (-)
XLOC_008192 CU469526.1 coding upstream 140184 52573476 ~ 52583021 (-)
XLOC_007641 CU855896.1 misc downstream 50010407 2407736 ~ 2407840 (-)
XLOC_007640 CU855896.2 misc downstream 50010816 2407328 ~ 2407431 (-)
XLOC_007639 CU855896.3 misc downstream 50011175 2406945 ~ 2407072 (-)
XLOC_008182 NA non-coding downstream 580860 51826078 ~ 51837387 (-)
XLOC_008181 CABZ01066915.1 non-coding downstream 665050 51753080 ~ 51753197 (-)

Expression


Co-expression Network

Homologous

species gene id symbol gene type chromosome NCBI id location
grasscarp (Ctenopharyngodon idella) CI01000000_02080057_02086228 REST coding CI01000000 null 2079831 ~ 2087510 (+)
bowfin (Amia calva) AMCG00017797 NA coding CM030131.1 CM030131.1 23844922 ~ 23857827 (+)