XLOC_008298 (bace2)


Basic Information

Item Value
gene id XLOC_008298
gene name bace2
gene type coding
species zebrafish (Danio rerio)
category of species model fish

Chromosome Information

Item Value
chromosome id NC_007126.7
NCBI id CM002899.2
chromosome length 48040578
location 6459847 ~ 6493615 (+)
genome version GRCz11_2017_zebrafish_Genome

Sequence

>TCONS_00016675
TTTCAGGAAGTTATCCATTGAACACATTACACACATACTTTATATCCCCGCGGCATCTGTCTGCTTCACATAAGCTCTGCCGAAGATCGTTCCCATAACTAATAACAAGAATGGAACTTACTACATCAATGACAGAGTCGTGCACTTTGGAGCAGAGCTGAGAGTCTGTTCAACGTGAAGTTCGGCGAGATGCGGCTCTACGGGCTACTGCTACTTTCTCTCACCTTCTGGAAGTCTCATTCAGTGTTTAAAATACCTTTAAACATATTTGCGGGGAAATTCAACGCGTCTGTGCAGCTGGACCTCAGGCCTTTGCAAAAGAATGAAGCCGCTGCTAAAAGTGGACTGTCCCTGGCGTCAGATCCAGCGGGGATTGTTAACTTTCTAGACATGATTAATAATTTAAAAGGGGACTCTGGTAGGGGATATTACATGCAGATGATCATTGGGACTCCAGGACAAACGCTAAACATCCTGGTGGATACTGGAAGCAGCAACTTTGCTGTAGCTGCAGCAGCACATCCCTACATCACACATTACTTTAACAGAGCACTTTCCAGTACATATCAGAGCACCGAGAGGGCAGTTGCAGTAAAATACACACAGGGCGAATGGGAAGGGGAACTGGGAACGGACCTCATCACCATTCCCGAAGGGCCCAGTGGTGCCATCACCATCAACATTGCCGCAATCCTCACCTCAGAAGGCTTCTTTTTGCCTGGAATCAATTGGCAGGGGATTCTTGGACTTGCATATCCTCTACTGGCTCGG
>TCONS_00016676
TTTCAGGAAGTTATCCATTGAACACATTACACACATACTTTATATCCCCGCGGCATCTGTCTGCTTCACATAAGCTCTGCCGAAGATCGTTCCCATAACTAATAACAAGAATGGAACTTACTACATCAATGACAGAGTCGTGCACTTTGGAGCAGAGCTGAGAGTCTGTTCAACGTGAAGTTCGGCGAGATGCGGCTCTACGGGCTACTGCTACTTTCTCTCACCTTCTGGAAGTCTCATTCAGTGTTTAAAATACCTTTAAACATATTTGCGGGGAAATTCAACGCGTCTGTGCAGCTGGACCTCAGGCCTTTGCAAAAGAATGAAGCCGCTGCTAAAAGTGGACTGTCCCTGGCGTCAGATCCAGCGGGGATTGTTAACTTTCTAGACATGATTAATAATTTAAAAGGGGACTCTGGTAGGGGATATTACATGCAGATGATCATTGGGACTCCAGGACAAACGCTAAACATCCTGGTGGATACTGGAAGCAGCAACTTTGCTGTAGCTGCAGCAGCACATCCCTACATCACACATTACTTTAACAGAGCACTTTCCAGTACATATCAGAGCACCGAGAGGGCAGTTGCAGTAAAATACACACAGGGCGAATGGGAAGGGGAACTGGGAACGGACCTCATCACCATTCCCGAAGGGCCCAGTGGTGCCATCACCATCAACATTGCCGCAATCCTCACCTCAGAAGGCTTCTTTTTGCCTGGAATCAATTGGCAGGGGATTCTTGGACTTGCATATCCTCTACTGGCTCGGCCAGACCCATCAGTGGAGCCATTCTTCAACTCTGTGGTGCGGCAGACTGGCATTCCAGATGTCTTTTCTCTCCAGATGTGTGGAGCAGGAGTTCCTGCCAGCACTACAGGTGACCCAGCGGGCGGCAGCCTGATCATGGGAGGAGTAGAGCCAACTTTGCACCGCGGTCCAATTTGGTACACACCAGTCCTGGAAGAGTGGTACTATCAAGTGGAAGTCCTCAAGCTTGAAGTTGGAGACCAAAATTTAAATCTAGACTGCAAAGAGtacaACTCGGATAAAGCCATTGTGGATAGTGGGACGACTCTTCTGCGACTTCCTGCAAATGTGTTCACTGCTGTAGTGGACACCATTATGCAAACATCCCtgATTGATGACTTCTCTGCTGGATTCTTTGATGGCACCAAGCTCGCATGTTGGATGAGAGGAGAGTCACCATGGAGGTTTTTTCCAAAAGTCTCAATCTACCTCAGAGGAACGAACACCAGCCAGTCCTTCAGAATCACTATTCTCCCACAGGTCAGGATTGTCCCATGAAAAGAGAAGATCTTTTCTTTTAAGGAGTCCTGACCAAAATGGCAGCACAAAAAGATTCACATTAAAGACAAATACAAAG

Function

symbol description
bace2 Predicted to enable aspartic-type endopeptidase activity. Acts upstream of or within melanocyte migration. Predicted to be located in endoplasmic reticulum and plasma membrane. Predicted to be integral component of membrane. Predicted to be active in endosome; membrane; and trans-Golgi network. Is expressed in neural crest; optic vesicle; pigment cell; polster; and retina. Human ortholog(s) of this gene implicated in Alzheimer's disease. Orthologous to human BACE2 (beta-secretase 2).

GO:

id name namespace
GO:0097324 melanocyte migration biological_process
GO:0050435 amyloid-beta metabolic process biological_process
GO:0006508 proteolysis biological_process
GO:0006509 membrane protein ectodomain proteolysis biological_process
GO:0005768 endosome cellular_component
GO:0005794 Golgi apparatus cellular_component
GO:0005802 trans-Golgi network cellular_component
GO:0016020 membrane cellular_component
GO:0016021 integral component of membrane cellular_component
GO:0004190 aspartic-type endopeptidase activity molecular_function
GO:0016787 hydrolase activity molecular_function
GO:0008233 peptidase activity molecular_function

KEGG:

id description
ko05010 Alzheimer disease
ko01002 Peptidases and inhibitors

ZFIN:

id description
ZDB-GENE-041010-68 Predicted to enable aspartic-type endopeptidase activity. Acts upstream of or within melanocyte migration. Predicted to be located in endoplasmic reticulum and plasma membrane. Predicted to be integral component of membrane. Predicted to be active in endosome; membrane; and trans-Golgi network. Is expressed in neural crest; optic vesicle; pigment cell; polster; and retina. Human ortholog(s) of this gene implicated in Alzheimer's disease. Orthologous to human BACE2 (beta-secretase 2).

Ensembl:

ensembl_id ENSDARG00000044781

RNA

RNA id representative length rna type GC content exon number start site end site
TCONS_00016675 False 771 mRNA 0.47 3 6459847 6481984
TCONS_00016676 True 1387 mRNA 0.47 7 6459847 6493615

Neighbor

gene id symbol gene type direction distance location
XLOC_008297 NA coding upstream 299344 6159009 ~ 6160503 (+)
XLOC_008296 PCP4 coding upstream 341179 6109861 ~ 6118668 (+)
XLOC_008295 igsf5b coding upstream 441927 5973909 ~ 6017920 (+)
XLOC_008294 sh3bgr coding upstream 501044 5923851 ~ 5958803 (+)
XLOC_008293 get1 coding upstream 543027 5901970 ~ 5916820 (+)
XLOC_008299 CU655863.1 coding downstream 65435 6559050 ~ 6559185 (+)
XLOC_008300 nop53 coding downstream 158781 6652396 ~ 6666303 (+)
XLOC_008301 CU633984.1 coding downstream 184906 6678521 ~ 6727082 (+)
XLOC_008302 CU694757.1 coding downstream 276971 6770586 ~ 6772120 (+)
XLOC_008303 si:ch1073-228b5.2 coding downstream 280261 6773876 ~ 6784965 (+)
XLOC_008463 BX663520.1 misc downstream 14758576 21252191 ~ 21252282 (+)
XLOC_008292 BX088654.1 non-coding upstream 604622 5855111 ~ 5855225 (+)
XLOC_008291 NA non-coding upstream 606505 5841557 ~ 5853342 (+)
XLOC_008289 NA non-coding upstream 988339 5468098 ~ 5471508 (+)
XLOC_008278 NA non-coding upstream 1203065 5256501 ~ 5256782 (+)
XLOC_008304 NA non-coding downstream 292034 6785649 ~ 6786055 (+)
XLOC_008306 NA non-coding downstream 373661 6867276 ~ 6875548 (+)

Expression


Co-expression Network

Homologous

species gene id symbol gene type chromosome NCBI id location
grasscarp (Ctenopharyngodon idella) CI01000092_03329908_03348045 NA coding CI01000092 null 3329908 ~ 3348319 (+)