XLOC_008315 (egln2)


Basic Information

Item Value
gene id XLOC_008315
gene name egln2
gene type coding
species zebrafish (Danio rerio)
category of species model fish

Chromosome Information

Item Value
chromosome id NC_007126.7
NCBI id CM002899.2
chromosome length 48040578
location 8335600 ~ 8382997 (+)
genome version GRCz11_2017_zebrafish_Genome

Sequence

>TCONS_00016696
GCCATCGCACACGGAAGCGGCTTTACCGAACCTACTATGGGGACGAATGGGCTCTTAAATATTACTCAGGCTACTTGATTGGACGCTTTAGGAGCCTCGTAATTCAATATTAATGAGCTCAGCCTCGGCCATAGTAGGATGAGTAGTTCTGCCACCCGCACGCTGTTTTATCAGATCCGAAGCATACTTACTCTTTGTTCACCAAGGGATGTAAGCACGCAAATTACAGTGTTGTCTGTCTCTGGAAACGTAgttttatatcattttttatatGTGACGTGTTAGATGTGGAACACAGGAATATAGGATAATCGCGGCTGATCCTTTAAACATATTGTGTTCCTCTCTGCCTTTAGACGCTCATAAACCCGTGTCCTGGAAATAAACAGCCACGTATAATAGTTATTAGTTAATTGAGTATTAACCGACTAATAAGCTGAGGAGAAGGGCCGCATATGCTGTGAAAGTTTACCGTGGTGATAACAGCGCCGCCAGGCAGGCATGAGCAGAGCCGAATCTGCAGAAAATGAGGATCGGACGTGAGCTACGTGCGCATCCAGGGGTAGACGACATGACATGGAGAGACTGGGAAATACGGACCTTATAAATGCACACGGACGCGAGAGTATCAGTTCAACGCCAGACAGAGTCCCAAATATAATGGGTCTGAACGCGACCACTGCGGGGGAGCTGCTGGCAGGACACACGTCCAGATCTGGATCTGGAATCACGCTCCTGAAGGACTCAAAAAGCGGCTTGTCTTTGTGTAATGGTGGAGGAGTGCTGTCGCCTTCACCTAAAGCCGACAGAAGTTACGATGAAGCACAGAGCAAGCGTTTACATCTAAATGGACTGGTAGAGACTCCCAATGGGGCCCTTACCAGTCATGGGGACAACAGGCCTATGAAGAGACCGATCGGAGAGCTGCGATTTAGACAAATCCAACACCAGAGGAGAAAAGACGAGGAAAACAGAGACTTCGGGACAAATGGTTGTTCTGCCAACGGGTCTGGATCTGGATGCTCCTCTGAAACGGACCCCATACATGAATGCAAAAGGAGAAAGGTTGAAATAGACTCCAAAACAGACTCTAGTAAAAGCATGCGGACTGTTCCGCCTCTTGCAGCCAATCACCAACACAAAAACTGCTCAGCGTCACACCCTAACGGGGTTTATCACAATGGCCACAAAGTTGCATTGAACCATGTGGCCCCTGGACAGGCCGAAGTGCGAACCGCACCACCTCTGGTGGCAACCTGCTCTCCAGAACACATGGCCCAGCAATACATAGTTCCCTGTATGAAGTTTTACGGCATTTGCGTCAAAGATACTTTCCTGGGGGAACGCCTGGGCAGTAGAGTTGTAGAGGAAGTGCAGACTCTCAATCGCAGTGGGAAGTTCAGAGGAGGCCAGTTGGTCATCCAGAAGAACATCCCATCTAAGAACATTCGCGGGGACCAGATAGCCTGGGTCGAAGGCAATGAGCCGGGCTGCGAGAACATTGGGACCCTCATGGCTCACATTGATGAGGCCATCATGCGCAGTGCTGCCAACGGACAGCTGGGGGATTGTGTCATCAATGGGCGCACACAGGCCATGGTGGCGTGTTACCCAGGCAGTGGCACAGGATACGTGCGACATGTGGACAATCCTAATGGTGACGGGCGCTGCATAACCTGCATCTACTATCTGAACAAGAACTGGGATGTGAAGGTTCATGGAGGTTTATTGCAGATCTACCCTGAGGGTCGTAATGTTGTCGCCAACATCGAGCCTGTTTTTGACCGTCTGCTCATTTTCTGGTCTGATCGGCGAAACCCACATGAAGTGATGCCAGCTTTTGCCACCCGTTATGCCATCACTGTTTGGTACTTTGATGCAAAAGAGCGAGCTGAAGCGAAGGAGAAGTACAGACTGGCTTCAGGACAGAAAGGAGTTCAAGTGCCCGTCACGCAGAGCAGCAAGACCTGA
>TCONS_00016697
GCCATCGCACACGGAAGCGGCTTTACCGAACCTACTATGGGGACGAATGGGCTCTTAAATATTACTCAGGCTACTTGATTGGACGCTTTAGGAGCCTCGTAATTCAATATTAATGAGCTCAGCCTCGGCCATAGTAGGATGAGTAGTTCTGCCACCCGCACGCTGTTTTATCAGATCCGAAGCATACTTACTCTTTGTTCACCAAGGGATGTAAGCACGCAAATTACAGTGTTGTCTGTCTCTGGAAACGTAgttttatatcattttttatatGTGACGTGTTAGATGTGGAACACAGGAATATAGGATAATCGCGGCTGATCCTTTAAACATATTGACGCTCATAAACCCGTGTCCTGGAAATAAACAGCCACGTATAATAGTTATTAGTTAATTGAGTATTAACCGACTAATAAGCTGAGGAGAAGGGCCGCATATGCTGTGAAAGTTTACCGTGGTGATAACAGCGCCGCCAGGCAGGCATGAGCAGAGCCGAATCTGCAGAAAATGAGGATCGGACGTGAGCTACGTGCGCATCCAGGGGTAGACGACATGACATGGAGAGACTGGGAAATACGGACCTTATAAATGCACACGGACGCGAGAGTATCAGTTCAACGCCAGACAGAGTCCCAAATATAATGGGTCTGAACGCGACCACTGCGGGGGAGCTGCTGGCAGGACACACGTCCAGATCTGGATCTGGAATCACGCTCCTGAAGGACTCAAAAAGCGGCTTGTCTTTGTGTAATGGTGGAGGAGTGCTGTCGCCTTCACCTAAAGCCGACAGAAGTTACGATGAAGCACAGAGCAAGCGTTTACATCTAAATGGACTGGTAGAGACTCCCAATGGGGCCCTTACCAGTCATGGGGACAACAGGCCTATGAAGAGACCGATCGGAGAGCTGCGATTTAGACAAATCCAACACCAGAGGAGAAAAGACGAGGAAAACAGAGACTTCGGGACAAATGGTTGTTCTGCCAACGGGTCTGGATCTGGATGCTCCTCTGAAACGGACCCCATACATGAATGCAAAAGGAGAAAGGTTGAAATAGACTCCAAAACAGACTCTAGTAAAAGCATGCGGACTGTTCCGCCTCTTGCAGCCAATCACCAACACAAAAACTGCTCAGCGTCACACCCTAACGGGGTTTATCACAATGGCCACAAAGTTGCATTGAACCATGTGGCCCCTGGACAGGCCGAAGTGCGAACCGCACCACCTCTGGTGGCAACCTGCTCTCCAGAACACATGGCCCAGCAATACATAGTTCCCTGTATGAAGTTTTACGGCATTTGCGTCAAAGATACTTTCCTGGGGGAACGCCTGGGCAGTAGAGTTGTAGAGGAAGTGCAGACTCTCAATCGCAGTGGGAAGTTCAGAGGAGGCCAGTTGGTCATCCAGAAGAACATCCCATCTAAGAACATTCGCGGGGACCAGATAGCCTGGGTCGAAGGCAATGAGCCGGGCTGCGAGAACATTGGGACCCTCATGGCTCACATTGATGAGGCCATCATGCGCAGTGCTGCCAACGGACAGCTGGGGGATTGTGTCATCAATGGGCGCACACAGGCCATGGTGGCGTGTTACCCAGGCAGTGGCACAGGATACGTGCGACATGTGGACAATCCTAATGGTGACGGGCGCTGCATAACCTGCATCTACTATCTGAACAAGAACTGGGATGTGAAGGTTCATGGAGGTTTATTGCAGATCTACCCTGAGGGTCGTAATGTTGTCGCCAACATCGAGCCTGTTTTTGACCGTCTGCTCATTTTCTGGTCTGATCGGCGAAACCCACATGAAGTGATGCCAGCTTTTGCCACCCGTTATGCCATCACTGTTTGGTACTTTGATGCAAAAGAGCGAGCTGAAGCGAAGGAGAAGTACAGACTGGCTTCAGGACAGAAAGGAGTTCAAGTGCCCGTCACGCAGAGCAGCAAGACCTGAATGTCTGtcagtaaagtgtgtgtgtgtgtgtgtgtgagtgtgtgtgtgtgtgcagtctgtGGCTGCTGCTGCCCTGCTATTGGAGGATTTTAGGTGGAGATGCAAGAAGCCTAACCAATCGCTGCTGTTTCTGTGGCCTCAGAAATCAAACCACAAGTTAGATACACTAAGGTGACTCGATGAACACCAGAAATTGACACGTCTCTTTACTTGACAGTGAAAGGCTGGCAGATATTTTCCTCGTCATTGAAAATCAACAGTTACCTTAGTAATTTGAGTCATTTCTGTATCTAATAATAATCAAGCCCTCACTTTTCCTGACACTACACCTGTGTGCGTGTGTAAGTGGACAGATGAGATTTTCCAGTGGCCTTTTGTCATATTGTGTTCATCCCTGTGAATGTGTAACCATGCAAAGTACGCTCCGCTAGATCATCAAACCTGACAGAAAATAACTAACGATCATATTATACACAGACGCTCCAAAGCACAGGATCCCCTACAATTGAGCCTGAGAAGAAGTTACGGTTAATTTGCTACAAATGAACAGCGCCCTCTGATGGTGTCCATTTTCACGCAATGCTTTGCTAAAGAAATTATGCAAATCTAGTAGCTGAACACAAATTTGTATGTCGCAGCTCCCCCCATTTGCAGCAGACATGAAGAACGTATTCTTACAGTCCGTCTGCACTTTTTTTTGGTAGTTGTCCTTGCCGTTGCATCAATTTACTTTGTATTTTCAGAAACAGATACATTTTGTAGACGGCAACCTTTATATGAGGATGCACTGATGTAAAACATCTGGACgataatttttatcattattattattgttttatgttatagTTGATTATGCTATAAATCGACAACGTTAAAAATTCTAAActattttgtaataataaatgtaaatagaaataaaacagtaaaaaaatttttttttaaatgctacaaTAAATTTAGGCATCACGATATTATAATGtacagtttaaaaataataatgtctaACACTGTTATATAATTATCCaagttttttaaacaaagttaaaGTGTTGCATTggataaaaatgctaaaaactaAATGTTAAGATACGGAAAAAATGAGCTGCACAAAAAAATTCAACTATGAagtatcaaaaataaaattaaatatcacCTGATACATAAAATGCCACAGATATATTGTACATCGCTTGctataacaagaaaaaaaaaaaaaaagattgcataTGAAATGCCCATCTACTTCGATTACAGTTCGAATTAATAAGGTTAATGGGATGCATATTTGTCAAACATACATAACTGAAACAAGACTTGTAACAGTAGACTGATTCTGTTAGAATACATATGTTTGTCATTTAATGCTATTATTATATCCAGTTGTATATTGATAGTTGCTAAGCATCAGTTATTACCTAAGtaattcccagcaggcacaggatgtaaACATCAGATTAacattgtaccccaatgtcgtgggacGTTg

Function

symbol description
egln2 Predicted to enable ferrous iron binding activity and peptidyl-proline 4-dioxygenase activity. Predicted to be involved in cellular response to hypoxia and peptidyl-proline hydroxylation to 4-hydroxy-L-proline. Predicted to be active in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in renal cell carcinoma. Orthologous to human EGLN2 (egl-9 family hypoxia inducible factor 2).

GO:

id name namespace
GO:0018401 peptidyl-proline hydroxylation to 4-hydroxy-L-proline biological_process
GO:0055114 oxidation-reduction process biological_process
GO:0071456 cellular response to hypoxia biological_process
GO:0005634 nucleus cellular_component
GO:0005737 cytoplasm cellular_component
GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen molecular_function
GO:0005506 iron ion binding molecular_function
GO:0031543 peptidyl-proline dioxygenase activity molecular_function
GO:0031545 peptidyl-proline 4-dioxygenase activity molecular_function
GO:0008198 ferrous iron binding molecular_function
GO:0016491 oxidoreductase activity molecular_function
GO:0031418 L-ascorbic acid binding molecular_function

KEGG: NA

ZFIN:

id description
ZDB-GENE-060503-757 Predicted to enable ferrous iron binding activity and peptidyl-proline 4-dioxygenase activity. Predicted to be involved in cellular response to hypoxia and peptidyl-proline hydroxylation to 4-hydroxy-L-proline. Predicted to be active in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in renal cell carcinoma. Orthologous to human EGLN2 (egl-9 family hypoxia inducible factor 2).

Ensembl:

ensembl_id ENSDARG00000062562

RNA

RNA id representative length rna type GC content exon number start site end site
TCONS_00016696 False 1971 mRNA 0.50 6 8335600 8381511
TCONS_00016697 True 3438 mRNA 0.43 6 8335600 8382997

Neighbor

gene id symbol gene type direction distance location
XLOC_008314 mipep coding upstream 100071 8192715 ~ 8235529 (+)
XLOC_008313 cadm2b coding upstream 184115 7992906 ~ 8151485 (+)
XLOC_008312 CR589941.1 coding upstream 529680 7805779 ~ 7805920 (+)
XLOC_008311 NA coding upstream 598069 7734489 ~ 7737531 (+)
XLOC_008310 her13 coding upstream 1145417 7187228 ~ 7190183 (+)
XLOC_008316 tmem160 coding downstream 11822 8394819 ~ 8400091 (+)
XLOC_008317 CR293508.2 coding downstream 299825 8682822 ~ 8682937 (+)
XLOC_008318 CR293508.3 coding downstream 348755 8731752 ~ 8731866 (+)
XLOC_008319 NA coding downstream 379477 8762474 ~ 8765029 (+)
XLOC_008320 ap2s1 coding downstream 384653 8767650 ~ 8799977 (+)
XLOC_008463 BX663520.1 misc downstream 12869194 21252191 ~ 21252282 (+)
XLOC_008306 NA non-coding upstream 1460052 6867276 ~ 6875548 (+)
XLOC_008304 NA non-coding upstream 1549545 6785649 ~ 6786055 (+)
XLOC_008302 CU694757.1 non-coding upstream 1563480 6770586 ~ 6772120 (+)
XLOC_008321 CR925772.1 non-coding downstream 656053 9039050 ~ 9039164 (+)
XLOC_008325 CU467862.1 non-coding downstream 822267 9205264 ~ 9211131 (+)

Expression


Co-expression Network

Homologous

species gene id symbol gene type chromosome NCBI id location
grasscarp (Ctenopharyngodon idella) CI01000154_01223636_01242177 NA coding CI01000154 null 1223550 ~ 1242177 (+)