XLOC_008386 (nek8)


Basic Information

Item Value
gene id XLOC_008386
gene name nek8
gene type coding
species zebrafish (Danio rerio)
category of species model fish

Chromosome Information

Item Value
chromosome id NC_007126.7
NCBI id CM002899.2
chromosome length 48040578
location 15479442 ~ 15514013 (+)
genome version GRCz11_2017_zebrafish_Genome

Sequence

>TCONS_00016797
GTTTTGGAGCCAGCGAAAACATGGAGAAGTATGAGAAGATTAAAGTGGTCGGCAGAGGAGCTTTCGGGATCGTGCACCTCTGTCGCAGACGCACTGATAGTGCGCTGGTGATCTTGAAGGAGATTCCCGTCGAGCAGATGACCCGTGATGAACGTCTGGCAGCTCAGAATGAATGCCAAGTCCTCAAGCTTCTCAGCCACCCCAACATTATTGAGTACTATGAAAACTTCCTGGAGGACAAGGCACTAATGATCGCAATGGAGTACGCCCCAGGTGGAACTCTGGCTGATTACATACAGAAGCGCTGCAACTCCCTGTTGGATGAGGACactattttacatttctttgttCAGATCTTACTGGCCCTTTATCATGTACACAACAAACTCATCCTACATCGAGACCTAAAAACCCAGAACATCCTCCTGGACAAGCACCAGATGATTGTCAAAATAGGAGATTTCGGGATCTCCAAGATCCTCGTCAGCAAAAGCAAAGCTTATACTGTTGTTGGGACGCCGTGTTATATCTCTCCGGAACTGTGTGAGGGAAAGCCATACAACCAGAAGAGCGACATTTGGGCCCTCGGCTGTGTGCTTTATGAGCTTGCTAGTCTCAAGAGAGCCTTTGAAGCAGCGAACCTGCCAGCCTTGGTGCTGAAGATCATGAGTGGCACATTTGCCCCCATATCAGATCGTTACAGTCCTGAGTTGAGACAGCTGATTCTCAACATGCTGAATCTAGACCCATCCAAAAGGCCCCAGCTCAATGAGATAATGGCTCACGCCATCTGCATCAGGCCTCTGCTCAATCTCTACACTGACATCGGCAATGTCAAAATGCGCAGAATAGAAAAGCCACTTTCTAATGTACAAGCAGGCCCTCATGGCAGACCTGGTGGTTGGATAACCAGTACCAGAACCAGAGGAGGTCTGTCCAGTCTGACGTCCTCAAAGATGATGCACCCGCTGCCTTTATCCTCAGTCTACACCTGGGGCAGTGGCATTTCAACTCCCCTGCGTCTGTCCATGTTAAACACTGAGGTCATTCAAGTGTCTCTGGGACGCACACAGAAGATGGGAGTCACCAAATCAGGGAGGCTCATCACATGGGAGGCGCCCTCGGTTGGATCCGGTGAGCCCACTCTGCCTGGCGCTGTTGAGCAGATGCAGCCCCAGTTCATCTCCCGCTTCCTAGAGGGCCAGTCTGGAGTCACCATCAAATCTGTGTCCTGTGGAGACCTCTTCACCACCTGCCTAACAGATAGAGGTATAATCATGACGTTTGGAAGTGGAAGCAATGGTTGTCTTGGACATGGGAACTTTAATGATGTGACACAGCCCAAGATAGTGGAGGCTCTGCTGGGTTATGAGCTGGTTCAAGTGTCTTGTGGAGCATCCCACGTCCTGGCAGTGACCAACGAGCGAGAGGTTTTCTCCTGGGGCCGAGGAGACAACGGCCGGCTCGGTTTGGCCACTCAGGATAGCCACAACTGCCCACAGCAGGTGAGTTTGCCAGCAGATTTCGAAGCCCAGCGCGTGTTGTGTGGCGTCGACTGCTCCATGATCATGAGCACACAGCACCAGATCCTCGCCTGTGGGAACAACAGATTTAACAAGCTGGGTTTGGATAAAGTCTCAGGGACGGAGGAACCCTCGTCTTTCTGTCAGGTGGAGGAGGTTCATCTGTTTCAGCTCGTCCAGTCGGCTCCTCTGAACACAGAGAAGATCGTGTATATAGACATCGGCACAGCACACTCTGTCGCAGTCACAGAAAAAGGTCAGTGTTTCACCTTTGGCAGTAACCAGCATGGACAGCTTGGCTGCAGTCACCGCAGAAGCAGTCGAGTGCCGTATCAGGTGTCGGGCCTGCAGGGCATCACGATGGCTGCGTGTGGTGATGCCTTCACTCTGGCTATTGGAGCAGAGGGTGAAGTGTACACTTGGGGTAAAGGCGCGCGCGGTCGACTCGGGAGGAAAGAGGAGGATTCTGGGATACCAAAACCAGTGCAGCTCGACGAGAGCCATGCTTTCACTGTCACCTCAGTGGCTTGTTGCCATGGAAACACTCTACTGGCTGTGAAACCATTTTTTGAAGAGCCTGGACCAAAGTGACATGACTCTGCCTCTGTCCAGATGAACATCAGAGCCTGCAGTAGACTTCACTCGACTTCGGTTTATCAGGAAACCATAGTGGGTTATGGATAGTTCacagtcatcatttattcacacttgacttgttccaaacctgtttgagtttcttacttctgttaaacataaaggaagatattctgaagaatgttgtgcacctgtaaccattgactgtaaaacaaatactatgaaagtcaatggttacaggtttacaacattcttcaaatgatcttattttgtgttcaacagaacaaaacatgtttggaacaagtgaagggtgagtaaaagatgacagaatttttgtatttggatgaactatcccattaacaGGAAATTCAAGCCAAGCTGTTGTGTTTATGACATGATATGATGCAAAGATAAGCATttttttactgacaaaatgtaaatacTAACTTAAGACAGCAGAATTGTTCAAATTCTGTATTTGCAGTATTACATCTTATGTGTGAAGAAAAGTGTACTGAACTAAGTTTACAATAACATTATTAGTAATGAGAGTGTAGTATTGTAAATAATGCCTTATTCCTGGCTGTGGCAagaaaaaactgtacaaatattttatataatttagtaataaagtgctgcttatgaaaatgaataaaataaatagcaa

Function

symbol description
nek8 Predicted to enable protein serine/threonine kinase activity. Acts upstream of or within heart looping; pronephros formation; and renal tubule development. Located in cilium. Human ortholog(s) of this gene implicated in nephronophthisis 9 and renal-hepatic-pancreatic dysplasia. Orthologous to human NEK8 (NIMA related kinase 8).

GO:

id name namespace
GO:0072116 pronephros formation biological_process
GO:0048793 pronephros development biological_process
GO:0009887 animal organ morphogenesis biological_process
GO:0006468 protein phosphorylation biological_process
GO:0007049 cell cycle biological_process
GO:0007059 chromosome segregation biological_process
GO:0051301 cell division biological_process
GO:0061326 renal tubule development biological_process
GO:0016310 phosphorylation biological_process
GO:0001947 heart looping biological_process
GO:0061371 determination of heart left/right asymmetry biological_process
GO:0005813 centrosome cellular_component
GO:0005634 nucleus cellular_component
GO:0005929 cilium cellular_component
GO:0005737 cytoplasm cellular_component
GO:0016740 transferase activity molecular_function
GO:0005524 ATP binding molecular_function
GO:0046872 metal ion binding molecular_function
GO:0000166 nucleotide binding molecular_function
GO:0004672 protein kinase activity molecular_function
GO:0004674 protein serine/threonine kinase activity molecular_function
GO:0016301 kinase activity molecular_function

KEGG:

id description
ko01001 Protein kinases
ko03036 Chromosome and associated proteins

ZFIN:

id description
ZDB-GENE-020509-1 Predicted to enable protein serine/threonine kinase activity. Acts upstream of or within heart looping; pronephros formation; and renal tubule development. Located in cilium. Human ortholog(s) of this gene implicated in nephronophthisis 9 and renal-hepatic-pancreatic dysplasia. Orthologous to human NEK8 (NIMA related kinase 8).

Ensembl:

ensembl_id ENSDARG00000045626

RNA

RNA id representative length rna type GC content exon number start site end site
TCONS_00016797 True 2784 mRNA 0.47 15 15479442 15514013

Neighbor

gene id symbol gene type direction distance location
XLOC_008385 zgc:174895 coding upstream 19309 15456536 ~ 15460133 (+)
XLOC_008384 NA coding upstream 26926 15450803 ~ 15452516 (+)
XLOC_008383 zgc:92630 coding upstream 41912 15415623 ~ 15437530 (+)
XLOC_008382 dhrs11b coding upstream 71329 15403560 ~ 15408113 (+)
XLOC_008381 ca4b coding upstream 77525 15390882 ~ 15401917 (+)
XLOC_008387 traf4a coding downstream 2599 15516612 ~ 15593263 (+)
XLOC_008388 NA coding downstream 115493 15629506 ~ 15665686 (+)
XLOC_008389 si:ch211-33e4.3 coding downstream 257405 15771418 ~ 15775182 (+)
XLOC_008390 NA coding downstream 264975 15778988 ~ 15782552 (+)
XLOC_008391 tada2a coding downstream 272147 15786160 ~ 15819598 (+)
XLOC_008463 BX663520.1 misc downstream 5738178 21252191 ~ 21252282 (+)
XLOC_008379 NA non-coding upstream 127985 15347642 ~ 15351457 (+)
XLOC_008368 NA non-coding upstream 1229513 14249389 ~ 14249929 (+)
XLOC_008363 BX927244.2 non-coding upstream 1425976 14045121 ~ 14053466 (+)
XLOC_008361 CABZ01056919.1 non-coding upstream 1521592 13957722 ~ 13957850 (+)
XLOC_008393 NA non-coding downstream 473041 15987054 ~ 16018789 (+)
XLOC_008394 BX511308.1 non-coding downstream 521856 16035869 ~ 16045504 (+)
XLOC_008398 CR847990.1 non-coding downstream 1004954 16518967 ~ 16519083 (+)

Expression


Co-expression Network

Homologous

species gene id symbol gene type chromosome NCBI id location
grasscarp (Ctenopharyngodon idella) CI01000053_02862161_02873752 NEK8 coding CI01000053 null 2861731 ~ 2873752 (-)
bowfin (Amia calva) AMCG00005496 nek8,LOC107672375 coding CM030142.1 CM030142.1 2811226 ~ 2821222 (-)