XLOC_008535 (pak4)


Basic Information

Item Value
gene id XLOC_008535
gene name pak4
gene type coding
species zebrafish (Danio rerio)
category of species model fish

Chromosome Information

Item Value
chromosome id NC_007126.7
NCBI id CM002899.2
chromosome length 48040578
location 25452092 ~ 25486010 (+)
genome version GRCz11_2017_zebrafish_Genome

Sequence

>TCONS_00017062
CACAGAGAGCACGAGCAGCGCGCTCATGAGGGCTTCACTCACTGATACGCGCACTTAGCCCGTTTAAGCTAACTTTACAGTCTAGAAACTTCACCGACCATATGAAGTTTATTTCTCCACAGACGCACTTCTCACTACAGGTCTGATGCCCTGCTGCAGCCATGTTCAGCAAGAAGAAAAAGCAACGCATCCAGATCTCAGCACCTTCGAACTTTGAGCATCGTGTCCACACTGATTTTGATGAACAGGAGCAGAAGTTTGTTGGCCTTCCACGCCAATGGCAGAGCCTCATTGAAGACACGGCCAAGAGGCCCAAACCCTTCATCGATGCCACAGTCATCACTACTGTTGAGCCACGCAAGACAATTGTCCGAGGTCGTAAGATCGGTGACGATGGCTCCCTCACCTGGCTCCTGGATGAGTTTGAAACCATGTCGGTGATCCGCTCCAACTCCCTGCGGAGAGGCAGTCCACCTTTACAACCACGCAGTGACTCTGGATCATCAGGAGGCCATGAGAACGGCGAACACCCCCAATATAGACACACTGATCGCTATGGGGACAGCAAAGAGAGGGAGAAACCACGTCAGGAGCACCCAGGCACTGATCCTAGACAGTCTCAACGTCCGGGCCGTTCGTCCAGAGAGGATGGCCGGCCTCAGCAGCAGCCTCGTGGTCAGGAGCCCAGCAGACACAAAGAACCTGACTGGATTACACCGGGCCAACACCGAGAACGAGAATGGGACAGAGAACGAGAACCACGTGATTATTCTGACCACGTAGTAAGGAGAGAGGGGGCCAACGATAAGAGGCCCAAATCCAGCTATACTGGGAGGGATAGCAGCCCACAGTCGCCTCGTGAGAAGAGACCACTGTCAGGGCCAAACATCCGCACTCCTAACCTACCTGTTACAGAGGGAGTGATAAAGGCAGCACAGCAGACTGGCCGACCTTTCAACACATACCCACGCTCTGAAAGTGACTCTGGGAGAACCCCCAGCGGTCAGGATTTAAAGCCAGCTAAATCTCACGAGTCTACCCACCACAATGGCCCCTCTGCTGGCCCAGTCCGGGGTggcagtagcagcagcagcagcggtgGTGGTCAAACTTCTTCTCAGGGGCCTCACAGATCAGAGCCTCAGCATCACGCCTCTCATCCAGCCTTGGGGCCTGAGCCTCCTCACGGCCAGCCCATGCCTCCTCCACCAAAACCATCTGGCCCGGCTGCACCATCCCAGCCGACACGCTCACCTCAGCGAGAGCCACAGCGGGTCTCACACGAGCAGTTCAGAGCTGCCCTGCAGATGGTAGTTGATCCTGGCGACCCGCGTACTTATCTGGATCACTACATTAAGATCGGAGAAGGCTCCACGGGCATTGTGTGCATAGCTACTGTGAAGACCACAGGCAAACTGGTGGCGGTGAAGAAGATGGACCTGCGAAAACAGCAGCGACGAGAACTGCTGTTCAATGAGGTGGTGATCATGCGGGACTATCACCATGAGAACGTGGTGGAGATGTACAACAGTTACTTGGTGGGGGATGAACTCTGGGTTGTCATGGAGTTTCTGGAGGGCGGCGCTTTGACTGATATAGTCACACATACAAGGATGAACGAGGAGCAGATCTCCACCGTGTGTCTGTCAGTGCTAAAAGCTCTCTCAGTCCTTCACTCTCAGGGAGTCATTCATAGAGACATCAAGAGTGACTCCATTCTTCTCACCCATGATGGCCGTGTGAAGCTGTCAGACTTTGGTTTTTGCGCCCAGGTCTCTAAAGAGGTGCAGCGCAGAAAGTCTCTGGTAGGAACGCCCTACTGGATGGCCCCTGAGCTCATCTCAAGACTCCCATATGGACCAGAGGTGGACATTTGGTCATTTGGCATTATGGTCATCGAAATGGTGGATGGAGAGCCGCCGTACTTCAACGAGCCACCGCTCAAGGCTATGAAGATGATCCGAGACAATTTGCCACCCAAGCTCAAAAATCTCCACAAGGTATCGCCTCTTCTCAAGGGATTCTTGGACAGGATGCTGGTGCGAGATCCTGCCCAGAGAGCCACAGCTCAAGAGCTGCTAAAACATCCCTTCCTGACTAAAGCAGGCCCTCCCTCCTGCATTGTTCCTCTCATGAGACAAAACCGCATGAGATGAGAAGAGAAGTCAGGGTGGATCTGACAGGCCCTCCGCTGAGCTCAAAGACCCAGGCAAAAACATGGAGTCTGTACTGCACACTTTAAATGATTGTACAGGTCAAGAATTTAAGGAGAACAGGCCATTGATGCTACAATTTTTTTTCCCTAAACAAACATTTATACCACTGTTTTTATTACATTAGAGGATACAGCACATGACATAGACATGATTAGGTCCTTCACAGTGTTCTGCTGGAAGAGGTTTTCCTCTCTGGCAAATTTAAGGAACACACAAACCATGTGTTCTCGGTGGTTTTGCCAAGTCTGCTTTGGGGTAAACCGAATTAAGAAGGTTGAGACGTTATGAAAATGAACCACTTGGAGATCCTAATCTGCCCTTAGTGTAAAGCAACCTTTTGATGGATTTGTTCCAAACCTCGAGCTTTCTTTTCCCTGCACTTGACCTTTTGCACCGTGACCACACTACTCAATAATCAGTTATTAATAGGAAAGCAACTACTGAAGAAAACCTTTACGTTTTATTAAAAAGAATGCAAATCTCTAGGCTTCTGTTACGACACTAAGCAAAGATAAACACTGGAGGCATTtcgttttttaattttgttttaatgaaagttgAGCTCTATATTGGTTTGTGTTTCGAGTGACAGTGATGCTCTTAAACACTGTTCTGAGCTGCACTCCAATATCAAACTTCCTCCTTTGACTCATTGTTCcacttttttaatataattaagggGGGAAGGGTTggatgtaggttttttttttttctctctctctcttccagaACATTCACAACGGCACCACGCCATATTAGTTAAGTAGATGGAGTTGTTGTTTTCAATGTAGGGCAGTCATTTCACGGACGCCCAAATCCTCCAGCTAAGTAGCTTACATCTTTGAGGTATCGTGGCCTTTCTCTGAAGGATTCATTTTGTCGGAGAGACTATACGAATGTATAGTGTGCGTGAAGGATGCTCTACTTTGAGAGCTTGTTCAAAGGAAGTGGACACTATAGTGAATAATTCCACACTAAAGCATTTGTACTGAGATAATTGGTCATTTACACTATGGGTAGTGGAACAACCAAAGACTTGCTGACGATTTATAATAGCAGTTGCTCCAAACATATTCCAAGTACACTACGTCTCATTGTGTTAAAGAGATAGGTCACCCAAAAAATTAATctttcctcatcatttactcagattcAAATGGTTCTAAACTTggtggtttctttcttctgttgaacacaaaacaagacgtTTTGATGAATGtcggaaaaaagcagccattgacatagTAGAAACCAAAAATAGTAAGGAAGTCAATAGCTGCTGCTTTCCAACGTTTTGTCTTcgacaaaagaaactcaaacaagttcaGAACTGAGTAAATTTCCAAAACTTTACTAAACCGTATGATACAGATTGGCCGATACATAATGCACTCACAGATGCCAAtcatcaacaacaaaaacacttgGTTTTGTCAGATCAATGTGTAACCTCTGATTGACTTCAAATGGAGTTTGCCAAGTTGTGAAAATATCTTGTAATCTGGTGATTGGCTGTTTTGATTGAAGTCTGTCAATGCATCAGCCTTTTAACTTGTTTTTGGACCCAATTGACTTACAGTATGGCCAAAATAGTTAGTTATTTTGTTCACTACAAGAAAGTCAGTCATACAagttttcatatttgggtgaactgtcccttcaagaGTCTCTCTTTATTTTGCTCAGCCACAATAATCCAGGATCAAAGTGGATCGAGAACGCTGACAAAATTGATAGGAATGCAGAAGGCAGATGAAATATTCCTATTCGATGGAGTGACTCCACACAAATACTAAACAAATCATTGAAAGTCAAACGAATGCATGTTTGGTCACATTTGCATTCAGTAATTTGAAGATGAATTGTAGCGATTTAATCCTAGACTAAAGTGGTAGCTTATGTATATATgagtttgttgttttcttttgctGAGGGCCTAAACTGTAACACTGCAACCATAACTCTAATTGTAGATGTGAAGAAGATTAATGACAGTTATTGACAgacataattaatataaaaaaatactactagggttggtttgtttgtttgtgtttttttttttttttcccaccagTAAAAATTTTATGGCATGTCTTTACATACTGGACTGCGCTACTTCTTCAGGACGCAAACAGAATGACAATCAAGCATCGGAGTGGAAGTATGCGCACTAAATGCCTATTCAGACATGAATAAGCAATGAAACTGAGAGAATTTTGTAGCCTCACGTTTATCTGTGAAATATTGCTAGGATTGTAGATTAACATCTTCAGTGCACTGAAGCAAAATGAGGTCAACATTCCtataaaaacaggaaaaaaaagccTTATAAGGAAAGTTGACCCACAAATGTAaatgtgctgttaatttactcaccctcaggccatctgAGATTTctttagtagaacattaaaggTTTTAGCTGAAGCTGTgttccttggtgattcataaattgGACGACTACCAACACTgagtcaagaaaaaaaaagacaaaacaaacaccTGTGTCTGCTGATGGTACATTGAGTCCTTATGAAGCAAAACAATTAGCTTTGCGCACAGACTGATAATTTCGCTTCATAAGACATCAATGTCTCGTCTGTAGCCATGGGtatctgttttgttttgcctgcaTAGTTTTTGACTCCGGAAATGCTGGTAgctgttgacttgcattttatcaACGATGACCACAGTTTCTGCTGAAAACAAATATGTGCGCTACTGAAAAATGAAAGTTGACTACATCTTTGAGTTAATTAATAactaaattttaatttctggCTGAACTACCCTTATAATGCGTAAATATATGAACATTATGAGCAATAGACGTTTCACAGTACTTTTTTTATTAGGTTTATTGACTGTTTGAAAAGCAGATACCTCCTATGACCACAAGCCTTATTTGATTGGGTGTGTGAATGGATGATGCTTTACTGCAAGCAGAATGCATGAGTTTGTGACTCAGTGAATGTGTTTTGAATGGCTTCTAGAAAGGACTTCTCTATTTTCTGACTTACATTCCCATGGTCGGTGAAAGCAcattctcgtgtgtgtgtgtgtgtgtggtcaggtaATGATCTGCTTTTTGTGTGTTACGTTTCCTGTTTCATGTTGTCATTTGGTGCTCAAAAGCAGTGCTGCGAATGCTCTGGAAGGGTACATTGTATTACGATACGGTTTCATCCGTTTTCTGTCACTGCATTAAAACTAATGAATGGCCCATA

Function

symbol description
pak4 Predicted to enable protein serine/threonine kinase activity. Acts upstream of or within embryonic morphogenesis and myeloid leukocyte differentiation. Predicted to be active in cytoplasm. Is expressed in post-vent region. Orthologous to human PAK4 (p21 (RAC1) activated kinase 4).

GO:

id name namespace
GO:0002573 myeloid leukocyte differentiation biological_process
GO:0023014 signal transduction by protein phosphorylation biological_process
GO:0032147 activation of protein kinase activity biological_process
GO:0048598 embryonic morphogenesis biological_process
GO:0006468 protein phosphorylation biological_process
GO:0031098 stress-activated protein kinase signaling cascade biological_process
GO:0016310 phosphorylation biological_process
GO:0005737 cytoplasm cellular_component
GO:0016740 transferase activity molecular_function
GO:0005524 ATP binding molecular_function
GO:0000166 nucleotide binding molecular_function
GO:0004672 protein kinase activity molecular_function
GO:0004674 protein serine/threonine kinase activity molecular_function
GO:0016301 kinase activity molecular_function

KEGG:

id description
ko04012 ErbB signaling pathway
ko04014 Ras signaling pathway
ko04510 Focal adhesion
ko04810 Regulation of actin cytoskeleton
ko04660 T cell receptor signaling pathway
ko04360 Axon guidance
ko05206 MicroRNAs in cancer
ko05211 Renal cell carcinoma
ko05170 Human immunodeficiency virus 1 infection
ko01001 Protein kinases

ZFIN:

id description
ZDB-GENE-040704-69 Predicted to enable protein serine/threonine kinase activity. Acts upstream of or within embryonic morphogenesis and myeloid leukocyte differentiation. Predicted to be active in cytoplasm. Is expressed in post-vent region. Orthologous to human PAK4 (p21 (RAC1) activated kinase 4).

Ensembl:

ensembl_id ENSDARG00000018110

RNA

RNA id representative length rna type GC content exon number start site end site
TCONS_00017062 True 5449 mRNA 0.44 10 25452092 25486010

Neighbor

gene id symbol gene type direction distance location
XLOC_008534 aifm4 coding upstream 3466 25438714 ~ 25448626 (+)
XLOC_008533 NA coding upstream 52518 25395901 ~ 25399574 (+)
XLOC_008532 NA coding upstream 74598 25370567 ~ 25377494 (+)
XLOC_008531 NA coding upstream 242250 25208392 ~ 25209842 (+)
XLOC_008530 slc35f2l coding upstream 282479 25156121 ~ 25169613 (+)
XLOC_008537 zgc:152863 coding downstream 3396 25489406 ~ 25499518 (+)
XLOC_008538 npat coding downstream 42280 25528290 ~ 25542592 (+)
XLOC_008539 NA coding downstream 82927 25568937 ~ 25570599 (+)
XLOC_008540 tsr1 coding downstream 149316 25635326 ~ 25656331 (+)
XLOC_008541 CT027805.2 coding downstream 181577 25667587 ~ 25667701 (+)
XLOC_008463 BX663520.1 misc upstream 4199810 21252191 ~ 21252282 (+)
XLOC_008529 NA non-coding upstream 356794 25094836 ~ 25095298 (+)
XLOC_008528 BX908796.5 non-coding upstream 382737 25063306 ~ 25069355 (+)
XLOC_008543 NA non-coding downstream 410455 25896465 ~ 25902650 (+)
XLOC_008544 CR848822.1 non-coding downstream 620305 26106315 ~ 26106433 (+)
XLOC_008546 CABZ01021926.1 non-coding downstream 954103 26440113 ~ 26440227 (+)

Expression


Co-expression Network

Homologous

species gene id symbol gene type chromosome NCBI id location
grasscarp (Ctenopharyngodon idella) CI01000072_02074797_02106818 PAK4, AIFM4 coding CI01000072 null 2073987 ~ 2106873 (-)