XLOC_008864 (bace1)


Basic Information

Item Value
gene id XLOC_008864
gene name bace1
gene type coding
species zebrafish (Danio rerio)
category of species model fish

Chromosome Information

Item Value
chromosome id NC_007126.7
NCBI id CM002899.2
chromosome length 48040578
location 93131 ~ 97205 (-)
genome version GRCz11_2017_zebrafish_Genome

Sequence

>TCONS_00017526
ATGCGCGCGGCGCGTCTGCTTCTGCTGTGCGGAGTCGCGGTGTGTGTCGCGCGGCTCTGCGCTTCCTCGGGCCCGGCGCTGCTCCGCGTTCCGCTACGCCAAGGGCCCTTGACCCCCCACAGCACCCCCGCGGCCCACAGGAGCCCCCACAGTCCCCGCGTGCGCTCCCGCAGAGCCACTTCCGGAATCAGCTTTATCAACATGATCGACAACCTGCGCGGGAAATCCGGACAGGGCTATTACATAGAGATGGCGGTGGGGAGTCCTGCGCAGAGGctCAACATCTTGGTTGATACGGGCAGCAGTAACTTTGCCGTGGGGGCTGCAGCTCATCCATTCCTGCACCGATATTACCACCGCTCACTctcctCCTCCTACAGGGATCTCGGTCGGGGTGTGTATGTGCCGTACACTCAGGGCCGCTGGGAGGGTGAGCTGGGCACTGATGTGGTGTCAGTCCCCTGCGGCCCCAACGTCTCCCTAAGGGCCAACATCGCCGCCATCACCCAATCAGATCGCTTCTTTATCAATGGCTCCAATTGGGAGGGCATCCTGGGCCTGGCCTATGCAGAGATTGCACGGCCGGATGAGACTCTGGAGCCGTTCTTTGACTCTCTGCTGCGGCAGAGCACTGTGGCGGATGTGTTCTCTCTGCCGCTCTGC

Function

symbol description
bace1 Predicted to enable aspartic-type endopeptidase activity. Acts upstream of or within myelination in peripheral nervous system and positive regulation of myelination. Predicted to be located in several cellular components, including endosome; lysosome; and membrane raft. Predicted to be integral component of membrane. Is expressed in brain. Human ortholog(s) of this gene implicated in Alzheimer's disease. Orthologous to human BACE1 (beta-secretase 1).

GO:

id name namespace
GO:0031643 positive regulation of myelination biological_process
GO:0006508 proteolysis biological_process
GO:0022011 myelination in peripheral nervous system biological_process
GO:0016020 membrane cellular_component
GO:0016021 integral component of membrane cellular_component
GO:0004190 aspartic-type endopeptidase activity molecular_function
GO:0016787 hydrolase activity molecular_function
GO:0008233 peptidase activity molecular_function

KEGG:

id description
ko05010 Alzheimer disease
ko01002 Peptidases and inhibitors

ZFIN:

id description
ZDB-GENE-040426-1835 Predicted to enable aspartic-type endopeptidase activity. Acts upstream of or within myelination in peripheral nervous system and positive regulation of myelination. Predicted to be located in several cellular components, including endosome; lysosome; and membrane raft. Predicted to be integral component of membrane. Is expressed in brain. Human ortholog(s) of this gene implicated in Alzheimer's disease. Orthologous to human BACE1 (beta-secretase 1).

Ensembl:

ensembl_id ENSDARG00000101716

RNA

RNA id representative length rna type GC content exon number start site end site
TCONS_00017526 True 663 mRNA 0.63 4 93131 97205

Neighbor

gene id symbol gene type direction distance location
XLOC_008863 NA coding downstream 3892 84837 ~ 89239 (-)
XLOC_008862 NA coding downstream 8916 81571 ~ 84215 (-)
XLOC_008860 cyp2y3 coding downstream 60980 16175 ~ 32151 (-)
XLOC_008865 apoa1b coding upstream 5720 102925 ~ 108414 (-)
XLOC_008866 BX640522.1 coding upstream 21852 119057 ~ 163586 (-)
XLOC_008867 limk1a coding upstream 70797 168002 ~ 252813 (-)
XLOC_008868 NA coding upstream 158080 255285 ~ 260813 (-)
XLOC_008869 BX640522.2 coding upstream 185526 282731 ~ 290507 (-)
XLOC_008870 FP102887.1 non-coding upstream 252246 349451 ~ 349567 (-)
XLOC_008871 NA non-coding upstream 277175 374380 ~ 378187 (-)
XLOC_008873 CABZ01056628.1 non-coding upstream 328490 425695 ~ 425756 (-)

Expression


Co-expression Network