XLOC_009693 (ccr2)


Basic Information

Item Value
gene id XLOC_009693
gene name ccr2
gene type coding
species zebrafish (Danio rerio)
category of species model fish

Chromosome Information

Item Value
chromosome id NC_007127.7
NCBI id CM002900.2
chromosome length 55266484
location 8673636 ~ 8681178 (+)
genome version GRCz11_2017_zebrafish_Genome

Sequence

>TCONS_00019431
AACATTCAGCTGCCATCACCTAGAGACATGACAGAGGAGCCAAGTACTGTGGCTGCTACAAAAACTGACTACAGCGATTACTATAATGAAGAAGGTGACTTTGAGCAACCATGCAACAATGGCCAAACAAAGGCATTCAGTGAGGTGTTCCTTCCCACCCTGTACAGCATAGTGTTCATCATTGGCTTCATTGGAAATGGTCTGGTCGTGTGGGTCCTTGTCAGATACCGCCACAAATCCAACATGACAGACGTGTGCCTCTTCAACCTAGCCCTAGCTGACCTACTCTTCCTTGTGTCACTGCCATTTTGGGCTCACAATGCCATGGATGAGTGGATTTTTGGCAGGTTTATGTGTCACACCATAACAGGTCTCTTCATGATCGGTCTCTACGCCAGCATCTTCTTCATGGTTCTCATGACACTGGATCGCTATGCCATCATCGTCCATGCCCACAGTGTGTTCTCCAGAAATCGCTCTACAAAAATGGGTTTGGCTCTGGCCTCGTTGGTATGGATGCTCAGCCTGTTGGTGTCCCTACCTAACATCATTTTTGCCAAAGATAAAAATGAGACAAACAGCAAAATATCCTGTGGATCTGATTTTCCTAAAGATTCATCCTGGATGCCATTTACTTATCTTAAGATGAACCTTCTGAGCTTGGTTTTCCCTCTGATTATCATGATCTTTTGTTATTCCCGGATTATCCCAACTCTGCTCAGCATGAAATCGCAAAAAAAGCACAAAGTGGTCAGACTGATCCTTGCTGTGGTagcggtttattttattttctggacTCCATACAACATTGTCATGTTTCTTATGTTCCTGCAGAAAATGGAGTACATGTTAACTTGCGAGTGGCATAATGGTTTGAGTCTTGCCATGCAGTGGGTGGAAACCATCGCCTTGAGCCACTGTTGCCTCAACCCAATCATCTATGCATTTGCTGGAGAGAAGTTCAGAGGAGCAGTCATCAAAGTCTTGAATGATCAGTTTCCAATGTGCTTTAAGCAATGCGCATCTTTCACTCACCAGTTATCTGAGAGGAGAAGCTCAATGTTCTCCAGATCTTCTGAAATTTCCAGCACACAAATTGCATAAGGCAAACATATTCCTCCAGAGAATCTTATTTTCAAGAGAACTTACACTGTAAATGCTGGGTTTCACTcagttgtcccaacataaatcgtTTTTTTACCAATAcaagtggattgaacgtaaagCAATTATGTTTTCCCCAAAGTATTTcagaattttgttgttttaactcaaCAAGCAGCAGCAAACGCCAGCTTTTGAGTGAACCTCGAGGTATTATTAGCAATGAATGTATATCTACTTCATTTTTTATGTAGcctttgttctttttttgtaaaacccaacagtaaactttatcaaatgaaacgagtgtagttaactctttctgaaagttaattctactcatctgaagagttttgaactcagtgttggaggtattgagttaattaaatatctcattactttaacttaaatggagtaagatcacactcatatagattagttgttTTAACTCGGTTAAAATGCAATCGGTTTGATGCAATCAGTTTTCTCAAAGGATTTGAGTtgcttattgggttttacagtactcaattagattgagttctcttcatttatcttCATTACTgtttaaattgctttatttactcaaatggattaagttcactgtactcattaggattagtttttgaacttaaatggtttgttgcaatcggtttcctcaaatggtttgagtttccTTAACTTTTTGGTTTTTAAAGTATGCCAATTTTGATTATAATGCTGAAATTAATGTTGTGCTTGTATATTGTGCATATATAATAGATTTGatacaaatatgcaaatgagacaaataatagttttgatattaaCTAAAGGCGTAGTTCACCCAAGACGGACAATTCCGTCATCATTTAGCccactcacccttcacttgttccaatgTCTGACTGttcaaaacaaatactgtggacatcagtggttacagtttttgagctttcttcaaaattctcttttttttacaaaaatattttccccTTTTTAAAGCCTTTTCCCTTGTGTTACTCACAAGAAACTCATTGGAACCActtagtaaatagtgagtaaatgttttgtgtgaactattccttatTGTAGATTTCTCTGATCAATGAATTAAATTGTTGATTCTGACCTCTGATAAATACATTGAggcaatatttgtttatttttttacaatattaaaagTTTGCTTCTGGTATTTGTACTGTTTAAAGGAttctattaaacatttttttatccaTTGTCTGGGTGATTGTGTATATTCAAACTCATATACTGTACCACAGTCTGACACTTATCTGTAAACCACATGTGCGTATCATTCTGTGATATCTATGAAATCTATTGAGCCACA
>TCONS_00019432
GAGACATGACAGAGGAGCCAAGTACTGTGGCTGCTACAAAAACTGACTACAGCGATTACTATAATGAAGAAGGTGACTTTGAGCAACCATGCAACAATGGCCAAACAAAGGCATTCAGTGAGGTGTTCCTTCCCACCCTGTACAGCATAGTGTTCATCATTGGCTTCATTGGAAATGGTCTGGTCGTGTGGGTCCTTGTCAGATACCGCCACAAATCCAACATGACAGACGTGTGCCTCTTCAACCTAGCCCTAGCTGACCTACTCTTCCTTGTGTCACTGCCATTTTGGGCTCACAATGCCATGGATGAGTGGATTTTTGGCAGGTTTATGTGTCACACCATAACAGGTCTCTTCATGATCGGTCTCTACGCCAGCATCTTCTTCATGGTTCTCATGACACTGGATCGCTATGCCATCATCGTCCATGCCCACAGTGTGTTCTCCAGAAATCGCTCTACAAAAATGGGTTTGGCTCTGGCCTCGTTGGTATGGATGCTCAGCCTGTTGGTGTCCCTACCTAACATCATTTTTGCCAAAGATAAAAATGAGACAAACAGCAAAATATCCTGTGGATCTGATTTTCCTAAAGATTCATCCTGGATGCCATTTACTTATCTTAAGATGAACCTTCTGAGCTTGGTTTTCCCTCTGATTATCATGATCTTTTGTTATTCCCGGATTATCCCAACTCTGCTCAGCATGAAATCGCAAAAAAAGCACAAAGTGGTCAGACTGATCCTTGCTGTGGTagcggtttattttattttctggacTCCATACAACATTGTCATGTTTCTTATGTTCCTGCAGAAAATGGAGTACATGTTAACTTGCGAGTGGCATAATGGTTTGAGTCTTGCCATGCAGTGGGTGGAAACCATCGCCTTGAGCCACTGTTGCCTCAACCCAATCATCTATGCATTTGCTGGAGAGAAGTTCAGAGGAGCAGTCATCAAAGTCTTGAATGATCAGTTTCCAATGTGCTTTAAGCAATGCGCATCTTTCACTCACCAGTTATCTGAGAGGAGAAGCTCAATGTTCTCCAGATCTTCTGAAATTTCCAGCACACAAATTGCATAAGGCAAACATATTCCTCCAGAGAATCTTATTTTCAAGAGAACTTACACTGTAAATGCTGGGTTTCACTcagttgtcccaacataaatcgtTTTTTTACCAATAcaagtggattgaacgtaaagCAATTATGTTTTCCCCAAAGTATTTcagaattttgttgttttaactcaaCAAGCAGCAGCAAACGCCAGCTTTTGAGTGAACCTCGAGGTATTATTAGCAATGAATGTATATCTACTTCATTTTTTATGTAGcctttgttct

Function

symbol description
ccr2 Predicted to enable C-C chemokine binding activity and C-C chemokine receptor activity. Acts upstream of or within monocyte activation. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in external side of plasma membrane. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); autoimmune disease (multiple); eye disease (multiple); gastrointestinal system cancer (multiple); and sarcoidosis (multiple). Orthologous to several human genes including CCR2 (C-C motif chemokine receptor 2); CCR4 (C-C motif chemokine receptor 4); and CCR5 (C-C motif chemokine receptor 5).

GO:

id name namespace
GO:0007186 G protein-coupled receptor signaling pathway biological_process
GO:0007204 positive regulation of cytosolic calcium ion concentration biological_process
GO:0042117 monocyte activation biological_process
GO:0006935 chemotaxis biological_process
GO:0006955 immune response biological_process
GO:0019722 calcium-mediated signaling biological_process
GO:0007165 signal transduction biological_process
GO:0060326 cell chemotaxis biological_process
GO:0009897 external side of plasma membrane cellular_component
GO:0016020 membrane cellular_component
GO:0016021 integral component of membrane cellular_component
GO:0016493 C-C chemokine receptor activity molecular_function
GO:0004930 G protein-coupled receptor activity molecular_function
GO:0004950 chemokine receptor activity molecular_function
GO:0019956 chemokine binding molecular_function
GO:0019957 C-C chemokine binding molecular_function

KEGG:

id description
ko04060 Cytokine-cytokine receptor interaction
ko04061 Viral protein interaction with cytokine and cytokine receptor
ko04062 Chemokine signaling pathway
ko04030 G protein-coupled receptors
ko04050 Cytokine receptors
ko04090 CD molecules

ZFIN:

id description
ZDB-GENE-151216-1 Predicted to enable C-C chemokine binding activity and C-C chemokine receptor activity. Acts upstream of or within monocyte activation. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in external side of plasma membrane. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); autoimmune disease (multiple); eye disease (multiple); gastrointestinal system cancer (multiple); and sarcoidosis (multiple). Orthologous to several human genes including CCR2 (C-C motif chemokine receptor 2); CCR4 (C-C motif chemokine receptor 4); and CCR5 (C-C motif chemokine receptor 5).

Ensembl:

ensembl_id ENSDARG00000105363

RNA

RNA id representative length rna type GC content exon number start site end site
TCONS_00019431 False 2434 mRNA 0.37 2 8673636 8681178
TCONS_00019432 True 1346 mRNA 0.42 2 8677112 8680112

Neighbor

gene id symbol gene type direction distance location
XLOC_009692 ccr2 coding upstream 3223 8668519 ~ 8670413 (+)
XLOC_009691 NA coding upstream 301066 8355479 ~ 8372570 (+)
XLOC_009690 pomgnt2 coding upstream 511256 8139515 ~ 8162380 (+)
XLOC_009689 ano10a coding upstream 632288 7985886 ~ 8041348 (+)
XLOC_009688 NA coding upstream 879868 7792721 ~ 7793768 (+)
XLOC_009694 si:cabz01093077.1 coding downstream 14417 8695595 ~ 8701100 (+)
XLOC_009695 cabz01093075.1 coding downstream 35622 8716800 ~ 8725803 (+)
XLOC_009696 NA coding downstream 283711 8964889 ~ 8965839 (+)
XLOC_009697 NA coding downstream 285031 8966209 ~ 8966926 (+)
XLOC_009698 dnah5 coding downstream 372097 9053275 ~ 9267496 (+)
XLOC_009682 CT574585.2 non-coding upstream 1107541 7564527 ~ 7566095 (+)
XLOC_009681 NA non-coding upstream 1158129 7514850 ~ 7515507 (+)
XLOC_009678 CU466278.2 non-coding upstream 1378683 7227584 ~ 7294953 (+)
XLOC_009699 CR394537.2 non-coding downstream 555954 9237132 ~ 9237246 (+)
XLOC_009702 NA non-coding downstream 823195 9504373 ~ 9505519 (+)
XLOC_009703 NA non-coding downstream 834148 9515326 ~ 9515807 (+)

Expression


Co-expression Network