XLOC_009784 (gba)


Basic Information

Item Value
gene id XLOC_009784
gene name gba
gene type coding
species zebrafish (Danio rerio)
category of species model fish

Chromosome Information

Item Value
chromosome id NC_007127.7
NCBI id CM002900.2
chromosome length 55266484
location 14216581 ~ 14231312 (+)
genome version GRCz11_2017_zebrafish_Genome

Sequence

>TCONS_00019568
GGAAATCAGTCGCATGGCGCGTGATTGACTGTTTACATTCTCGAAACACATCAGACTGgacttttaaacatcttttagaGAACCATAATGACATTGCCATTTTCGTTTTTAGGCCTCGGATAAACTTTAAATCGTCACAAATCTTAAAAGATTAAGTATTTGAATGGGCGTTCATTAACGTACACGGGAGTCTCATCGGCAGGATGAGAGAAACGGCTCTTTTTATTCTGCTCGCCGGAATAATCACCACAGCAAGAGCTGACAGTAAAGACGGTTGTCTAGCACTGAATTTCGGTCATGGctcggttgtgtgtgtgtgcaatgcgACATACTGCGACTCTCTCGGCCGGACTGTGCTGCCAGATGCTGGTCAGTTCTTATCATATGTCAGCAATAAAGCTGGCAGCAGACTGATGGAGAGTCAAGGACAGTTCCAGAAGAACAGCACAGGTGCAGCTCTCAGAATCACTCTGAACCCCAGTCAGAAGTTCCAGCACATTAAGGGATTCGGGGGAGCCATGACGGATGCAGCAGCCATTAATATTTTGTCTCTGTCTTCCGGAGCTCAGGACCAGCTGCTCAGACAGTACTTCTCCACAGATGGTATAGAGTACCGTTTCGTGAGAGTGCCGGTGGCCAGCTGTGATTTTTCAACTCGACTCTACACGTATGCTGACACTCCAGAAGACTACGATCTCCAGAACTTCACCCTGGCCAAAGAGGATGTTCACATGAAGATTCCCCTTCTGCAGCGGGCACAGGCTCTATCTGCTCAGCCTCTCTATCTGTTCGCCAGTGCCTGGAGCGCCCCCGCCTGGCTGAAGACCAACGGCGCACTGATAGGGAAGGGCTCCCTCAAAGGCAAACCAGGAGGCAAAGAACACAAGACCTGGGCTCAGTACTATATCAGGTTTCTAGAGGAATACAGGAAGTATAATCTTTCGTTCTGGGGGCTGACGTCAGGGAATGAGCCCACTGCAGGTGAAATGACAAATTACAGTTTTCAGGCTTTGGGTTTTACTCCGGAGACGCAGCGTGACTGGATTGCCCTGGATCTAGGTCCAGCACTCCATTCCTCATCCTTTTCCAAGACCCAACTAATGATTCTTGATGACAACCGCCTTATGCTGCCACATTGGGCCAAAGTGGTTCTAAGTGACATTAAAGCAGCACGATATGTCCACGGCATTGGTGTTCACTGGTATTTTGATCGCCTTGTGCCGCCTGACGTCACCCTGACCTCCACACACCATCTGTACCCTGATTACTTCCTATTTGCAACTGAGGCATGCGCTGGGTGGAGTCCAGTGGATCGTGGTGTGCGTCTGGGCAGCTGGGACAGGGCAGAGGACTACGCCCATGACATCATCCAGGACCTGAATAATTATGTGACCGGCTGGACCGACTGGAATTTGGCCCTTAATCAGGATGGAGGACCCAACTGGGTCAAGAACTTTGTGGACAGTCCCATAATTGTGGACCCAAGCAAAGATATATTTTACAAGCAGCCCACATTCTACAGCATGGCCCACTTCAGCAAGTTCCTGTGGGAGGAGTCTCAGCGAGTAGGTGTGTCCTTTAGTCAGCAGACCAGCCTAGAAATGTCTGCATTCATCAGACCTGACGCCTCAGCAGTATTAATCATTCTAAACAGGTCTGAAGAGGAGGTGCCATTTGAAGTCTGGGATCAAACGGTGGGCTTTTTGCCAGGAAGTGCTCCACCTCACTCCATTCTCACACTACTGTGGAACAGACAGTAAACAAAATCTGGGTCAGTAACCCATATAAGCACCTTAATAAGGAACTCTAATCATTTCAGTCATGCCTTAAGACAGAAACATCCGAAAGCTTAACAACCATGATTAGcaaataaattatttcaatacTGAGTCGATAGTGATTTAAAGTCGAAAATACATTTGCTTTATAGGCTGTAATACTGGGTTCACATCAGACACCAAACAGAGCGTCACTTGCTCTAGATTAGATATAGAATGTTTATGGAGAGAAAGCTtaaaaatgtgcaaattttaGATCTTGAAGATTGTGTTGTTACTTTTACACATGAAAAGTGCAATGTATGAGTAAACTACTTGCAAACACATATTTGACAAATTTAGTTTGAGATTTTAAAAGCCCCAGCTACTGGGCCAGCTTGAACACATGAACGTGATTGGCTGCTGAGAATTATCATTAGACCATTACTGTTGGCCAAGAAGATGGCTGTCCAATCCTGTACTTTATACCACCAAAATGCCTCTAACTTGTAAAGGATccaattttttgtgtgtttttcttccACATTGAATAGACAGTAttaaaacatactttaaaataaacatcacTGTACACTGAGTGCAAAAATCTGCCTTGTtggctgaaggctgatttatacgttTGCGTCGAGTGCACGCAGCCTGTGTGTGGTCGCATAGCCCGTCTCCAACGCTGACCtcccaaaaaatgtaactacaagtcgcaaggatgcgtagtgcaagctctgtgattgatcggcttggtagcgctgatgagtgtgggcaggGCTGAGAGCTGCGCGAGCCTGATCAAGCGAGTGTCAACAAATATCGAGTCATGGGAAGGAGCTCCAGatagaaactgttgttttgtgtttaccttttgaTTAAGTTGTTGCATTTacacttctgtgtgctgtttgtgtagctctgcaataacactagCTGGCAGGAGGtgtttttgttcctctgtgttgtttctttgctggtgtttttttcctGAACACTACCTATATGTTCAAGTAACTCAAACTCACTCTTTTAGAGGTGGGAAACAGCAGGcaagcaacaactttaatcataaggtaaacacaaaacaacagtttccaccGAGAGCTTTTTTCCCAGGACTCGACACTTGcaaacactcgctccatctggCTTGCGTGACTATCACCttcgcccacactcgtcagccgaccaatcacagagctagcACAATGCATTGTTGcaacatgtagttaaatttttttagagTTGCGCATCAGCATCGCCGTCGGCCACGTAACCATGTATAGGCTGTGCCGGAGCATACAAGTCGTGCCGATCACTCGATGGAGAAGTATAAAAAGGCTTGAGGCTATGCACATTAATTAAGTGCCAAATTTGTGTATGAAATATAGCTAAACAAGACACCTGAGGCATTTGAGTCCAAACTTGTTTCAGCATTGCTATTGCAATGtgcgcatccacaatagtcacatggcaggatatgcaatgttcgAATTATAGTTGCCCAGGAGCTACAGAAACGTATTTAATTACtgtctttaattcttttttaaacaaacattttttctaacttagaatttttgtcttgtttttagtccaaatatctgcatTTCAATGCAGCATCATTACAAAAGCAAGATTTGCTTACCCGGCTGAGAGATAATtgtacttgttttaaggaaaaaacttttcattttgattaattctgaaggtgaaaacaaaacaatagttttaCTTGCGCTAAGAGTTGttttatatttggactagaaatgagacattGCAAAGTTAGAACAGCagttttttgcattgtgatctttcaatttctgtacctaaatactgtCAGACCAAAGGAAACCATTAAGTTATATTGTTCAAACTATTCaaatcttgtgaaactgtattcatatcacaatatttatcgcagaaaaataaaatattgcattatCAGATCTTTtcaatatcgtccagccctatgtCTAACCTCCTTTTGTTAAATATGTTCTCTATTTTTATATCACATATCAGATTGAAGGCATTCGCTTTAATAGAAATACAGGAAACATTCTAAAAGGGACAATGAGCACGACTGGTATTTAATAATGTGAAGAGTATACTCGCATGAAAAATACTACGGTAAATTATAGTCAATTTTCAAGTCAGGAAGACGCGAGTGAGGTGAATTCTGCACGTTCATTTTGTATCTAATCTATTCGCATTTGTGGTGTGAACCCAGCAAGCTGCTCTCATCAACTTTTTAGTCTTGTATTAATAATTCTTCTAACACCCCTGGGAAAACTTGATATTTAAACATTCTTGCACTGATACTGTGAATTAAAAACCAAATAAAGACAACATATAAAAGCTGA
>TCONS_00019569
GATGAGAGAAACGGCTCTTTTTATTCTGCTCGCCGGAATAATCACCACAGCAAGAGGTGTGTAACAATAATCAGACGGATTATATAAGATTTACCTTTCTGTCCAAGTGTTTGTTTTGATCTTTCTGCTTTTTTGTTTCACTTTGGCTCAGCTGACAGTAAAGACGGTTGTCTAGCACTGAATTTCGGTCATGGctcggttgtgtgtgtgtgcaatgcgACATACTGCGACTCTCTCGGCCGGACTGTGCTGCCAGATGCTGGTCAGTTCTTATCATATGTCAGCAATAAAGCTGGCAGCAGACTGATGGAGAGTCAAGGACAGTTCCAGAAGAACAGCACAGGTGCAGCTCTCAGAATCACTCTGAACCCCAGTCAGAAGTTCCAGCACATTAAGGGATTCGGGGGAGCCATGACGGATGCAGCAGCCATTAATATTTTGTCTCTGTCTTCCGGAGCTCAGGACCAGCTGCTCAGACAGTACTTCTCCACAGATGGTATAGAGTACCGTTTCGTGAGAGTGCCGGTGGCCAGCTGTGATTTT

Function

symbol description
gba Enables glucosylceramidase activity. Acts upstream of or within neuron cellular homeostasis; regulation of ossification; and swimming. Predicted to be located in lysosomal membrane. Is expressed in brain; fin; and liver. Used to study Gaucher's disease. Human ortholog(s) of this gene implicated in Gaucher's disease (multiple); Lewy body dementia; Parkinson's disease (multiple); and Parkinsonism. Orthologous to human GBA (glucosylceramidase beta).

GO:

id name namespace
GO:0006629 lipid metabolic process biological_process
GO:0008152 metabolic process biological_process
GO:0006665 sphingolipid metabolic process biological_process
GO:0006680 glucosylceramide catabolic process biological_process
GO:0070050 neuron cellular homeostasis biological_process
GO:0030278 regulation of ossification biological_process
GO:0036268 swimming biological_process
GO:0016787 hydrolase activity molecular_function
GO:0016798 hydrolase activity, acting on glycosyl bonds molecular_function
GO:0004348 glucosylceramidase activity molecular_function

KEGG:

id description
ko00600 Sphingolipid metabolism
ko00511 Other glycan degradation
ko04142 Lysosome

ZFIN:

id description
ZDB-GENE-100922-270 Enables glucosylceramidase activity. Acts upstream of or within neuron cellular homeostasis; regulation of ossification; and swimming. Predicted to be located in lysosomal membrane. Is expressed in brain; fin; and liver. Used to study Gaucher's disease. Human ortholog(s) of this gene implicated in Gaucher's disease (multiple); Lewy body dementia; Parkinson's disease (multiple); and Parkinsonism. Orthologous to human GBA (glucosylceramidase beta).

Ensembl:

ensembl_id ENSDARG00000076058

RNA

RNA id representative length rna type GC content exon number start site end site
TCONS_00019568 False 4132 mRNA 0.43 10 14216581 14231312
TCONS_00019569 True 543 lncRNA 0.48 3 14216783 14220351

Neighbor

gene id symbol gene type direction distance location
XLOC_009783 dap3 coding upstream 964 14201401 ~ 14215617 (+)
XLOC_009782 NA coding upstream 57856 14153990 ~ 14158725 (+)
XLOC_009781 si:dkey-85k15.11 coding upstream 124736 14078748 ~ 14091845 (+)
XLOC_009780 rusc1 coding upstream 161272 14029283 ~ 14055309 (+)
XLOC_009779 zgc:162509 coding upstream 191485 13993285 ~ 14025096 (+)
XLOC_009785 polr3c coding downstream 18234 14249546 ~ 14280600 (+)
XLOC_009786 NA coding downstream 229950 14461262 ~ 14493478 (+)
XLOC_009787 NA coding downstream 243544 14474856 ~ 14481801 (+)
XLOC_009788 BX324006.1 coding downstream 247848 14479160 ~ 14484367 (+)
XLOC_009789 BX005402.1 coding downstream 248239 14479551 ~ 14508200 (+)
XLOC_009777 NA non-coding upstream 262434 13950017 ~ 13954147 (+)
XLOC_009776 NA non-coding upstream 271005 13942073 ~ 13945576 (+)
XLOC_009769 NA non-coding upstream 602393 13612654 ~ 13614188 (+)
XLOC_009768 NA non-coding upstream 714616 13499361 ~ 13501965 (+)
XLOC_009791 NA non-coding downstream 391212 14622524 ~ 14622765 (+)

Expression


Co-expression Network