XLOC_010013 (mcl1b)


Basic Information

Item Value
gene id XLOC_010013
gene name mcl1b
gene type coding
species zebrafish (Danio rerio)
category of species model fish

Chromosome Information

Item Value
chromosome id NC_007127.7
NCBI id CM002900.2
chromosome length 55266484
location 29586004 ~ 29587969 (+)
genome version GRCz11_2017_zebrafish_Genome

Sequence

>TCONS_00019926
gagaagaagaaaaaatgtaGAGTTGTttggatatttatatttactttaaaaggAAGCGGTTTCACCCCAAATTCATCTTCGATTGATTTGATTAAAGGCGTTTATGTGGAATTGAAAACAGAAAATGTTCGCTGGAAGAAACAACGACAACGGCTTTTGGCCATGCACTGGATTACAAAGCAAACCACTGGTTATTCCAGAACTGAAAGCGCATAACCAGTTTGCGGTGGACTCTCTCCAGGGCTCGGTACCGTCCTCGCCTTCGGACGAAACGGGGGATTATCCCCCCACCGCCCTTGACATGGACACGCGGGAGATTATTGACACTTTCTTAAAAATCTTTACAGGACTCCCTCATTCTAAAAGTGGACGAAAACAAGTACTGTCAACAATGAGGCGGGTTGTGGACAATCTCGCGGTGAAGCACGAGCTCGCTTACAAAGGTATGATTGCACGGCTGAATCTGGAGCAGAAAGGAGAAGATGTAAGTTTCATCAAGCAAGTGGCAACAGAGCTCTTTAGCGATGGCACCACAAACTGGGGTCGTATTGCCAGCCTGCTGACATTTGGGGCAATGCTGTGCAAATACCAGAATGACAGAGGACATAGCAAGTATGTGAGGTTGGTAGGGGAGGAGATCTCGTCTTATCTACTTACAGAGCAGCGGGACTGGATACTCAGAAACAAAGCATGGGATGGCTTTGTGGAGTTTTTTCATGTCCCGGATACAGAGGCAGCTGTGAGAAACACACTTCTAACAATTGGTGGTGTGGCTACATTAAGTGCAGCACTTGCCTATTGGATACGGTGAATCCATATGGACTTTctaaaaactaacaaaacaaagaatGGATTCagaactttcaaactatttttgtattgttttttttttttttttttgagatcaTTTTCACCATTTTTCCTTTTCGAAGTGCTCACTGTATTTAAAAACTGGTTTAAACCTTTATTTGAGAAGTTAAATgctatttttgtattaaaaagtaaaatttttaaatcatttcCAGCCGTTCACATCTGAATTGTTCACCTACCAGGGATTAACACTTGCAacgccagtttttttttttttttttttttttttttttttttttgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgcagtttacaTATCACAATCACATTTGAAATTGTACATACATATCCACCAGTgttctttaaaaataatgcaaaatttgattaaaactaaaaatgtctGTTGCACCCACACTATAACTGCATTTACGTTGACCCCTTTTCATATaaatattagaattattttatGCAATGTATTGCACAGATAACTTCAGGTGCTGGCTTTATCTGATGAATGAGCTTTAAAGCTTTTATCTAAAAGCTAATGGTGGTTCTGTTTTGAGTGCTACTTGATAGCACTGTGATAGTAATTAACCACACAAGGCTGCTTAAACTTTTGTCTGACTGATTGAAATATTTAGGGAAGTTTGAGAGCATGTTCTCCTCTCTgagctttctctgtgaatttactGTTCTCTAAACTGCCAATTAAACTGATAAGCTAAtaa
>TCONS_00019927
CAAGTAACGCTCTGTTTCCCTTTCACTCTTTCATAATGTTTAGTGGTTGATAAGTccagttaaacattatttaaatgaccTGCCTCACCCTCTATACACGCACCTGGCCTGGCAGGTTGCTCCACTTTATGCCACGTATAGTCGTTTATGATTCTCTGGACTCTTTCAGGTATGATTGCACGGCTGAATCTGGAGCAGAAAGGAGAAGATGTAAGTTTCATCAAGCAAGTGGCAACAGAGCTCTTTAGCGATGGCACCACAAACTGGGGTCGTATTGCCAGCCTGCTGACATTTGGGGCAATGCTGTGCAAATACCAGAATGACAGAGGACATAGCAAGTATGTGAGGTTGGTAGGGGAGGAGATCTCGTCTTATCTACTTACAGAGCAGCGGGACTGGATACTCAGAAACAAAGCATGGGATGGCTTTGTGGAGTTTTTTCATGTCCCGGATACAGAGGCAGCTGTGAGAAACACACTTCTAACAATTGGTGGTGTGGCTACATTAAGTGCAGCACTTGCCTATTGGATACGGTGAATCCATATGGACTTTctaaaaactaacaaaacaaagaatGGATTCagaactttcaaactatttttgtattgttttttttttttttttttgagatcaTTTTCACCATTTTTCCTTTTCGAAGTGCTCACTGTATTTAAAAACTGGTTTAAACCTTTATTTGAGAAGTTAAATgctatttttgtattaaaaagtaaaatttttaaat

Function

symbol description
mcl1b Enables protein heterodimerization activity. Acts upstream of or within chordate embryonic development; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; and negative regulation of mitotic nuclear division. Predicted to be active in mitochondrial outer membrane. Is expressed in brain; digestive system; eye; heart; and pleuroperitoneal region. Orthologous to human MCL1 (MCL1 apoptosis regulator, BCL2 family member).

GO:

id name namespace
GO:0042981 regulation of apoptotic process biological_process
GO:2001243 negative regulation of intrinsic apoptotic signaling pathway biological_process
GO:0043009 chordate embryonic development biological_process
GO:0043066 negative regulation of apoptotic process biological_process
GO:0045839 negative regulation of mitotic nuclear division biological_process
GO:0097192 extrinsic apoptotic signaling pathway in absence of ligand biological_process
GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process biological_process
GO:0007088 regulation of mitotic nuclear division biological_process
GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage biological_process
GO:0005741 mitochondrial outer membrane cellular_component
GO:0042803 protein homodimerization activity molecular_function
GO:0046982 protein heterodimerization activity molecular_function

KEGG: NA

ZFIN:

id description
ZDB-GENE-030825-1 Enables protein heterodimerization activity. Acts upstream of or within chordate embryonic development; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; and negative regulation of mitotic nuclear division. Predicted to be active in mitochondrial outer membrane. Is expressed in brain; digestive system; eye; heart; and pleuroperitoneal region. Orthologous to human MCL1 (MCL1 apoptosis regulator, BCL2 family member).

Ensembl:

ensembl_id ENSDARG00000008363

RNA

RNA id representative length rna type GC content exon number start site end site
TCONS_00019926 False 1669 mRNA 0.39 3 29586004 29587969
TCONS_00019927 True 742 mRNA 0.40 2 29586468 29587316

Neighbor

gene id symbol gene type direction distance location
XLOC_010012 ensab coding upstream 8296 29555801 ~ 29577708 (+)
XLOC_010011 ctss2.2 coding upstream 66027 29514473 ~ 29519977 (+)
XLOC_010010 ctss2.1 coding upstream 72570 29509133 ~ 29513434 (+)
XLOC_010009 ctsk coding upstream 83217 29492749 ~ 29502787 (+)
XLOC_010008 rrnad1 coding upstream 201069 29376751 ~ 29384935 (+)
XLOC_010014 NA coding downstream 3150 29591119 ~ 29600668 (+)
XLOC_010015 vps72b coding downstream 42996 29630965 ~ 29647738 (+)
XLOC_010016 tmod4 coding downstream 62729 29650698 ~ 29684858 (+)
XLOC_010017 lysmd1 coding downstream 102739 29690708 ~ 29696789 (+)
XLOC_010018 NA coding downstream 133658 29721627 ~ 29813252 (+)
XLOC_010006 NA non-coding upstream 335156 29245880 ~ 29250848 (+)
XLOC_010005 NA non-coding upstream 355157 29211362 ~ 29230847 (+)
XLOC_009994 NA non-coding upstream 918671 28660395 ~ 28667333 (+)
XLOC_009989 CR936250.1 non-coding upstream 1197841 28388046 ~ 28388163 (+)
XLOC_009987 NA non-coding upstream 1214674 28270015 ~ 28371330 (+)
XLOC_010019 AL928927.1 non-coding downstream 315675 29903644 ~ 29908970 (+)
XLOC_010021 FP103008.1 non-coding downstream 492574 30080543 ~ 30080661 (+)
XLOC_010024 NA non-coding downstream 741894 30329863 ~ 30330881 (+)

Expression


Co-expression Network

Homologous

species gene id symbol gene type chromosome NCBI id location
grasscarp (Ctenopharyngodon idella) G143314 NA non-coding CI01000027 null 8032981 ~ 8033981 (-)