XLOC_010026 (mc2r)


Basic Information

Item Value
gene id XLOC_010026
gene name mc2r
gene type coding
species zebrafish (Danio rerio)
category of species model fish

Chromosome Information

Item Value
chromosome id NC_007127.7
NCBI id CM002900.2
chromosome length 55266484
location 30575901 ~ 30577136 (+)
genome version GRCz11_2017_zebrafish_Genome

Sequence

>TCONS_00019946
ATTTGTAGTAATTCTATAAATGATTAATTGAATGCATCTTTACTGTGCTAAACTAGCCCATAAAATGTATGCATCGATCTGCACATTGCAAAATTATCCacctaataaaaacatttttttcttaatttgtttccTCTAGGTCAAATTTTCAACTGATCTACAATTAAGAGTGATCATCGATCCATCATGAACCCCAGCGCTGAATCTCCCTCCAGCATCCACACTGACTGCGCTGAGGTCCAGGTCCCTGGGCAGGTGTTTCTGGTCATCGCAGTGGCCAGTTTGAGCGAAAACCTCTTGGTGATTGTGGCTGTGATCAAAAACAAGAATCTGCACTCTCCCATGTACTGCTTTATCTGTAACCTGGCTGTGTTTAACACCATCTCTAGCTTCTCCAAGGCACTAGAAAATATACTACTGTTGTTTAAAGACGCCGGACGCCTGAACTCACGCGGCCCTTTTGAGCTGAAGATAGACGATATCATGGACTCTTTACTCTGCATGTGCTTTCTAGGTTCAATCTTCAGCATCCTCGCCATAGCTGTGGATCGGTACATTAGCATTTTCCATGCGCTACGCTATCACATGCTCATGACCATGCGGCGTGTGCTGATCATTTTGTTCACTATATGGGTTTTGTGTGGCACCAGTGGAGCCCTAATGGTCGGCTTTTTTGAGGCAGCCACTGTAAAAATCTTCTTCATCGTGCTCTTCTTCACAGCTCTGCTCCTGATCCTCCTGCTTTATGTTCATATGTTCCTGTTAGCACGCCATCATGCAAACCGAATCGCGTCTATGCCTGGTGCTCAGGCGCAACACAGGAAAAGCGGCCTGAGGGGGGCGCTGACGCTCACCATATTGATCGGGGTATTCGTGGCCTGCTGGGCTCCGTTCTCCCTTCATCTGCTGATTATGATGATTTGCCCAGAGAACCCGTATTGTGAATGCTACCGTTCACTCTTTCAGCTGCATGTAGTGTTACTGGTGAGTCACGCTGTTATTGATCCGGCAATTTACGCTTTCCGTAGCGTGGAGCTGCGCAACACCTATAAGAAGATGCTTCTGTCCTCAGCTTCAAGGATCTGCAAGCGGTGTGCTTGAATGAGAACCAGGTGTTTCATGTGATaattatgaaaaattataattattaaagctcctgtatgtatgttttttgattcttctaaagcattaaaaaacataatatgtttgtagatatttaagaaacatgccaagtga

Function

symbol description
mc2r Enables corticotropin receptor activity. Acts upstream of or within adenylate cyclase-activating G protein-coupled receptor signaling pathway; adrenal gland development; and multicellular organismal response to stress. Located in cytoplasm and plasma membrane. Is expressed in adipose tissue; integument; pleuroperitoneal region; and steroid hormone secreting cell. Human ortholog(s) of this gene implicated in West syndrome and glucocorticoid deficiency 1. Orthologous to human MC2R (melanocortin 2 receptor).

GO:

id name namespace
GO:0007186 G protein-coupled receptor signaling pathway biological_process
GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway biological_process
GO:0019222 regulation of metabolic process biological_process
GO:0033555 multicellular organismal response to stress biological_process
GO:0030325 adrenal gland development biological_process
GO:0007165 signal transduction biological_process
GO:0005886 plasma membrane cellular_component
GO:0016020 membrane cellular_component
GO:0016021 integral component of membrane cellular_component
GO:0005737 cytoplasm cellular_component
GO:0004930 G protein-coupled receptor activity molecular_function
GO:0004977 melanocortin receptor activity molecular_function
GO:0004978 corticotropin receptor activity molecular_function

KEGG:

id description
ko04024 cAMP signaling pathway
ko04080 Neuroactive ligand-receptor interaction
ko04925 Aldosterone synthesis and secretion
ko04927 Cortisol synthesis and secretion
ko04934 Cushing syndrome
ko04030 G protein-coupled receptors

ZFIN:

id description
ZDB-GENE-030502-2 Enables corticotropin receptor activity. Acts upstream of or within adenylate cyclase-activating G protein-coupled receptor signaling pathway; adrenal gland development; and multicellular organismal response to stress. Located in cytoplasm and plasma membrane. Is expressed in adipose tissue; integument; pleuroperitoneal region; and steroid hormone secreting cell. Human ortholog(s) of this gene implicated in West syndrome and glucocorticoid deficiency 1. Orthologous to human MC2R (melanocortin 2 receptor).

Ensembl:

ensembl_id ENSDARG00000054949

RNA

RNA id representative length rna type GC content exon number start site end site
TCONS_00019946 True 1236 mRNA 0.44 1 30575901 30577136

Neighbor

gene id symbol gene type direction distance location
XLOC_010025 pear1 coding upstream 55744 30438041 ~ 30520157 (+)
XLOC_010024 NA coding upstream 245020 30329863 ~ 30330881 (+)
XLOC_010023 tmem79b coding upstream 249846 30316177 ~ 30326055 (+)
XLOC_010022 LO017848.1 coding upstream 269543 30301539 ~ 30306358 (+)
XLOC_010020 sema6e coding upstream 304457 30002605 ~ 30271444 (+)
XLOC_010027 fam210ab coding downstream 27251 30604387 ~ 30612730 (+)
XLOC_010028 gstk2 coding downstream 355908 30933044 ~ 31006689 (+)
XLOC_010029 BX510336.1 coding downstream 393365 30970501 ~ 30971157 (+)
XLOC_010030 NA coding downstream 513862 31090998 ~ 31094580 (+)
XLOC_010031 NA coding downstream 544620 31121756 ~ 31135431 (+)
XLOC_010021 FP103008.1 non-coding upstream 495240 30080543 ~ 30080661 (+)
XLOC_010019 AL928927.1 non-coding upstream 666931 29903644 ~ 29908970 (+)
XLOC_010018 NA non-coding upstream 762649 29721627 ~ 29813252 (+)
XLOC_010014 NA non-coding upstream 975233 29591119 ~ 29600668 (+)
XLOC_010035 CR855311.5 non-coding downstream 1057334 31634470 ~ 31634595 (+)
XLOC_010041 NA non-coding downstream 1383772 31960908 ~ 31985059 (+)

Expression


Co-expression Network

Homologous

species gene id symbol gene type chromosome NCBI id location