XLOC_016080 (pth1r)


Basic Information

Item Value
gene id XLOC_016080
gene name pth1r
gene type coding
species zebrafish (Danio rerio)
category of species model fish

Chromosome Information

Item Value
chromosome id NC_007113.7
NCBI id CM002886.2
chromosome length 59640629
location 2290148 ~ 2451181 (-)
genome version GRCz11_2017_zebrafish_Genome

Sequence

>TCONS_00031755
GTCGATGCTGATGATGTCCTCACAAAGGAGGAGCAAATCTATCTTCTGTTCAACGCAAAACGAAAATGTGAGCGAGCAATCAAGTCAAAGCATAAAACGTCTGAGGGATCCTGTCTGCCAGAGTGGGATGGCATCCTATGTTGGCCCGAGGGAGTTCCTGGAAAGATGGTGTCCACTTCATGCCCAGAGTACATATATGACTTCAACCACAAAGGTCATGCCTACCGCCGCTGCGACCTGAACGGGACCTGGGAACTGGCCTCACATAACAACAAAACCTGGGCTAATTACAGCGAATGTGCCAAATTCTTCCCCCATTATAACCAGAACCAGGAGAGGGAGGTTTTCGACAGACTTTACCTGATCTACACAGTGGGCTACTCCATCTCTTTGGGATCACTTATGGTGGCCACAGTCATCCTCGGATACTTTCGACGGCTCCACTGCACCAGGAACTACATCCACATGCACCTGTTTCTATCGTTCATGTTGAGGGCCATTAGTATCTTCGTGAAGGATGTGGTGCTGTACTCTGGTTCGGCGCTGCAGGAAATGGAACGAATCACTGTGGAGGATCTCAAATCCATCACTGAAGCCCCTCCTGCCAACAAAACCCAGTTTATCGGCTGTAAGGTGGCGGTGACGCTCTTCTTGTACTTCTTGGCCACTAATTATTACTGGATTCTGGTGGAAGGCCTGTACCTGCACAGCCTTATCTTCATGACCTTCTTCTCAGACAGGAAGTACCTCTGGGGCTTCACTCTGATTGGTTGGGGTGTTCCTGCGATGTTTGTCACCATCTGGGCGAGTGTTAGAGCCACACTTGCTGACACTGAGTGCTGGGATTTGAGTGCAGGAAACCTGAAATGGATTGTGCAGATCCCCATTCTCACTGCAATTGTTGTCAATTTTTTGTTGTTCCTGAATATAATTCGAGTCTTGGCAACAAAACTTCGAGAAACAAATGCGGGCAGATGTGACACCAGACAACAATATAGGAAGCTGCTGAAGTCGACTCTGGTCCTCATGCCGTTGTTCGGTGTTCACTACATAGTCTTCATGGCGATGCCTTACACAGAAGTTTCTGGAGTACTGTGGCAAATCCAGATGCATTATGAAATGCTCTTTAACTCAGTCCAGGGATTCTTTGTTGCGATTATATATTGCTTCTGCAACGGAGAGGTCCAAGCGGAAATCAAGAAGGCCTGGAACAGAAGGACTCTTGCTCTGGACTTCAAGAGAAAAGCCAGGAGCGGCAGTAACACATACAGCTATGGACCCATGGTTTCTCACACCAGTGTTACCAATGTGACGGCGCGGGGGCCGCTGGCCCTTCACCTCACCAACCGACTGGGGCACGTCACCACTAACGGCCACAGGAACCTTCCGGGATACATAAAAAACGGCTCCGTTTCAGAAAACTCCATCCCGTCCTCGGGTCACGAGCTTCACATTCAGGAGGAAGAGCCTTCGAAGACCTTCCAGATGGAGAAAACCATCCAGGTGGTGGAGGAGGAAAGAGAAACCGTCATGTGACTTTACTGACGGACAAATGCTAGATATATTGAAGGATTCAAGAGTCCTTCGCTTCTCAGGATTTCCTTACAATTGCTGTTGTTGGAGACACAGAGAAAGACCGGAGAAATGAGCCACGAGTCTGGAAGCTACTGCAGCATCTTCACCAGCAGCATTTGGTAAAGGAGAACAGACTTTgctttggatttttttaaatattagataTTCGCACTGTAGACAAGCAACTGCAGTGCTTTCAGGTCGTCATATCACCTCCATACATGAAGAACGGTGAGTTTGCATCAGGATCACGTCATATAAAGCATTGTGGGACCGTGAATTGTACATAAAGAAGACACTCGTGTTATTTTTAAA
>TCONS_00031756
ACTTTTTTATATACCAGCAAACGATGTACTAATGGGAGGGGAGGAGATGGAAGCGAAATGACTGGCTCTTTGAAGGCGCTTAAACAGACGTAAACACCAGAGAAATCCCATTTTAAACTGACAGCACATTTGCGTGAACTTGCGTCGGGATGGGAGCCACGCTTATCGTACGCACTTTAGGCTTTCTCTTCTGCGGCACCTTGCTGAGTTTCGTCTATGGTCTGGTCGATGCTGATGATGTCCTCACAAAGGAGGAGCAAATCTATCTTCTGTTCAACGCAAAACGAAAATGTGAGCGAGCAATCAAGTCAAAGCATAAAACGTCTGAGGGATCCTGTCTGCCAGAGTGGGATGGCATCCTATGTTGGCCCGAGGGAGTTCCTGGAAAGATGGTGTCCACTTCATGCCCAGAGTACATATATGACTTCAACCACAAAGGTCATGCCTACCGCCGCTGCGACCTGAACGGGACCTGGGAACTGGCCTCACATAACAACAAAACCTGGGCTAATTACAGCGAATGTGCCAAATTCTTCCCCCATTATAACCAGAACCAGGAGAGGGAGGTTTTCGACAGACTTTACCTGATCTACACAGTGGGCTACTCCATCTCTTTGGGATCACTTATGGTGGCCACAGTCATCCTCGGATACTTTCGACGGCTCCACTGCACCAGGAACTACATCCACATGCACCTGTTTCTATCGTTCATGTTGAGGGCCATTAGTATCTTCGTGAAGGATGTGGTGCTGTACTCTGGTTCGGCGCTGCAGGAAATGGAACGAATCACTGTGGAGGATCTCAAATCCATCACTGAAGCCCCTCCTGCCAACAAAACCCAGTTTATCGGCTGTAAGGTGGCGGTGACGCTCTTCTTGTACTTCTTGGCCACTAATTATTACTGGATTCTGGTGGAAGGCCTGTACCTGCACAGCCTTATCTTCATGACCTTCTTCTCAGACAGGAAGTACCTCTGGGGCTTCACTCTGATTGGTTGGGGTGTTCCTGCGATGTTTGTCACCATCTGGGCGAGTGTTAGAGCCACACTTGCTGACACTGAGTGCTGGGATTTGAGTGCAGGAAACCTGAAATGGATTGTGCAGATCCCCATTCTCACTGCAATTGTTGTCAATTTTTTGTTGTTCCTGAATATAATTCGAGTCTTGGCAACAAAACTTCGAGAAACAAATGCGGGCAGATGTGACACCAGACAACAATATAGGAAGCTGCTGAAGTCGACTCTGGTCCTCATGCCGTTGTTCGGTGTTCACTACATAGTCTTCATGGCGATGCCTTACACAGAAGTTTCTGGAGTACTGTGGCAAATCCAGATGCATTATGAAATGCTCTTTAACTCAGTCCAGGGATTCTTTGTTGCGATTATATATTGCTTCTGCAACGGAGAGGTCCAAGCGGAAATCAAGAAGGCCTGGAACAGAAGGACTCTTGCTCTGGACTTCAAGAGAAAAGCCAGGAGCGGCAGTAACACATACAGCTATGGACCCATGGTTTCTCACACCAGTGTTACCAATGTGACGGCGCGGGGGCCGCTGGCCCTTCACCTCACCAACCGACTGGGGCACGTCACCACTAACGGCCACAGGAACCTTCCGGGATACATAAAAAACGGCTCCGTTTCAGAAAACTCCATCCCGTCCTCGGGTCACGAGCTTCACATTCAGGAGGAAGAGCCTTCGAAGACCTTCCAGATGGAGAAAACCATCCAGGTGGTGGAGGAGGAAAGAGAAACCGTCATGTGACTTTACTGACGGACAAATGCTAGATATATTGAAGGATTCAAGAGTCCTTCGCTTCTCAGGATTTCCTTACAATTGCTGTTGTTGGAGACACAGAGAAAGACCGGAGAAATGAGCCACGAGTCTGGAAGCTACTGCAGCATCTTCACCAGCAGCATTTGGTAAAGGAGAACAGACTTTgctttggatttttttaaatattagataTTCGCACTGTAGACAAGCAACTGCAGTGCTTTCAGGTCGTCATATCACCTCCATACATGAAGAACGGTGAGTTTGCATCAGGATCACGTCATATAAAGCATTGTGGGACCGTGAATTGTACATAAAGAAGACACTCGTGTTATTTTT

Function

symbol description
pth1r Enables parathyroid hormone receptor activity and peptide hormone binding activity. Acts upstream of or within dorsal aorta development and positive regulation of inositol phosphate biosynthetic process. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including bone tissue; gill; liver; opercular flap; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in Eiken syndrome; Jansen's metaphyseal chondrodysplasia; chondrodysplasia Blomstrand type; osteochondrodysplasia; and primary failure of tooth eruption. Orthologous to human PTH1R (parathyroid hormone 1 receptor).

GO:

id name namespace
GO:0007186 G protein-coupled receptor signaling pathway biological_process
GO:0007188 adenylate cyclase-modulating G protein-coupled receptor signaling pathway biological_process
GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway biological_process
GO:0060732 positive regulation of inositol phosphate biosynthetic process biological_process
GO:0035907 dorsal aorta development biological_process
GO:0007165 signal transduction biological_process
GO:0007166 cell surface receptor signaling pathway biological_process
GO:0006874 cellular calcium ion homeostasis biological_process
GO:0005886 plasma membrane cellular_component
GO:0016020 membrane cellular_component
GO:0016021 integral component of membrane cellular_component
GO:0017046 peptide hormone binding molecular_function
GO:0008528 G protein-coupled peptide receptor activity molecular_function
GO:0004888 transmembrane signaling receptor activity molecular_function
GO:0004930 G protein-coupled receptor activity molecular_function
GO:0004991 parathyroid hormone receptor activity molecular_function

KEGG: NA

ZFIN:

id description
ZDB-GENE-991123-8 Enables parathyroid hormone receptor activity and peptide hormone binding activity. Acts upstream of or within dorsal aorta development and positive regulation of inositol phosphate biosynthetic process. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including bone tissue; gill; liver; opercular flap; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in Eiken syndrome; Jansen's metaphyseal chondrodysplasia; chondrodysplasia Blomstrand type; osteochondrodysplasia; and primary failure of tooth eruption. Orthologous to human PTH1R (parathyroid hormone 1 receptor).

Ensembl:

ensembl_id ENSDARG00000020957

RNA

RNA id representative length rna type GC content exon number start site end site
TCONS_00031755 False 1890 mRNA 0.48 12 2290148 2380872
TCONS_00031756 True 2111 mRNA 0.48 13 2290151 2451181

Neighbor

gene id symbol gene type direction distance location
XLOC_016079 CU929426.1 coding downstream 117509 2171371 ~ 2172639 (-)
XLOC_016078 slc22a23 coding downstream 194093 2024610 ~ 2096055 (-)
XLOC_016077 tubb2 coding downstream 270104 2010277 ~ 2020044 (-)
XLOC_016076 NA coding downstream 642165 1645559 ~ 1647983 (-)
XLOC_016075 prkacbb coding downstream 667507 1594344 ~ 1622641 (-)
XLOC_016082 NA coding upstream 34254 2485435 ~ 2494300 (-)
XLOC_016083 CABZ01088149.1 coding upstream 170219 2621400 ~ 2623983 (-)
XLOC_016084 serbp1b coding upstream 179007 2630188 ~ 2642476 (-)
XLOC_016085 usp14 coding upstream 339392 2790573 ~ 2813259 (-)
XLOC_016086 si:ch1073-82l19.1 coding upstream 476282 2927463 ~ 2957970 (-)
XLOC_016069 NA non-coding downstream 883995 1405511 ~ 1406153 (-)
XLOC_016067 NA non-coding downstream 958606 1315166 ~ 1331542 (-)
XLOC_016061 NA non-coding downstream 1094236 931068 ~ 1195912 (-)
XLOC_016090 FO818692.1 non-coding upstream 674777 3125958 ~ 3126074 (-)
XLOC_016092 CU633991.2 non-coding upstream 960895 3412076 ~ 3416207 (-)
XLOC_016095 NA non-coding upstream 1068402 3519583 ~ 3520166 (-)
XLOC_016100 NA non-coding upstream 1662830 4114011 ~ 4118815 (-)

Expression


Co-expression Network

Homologous

species gene id symbol gene type chromosome NCBI id location
grasscarp (Ctenopharyngodon idella) CI01000004_17214619_17236647 PTH1R, PTH1RA coding CI01000004 null 17214619 ~ 17236674 (+)
bowfin (Amia calva) AMCG00019162 pth1r,LOC107671674,LOC106599896,LOC107660418 coding CM030124.1 CM030124.1 6485078 ~ 6566493 (+)