XLOC_016172 (txndc12)


Basic Information

Item Value
gene id XLOC_016172
gene name txndc12
gene type coding
species zebrafish (Danio rerio)
category of species model fish

Chromosome Information

Item Value
chromosome id NC_007113.7
NCBI id CM002886.2
chromosome length 59640629
location 9592319 ~ 9607879 (-)
genome version GRCz11_2017_zebrafish_Genome

Sequence

>TCONS_00031905
AATGCGCTAAACCTGACAGGATTTAGGACCCAGCGGTTTTTGTCCGACATATCCATTCCAGGCAGCTCAAGGCTAGCTACAGTCGGAATAAAAATGCCGTCGTCTGTACTCAACATTGCGCTGGTCTCGTTTATACAGTTTTTTATAGCGTCACATTTCGTGGAGGTGTCAGCGGATGGCAATGGACGAGGATTTGGGGATCACATTCATTGGCGGAGCCTTGAAGATGGAAAGAAGGAGGCTGAAGCAAGTGGGCTTCCTCTGATGGTCATTGTTCACAAGACTTGGTGTGGAGCCTGCAAAGCACTAAAGCCCAAGTTTGCTGAATCCAAGGACATATCTGAGCTGGCTCACAACTTTGTCATGATAAACTTGGAGGATGAAGAGGAGCCCAAGGATGAAGCCTTCAGTCCAGATGGCGGTTACATTCCCAGAATTCTCTTCCTTGATCCCACCGGGAAGGTCCACTCAGAGATCACAAACAAGAATGGGAATCCCAACTACAAGTACTTTTACAGCAACGCAGATCAAGTTGTGGCGAGCATGAAGGAGGCCCAAGAAAAGCTGACTGGAGATGCCTTCAGAACCGCTCATGTTGGAGATGAACTGTAAGAAGAATGGGAAGATCAGCCAGAACAATGCATCACTCCGATGGGCATCCACCCAATCCTCAACCAGCTCCTGTCATTTCATTTGATCTGCTATTGCACAAGACAAGCTTCAAAAATGAAGTTATAATGCATCTACCGACTACATTTGAAGGATTCGCGGCTTGCATTAGATTGGCTTCTTACTTTGAGAACCAAAGCTTACTCTCCATGCACATAATGGGtgctaaaatgtgtttttttggtCTTAATTTCATATCCATATTGAATATTTGTGTTAAACTGTCACTGTGTTCTTGAGGCACATTTTGTCCGACTAGGAAACCCTTTCCAATTCTCATGTGCTTCCAAGCCATATCTTGCAAGCTGTGTAAAATGGATTGTTACCCGAAGTTTTATAATATCTGTACCACCTAAAAATTATCGTTTTTTCTGCAGGTtcttataaattgtttaaaattgcCAAGTTTTTGTTCTCAATTGATGCAGTTGCCTTTGGTTTTAAAAGACAGATTTTTACTATTGACAGTACCCATGAATTACACGAACACTTatataggcttattttacaattctcctagagttaaacagttacgttttaccttttttgtttaagtgaagttttacaaactaatttcgagaggagcatgtgatagggatcagctgtagtcaatcctatcacTAATCACTTACTAACCAATCAGAtcattacaaatttaatataaatattcagcCTATACTTCATTCCTCATCTTTGTTTTGGAAACAACCATCCCCCTTCCCTTCTCCTCTATTGTAAGTtcgggtgacatggtggctcaggggCTAACACTGATGCCCAACAGCAAGGGAGTCGCTGGATTAAACACTAGCTGAGCCAGTCGACACtcactgtttggagtttgcatgttctccctgtgtttgcgtgggttttccccgggtactccggtttcctctcacatttaaaaaacatgcaacaaaagttaGGTGCAAGCACCTACTACGTACAAACTGGCACAGTTAGTGGTCTACTCTTGGGAAGTTATCAACAACTACCCGACCTCGTATCCCTTCTAATGCTTATTGAACAGACGGGAGCCTTGGGCTCgtctatctccaagctcagggttctctccaaggacagcatgccaaacctgctaaaatagtcaagcattatcgaagtatgaactcttgaaaccacttttagcttagcataatcaTTAAATCGGagtagaccattagcatcttgctcaaaaatgaccagagtTTGGCTACTTGTCTTATTTAAAGCTCTACTTTTGTAGTGTACAATTTTATGTTATTGCCATTTTCTAGACCGATGTCTATTTTCATACTagcgtaataatcaagaaactttgccATAGTACCATTGGCTGTAGCAGGAGCAATAACATTACGCAGTGCTCAAAAATAGTACACAGATAGGTGACCAGAGATCGGTTGAATTGGTTAAATATAATGAACTTCAACTGTTTACCTCTGGGGGAGTggtaaaattagcctattttcaaaaaagtgtAGTGTTTCTTTATGGCCTGTTATGTAAATTGGgactattattacatttttttttttttttttttttgcaaattgtgAGGGAATTGCCTTTGCCATACTGTATTTTCTTAACATGTAAAATAAGGCTACAAATAAAGTTGATATAAAATGTTGGAAAATTA

Function

symbol description
txndc12 Enables protein-disulfide reductase (NAD(P)) activity. Acts upstream of or within DNA damage response, detection of DNA damage and detoxification of hydrogen peroxide. Predicted to be active in endoplasmic reticulum. Is expressed in several structures, including brain; digestive system; immune system; pectoral fin bud; and ventricular zone. Orthologous to human TXNDC12 (thioredoxin domain containing 12).

GO:

id name namespace
GO:0045454 cell redox homeostasis biological_process
GO:0061691 detoxification of hydrogen peroxide biological_process
GO:0042769 DNA damage response, detection of DNA damage biological_process
GO:0060548 negative regulation of cell death biological_process
GO:0005783 endoplasmic reticulum cellular_component
GO:0047134 protein-disulfide reductase activity molecular_function

KEGG:

id description
ko00480 Glutathione metabolism
ko04131 Membrane trafficking

ZFIN:

id description
ZDB-GENE-050522-497 Enables protein-disulfide reductase (NAD(P)) activity. Acts upstream of or within DNA damage response, detection of DNA damage and detoxification of hydrogen peroxide. Predicted to be active in endoplasmic reticulum. Is expressed in several structures, including brain; digestive system; immune system; pectoral fin bud; and ventricular zone. Orthologous to human TXNDC12 (thioredoxin domain containing 12).

Ensembl:

ensembl_id ENSDARG00000038980

RNA

RNA id representative length rna type GC content exon number start site end site
TCONS_00031905 True 2308 mRNA 0.40 7 9592319 9607879

Neighbor

gene id symbol gene type direction distance location
XLOC_016171 slc25a24l coding downstream 48158 9529488 ~ 9544161 (-)
XLOC_016170 cope coding downstream 65109 9513160 ~ 9527210 (-)
XLOC_016168 st6galnac3 coding downstream 102708 9330146 ~ 9489611 (-)
XLOC_016169 CR385076.1 coding downstream 185644 9406558 ~ 9406675 (-)
XLOC_016167 st6galnac5a coding downstream 332317 9160947 ~ 9260002 (-)
XLOC_016173 zmp:0000001127 coding upstream 13410 9621289 ~ 9625548 (-)
XLOC_016174 zgc:153615 coding upstream 21679 9629558 ~ 9646857 (-)
XLOC_016175 selenot1a coding upstream 76426 9684305 ~ 9696283 (-)
XLOC_016176 CU633992.1 coding upstream 80176 9688055 ~ 9688185 (-)
XLOC_016177 dvl3a coding upstream 94174 9702053 ~ 9744081 (-)
XLOC_016165 NA non-coding downstream 751435 8835922 ~ 8840884 (-)
XLOC_016162 CT027589.1 non-coding downstream 957187 8634240 ~ 8635132 (-)
XLOC_016159 NA non-coding downstream 1097603 8490588 ~ 8494716 (-)
XLOC_016156 NA non-coding downstream 1675932 7915351 ~ 7916387 (-)
XLOC_016178 NA non-coding upstream 138558 9746437 ~ 9748216 (-)
XLOC_016181 BX470264.1 non-coding upstream 254954 9862833 ~ 9863388 (-)
XLOC_016199 CR450845.2 non-coding upstream 1297183 10905062 ~ 10905179 (-)
XLOC_016204 BX901918.3 non-coding upstream 1722845 11330724 ~ 11331316 (-)

Expression


Co-expression Network

Homologous

species gene id symbol gene type chromosome NCBI id location
grasscarp (Ctenopharyngodon idella) CI01000003_01921110_01928830 TXNDC12 coding CI01000003 null 1920837 ~ 1929621 (+)
tiger barb (Puntius tetrazona) G126916 NA non-coding NC_056716.1 CM032085.1 16347496 ~ 16397206 (-)
mexican tetra (Astyanax mexicanus) G138515 txndc12,LOC107690994,LOC107566463,LOC107708672 non-coding NC_035912.1 CM008315.1 3150921 ~ 3156055 (-)