XLOC_016221 (kdsr)


Basic Information

Item Value
gene id XLOC_016221
gene name kdsr
gene type coding
species zebrafish (Danio rerio)
category of species model fish

Chromosome Information

Item Value
chromosome id NC_007113.7
NCBI id CM002886.2
chromosome length 59640629
location 13223755 ~ 13254821 (-)
genome version GRCz11_2017_zebrafish_Genome

Sequence

>TCONS_00031996
CCCACCCATCCCTTTTAGTGCATGGATTCTGTGTTTTGGTTCGTATACGTTAGTGAACAGAAGGAGTTAGAATTTGCGGTTTTATGgctttaacttaatatttaaccCTTCGCAAAAGCTTCTAATAGATCACCAGGTAAGACTGTAAACCACTCACCTAAAAGCTAACAATCTTCTGTTCGCGAGACGGGAGAGTGTCTGGAATTGCAGATTTAGCCTGTGAGCTAACATCAACAGCATCAGGTTGACCCATGTCCTCTGAGGAAACTCTCGACTCCGTTCTCTCACACTGGCTTTTCTTTAACACCTGGTGGCTTCTCCTGCCTTTTATTATGCTGCTTGTAGTGGCTGCTTTTATTGTGGCATTCGTTCTGCTGTTGTACATGATATCACCGTTAATAAGCCCCAAGCCTCTCAAACTCAACGGTGCCCATGTGGTGGTAACTGGAGGCAGCAGCGGGATTGGGAAGTGTATTGCCATGGAATGTTACAAACATGGTGCCTTCATCACCTTGGTGGCACGAGATGAGCACAAATTGGTTCAGGCTAAGAAAGAAGTGGAGAAGTTTGCCATAAATGATAAGCAAGTGGTTCTTTGCATTTCTGTTGATGTGGCGAAAGACTACAGCCAAGTGGAGAGTGTCATAAAACAAGCTCAAGAGAAGCTGGGTCCTGTGGACATGCTGGTGAATTGTGCCGGGACATCATTATCTGGGAAGTTTGAGGAAGTGGAAGTTGACCATTTCAAGAAAATGATGGAGGTGAATTATCTGGGCAGTGTTTACCCCACCCGTGCAGTGATCACCACTATGAAAGAAAGGCGGATGGGTCGCATCATGTTTGTGTCATCACAGGCAGGGCAGATCGGCCTCTTTGGCTACACGGCCTACTCACCCTCCAAATTTGCCTTGCGTGGTCTGGCTGAGGCCTTGCAGATGGAAATGAAACCCTATAATATCTATGTTACTGTGGCATATCCTCCAGACACAGATACACCAGGTTTTGCAGAAGAGAATAAAACTAAACCTCTGGAAACCAAGTTAATTTCAGAGACATCTGGTGTCTCTCAACCGGAGCAAGTGGCAAAAATTGTGGTGAAAGATGCGGTGCAGGGAAATTTCACTAGCTCATTTGGTCCTGATGGGTACATGCTGTCAGCACTGACCTGTGGGATGTCGCCTGTTACCTCCATTACTGAAGGGCTGCAGCAGATTGTGACCATGGGCCTGTTCCGTACCATTGCTCTCTTCTATCTGGGCAGCTTTGACAGCATCGTCCGCCGTTGTATGATCCAGCGAGAACAGTGCAAAGCAGCTGACAAGAGGGAGTAGCACCAGCATTCCCCCCACCCATCCACCTCTATTGCCAACactacatttacacacatgcctCCACACACCACCTGCAAGACATTTTTCAGTGGGTTTACAATGTCATGCACTTCAGCGACAAAGTTTCTGCTATTTTTTTCCAGTATATTTTTCATGATGTGTATTTCAGGATCCTCATAATTTTCATCAGTATTTCAAGCTCCTTAAGACATATTTACTCTTTAGCTCTCACTGCCTTATGTGCATTCTCGTATTTCAAAATCTGTGTTGTTCTCAAGCGTGCATCCACAAATGCTTCTTGCTTCAACCTGTTGGCACAATTTAATTTCAAAACTAGATGTAATTTCAATTAGCagttatttatattaatgccATAAAGCTTGGAATCCTCTCTATTTGTCAAGAATTCCAAATTCCCTTACGTTCCATTGAGGTGAAGAGCTGTGATGTGATGTTTGTAGCCTAGCACTGTATCTCCCTGCTTTTAGACTTCCTAGTTTTAAGGTATGGACACAGAaaatcggtgtgtgtgtgtgtttgtcttgttttgtgtgtatattgtttagtttttttattttttggatgaaACTGCCTGAGTCTGCCACTTTGCCTTATCTCTTTGCTCTGGCTGAGGATTTCGGAAGGAAATGTTTACCTTGtaaatgcgtgtgtgtgagtgtaattCTATTGTCTGCTTGTACGCATGAGTTTAGGTGACCTCAGGGTCTTGTAGAGTTCACTGAACTGAAAGATGGGTCTGGATAAGCCAATGTGGTTTTGATGGCTCGCTGGTCGAGTCACTGCACCTGTCTGCCAACAGATGGACCTGGAGATCCAAGCAGCTCATGTTTGAATAATCATAGTTAGACCTGAGTGGTTTAATGTCCACAACCCCAGAGCTCTGTTATTAAAGAATGCATTGATTGTTTACTCATTTGTTTCAAGTATTGTAGATGTTGTAAAGCTTAATCTGTTTGTACACCAAAATAGGCAATGTAGCCTCCACAAGTGAAGTGAATCACCTCGTGCTTTGCTCTGTCAAAATGTGAAATGGATGGTTAACATTCAAAATGTTTTCTGATTTAGGCCTTCTAAATTTGCTTCTAAATTTTATTGACGATGGACTAGCTAGAGAGAAAATGACATTTTCATGCTGTTACAGTCTTTACTGTCACAAGCAAACAGAGAGCATGTGATGTGATCACACCCTATGGTTATTCGAGCGCATGTTTATGCAGAGTCCATCTCTTTAATGCCTGAAAGCAGTGGTCAATTTGAAAGGGGTCAATCTGATGTCACCTTTCACAATTTTACATGTCATTGTTTAttcaccttcatgttgttccaaacctgtataattttcagttttataacaCAAAAGGGATAAGTTCAGTCAAATGTTTATGCTACTCTTCCCACATACAATAAAATTGAATGAGGACAGCAAAACCCTGAAGAAAAAAA
>TCONS_00031997
ACATCAACAGCATCAGGTTGACCCATGTCCTCTGAGGAAACTCTCGACTCCGTTCTCTCACACTGGCTTTTCTTTAACACCTGGTGGCTTCTCCTGCCTTTTATTATGCTGCTTGTAGTGGCTGCTTTTATTGTGGCATTCGTTCTGCTGTTGTACATGATATCACCGTTAATAAGCCCCAAGCCTCTCAAACTCAACGGTGCCCATGTGGTGGTAACTGGAGGCAGCAGCGGGATTGGGAAGTGTATTGCCATGGAATGTTACAAACATGGTGCCTTCATCACCTTGGTGGCACGAGATGAGGTGGTTCTTTGCATTTCTGTTGATGTGGCGAAAGACTACAGCCAAGTGGAGAGTGTCATAAAACAAGCTCAAGAGAAGCTGGGTCCTGTGGACATGCTGGTGAATTGTGCCGGGACATCATTATCTGGGAAGTTTGAGGAAGTGGAAGTTGACCATTTCAAGATTGTGACCATGGGCCTGTTCCGTACCATTGCTCTCTTCTATCTGGGCAGCTTTGACAGCATCGTCCGCCGTTGTATGATCCAGCGAGAACAGTGCAAAGCAGCTGACAAGAGGGAGTAGCACCAGCATTCCCCCCACCCATCCACCTCTATTGCCAACactacatttacacacatgcctCCACACACCACCTGCAAGACATTTTTCAGTGGGTTTACAATGTCATGCACTTCAGCGACAAAGTTTCTGCTATTTTTTTCCAGTATATTTTTCATGATGTGTATTTCAGGATCCTCATAATTTTCATCAGTATTTCAAG
>TCONS_00031998
GATTCTGTGTTTTGGTTCGTATACGTTAGTGAACAGAAGGAGTTAGAATTTGCGGTTTTATGgctttaacttaatatttaaccCTTCGCAAAAGCTTCTAATAGATCACCAGGTAACTGGAGGCAGCAGCGGGATTGGGAAGTGTATTGCCATGGAATGTTACAAACATGGTGCCTTCATCACCTTGGTGGCACGAGATGAGCACAAATTGGTTCAGGCTAAGAAAGAAGTGGAGAAGTTTGCCATAAATGATAAGCAAGT

Function

symbol description
kdsr Predicted to enable 3-dehydrosphinganine reductase activity. Acts upstream of or within several processes, including cellular sphingolipid homeostasis; platelet formation; and sphingomyelin biosynthetic process. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in endoplasmic reticulum membrane. Used to study liver disease and thrombocytopenia. Human ortholog(s) of this gene implicated in erythrokeratodermia variabilis et progressiva 4 and follicular lymphoma. Orthologous to human KDSR (3-ketodihydrosphingosine reductase).

GO:

id name namespace
GO:0090520 sphingolipid mediated signaling pathway biological_process
GO:0030148 sphingolipid biosynthetic process biological_process
GO:0006666 3-keto-sphinganine metabolic process biological_process
GO:0006686 sphingomyelin biosynthetic process biological_process
GO:0030220 platelet formation biological_process
GO:0090156 cellular sphingolipid homeostasis biological_process
GO:0005783 endoplasmic reticulum cellular_component
GO:0005789 endoplasmic reticulum membrane cellular_component
GO:0016020 membrane cellular_component
GO:0016021 integral component of membrane cellular_component
GO:0047560 3-dehydrosphinganine reductase activity molecular_function

KEGG:

id description
ko00600 Sphingolipid metabolism

ZFIN:

id description
ZDB-GENE-040426-853 Predicted to enable 3-dehydrosphinganine reductase activity. Acts upstream of or within several processes, including cellular sphingolipid homeostasis; platelet formation; and sphingomyelin biosynthetic process. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in endoplasmic reticulum membrane. Used to study liver disease and thrombocytopenia. Human ortholog(s) of this gene implicated in erythrokeratodermia variabilis et progressiva 4 and follicular lymphoma. Orthologous to human KDSR (3-ketodihydrosphingosine reductase).

Ensembl:

ensembl_id ENSDARG00000012021

RNA

RNA id representative length rna type GC content exon number start site end site
TCONS_00031996 False 2795 mRNA 0.42 10 13223755 13254821
TCONS_00031997 False 784 mRNA 0.47 5 13225020 13254594
TCONS_00031998 True 261 processed_transcript 0.41 3 13252152 13254797

Neighbor

gene id symbol gene type direction distance location
XLOC_016220 NA coding downstream 7486 13184227 ~ 13216269 (-)
XLOC_016219 BX908750.2 coding downstream 402224 12819999 ~ 12821531 (-)
XLOC_016218 NA coding downstream 519371 12703957 ~ 12704384 (-)
XLOC_016217 dpp6b coding downstream 590994 12406713 ~ 12632761 (-)
XLOC_016215 gpr158b coding downstream 980542 12104389 ~ 12243213 (-)
XLOC_016222 vps4b coding upstream 1165 13255986 ~ 13333991 (-)
XLOC_016223 nmur1b coding upstream 121278 13376099 ~ 13382726 (-)
XLOC_016224 NA coding upstream 295746 13550567 ~ 13573898 (-)
XLOC_016225 NA coding upstream 417291 13672112 ~ 13673864 (-)
XLOC_016226 CABZ01044235.1 coding upstream 433803 13688624 ~ 13691834 (-)
XLOC_016216 CR376724.1 non-coding downstream 999216 12224423 ~ 12224539 (-)
XLOC_016213 CT573433.1 non-coding downstream 1242450 11976261 ~ 11981305 (-)
XLOC_016227 CU657977.1 non-coding upstream 528572 13783393 ~ 13786658 (-)
XLOC_016228 NA non-coding upstream 620874 13875695 ~ 13877521 (-)
XLOC_016230 NA non-coding upstream 747574 14002395 ~ 14004942 (-)

Expression


Co-expression Network