XLOC_001793 (gdnfa)


Basic Information

Item Value
gene id XLOC_001793
gene name gdnfa
gene type coding
species zebrafish (Danio rerio)
category of species model fish

Chromosome Information

Item Value
chromosome id NC_007121.7
NCBI id CM002894.2
chromosome length 45420867
location 1396940 ~ 1414161 (+)
genome version GRCz11_2017_zebrafish_Genome

Sequence

>TCONS_00003592
GAGACGCGCGTGTGGATCATAACTGCGTTGagctgacagacacacacatatgatCGGTCTGCAGCTacattacgcacacacacacactctcaactGATCAAAGTGGATATTGGTGAACGTTCACCTGGATTTCTTCACCTGTGCGCAGGGTTTTGGAGGCAGAATGCGGCGCGTTTATATAGACACGGGAAACTATCAGAGTTAGTGCGGATtttggatgtgtgtttggatCCCGATGTCTTCATGTGAGCTGTTGCTGCAGCTGCTGATTTTCCCTTATTTTACAGACGCCGCGCGCGGCAGCATCACGGTCACGCGCGTCGCGTTGCGTTGCGCGCGGTGAGCTGAGCGACGCGCGCGTCTTCTGGACACTTGGATCTAGCGGATAACATGCTGTGAATGGACCTGGAACAGTGATATTTCTTGGATAACTCACGGATTTTATCTTTTGGATCTGTTCAATGTTTCCTGGTTTACTGAGAATTTGGCTTTTCTGAAGCTCCGGTCTGTATGGACCCCATTTAAGCTTCCCTCAAAGGAACTGAGTCTAAAATGAAGTTATGGGACATTCTAGCCACGTGTTTGTTGCTCCTGAGCTCCGTGTCCACACGTCCCCTTTTCCACAAACTGCAGCCATCCAAGAGAGCTGTGGTCCGCAGTGAGAGCCCCGCTCTGGACCCCATCATCGACTCCCAACCTGAAACCTCAAACCCAAAACAAGCCTCCATGGAGGAACAATATGACCTAACGGGACTGTACCCGGAGCAGTTCGAGGACGTAATGGACTTCATCGAAGCCACTCTGGGCCGCCTGCGCAGATCCTCAGACGTAGAACCTCAGATGAAGCGGGACAGGGTCCGACAGAAAGCAGCAGCAAACACGGAGAAATACGGAGGACGGGGACGAGGAGAGCGCAAGAGGAGCCGCGGACGGGCCCGGAGCAGAGACGACCGGGTCAAAGGTCAAGGGCGCGGCTGCCTACTTAAAGAGATCCATCTGAACGTCACAGACCTGGACTTGGGTTACAGGACCAAAGAGGAGCTGATCTTCCGCTACTGCAGCGGCCCGTGTCACGATGCCGAGACCAACTACGACAAGATCCTCAACAATCTCACCCACAACAAGAAGCTAGACAAGGACACGCCGTCCCGAACCTGCTGCCGGCCCATCGCATTCGACGACGACATCTCTTTTCTGGACGACAGCTTGGAGTATCACACGCTGAAGAAGCATTCCGCTAAAAAGTGTGCTTGCGTTTGACCGCACAGGAACAGGACTCTCTCTAGAAGAGAGCAGACGAGGGTGTTTTCAGTATTCACTTTGTTACCGAACCACGAGCATTCATACAGCAACAAACACCTGTTGTTTTGGTGGAATAAGGAAGCTTCAGTGGGATTATAATGTCAGAGAGACGCCGCCACGATGACAGCAGACTGCAAATCTTTAATATCCAGAAAGCTATCATtatatataaatagtatatatgaaaatgtatttattgagatttaattaagttattgttatttattgcaATCCATTGTATTAGAGTGTTTGTTTCTCTTATTTATTTgaggaggttttttttttgtttttttggattgTTGTTCTCTATCTTGGATGGTGCCAAATCGGAGCAGGTGTTTTTAAAGGAGCCGCTCGCTGTTGGTCATTTACTCAGCATCATGTTGTTTCAGCATCGTGGCATGTGGTTTAGTTTTTTCTGTCAAATGCAAAATGAGATTTGGGGCTCAAGATGAGGGCGTAGACACATTACAAAACCCTTgacaaaatatacagttgaagtcagaattattagcccccctgaattattagcgcccctgtttattcttttccccaatttctgtttaatggagggaagattgtttcagcacatttctgagcataatagttttaataactcatctctaataactgatttattttatctttgtcatgatgacagtaaataatattagactagatattcttcaagacacttctatacagcttaaagtgacatttaaaggcttcactagggtaattaggtgaactaggcaggttagggtaattaggcaagttattgtataatgatggtttgttctgcagattatcgaaaaaaaatattctagatatattttattctagccgaaataaaacaaataagactttctccagaagaaaaaatattatcagacatactgtaaaagtttccttgctctgttaaacattattgaggaaatatttaaaaagaaaaaaat

Function

symbol description
gdnfa Enables MAP kinase kinase kinase activity. Acts upstream of or within enteric nervous system development and protein-containing complex assembly. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in several structures, including brain; digestive system; eye; intermediate mesoderm; and lateral line system. Human ortholog(s) of this gene implicated in Hirschsprung's disease; Parkinsonism; congenital central hypoventilation syndrome; epilepsy; and pheochromocytoma. Orthologous to human GDNF (glial cell derived neurotrophic factor).

GO:

id name namespace
GO:0021784 postganglionic parasympathetic fiber development biological_process
GO:0048484 enteric nervous system development biological_process
GO:0048485 sympathetic nervous system development biological_process
GO:0065003 protein-containing complex assembly biological_process
GO:0072107 positive regulation of ureteric bud formation biological_process
GO:0001755 neural crest cell migration biological_process
GO:0030432 peristalsis biological_process
GO:0060688 regulation of morphogenesis of a branching structure biological_process
GO:0048255 mRNA stabilization biological_process
GO:0051584 regulation of dopamine uptake involved in synaptic transmission biological_process
GO:0032770 positive regulation of monooxygenase activity biological_process
GO:0045944 positive regulation of transcription by RNA polymerase II biological_process
GO:0090190 positive regulation of branching involved in ureteric bud morphogenesis biological_process
GO:0001656 metanephros development biological_process
GO:0001658 branching involved in ureteric bud morphogenesis biological_process
GO:0007422 peripheral nervous system development biological_process
GO:0031175 neuron projection development biological_process
GO:0043524 negative regulation of neuron apoptotic process biological_process
GO:0005576 extracellular region cellular_component
GO:0005615 extracellular space cellular_component
GO:0005515 protein binding molecular_function
GO:0042803 protein homodimerization activity molecular_function
GO:0004709 MAP kinase kinase kinase activity molecular_function
GO:0008083 growth factor activity molecular_function

KEGG: NA

ZFIN:

id description
ZDB-GENE-010226-1 Enables MAP kinase kinase kinase activity. Acts upstream of or within enteric nervous system development and protein-containing complex assembly. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in several structures, including brain; digestive system; eye; intermediate mesoderm; and lateral line system. Human ortholog(s) of this gene implicated in Hirschsprung's disease; Parkinsonism; congenital central hypoventilation syndrome; epilepsy; and pheochromocytoma. Orthologous to human GDNF (glial cell derived neurotrophic factor).

Ensembl:

ensembl_id ENSDARG00000039959

RNA

RNA id representative length rna type GC content exon number start site end site
TCONS_00003592 True 2258 mRNA 0.45 3 1396940 1414161

Neighbor

gene id symbol gene type direction distance location
XLOC_001792 unc5c coding upstream 289382 1052591 ~ 1107558 (+)
XLOC_001791 NA coding upstream 459898 859355 ~ 937042 (+)
XLOC_001790 CU694495.1 coding upstream 591581 805244 ~ 805359 (+)
XLOC_001789 NA coding upstream 600046 733787 ~ 796894 (+)
XLOC_001788 smad4a coding upstream 804080 573667 ~ 592860 (+)
XLOC_001794 NA coding downstream 124138 1538299 ~ 1540732 (+)
XLOC_001795 ora5 coding downstream 176443 1590604 ~ 1591103 (+)
XLOC_001796 sgsm1b coding downstream 224715 1638876 ~ 1675362 (+)
XLOC_001797 CU929183.1 coding downstream 250761 1664922 ~ 1665038 (+)
XLOC_001798 triap1 coding downstream 267357 1681518 ~ 1684882 (+)
XLOC_001786 NA non-coding upstream 853351 540293 ~ 543589 (+)
XLOC_001779 NA non-coding upstream 976048 419233 ~ 420892 (+)
XLOC_001799 NA non-coding downstream 283904 1698065 ~ 1713235 (+)
XLOC_001800 NA non-coding downstream 289744 1703905 ~ 1712770 (+)
XLOC_001803 NA non-coding downstream 490194 1904355 ~ 1921020 (+)

Expression


Co-expression Network

Homologous

species gene id symbol gene type chromosome NCBI id location
grasscarp (Ctenopharyngodon idella) CI01000168_00010773_00020973 GDNFA coding CI01000168 null 10678 ~ 21201 (-)