| Item | Value |
|---|---|
| gene id | XLOC_001801 |
| gene name | apc |
| gene type | coding |
| species | zebrafish (Danio rerio) |
| category of species | model fish |
| Item | Value |
|---|---|
| chromosome id | NC_007121.7 |
| NCBI id | CM002894.2 |
| chromosome length | 45420867 |
| location | 1849874 ~ 1893095 (+) |
| genome version | GRCz11_2017_zebrafish_Genome |
| symbol | description |
|---|---|
| apc | Predicted to enable beta-catenin binding activity; microtubule binding activity; and protein kinase regulator activity. Involved in somitogenesis. Acts upstream of or within several processes, including animal organ development; chordate embryonic development; and embryonic pectoral fin morphogenesis. Predicted to be located in several cellular components, including centrosome; kinetochore; and lateral plasma membrane. Predicted to be part of beta-catenin destruction complex. Is expressed in hypochord; nervous system; neural tube; and trigeminal placode. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); endometrial cancer (multiple); familial adenomatous polyposis 1; hereditary desmoid disease; and medulloblastoma. Orthologous to human APC (APC regulator of WNT signaling pathway). |
| id | name | namespace |
|---|---|---|
| GO:0090244 | Wnt signaling pathway involved in somitogenesis | biological_process |
| GO:0061380 | superior colliculus development | biological_process |
| GO:0001754 | eye photoreceptor cell differentiation | biological_process |
| GO:0001756 | somitogenesis | biological_process |
| GO:0055001 | muscle cell development | biological_process |
| GO:0031290 | retinal ganglion cell axon guidance | biological_process |
| GO:0003146 | heart jogging | biological_process |
| GO:0071599 | otic vesicle development | biological_process |
| GO:0016477 | cell migration | biological_process |
| GO:0031016 | pancreas development | biological_process |
| GO:0003157 | endocardium development | biological_process |
| GO:0030178 | negative regulation of Wnt signaling pathway | biological_process |
| GO:0031017 | exocrine pancreas development | biological_process |
| GO:0031018 | endocrine pancreas development | biological_process |
| GO:0001501 | skeletal system development | biological_process |
| GO:0006974 | cellular response to DNA damage stimulus | biological_process |
| GO:0003170 | heart valve development | biological_process |
| GO:0035050 | embryonic heart tube development | biological_process |
| GO:0043065 | positive regulation of apoptotic process | biological_process |
| GO:1905067 | negative regulation of canonical Wnt signaling pathway involved in heart development | biological_process |
| GO:0048565 | digestive tract development | biological_process |
| GO:0090090 | negative regulation of canonical Wnt signaling pathway | biological_process |
| GO:0007026 | negative regulation of microtubule depolymerization | biological_process |
| GO:1900052 | regulation of retinoic acid biosynthetic process | biological_process |
| GO:0007050 | cell cycle arrest | biological_process |
| GO:0070365 | hepatocyte differentiation | biological_process |
| GO:0007051 | spindle organization | biological_process |
| GO:0035118 | embryonic pectoral fin morphogenesis | biological_process |
| GO:0008285 | negative regulation of cell population proliferation | biological_process |
| GO:0061031 | endodermal digestive tract morphogenesis | biological_process |
| GO:0001889 | liver development | biological_process |
| GO:0055123 | digestive system development | biological_process |
| GO:0030855 | epithelial cell differentiation | biological_process |
| GO:0048920 | posterior lateral line neuromast primordium migration | biological_process |
| GO:0044030 | regulation of DNA methylation | biological_process |
| GO:0048384 | retinoic acid receptor signaling pathway | biological_process |
| GO:0033334 | fin morphogenesis | biological_process |
| GO:0022006 | zona limitans intrathalamica formation | biological_process |
| GO:0060041 | retina development in camera-type eye | biological_process |
| GO:0001947 | heart looping | biological_process |
| GO:0030917 | midbrain-hindbrain boundary development | biological_process |
| GO:0000281 | mitotic cytokinesis | biological_process |
| GO:0016055 | Wnt signaling pathway | biological_process |
| GO:0000776 | kinetochore | cellular_component |
| GO:0030426 | growth cone | cellular_component |
| GO:0005813 | centrosome | cellular_component |
| GO:0005634 | nucleus | cellular_component |
| GO:0030877 | beta-catenin destruction complex | cellular_component |
| GO:0016328 | lateral plasma membrane | cellular_component |
| GO:0005737 | cytoplasm | cellular_component |
| GO:0019887 | protein kinase regulator activity | molecular_function |
| GO:0008013 | beta-catenin binding | molecular_function |
| GO:0008017 | microtubule binding | molecular_function |
| id | description |
|---|---|
| ko00642 | Ethylbenzene degradation |
| ko04310 | Wnt signaling pathway |
| ko04390 | Hippo signaling pathway |
| ko04550 | Signaling pathways regulating pluripotency of stem cells |
| ko04810 | Regulation of actin cytoskeleton |
| ko05200 | Pathways in cancer |
| ko05206 | MicroRNAs in cancer |
| ko05210 | Colorectal cancer |
| ko05225 | Hepatocellular carcinoma |
| ko05226 | Gastric cancer |
| ko05217 | Basal cell carcinoma |
| ko05213 | Endometrial cancer |
| ko05224 | Breast cancer |
| ko05165 | Human papillomavirus infection |
| ko05010 | Alzheimer disease |
| ko05022 | Pathways of neurodegeneration - multiple diseases |
| ko04934 | Cushing syndrome |
| ko01009 | Protein phosphatases and associated proteins |
| ko03036 | Chromosome and associated proteins |
| ko04812 | Cytoskeleton proteins |
| id | description |
|---|---|
| ZDB-GENE-031112-7 | Predicted to enable beta-catenin binding activity; microtubule binding activity; and protein kinase regulator activity. Involved in somitogenesis. Acts upstream of or within several processes, including animal organ development; chordate embryonic development; and embryonic pectoral fin morphogenesis. Predicted to be located in several cellular components, including centrosome; kinetochore; and lateral plasma membrane. Predicted to be part of beta-catenin destruction complex. Is expressed in hypochord; nervous system; neural tube; and trigeminal placode. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); endometrial cancer (multiple); familial adenomatous polyposis 1; hereditary desmoid disease; and medulloblastoma. Orthologous to human APC (APC regulator of WNT signaling pathway). |
| ensembl_id | ENSDARG00000058868 |
| RNA id | representative | length | rna type | GC content | exon number | start site | end site |
|---|---|---|---|---|---|---|---|
| TCONS_00003600 | False | 8265 | mRNA | 0.49 | 16 | 1849874 | 1892146 |
| TCONS_00003601 | True | 9187 | mRNA | 0.47 | 15 | 1849874 | 1893095 |
| gene id | symbol | gene type | direction | distance | location |
|---|---|---|---|---|---|
| XLOC_001799 | NA | coding | upstream | 136639 | 1698065 ~ 1713235 (+) |
| XLOC_001800 | NA | coding | upstream | 137104 | 1703905 ~ 1712770 (+) |
| XLOC_001798 | triap1 | coding | upstream | 164992 | 1681518 ~ 1684882 (+) |
| XLOC_001796 | sgsm1b | coding | upstream | 174512 | 1638876 ~ 1675362 (+) |
| XLOC_001797 | CU929183.1 | coding | upstream | 184836 | 1664922 ~ 1665038 (+) |
| XLOC_001802 | C3AR1 | coding | downstream | 6500 | 1899595 ~ 1900662 (+) |
| XLOC_001803 | NA | coding | downstream | 11260 | 1904355 ~ 1921020 (+) |
| XLOC_001804 | NA | coding | downstream | 73762 | 1966857 ~ 1991468 (+) |
| XLOC_001805 | cntnap3 | coding | downstream | 282488 | 2175583 ~ 2393791 (+) |
| XLOC_001806 | NA | coding | downstream | 509213 | 2402308 ~ 2437908 (+) |
| XLOC_001794 | NA | non-coding | upstream | 309142 | 1538299 ~ 1540732 (+) |
| XLOC_001791 | NA | non-coding | upstream | 912832 | 859355 ~ 937042 (+) |
| XLOC_001807 | NA | non-coding | downstream | 606438 | 2499533 ~ 2504042 (+) |
| XLOC_001815 | FP085363.1 | non-coding | downstream | 795470 | 2688565 ~ 2688681 (+) |
| species | gene id | symbol | gene type | chromosome | NCBI id | location |
|---|---|---|---|---|---|---|
| grasscarp (Ctenopharyngodon idella) | CI01000178_00253091_00283195 | APC | coding | CI01000178 | null | 252119 ~ 284118 (+) |
| bowfin (Amia calva) | AMCG00010712 | NA | coding | CM030129.1 | CM030129.1 | 39813432 ~ 39834594 (+) |