XLOC_018359 (runx2b)


Basic Information

Item Value
gene id XLOC_018359
gene name runx2b
gene type coding
species zebrafish (Danio rerio)
category of species model fish

Chromosome Information

Item Value
chromosome id NC_007131.7
NCBI id CM002904.2
chromosome length 55201332
location 43994848 ~ 44090660 (-)
genome version GRCz11_2017_zebrafish_Genome

Sequence

>TCONS_00036131
CGCTGAGCGCACGGAGAGGGACTGACGGCGCTCCTTTCACGCAAACGGAGGACATACGGTGCTCTTTGGCTAATTTAGACTGTTGTGATGCGCATTCCCGTAGATCCCAGCGCCGGCCGGAGGTTCAGCCCGCCGGTGTCGGTGAAGATGAACGACGTGAACTCGAATGCAGGACCTCAGCAGCAGCAGGACGGCGCGGTGGTGCCCAGACTCCGCGCGCAGGAGAACCGCTCCATGGCCGAGATCATCGCCGATCACCCGGCCGAACTGGTGCGCACGGACAGTCCCAACTTTCTCTGCTCGGTTTTGCCTTCTCATTGGAGGTGTAATAAAACCCTACCGGTCGCGTTTAAGGTGGTGGCCCTGGGTGAGGTTCCCGATGGGACTGTGGTCACAGTGATGGCCGGAAATGATGAGAATTATTCAGCGGAGCTCAGGAATGCCTCAGGGGTTATGAAGAACCAGGTGGCCCGCTTCAATGACCTGCGCTTTGTGGGACGAAGCGGAAGAGGGAAGAGCTTCACCCTGACGATTACAGTATTCACAAACCCACCGCAAGTGGCCACTTACCACAGAGCCATTAAGGTCACGGTGGACGGACCGCGCGAGCCCAGGAGACACAGGCCGAAGCTGGATGACTCTCCGAAGGCCGGACTGTTCTCTGACCGTCTCAGTGAACTGGAGCGCATCCGTCAGACCACCATGAGGGTCACTGTGCCAACACAAACACCCAGACCCTCACTCAGCAGCCCCAACTCCTACACGCCGCAGGGCCAAACGCAGATTACAGATCCACGACAGGCTCAATCTTCCCCACCATGGTCATACGACCAGACATACCCATCGTACCTAAGTCCCATGGCCTCCCCGTCGGTTCACTCCACCACTCCGCTGTCGTCCAGCCGGGCCACGGGTCTGCCCTCCATCAGCGATGTGCCCAGACGTCTTCCAGGTTCGACAGACTTGAGTCCTTTCCCTGGCCAGTTTGAGCGCCAGTTCCCTGCCTTCTCCTCACTCACCGAGAGCCGCTTTTCCAGTCCCAGAATGCACTACCCGGCCACCTTCACCTACACGCCAACCCCGGTCACCACAGGCATGTCATTGGGCAGCGCTCATTACCACACGTACCTCCCGCCGCCGTACCCCGGATCCACCCAGAGCCAAAGCGGACCCTTCCAGAGCAGCAGCACCCCTTATCTCTATTACGGTGCTTCCTCCGGCTCCTACCAGTTCTCCATGGTTCCTGGAGGAGAGCGATCACCCACCCGCATGATGCCCCCCTGCACCAGCGCATCCACAGGGACCAGCCTGGTCAATCCCAACCTCCCGGTTCAGGCTGACGGAAGTGGAGGAGTGGAGGGAGATGGAAGTCATAGCAATTCCCCGACTCTGCTTAATCCTGCTGGAAGAATGGATGAAGGCGTTTGGAGGCCGTATTGATCAGACagtagaccttttttttttttcaatctgtaCTCTTCCACTCGCTATGGTGGATTGTTGTTGGATGTTGGTCGCCCAGCAGTCGAAACACAAAATATATCATTTCACAAATCTTTCAAAGGACGGAAAATATTGGAGAAAGTTAGATTGTTCAAATTAGACGGTGGAAAAAGAAACACCAGAAAACATCTCTGCTCATTACAATAATAGAAACTATCTTACaatttgtaatagttttaatagttctAATGTAAATTAGGTTTTAATGGAAGCTGAAATAGTCATAAGGAGTCTCCACTGGTAGTTCATTGCCTTCTATTTGTGGTAAAACCCATAAAACCTATTTTGCCGGAAATATAAACGGTTACTTTAATAGAAAATGTGCGTGCTGCCGtcggttaggacaaaaactccttttgaGTTTTTGATGAAAGATGTCTTTATCGCGTGTGTTGTTAGTTTATGATGTCTCTCATGATGTTTGGAGACAGTAAAATGTTTTTAgcataattttaatgttttagcCCTCTGGGGTTGCCAAATGCTCTGGTGTGTTTACTCACATGTTTTTCTGATGACAGTGAAAATACCTTAAGATACTTTGTTTGTCATTTTCATATTACAGATATGAGTAAGACatcatttaaaattgtttttaaaaagtatatcgTTTTTATTCCTGTGATTGAAAACCAggacatgctgcttaggtatgcTTTAAAGCATTGCTACTGGTCATGAGCTAGTTTAAGCTTGTTCTTAGGGTTGAAGATGGTTCTTAGATGGCCATGAGTTGGTTTAAACTGTTTCTTAGCTAGACATTAACTAGTTTAATCTGGTTCTTAGCTGGTTTAAACGATTTTTTAGCAAGTCATAAACTGGATTAATCTGGTTTTTAGCTGGTTCTTAGCTAGTAATTAACTGGTTTAATCTGGTTCTTAGCTGGTTTAAACTTCTTCTTAGCTAGACATTAACTGGTTTAATCTAGTTCTTAGCTGGTTTAGGATGGTTCTTAGCTAGTCATGAACTTAATTAATCTGGTTTTTAG
>TCONS_00036132
AACCACGGAGAGGCCAAATTTGGGAGCGAAAGTGGCGACCATGGCGTCCAACAGCCTGTTTAGTTCTGTGACCCCATGTCAGCAGAACTTCTTCTGGGATCCCAGCGCCGGCCGGAGGTTCAGCCCGCCGGTGTCGGTGAAGATGAACGACGTGAACTCGAATGCAGGACCTCAGCAGCAGCAGGACGGCGCGGTGGTGCCCAGACTCCGCGCGCAGGAGAACCGCTCCATGGCCGAGATCATCGCCGATCACCCGGCCGAACTGGTGCGCACGGACAGTCCCAACTTTCTCTGCTCGGTTTTGCCTTCTCATTGGAGGTGTAATAAAACCCTACCGGTCGCGTTTAAGGTGGTGGCCCTGGGTGAGGTTCCCGATGGGACTGTGGTCACAGTGATGGCCGGAAATGATGAGAATTATTCAGCGGAGCTCAGGAATGCCTCAGGGGTTATGAAGAACCAGGTGGCCCGCTTCAATGACCTGCGCTTTGTGGGACGAAGCGGAAGAGGGAAGAGCTTCACCCTGACGATTACAGTATTCACAAACCCACCGCAAGTGGCCACTTACCACAGAGCCATTAAGGTCACGGTGGACGGACCGCGCGAGCCCAGGAGACACAGGCCGAAGCTGGATGACTCTCCGAAGGCCGGACTGTTCTCTGACCGTCTCAGTGAACTGGAGCGCATCCGTCAGACCACCATGAGGGTCACTGTGCCAACACAAACACCCAGACCCTCACTCAGCAGCCCCAACTCCTACACGCCGCAGGGCCAAACGCAGATTACAGATCCACGACAGGCTCAATCTTCCCCACCATGGTCATACGACCAGACATACCCATCGTACCTAAGTCCCATGGCCTCCCCGTCGGTTCACTCCACCACTCCGCTGTCGTCCAGCCGGGCCACGGGTCTGCCCTCCATCAGCGATGTGCCCAGACGTCTTCCAGGTTCGACAGACTTGAGTCCTTTCCCTGGCCAGTTTGAGCGCCAGTTCCCTGCCTTCTCCTCACTCACCGAGAGCCGCTTTTCCAGTCCCAGAATGCACTACCCGGCCACCTTCACCTACACGCCAACCCCGGTCACCACAGGCATGTCATTGGGCAGCGCTCATTACCACACGTACCTCCCGCCGCCGTACCCCGGATCCACCCAGAGCCAAAGCGGACCCTTCCAGAGCAGCAGCACCCCTTATCTCTATTACGGTGCTTCCTCCGGCTCCTACCAGTTCTCCATGGTTCCTGGAGGAGAGCGATCACCCACCCGCATGATGCCCCCCTGCACCAGCGCATCCACAGGGACCAGCCTGGTCAATCCCAACCTCCCGGTTCAGGCTGACGGAAGTGGAGGAGTGGAGGGAGATGGAAGTCATAGCAATTCCCCGACTCTGCTTAATCCTGCTGGAAGAATGGATGAAGGCGTTTGGAGGCCGTATTGATCAGACagtagaccttttttttttttcaatctgtaCTCTTCCACTCGCTATGGTGGATTGTTGTTGGATGTTGGTCGCCCAGCAGTCGAAACACAAAATATATCATTTCACAAATCTTTCAAAGGACGGAAAATATTGGAGAAAGTTAGATTGTTCAAATTAGACGGTGGAAAAAGAAACACCAGAAAACATCTCTGCTCATTACAATAATAGAAACTATCTTACaatttgtaatagttttaatagttctAATGTAAATTAGGTTTTAATGG
>TCONS_00036133
AGCACTTCCCAAACTCATCAGACTGCAGCGCTGAGCGCACGGAGAGGGACTGACGGCGCTCCTTTCACGCAAACGGAGGACATACGGTGCTCTTTGGCTAATTTAGACTGTTGTGATGCGCATTCCCGTAGATCCCAGCGCCGGCCGGAGGTTCAGCCCGCCGGTGTCGGTGAAGATGAACGACGTGAACTCGAATGCAGGACCTCAGCAGCAGCAGGACGGCGCGGTGGTGCCCAGACTCCGCGCGCAGGAGAACCGCTCCATGGCCGAGATCATCGCCGATCACCCGGCCGAACTGGTGCGCACGGACAGTCCCAACTTTCTCTGCTCGGTTTTGCCTTCTCATTGGAGGTGTAATAAAACCCTACCGGTCGCGTTTAAGGTGGTGGCCCTGGGTGAGGTTCCCGATGGGACTGTGGTCACAGTGATGGCCGGAAATGATGAGAATTATTCAGCGGAGCTCAGGAATGCCTCAGGGGTTATGAAGAACCAGGTGGCCCGCTTCAATGACCTGCGCTTTGTGGGACGAAGCGGAAGAGGGAAGAGCTTCACCCTGACGATTACAGTATTCACAAACCCACCGCAAGTGGCCACTTACCACAGAGCCATTAAGGTCACGGTGGACGGACCGCGCGAGCCCAGGAGACACAGGCCGAAGCTGGATGACTCTCCGAAGGCCGGACTGTTCTCTGACCGTCTCAGTGAACTGGAGCGCATCCGTCAGACCACCATGAGGGTCACTGTGCCAACACAAACACCCAGACCCTCACTCAGCAGCCCCAACTCCTACACGCCGCAGGGCCAAACGCAGATTACAGATCCACGACAGGCTCAATCTTCCCCACCATGGTCATACGACCAGACATACCCATCGTACCTAAGTCCCATGGCCTCCCCGTCGGTTCACTCCACCACTCCGCTGTCGTCCAGCCGGGCCACGGGTCTGCCCTCCATCAGCGATGTGCCCAGACGTCTTCCAGGTTCGACAGACTTGAGTCCTTTCCCTGGCCAGTTTGAGCGCCAGTTCCCTGCCTTCTCCTCACTCACCGAGAGCCGCTTTTCCAGTCCCAGAATGCACTACCCGGCCACCTTCACCTACACGCCAACCCCGGTCACCACAGGCATGTCATTGGGCAGCGCTCATTACCACACGTACCTCCCGCCGCCGTACCCCGGATCCACCCAGAGCCAAAGCGGACCCTTCCAGAGCAGCAGCACCCCTTATCTCTATTACGGTGCTTCCTCCGGCTCCTACCAGTTCTCCATGGTTCCTGGAGGAGAGCGATCACCCACCCGCATGATGCCCCCCTGCACCAGCGCATCCACAGGGACCAGCCTGGTCAATCCCAACCTCCCGGTTCAGGCTGACGGAAGTGGAGGAGTGGAGGGAGATGGAAGTCATAGCAATTCCCCGACTCTGCTTAATCCTGCTGGAAGAATGGATGAAGGCGTTTGGAGGCCGTATTGATCAGACagtagaccttttttttttttcaatctgtaCTCTTCCACTCGCTATGGTGGATTGTTGTT
>TCONS_00036134
TAAAAGGCGTCAAGGGTCACCAGAAACCACGGAGAGGCCAAATTTGGGAGCGAAAGTGGCGACCATGGCGTCCAACAGCCTGTTTAGTTCTGTGACCCCATGTCAGCAGAACTTCTTCTGGGGTTCGACAGACTTGAGTCCTTTCCCTGGCCAGTTTGAGCGCCAGTTCCCTGCCTTCTCCTCACTCACCGAGAGCCGCTTTTCCAGTCCCAGAATGCACTACCCGGCCACCTTCACCTACACGCCAACCCCGGTCACCACAGGCATGTCATTGGGCAGCGCTCATTACCACACGTACCTCCCGCCGCCGTACCCCGGATCCACCCAGAGCCAAAGCGGACCCTTCCAGAGCAGCAGCACCCCTTATCTCTATTACGGTGCTTCCTCCGGCTCCTACCAGTTCTCCATGGTTCCTGGAGGAGAGCGATCACCCACCCGCATGATGCCCCCCTGCACCAGCGCATCCACAGGGACCAGCCTGGTCAATCCCAACCTCCCGGTTCAGGCTGACGGAAGTGGAGGAGTGGAGGGAGATGGAAGTCATAGCAATTCCCCGACTCTGCTTAATCCTGCTGGAAGAATGGATGAAGGCGTTTGGAGGCCGTATTGATCAGACagtagaccttttttttttttcaatctgtaCTCTTCCACTCGCTATGGTGGATTGTTGTT
>TCONS_00036135
GCACTCCTAACCTAAAAGGCGTCAAGGGTCACCAGAAACCACGGAGAGGCCAAATTTGGGAGCGAAAGTGGCGACCATGGCGTCCAACAGCCTGTTTAGTTCTGTGACCCCATGTCAGCAGAACTTCTTCTGGGGGAAGAGCTTCACCCTGACGATTACAGTATTCACAAACCCACCGCAAGTGGCCACTTACCACAGAGCCATTAAGGTCACGGTGGACGGACCGCGCGAGCCCAGGAGACACAGGCCGAAGCTGGATGACTCTCCGAAGGCCGGACTGTTCTCTGACCGTCTCAGTGAACTGGAGCGCATCCGTCAGACCACCATGAGGGTCACTGTGCCAACACAAACACCCAGACCCTCACTCAGCAGCCCCAACTCCTACACGCCGCAGGGCCAAACGCAGATTACAGATCCACGACAGGCTCAATCTTCCCCACCATGGTCATACGACCAGACATACCCATCGTACCTAAGTCCCATGGCCTCCCCGTCGGTTCACTCCACCACTCCGCTGTCGTCCAGCCGGGCCACGGGTCTGCCCTCCATCAGCGATGTGCCCAGACGTCTTCCAGGTTCGACAGACTTGAGTCCTTTCCCTGGCCAGTTTGAGCGCCAGTTCCCTGCCTTCTCCTCACTCACCGAGAGCCGCTTTTCCAGTCCCAGAATGCACTACCCGGCCACCTTCACCTACACGCCAACCCCGGTCACCACAGGCATGTCATTGGGCAGCGCTCATTACCACACGTACCTCCCGCCGCCGTACCCCGGATCCACCCAGAGCCAAAGCGGACCCTTCCAGAGCAGCAGCACCCCTTATCTCTATTACGGTGCTTCCTCCGGCTCCTACCAGTTCTCCATGGTTCCTGGAGGAGAGCGATCACCCACCCGCATGATGCCCCCCTGCACCAGCGCATCCACAGGGACCAGCCTGGTCAATCCCAACCTCCCGGTTCAGGCTGACGGAAGTGGAGGAGTGGAGGGAGATGGAAGTCATAGCAATTCCCCGACTCTGCTTAATCCTGCTGGAAGAATGGATGAAGGCGTTTGGAGGCCGTATTGATCAGACagtagaccttttttttttttcaatctgtaCTCTTCCACTCGCTATGGTGGATTGTTGTT

Function

symbol description
runx2b Enables DNA-binding transcription factor activity and vitamin D receptor binding activity. Acts upstream of or within chondrocyte differentiation; dorsal/ventral pattern formation; and positive regulation of transcription, DNA-templated. Predicted to be located in nucleus. Is expressed in several structures, including EVL; cranium; fin; osteoblast; and pharyngeal arch. Human ortholog(s) of this gene implicated in cleidocranial dysplasia and metaphyseal dysplasia-maxillary hypoplasia-brachydacty syndrome. Orthologous to human RUNX2 (RUNX family transcription factor 2).

GO:

id name namespace
GO:0030097 hemopoiesis biological_process
GO:0006355 regulation of transcription, DNA-templated biological_process
GO:0006357 regulation of transcription by RNA polymerase II biological_process
GO:0030182 neuron differentiation biological_process
GO:0001503 ossification biological_process
GO:0002062 chondrocyte differentiation biological_process
GO:0051216 cartilage development biological_process
GO:0045595 regulation of cell differentiation biological_process
GO:0009953 dorsal/ventral pattern formation biological_process
GO:0045893 positive regulation of transcription, DNA-templated biological_process
GO:0005634 nucleus cellular_component
GO:0005524 ATP binding molecular_function
GO:0003677 DNA binding molecular_function
GO:0042809 vitamin D receptor binding molecular_function
GO:0003700 DNA-binding transcription factor activity molecular_function
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific molecular_function

KEGG: NA

ZFIN:

id description
ZDB-GENE-040629-4 Enables DNA-binding transcription factor activity and vitamin D receptor binding activity. Acts upstream of or within chondrocyte differentiation; dorsal/ventral pattern formation; and positive regulation of transcription, DNA-templated. Predicted to be located in nucleus. Is expressed in several structures, including EVL; cranium; fin; osteoblast; and pharyngeal arch. Human ortholog(s) of this gene implicated in cleidocranial dysplasia and metaphyseal dysplasia-maxillary hypoplasia-brachydacty syndrome. Orthologous to human RUNX2 (RUNX family transcription factor 2).

Ensembl:

ensembl_id ENSDARG00000059233

RNA

RNA id representative length rna type GC content exon number start site end site
TCONS_00036131 False 2491 mRNA 0.49 8 43994848 44055095
TCONS_00036132 False 1707 mRNA 0.55 7 43996041 44090624
TCONS_00036133 False 1533 mRNA 0.58 6 43996248 44055123
TCONS_00036134 False 675 mRNA 0.56 2 43996248 44090648
TCONS_00036135 True 1128 mRNA 0.57 5 43996248 44090660

Neighbor

gene id symbol gene type direction distance location
XLOC_018358 mark3b coding downstream 77159 43792866 ~ 43917689 (-)
XLOC_018357 laptm4a coding downstream 208333 43775793 ~ 43786515 (-)
XLOC_018356 matn3a coding downstream 219304 43760059 ~ 43775544 (-)
XLOC_018355 ttc32 coding downstream 244077 43746523 ~ 43750771 (-)
XLOC_018354 zpax1 coding downstream 251148 43737022 ~ 43743700 (-)
XLOC_018360 NA coding upstream 2243 44092903 ~ 44095025 (-)
XLOC_018361 NA coding upstream 33143 44123803 ~ 44275988 (-)
XLOC_018362 NA coding upstream 255327 44345987 ~ 44361396 (-)
XLOC_018363 BX664630.1 coding upstream 258282 44348942 ~ 44349057 (-)
XLOC_018364 mut coding upstream 282085 44372745 ~ 44460789 (-)
XLOC_017928 CU539064.1 misc downstream 33941147 10053405 ~ 10053701 (-)
XLOC_018344 NA non-coding downstream 583241 43397723 ~ 43411607 (-)
XLOC_018345 AL928920.1 non-coding downstream 587343 43406707 ~ 43407505 (-)
XLOC_018342 AL845420.1 non-coding downstream 911781 43082949 ~ 43083067 (-)
XLOC_018339 AL845420.2 non-coding downstream 1027460 42967274 ~ 42967388 (-)
XLOC_018338 NA non-coding downstream 1142518 42849227 ~ 42852330 (-)
XLOC_018365 NA non-coding upstream 373685 44464345 ~ 44496245 (-)

Expression


Co-expression Network

Homologous

species gene id symbol gene type chromosome NCBI id location
grasscarp (Ctenopharyngodon idella) CI01000029_04246988_04247383 RUNX2B coding CI01000029 null 4245107 ~ 4249051 (-)