XLOC_021698 (casp9)


Basic Information

Item Value
gene id XLOC_021698
gene name casp9
gene type coding
species zebrafish (Danio rerio)
category of species model fish

Chromosome Information

Item Value
chromosome id NC_007134.7
NCBI id CM002907.2
chromosome length 46223584
location 24973773 ~ 24985272 (+)
genome version GRCz11_2017_zebrafish_Genome

Sequence

>TCONS_00043062
TGACGTCAGCGCAGGCATGATGTAAACAAGGAAGCGAATGGGAGCTGCTCGTATGAGGAcagttcatttttttatgttcattgCCGATCAGTTCAACATAATTCATCTTTACTGTGTTTGACGCGTTTACTGAGTATTATTGACACACATTAgcaaccaaaaatatatattgtttcgAAATCGTCGGAGTCATAAACACTGGAAACTCTTGTCAGAATGGAGCAGAAACACAGACAGATTCTTCAGCGGCACAGGTTAAACCTCGTCAAGGCATTGAATCCCGAAGACGTCTGTGATAAGCTTCTGTCAAAGGGGGTCTTCACTCAGGACATGATCGATGAAATACAGagcaaggcaacCAGACGTGACCAAGCCAGGCAACTGGTGAAAGACCTGGAGACGAGAGGAAGTCTTGCTTTCCCAGCCTTTCTTGATTCCCTGCGTGAGACTGGCCACAATGATCTTGCAGAGCTCCTTCAAAGCGGAGATGGTGTTCATCGCCCTCCTGTCATTTCTGTACAGCCTTCACCGATCCCTCTGCCAGTCCAAAATCTAAATCATACTGAAAAGCCAGACAAACCTGATATCGCTTCTCCACGATTAGTACCACTGAGACCTGAAAGCCTGCCGGTGCACAAGACATATAGTCCACCTTCTGAAACTGTGGTGAGACCAACCAGGCCAAGACGTGACAGTATACAGTGCTACAAGATGGATGCCAGTCCGTGTGGGGTCTGCTTGATCATAAACAATATCAACTTTGAAAAAGCCTCTGAACTAAATGACCGCAAGGGCTCCAACATCGACTGCGACAAGCTGGAGAAAAGATTTAAAGCGCTCAACTTTGAGGTTACAGTAAAAAGGAACTTGAAATCTAAACGCATAAGGCACGAGATGGCATCTTTAGCGAAGAAAGATCACTCTACATACGACTGCTGTGTGGTCATCATCCTTTCACATGGCACTGAGGCAAGCCATAATCGATTCCCTGGTGCAGTTCATGGTGTTGACGGACCGGCTGTCCCAATTCAGATAATCACAAACTACCTCAATGGCCAGAACTGTCCTTCTCTTCAGGGCAAGCCCAAGTTATTTTTCATCCAGGCCTGCGGAGGAGGTGAGAAGGATATTGGTTTTGAGGTTTCTCCAGATGACGTTCAACCATCTATAGGTGGGATAGATGACGAGATGGACGCTATTCCCATGTCCTCTAGCAGTGACTCTCTCAGcacagcgtctgatgaacttgATGCACGGGCAAGTTTGCCCACGCCCAGTGACATCCTGGTGTCCTACTCAACATTTCCAGGTTATGTCTCCTGGAGGGACACAGAGGCCGGCTCTTGGTATGTGGAGAATCTTGATCGTGTGCTGGAGGAAAACGCTATCACAGATGATCTGGTGACCATGCTGATGTTGGTAAATGATGCAGTCTCACAAATATCTGCCAAAGGCCTGTATAAACAAATGCCTGGGTCTTTCAACTTCCTCCGAAAACTTCTCTACTTTCAGTCTTCACAGTCATGATCAGTAAAGATTTGCATGATAATTGCTGTGCTGTGAGACCATTACCAtgtacctgaaaaaaaaaaaacatttgtatttttttttacctctaaCTGAGCCTTATGATTATGACATTTGACtgaagtatttgtttttattgtaattctgtttatttttacacttgcaaataattaataaaaagtaaactTCACAATCATAAacaattaa
>TCONS_00043063
ATGGACTCCAAACATCAGTGGAACCATTTAAACAACCcaagactttattttaattgaatgtttTCCATGTTGATTGCTATTTTTCAAACTATGGAACTGTCTATTGTTTGCTCCTGTAGGTGAGAAGGATATTGGTTTTGAGGTTTCTCCAGATGACGTTCAACCATCTATAGGTGGGATAGATGACGAGATGGACGCTATTCCCATGTCCTCTAGCAGTGACTCTCTCAGcacagcgtctgatgaacttgATGCACGGGCAAGTTTGCCCACGCCCAGTGACATCCTGGTGTCCTACTCAACATTTCCAGGTTATGTCTCCTGGAGGGACACAGAGGCCGGCTCTTGGTATGTGGAGAATCTTGATCGTGTGCTGGAGGAAAACGCTATCACAGATGATCTGGTGACCATGCTGATGTTGGTACGTCTTTGTCCTGTAAATCTTCTGAAGTTTGATTTATGTGATGGAAACTGCCACATATAGATgcattatacagtatatgcatcAATAATGATTAGAGCAATGTGTATATATTCTATACAGCtttatacaattataaataaCTATGTAGCTTattattaattgtgtaatttttcAATCTTACCTTGAGgtttaaagtctgtgtgtatgaaaacaaaaaaacatttatattttaaa

Function

symbol description
casp9 Predicted to enable cysteine-type endopeptidase activity involved in apoptotic signaling pathway and cysteine-type endopeptidase activity involved in execution phase of apoptosis. Acts upstream of or within several processes, including positive regulation of apoptotic process; regulation of collateral sprouting in absence of injury; and renal filtration. Predicted to be active in cytoplasm. Is expressed in gut; muscle cell; nervous system; and pharyngeal arch. Human ortholog(s) of this gene implicated in several diseases, including Parkinson's disease; colorectal cancer; lung non-small cell carcinoma; pancreatic cancer; and type 2 diabetes mellitus. Orthologous to human CASP9 (caspase 9).

GO:

id name namespace
GO:0042981 regulation of apoptotic process biological_process
GO:0006915 apoptotic process biological_process
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process biological_process
GO:0043065 positive regulation of apoptotic process biological_process
GO:0001822 kidney development biological_process
GO:0097205 renal filtration biological_process
GO:0006508 proteolysis biological_process
GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage biological_process
GO:0048696 regulation of collateral sprouting in absence of injury biological_process
GO:0005737 cytoplasm cellular_component
GO:0004197 cysteine-type endopeptidase activity molecular_function
GO:0016787 hydrolase activity molecular_function
GO:0008233 peptidase activity molecular_function
GO:0008234 cysteine-type peptidase activity molecular_function
GO:0097153 cysteine-type endopeptidase activity involved in apoptotic process molecular_function
GO:0097199 cysteine-type endopeptidase activity involved in apoptotic signaling pathway molecular_function
GO:0097200 cysteine-type endopeptidase activity involved in execution phase of apoptosis molecular_function

KEGG:

id description
ko04370 VEGF signaling pathway
ko04151 PI3K-Akt signaling pathway
ko04210 Apoptosis
ko04215 Apoptosis - multiple species
ko04115 p53 signaling pathway
ko04919 Thyroid hormone signaling pathway
ko05200 Pathways in cancer
ko05210 Colorectal cancer
ko05212 Pancreatic cancer
ko05215 Prostate cancer
ko05213 Endometrial cancer
ko05222 Small cell lung cancer
ko05223 Non-small cell lung cancer
ko05170 Human immunodeficiency virus 1 infection
ko05161 Hepatitis B
ko05160 Hepatitis C
ko05164 Influenza A
ko05162 Measles
ko05168 Herpes simplex virus 1 infection
ko05163 Human cytomegalovirus infection
ko05167 Kaposi sarcoma-associated herpesvirus infection
ko05169 Epstein-Barr virus infection
ko05130 Pathogenic Escherichia coli infection
ko05134 Legionellosis
ko05152 Tuberculosis
ko05145 Toxoplasmosis
ko05010 Alzheimer disease
ko05012 Parkinson disease
ko05014 Amyotrophic lateral sclerosis
ko05016 Huntington disease
ko05020 Prion disease
ko05022 Pathways of neurodegeneration - multiple diseases
ko05417 Lipid and atherosclerosis
ko05416 Viral myocarditis
ko01524 Platinum drug resistance
ko01009 Protein phosphatases and associated proteins
ko01002 Peptidases and inhibitors

ZFIN:

id description
ZDB-GENE-030825-5 Predicted to enable cysteine-type endopeptidase activity involved in apoptotic signaling pathway and cysteine-type endopeptidase activity involved in execution phase of apoptosis. Acts upstream of or within several processes, including positive regulation of apoptotic process; regulation of collateral sprouting in absence of injury; and renal filtration. Predicted to be active in cytoplasm. Is expressed in gut; muscle cell; nervous system; and pharyngeal arch. Human ortholog(s) of this gene implicated in several diseases, including Parkinson's disease; colorectal cancer; lung non-small cell carcinoma; pancreatic cancer; and type 2 diabetes mellitus. Orthologous to human CASP9 (caspase 9).

Ensembl:

ensembl_id ENSDARG00000004325

RNA

RNA id representative length rna type GC content exon number start site end site
TCONS_00043062 False 1734 mRNA 0.44 10 24973773 24985272
TCONS_00043063 True 658 processed_transcript 0.38 2 24983302 24984858

Neighbor

gene id symbol gene type direction distance location
XLOC_021697 nol9 coding upstream 2310 24954951 ~ 24971463 (+)
XLOC_021696 klhl21 coding upstream 34625 24926407 ~ 24939148 (+)
XLOC_021695 olfml3a coding upstream 176187 24789205 ~ 24797586 (+)
XLOC_021694 c1qtnf12 coding upstream 222838 24705424 ~ 24750935 (+)
XLOC_021693 kansl2 coding upstream 311823 24598910 ~ 24661950 (+)
XLOC_021699 arhgap4a coding downstream 4115 24989387 ~ 25015393 (+)
XLOC_021700 fam3a coding downstream 150586 25135858 ~ 25150288 (+)
XLOC_021701 si:dkey-151g10.3 coding downstream 187410 25172682 ~ 25204313 (+)
XLOC_021702 si:dkey-151g10.3 coding downstream 225681 25210953 ~ 25222673 (+)
XLOC_021703 erbb3b coding downstream 247139 25232411 ~ 25287666 (+)
XLOC_021691 BX957326.2 non-coding upstream 412900 24556455 ~ 24560873 (+)
XLOC_021689 NA non-coding upstream 481736 24483312 ~ 24492037 (+)
XLOC_021687 CR925709.3 non-coding upstream 825002 24148055 ~ 24148771 (+)
XLOC_021686 NA non-coding upstream 833363 24133781 ~ 24140410 (+)
XLOC_021683 dre-mir-7149 non-coding upstream 899618 24074083 ~ 24074155 (+)
XLOC_021714 AL845287.1 non-coding downstream 1009755 25995027 ~ 25995141 (+)
XLOC_021722 NA non-coding downstream 1605852 26591124 ~ 26625133 (+)
XLOC_021724 CT573349.1 non-coding downstream 1943471 26928743 ~ 26928858 (+)
XLOC_021731 NA non-coding downstream 2523595 27508867 ~ 27516273 (+)
XLOC_021738 NA non-coding downstream 2885467 27870739 ~ 27872705 (+)

Expression


Co-expression Network