XLOC_021834 (sars1)


Basic Information

Item Value
gene id XLOC_021834
gene name sars1
gene type coding
species zebrafish (Danio rerio)
category of species model fish

Chromosome Information

Item Value
chromosome id NC_007134.7
NCBI id CM002907.2
chromosome length 46223584
location 34030550 ~ 34043651 (+)
genome version GRCz11_2017_zebrafish_Genome

Sequence

>TCONS_00043290
ATTCCTCCACACTTTTTGGATTTTCCTTTCCTCCTCCATTCATCCGCACCGCGCACCTCGTCTACAGGCATAATGGTGCTCGATTTAGACCTGTTTCGCACCGACAAAGGCGGCGATCCTGAAATTATCCGGGAAACTCAGAGGAAACGGTTCAAAGATGTGTCTCTGGTGGATAAACTGGTCCAGGCGGACACAGAATGGAGAAAATGTCGTTTCACAGCAGATAACCTTAACAAGGCCAAGAATCTCTGCAGCAAATCCATCGGTGAAAAGATGAAGAAGAAAGAGCCAGTAGGGGATGATGACACTCTTCCAGAAGAGGCTCAGAATCTGGAAGCCCTCACTGCAGAAACGTTATCGCCGCTTACTGTGACTCAGATAAAGAAAGTGCGGGTTCTGGTGGATGAGGCTGTGCAGAAGACAGACAGTGACCGGCTGAAGCTGGAGGCAGAGCGCTTTGAGTATCTGCGAGAGATCGGCAACCTCCTACATCCCTCTGTGCCCATCAGCAACGATGAGGATGCTGATAATAAAGTGGAGCGCACCTGGGGTGACTGCACGGTGCAGAAGAAGTACTCTCATGTGGACCTGGTCGTCATGGTTGATGGATATGAGGGGGAAAAAGGAGCCATTGTTGCTGGAAGCAGAGGATACTTTCTCAAGgGGCCTTTAGTGTTCTTGGAGCAAGCTTTGATTAACTATGCGCTGCGGATCCTGTACAGCAAGAACTACAACCTCCTGTACACACCCTTCTTCATGAGGAAAGAAGTCATGCAGGAGGTCGCTCAGCTCAGCCAGTTTGACGAGGAGCTCTACAAGGTGATCGGGAAAGGAAGTGAGAAGTCTGATGATAACACAGTGGACGAGAAGTACTTGATTGCCACATCAGAGCAGCCAATCGCAGCCTTCCTGAGAGATGAGTGGCTGAAGCCAGAAGAACTTCCTATCCGCTACGCTGGCCTCTCCACCTGCTTCAGACAGGAAGTGGGCTCTCATGGCAGAGACACGCGCGGGATCTTCAGGGTCCATCAGTTTGAGAAGATTGAGCAGTTTGTGTACGCCTCTCCTCATGATGGCAAATCCTGGGAGATGTTTGATGAAATGATTGGAACCGCTGAATCCTTTTATCAAACATTAGGAATTCCTTATCGAATTGTCAACATCGTGTCAGGTGCTTTGAACCACGCAGCTAGTAAAAAGCTGGATTTAGAGGCTTGGTTTCCTGGTTCCCAGGCTTTTAGAGAGCTTGTGTCATGCTCAAACTGTACAGACTATCAGGCTCGTCGCTTGCGGATTCGATACGGGCAAACTAAGAAAATGATGGACAAGGCTGAGTTTGTGCACATGCTCAATGCCACCATGTGTGCGACCACTCGTGTCATCTGTGCCATCCTGGAGAACTTCCAAACAGAGGAAGGCATCATTGTTCCAGAACCCCTCAAGGCATTCATGCCTCCAGgtttaacagaaataattaagTTTGTGAAGCCAGCCCCCATTGACCAGGAAACCACAAAGAAGCAGAAGAAACAGCAGGAAGGAGGAAAGAAGAAGAAACATCAGGGCGGCGATGCTGATCTAGAGAACAAAGTGGAGAACATGTCTGTCAATGACTCTTAGACACGCCCTCCACAGTCTCATCCAATCATATTGGTTCACAGGTTCTTCATTTCGTGTAACCTGATCACAATTGCTGTCCCCTGGAGCTCTCACTTTTTCATCCAGGACAGTCCTACTGGAACTAAAGGTGATGCTGTCATGCTTATAATCTTATCTCATATCAACCAATCATTTTCATGCCAAGGGGTCTTTagaaatattcaattaaatgCATGGTGACAAGACATTTAGCCATTAGACTGAAATGCTTTTACAGCACTTTAATTTCCTGAAGGCACTGCATTTCAAACCTGCCAATGAATTAAAGGGAACATGACAGTCAGTACTGGGATTAGAGGTGGGAGTTTTCGAACATTCTGGAAATTGGTTATGATAACGGACAGACCTCTTTCAATATCCTGTCTTATAATTAACATTTGTGCTATATTTCAAGTAGAGGTAATCATTGATTACTGTGCACCTAACATTCACATCGTCACAACAGTTAAAGCCAGCAGAATGCAGCTTTCCATCACGTCCATCACGTCTTTCCTTCATAGAAATATTTCTTTTCGTGATTTGTCTGTAAAAGAGGAAATGTTATTATATGTACAGTACTAACTAAAGATGCTTTgtgtgaggaggaggaggaggacggcATTTGAGAATAAATCAATACCTGAAGGA
>TCONS_00043291
TGAATTAAGTTGATTTTCATTACAGTTAGACCTTAGCACAAAGTCAAAATGACTCTGTTATGAATCCCACAACCTCTCTTTCCAGATTGAGCAGTTTGTGTACGCCTCTCCTCATGATGGCAAATCCTGGGAGATGTTTGATGAAATGATTGGAACCGCTGAATCCTTTTATCAAACATTAGGAATTCCTTATCGAATTGTCAACATCGTGTCAGGTGCTTTGAACCACGCAGCTAGTAAAAAGCTGGATTTAGAGGCTTGGTTTCCTGGTTCCCAGGCTTTTAGAGAGCTTGTGTCATGCTCAAACTGTACAGACTATCAGGCTCGTCGCTTGCGGATTCGATACGGGCAAACTAAGAAAATGATGGACAAGGCTGAGTTTGTGCACATGCTCAATGCCACCATGTGTGCGACCACTCGTGTCATCTGTGCCATCCTGGAGAACTTCCAAACAGAGGAAGGCATCATTGTTCCAGAACCCCTCAAGGCATTCATGCCTCCAGgtttaacagaaataattaagTTTGTGAAGCCAGCCCCCATTGACCAGGAAACCACAAAGAAGCAGAAGAAACAGCAGGAAGGAGGAAAGAAGAAGAAACATCAGGGCGGCGATGCTGATCTAGAGAACAAAGTGGAGAACATGTCTGTCAATGACTCTTAGACACGCCCTCCACAGTCTCATCCAATCATATTGGTTCACAGGTTCTTCATTTCGTGTAACCTGATCACAATTGCTGTCCCCTGGAGCTCTCACTTTTTCATCCAGGACAGTCCTACTGGAACTAAAGGTGATGCTGTCATGCTTATAATCTTATCTCATATCAACCAATCATTTTCATGCCAAGGGGTCTTTagaaatattcaattaaatgCATGGTGACAAGACATTTAGCCATTAGACTGAAATGCTTTTACAGCACTTTAATTTCCTGAAGGCACTGCATTTCAAACCTGCCAATGAATTAAAGGGAACATGAC

Function

symbol description
sars1 Enables serine-tRNA ligase activity. Involved in negative regulation of sprouting angiogenesis; negative regulation of vascular endothelial growth factor production; and seryl-tRNA aminoacylation. Acts upstream of or within branching involved in blood vessel morphogenesis; cerebellum vasculature development; and negative regulation of angiogenesis. Located in nucleus. Is expressed in several structures, including alar plate midbrain region; immature eye; liver; midbrain; and musculature system. Used to study arteriovenous malformations of the brain. Human ortholog(s) of this gene implicated in intellectual disability. Orthologous to human SARS1 (seryl-tRNA synthetase 1).

GO:

id name namespace
GO:1903671 negative regulation of sprouting angiogenesis biological_process
GO:0006412 translation biological_process
GO:0006418 tRNA aminoacylation for protein translation biological_process
GO:0000122 negative regulation of transcription by RNA polymerase II biological_process
GO:0001525 angiogenesis biological_process
GO:1901342 regulation of vasculature development biological_process
GO:0006434 seryl-tRNA aminoacylation biological_process
GO:0016525 negative regulation of angiogenesis biological_process
GO:1904046 negative regulation of vascular endothelial growth factor production biological_process
GO:0001569 branching involved in blood vessel morphogenesis biological_process
GO:0061300 cerebellum vasculature development biological_process
GO:0001944 vasculature development biological_process
GO:0005829 cytosol cellular_component
GO:0005634 nucleus cellular_component
GO:0005737 cytoplasm cellular_component
GO:0000049 tRNA binding molecular_function
GO:0004812 aminoacyl-tRNA ligase activity molecular_function
GO:0005524 ATP binding molecular_function
GO:0004828 serine-tRNA ligase activity molecular_function
GO:0003677 DNA binding molecular_function
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding molecular_function
GO:0000166 nucleotide binding molecular_function
GO:0016874 ligase activity molecular_function

KEGG: NA

ZFIN:

id description
ZDB-GENE-040831-1 Enables serine-tRNA ligase activity. Involved in negative regulation of sprouting angiogenesis; negative regulation of vascular endothelial growth factor production; and seryl-tRNA aminoacylation. Acts upstream of or within branching involved in blood vessel morphogenesis; cerebellum vasculature development; and negative regulation of angiogenesis. Located in nucleus. Is expressed in several structures, including alar plate midbrain region; immature eye; liver; midbrain; and musculature system. Used to study arteriovenous malformations of the brain. Human ortholog(s) of this gene implicated in intellectual disability. Orthologous to human SARS1 (seryl-tRNA synthetase 1).

Ensembl:

ensembl_id ENSDARG00000008237

RNA

RNA id representative length rna type GC content exon number start site end site
TCONS_00043290 False 2286 mRNA 0.46 11 34030550 34043651
TCONS_00043291 True 981 lncRNA 0.43 4 34039394 34043302

Neighbor

gene id symbol gene type direction distance location
XLOC_021832 fam50a coding upstream 6918 33987382 ~ 34023632 (+)
XLOC_021833 AL954678.1 coding upstream 27677 34002757 ~ 34002873 (+)
XLOC_021831 NA coding upstream 47118 33978711 ~ 33983432 (+)
XLOC_021830 plpbp coding upstream 54434 33963619 ~ 33976116 (+)
XLOC_021829 snrpg coding upstream 68561 33957350 ~ 33961989 (+)
XLOC_021835 chchd6a coding downstream 3762 34047413 ~ 34185019 (+)
XLOC_021836 plxna1a coding downstream 277586 34321237 ~ 34753811 (+)
XLOC_021837 NA coding downstream 721292 34764943 ~ 34768352 (+)
XLOC_021838 CR352218.1 coding downstream 806064 34849715 ~ 34987363 (+)
XLOC_021839 NA coding downstream 902796 34946447 ~ 34948499 (+)
XLOC_021826 CR381531.1 non-coding upstream 200360 33828665 ~ 33830190 (+)
XLOC_021824 CR354542.1 non-coding upstream 269885 33759747 ~ 33760665 (+)
XLOC_021821 CT027694.1 non-coding upstream 492381 33538051 ~ 33538169 (+)
XLOC_021841 CU459147.1 non-coding downstream 1152089 35195740 ~ 35208386 (+)
XLOC_021843 NA non-coding downstream 1441243 35484894 ~ 35487575 (+)

Expression


Co-expression Network