XLOC_002624 (dbh)


Basic Information

Item Value
gene id XLOC_002624
gene name dbh
gene type coding
species zebrafish (Danio rerio)
category of species model fish

Chromosome Information

Item Value
chromosome id NC_007121.7
NCBI id CM002894.2
chromosome length 45420867
location 10564261 ~ 10607118 (-)
genome version GRCz11_2017_zebrafish_Genome

Sequence

>TCONS_00004881
CGCAGATCTCCAGCATTCAGACTGTCAATACGAGCCCACACACTCGCTCAAGCTGCCAATTTAATGCTAACCTGCCAACAGACATTCACTGGAGCTCTGCAAATAGCCtttgtgaacgtgtgtgtgtggtgtttctcACAGGGCGATGCTCTGCTCACGACGTGCAGATTCAACACCGAGGACAGAAGCAAAGTTACTGTGGGTGGTTTTGGAATTATGGAGGAGATGTGCGTCAATTACGTCCATTATTACCCCCGAACGCAACTTGAGCTGTGCAAAAGCCACGTGGACACAGATTACCTGCAGAAATACTTCAGCCTCATCAACagGTTTCAGGGCCGCGAGAGCTGCAGTTGTCCTCAGACCTCTGTGGAAGAACAGTTCTCCTCAGTGTCCTGGGACAGTTTCAGTGGAGAGGTGCTGAACTCGCTCTACGTCACAGCACCATTTTCAATGCACTGCAACCAGTCCACAGCGCAGCTCTTTCCTGGTGACTGGGAGAAGCAGGAGATCCCGGTGGTGACAGCGCAGCTTCAGAGAGCCCCATACCCATGTGAAATAAACAGGAGAGTGGCTTCTAATAATGACAGCCCTACAGAGGTGCGAGCGGACAGCAGCGGCTGATCTGCACCTTTACCATCTGAAGCTCGATAACAGATCCACACAGCGGCCCGCTCATTACACTCTCCACAATTAATTACTCAATAACTGCTTTGTGTTTAGACTGTTATTGAAGACTATGTTACGATTCGCATGAGAAcactaaaaaaaactatttattcttagaaattatcatttaattgtgcaaaatatgataaaaatacaGCAAGCAGCagctactgcaaaaaaaaaccaaaa
>TCONS_00004882
TGAGAGAATCTGTTTAGGGAAGCCTTACTATCAAGGAAAAACTTAGAAAGGCCTTCAAAAATGCGTCTCATAAACAAAGACCTCCGGCTCCAAGACGTAACCCTGATGTACCTCACCGTTTTAGCCACTGTGGTGGTGCTTTTAGTGGCATCCTACCAGGCTCCTGCGGGCCAATCCAGACCCACCCTGGCCTATCATATCCCGCTGGATCCGTCAGGACAGCTGGAACTGTCCTGGAACATCAGTTATCCCAAGCAGGAGGTTTTGCTCGAGGTCAAAGTCAAAGAGCTCCATCATGGCATTATTCTGGGCATGTCTGATCGTGGAGAGCCTACGAATGCTGATTTGGTGATTCTGTGGGATGACGGTCACAAATCCTATTTTGGGGATGCGTGGAGTGACAGTGAAGGCAGAGTGACACTGGACACTCAACAGGACTATCAGCTGCTGGAAACCCATCAGTCCACTGAAGGCTTCTTTCTGCTCTTCAAAAGATCATTCAGCACCTGTGACCCACACGACTACATCATAGAGGAAGGCACTGTCCACATAATCTACACCATGCTGGAGCATCCCATCCTATCGTTGCATGAGCTCAATATATCCCGTCTCCAGCCTGGCGTCCAGCGAGTCCTGCTCCTGCGTCCAGACACCCCGTCCCCCCATCTCCCGAAAGATGTACGCACCCTGGAGGTCCTGGCCCCTGATGTCATCATCCCCACACAAGAGACTACTTACTGGTGCCATATCTATCAGCTCCCGCCAAATCTGCCCAAGAACCACATTGTCATGtatGAGTCAGTGATCACTCCAGGTAATGAAGCCATTGTTCATCACATTGAAGTGTTCGAATGCTCCCCTCAGATGGACATCGTACCACAGTACAGCGGCTCCTGTGATTCAAAGATGAAGCCGCGCAATCTTAATTATTGCAGACATGTTCTGGCTGCCTGGGCCATGGGAGCAGAGCCATTCTACTATCCTGCTGACGCTGGTTTGCCTATGGGAGGAGAAGGATCTTCTAGGTTTCTTCGTCTTGAAGTTCATTACCACAACCCTCTCCTTTTATCAGGGCGGAGGGACTCCTCGGGCATTCGTTTATGGTACAGTCCATCTCTGCGGAGGTTTGACGCAGGCATCATGGAGCTTGGGCTGGTCTACACTCCTGTGATGGCCATTCCCCCCCGCCAGCGCTCTTTCCAGCTCACTGGATACTGCACCGCCAAATGCACACAGACGGCTCTTCCAGTAGGGGGCATACACATCTTTGCCTCCCAGCTGCACACTCATCTGGCCGGTCTTGGGGTCAGGACTGTCTTGGTGCGAGGAGGTCAAGAGGTGGAGGTGGTGCAGGAGGACAAACATTTCAGCACACATTACCAGATCATCCGTGTTTTACAGAAGATGGTGACTGTTCTGCCAGGCGATGCTCTGCTCACGACGTGCAGATTCAACACCGAGGACAGAAGCAAAGTTACTGTGGGTGGTTTTGGAATTATGGAGGAGATGTGCGTCAATTACGTCCATTATTACCCCCGAACGCAACTTGAGCTGTGCAAAAGCCACGTGGACACAGATTACCTGCAGAAATACTTCAGCCTCATCAACagGTTTCAGGGCCGCGAGAGCTGCAGTTGTCCTCAGACCTCTGTGGAAGAACAGTTCTCCTCAGTGTCCTGGGACAGTTTCAGTGGAGAGGTGCTGAACTCGCTCTACGTCACAGCACCATTTTCAATGCACTGCAACCAGTCCACAGCGCAGCTCTTTCCTGGTGACTGGGAGAAGCAGGAGATCCCGGTGGTGACAGCGCAGCTTCAGAGAGCCCCATACCCATGTGAAATAAACAGGAGAGTGGCTTCTAATAATGACAGCCCTACAGAGGTGCGAGCGGACAGCAGCGGCTGATCTGCACCTTTACCATCTGAAGCTCGATAACAGATCCACACAGCGGCC

Function

symbol description
dbh Predicted to enable copper ion binding activity and dopamine beta-monooxygenase activity. Acts upstream of or within sleep. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in extracellular space and secretory granule membrane. Is expressed in endocrine system; head; interrenal primordium; and nervous system. Human ortholog(s) of this gene implicated in several diseases, including alcohol use disorder; attention deficit hyperactivity disorder; dopamine beta-hydroxylase deficiency; hypertension; and migraine with aura. Orthologous to human DBH (dopamine beta-hydroxylase).

GO:

id name namespace
GO:0048731 system development biological_process
GO:0009259 ribonucleotide metabolic process biological_process
GO:1902600 proton transmembrane transport biological_process
GO:0042420 dopamine catabolic process biological_process
GO:0042421 norepinephrine biosynthetic process biological_process
GO:0046034 ATP metabolic process biological_process
GO:0030431 sleep biological_process
GO:0006091 generation of precursor metabolites and energy biological_process
GO:0031290 retinal ganglion cell axon guidance biological_process
GO:0009060 aerobic respiration biological_process
GO:0001501 skeletal system development biological_process
GO:0042773 ATP synthesis coupled electron transport biological_process
GO:0042775 mitochondrial ATP synthesis coupled electron transport biological_process
GO:0006119 oxidative phosphorylation biological_process
GO:0007275 multicellular organism development biological_process
GO:0006123 mitochondrial electron transport, cytochrome c to oxygen biological_process
GO:0043062 extracellular structure organization biological_process
GO:0030198 extracellular matrix organization biological_process
GO:0030199 collagen fibril organization biological_process
GO:0022900 electron transport chain biological_process
GO:0022904 respiratory electron transport chain biological_process
GO:0006163 purine nucleotide metabolic process biological_process
GO:0017144 drug metabolic process biological_process
GO:0009117 nucleotide metabolic process biological_process
GO:0097435 supramolecular fiber organization biological_process
GO:0009123 nucleoside monophosphate metabolic process biological_process
GO:0009124 nucleoside monophosphate biosynthetic process biological_process
GO:0009126 purine nucleoside monophosphate metabolic process biological_process
GO:0009127 purine nucleoside monophosphate biosynthetic process biological_process
GO:0055086 nucleobase-containing small molecule metabolic process biological_process
GO:0019637 organophosphate metabolic process biological_process
GO:0006753 nucleoside phosphate metabolic process biological_process
GO:0006754 ATP biosynthetic process biological_process
GO:0019646 aerobic electron transport chain biological_process
GO:0009141 nucleoside triphosphate metabolic process biological_process
GO:0009142 nucleoside triphosphate biosynthetic process biological_process
GO:0009144 purine nucleoside triphosphate metabolic process biological_process
GO:0009145 purine nucleoside triphosphate biosynthetic process biological_process
GO:0009150 purine ribonucleotide metabolic process biological_process
GO:1901135 carbohydrate derivative metabolic process biological_process
GO:0009156 ribonucleoside monophosphate biosynthetic process biological_process
GO:0072521 purine-containing compound metabolic process biological_process
GO:0055114 oxidation-reduction process biological_process
GO:0072522 purine-containing compound biosynthetic process biological_process
GO:0009161 ribonucleoside monophosphate metabolic process biological_process
GO:0009167 purine ribonucleoside monophosphate metabolic process biological_process
GO:0009168 purine ribonucleoside monophosphate biosynthetic process biological_process
GO:0015980 energy derivation by oxidation of organic compounds biological_process
GO:0015985 energy coupled proton transport, down electrochemical gradient biological_process
GO:0019693 ribose phosphate metabolic process biological_process
GO:0015986 ATP synthesis coupled proton transport biological_process
GO:0009199 ribonucleoside triphosphate metabolic process biological_process
GO:0009201 ribonucleoside triphosphate biosynthetic process biological_process
GO:0009205 purine ribonucleoside triphosphate metabolic process biological_process
GO:0009206 purine ribonucleoside triphosphate biosynthetic process biological_process
GO:0045333 cellular respiration biological_process
GO:0006589 octopamine biosynthetic process biological_process
GO:0030667 secretory granule membrane cellular_component
GO:0098803 respiratory chain complex cellular_component
GO:0005743 mitochondrial inner membrane cellular_component
GO:0005746 mitochondrial respirasome cellular_component
GO:0005751 mitochondrial respiratory chain complex IV cellular_component
GO:0005753 mitochondrial proton-transporting ATP synthase complex cellular_component
GO:0044421 obsolete extracellular region part cellular_component
GO:0044429 obsolete mitochondrial part cellular_component
GO:0016469 proton-transporting two-sector ATPase complex cellular_component
GO:0044455 obsolete mitochondrial membrane part cellular_component
GO:0031012 extracellular matrix cellular_component
GO:0062023 collagen-containing extracellular matrix cellular_component
GO:0019866 organelle inner membrane cellular_component
GO:0098643 banded collagen fibril cellular_component
GO:0098644 complex of collagen trimers cellular_component
GO:0005576 extracellular region cellular_component
GO:0070069 cytochrome complex cellular_component
GO:0005581 collagen trimer cellular_component
GO:0005583 fibrillar collagen trimer cellular_component
GO:0005615 extracellular space cellular_component
GO:0031090 organelle membrane cellular_component
GO:0045259 proton-transporting ATP synthase complex cellular_component
GO:0045263 proton-transporting ATP synthase complex, coupling factor F(o) cellular_component
GO:0045277 respiratory chain complex IV cellular_component
GO:0031966 mitochondrial membrane cellular_component
GO:0031967 organelle envelope cellular_component
GO:0031975 envelope cellular_component
GO:0016020 membrane cellular_component
GO:0016021 integral component of membrane cellular_component
GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o) cellular_component
GO:0070469 respirasome cellular_component
GO:0098796 membrane protein complex cellular_component
GO:0098798 mitochondrial protein-containing complex cellular_component
GO:0005737 cytoplasm cellular_component
GO:0005739 mitochondrion cellular_component
GO:0098800 inner mitochondrial membrane protein complex cellular_component
GO:0005740 mitochondrial envelope cellular_component
GO:0016715 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen molecular_function
GO:0004497 monooxygenase activity molecular_function
GO:0004500 dopamine beta-monooxygenase activity molecular_function
GO:0005507 copper ion binding molecular_function
GO:0019829 ATPase-coupled cation transmembrane transporter activity molecular_function
GO:0009055 electron transfer activity molecular_function
GO:0022853 active ion transmembrane transporter activity molecular_function
GO:0022857 transmembrane transporter activity molecular_function
GO:0044769 ATPase activity, coupled to transmembrane movement of ions, rotational mechanism molecular_function
GO:0022890 inorganic cation transmembrane transporter activity molecular_function
GO:0015002 heme-copper terminal oxidase activity molecular_function
GO:0005198 structural molecule activity molecular_function
GO:0046933 proton-transporting ATP synthase activity, rotational mechanism molecular_function
GO:0005201 extracellular matrix structural constituent molecular_function
GO:0015318 inorganic molecular entity transmembrane transporter activity molecular_function
GO:0005215 transporter activity molecular_function
GO:0015075 ion transmembrane transporter activity molecular_function
GO:0015077 monovalent inorganic cation transmembrane transporter activity molecular_function
GO:0015078 proton transmembrane transporter activity molecular_function
GO:0042625 ATPase-coupled ion transmembrane transporter activity molecular_function
GO:0042626 ATPase-coupled transmembrane transporter activity molecular_function
GO:0008324 cation transmembrane transporter activity molecular_function
GO:0015399 primary active transmembrane transporter activity molecular_function
GO:0003824 catalytic activity molecular_function
GO:0004129 cytochrome-c oxidase activity molecular_function
GO:0050840 extracellular matrix binding molecular_function
GO:0016675 oxidoreductase activity, acting on a heme group of donors molecular_function
GO:0016676 oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor molecular_function

KEGG:

id description
ko00350 Tyrosine metabolism
ko03400 DNA repair and recombination proteins

ZFIN:

id description
ZDB-GENE-990621-3 Predicted to enable copper ion binding activity and dopamine beta-monooxygenase activity. Acts upstream of or within sleep. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in extracellular space and secretory granule membrane. Is expressed in endocrine system; head; interrenal primordium; and nervous system. Human ortholog(s) of this gene implicated in several diseases, including alcohol use disorder; attention deficit hyperactivity disorder; dopamine beta-hydroxylase deficiency; hypertension; and migraine with aura. Orthologous to human DBH (dopamine beta-hydroxylase).

Ensembl:

ensembl_id ENSDARG00000069446

RNA

RNA id representative length rna type GC content exon number start site end site
TCONS_00004881 False 858 lncRNA 0.47 4 10564261 10578832
TCONS_00004882 True 1953 mRNA 0.52 12 10564447 10607118

Neighbor

gene id symbol gene type direction distance location
XLOC_002623 BX323065.1 coding downstream 231834 10319308 ~ 10332427 (-)
XLOC_002621 NA coding downstream 275578 10261345 ~ 10288683 (-)
XLOC_002622 NA coding downstream 285728 10273729 ~ 10278533 (-)
XLOC_002620 strbp coding downstream 545467 9834896 ~ 10018794 (-)
XLOC_002619 NA coding downstream 902569 9646362 ~ 9661692 (-)
XLOC_002625 NA coding upstream 105060 10712178 ~ 10714227 (-)
XLOC_002626 NA coding upstream 177216 10784334 ~ 10787649 (-)
XLOC_002627 nrarpa coding upstream 253641 10860759 ~ 10864331 (-)
XLOC_002628 exd3 coding upstream 272419 10879537 ~ 10969596 (-)
XLOC_002629 ak3 coding upstream 393776 11000894 ~ 11012000 (-)
XLOC_002618 BX248511.1 non-coding downstream 1025926 9534615 ~ 9538335 (-)
XLOC_002638 NA non-coding upstream 1288255 11895373 ~ 11898575 (-)
XLOC_002642 NA non-coding upstream 2691721 13298839 ~ 13301973 (-)
XLOC_002643 CR759894.1 non-coding upstream 2697947 13305065 ~ 13305183 (-)

Expression


Co-expression Network

Homologous

species gene id symbol gene type chromosome NCBI id location
grasscarp (Ctenopharyngodon idella) CI01000304_05277392_05292162 DBH coding CI01000304 null 5277101 ~ 5292162 (+)