XLOC_033240 (cyp24a1)


Basic Information

Item Value
gene id XLOC_033240
gene name cyp24a1
gene type coding
species zebrafish (Danio rerio)
category of species model fish

Chromosome Information

Item Value
chromosome id NC_007117.7
NCBI id CM002890.2
chromosome length 60270059
location 55852274 ~ 55864687 (-)
genome version GRCz11_2017_zebrafish_Genome

Sequence

>TCONS_00064546
ACTGACAACTTTTACGCACGCTGTTTTACACACGCCTCAAGATGAGAGCGCACTTGCAGAGAGCTCCTCAGATTCTGGAGCTGCTGAAGAAGAAGACTGCGGGGCTCCAGCACTGTAAACCCACATCCTCCGTGTGCGTGCTCGACTCGAAGGATGCTGCTGGGAGCGCGCCCTGTGCGCACAGTCTCGACTCCATCCCTGGACCAACCAACTGGCCGCTGTTCGGCAGCCTCATCGAGGTGATCCGGAATGGGGGATTGAAAAGGCAACACGAGACGCTGATCCATTTTCATAAGAAGTTTGGGAAGATCTTCCGGATGAAGCTGGGCTCTTTTGAGTCGGTTCACATTGGTTCTCCATGTTTACTGGAGGCTCTGTACCGGAAAGAGGGCAGCTATCCTGAGAGACTGGAGATCAAACCATGGAAAGCCTACAGAGACATGCGGGACGAGGCTTACGGGCTGCTCATACTGGAAGGGAGAGACTGGCAGCGGGTGCGCAGCGCTTTCCAGCAGAAGCTCATGAAACCCACTGAAGTCATGAAGCTGGACGGCAAAATCAATGAAGTTGCAGCTGATTTGATCAAAAGGATTGGAAAAGTCAACGGCAAAATGGATGatttgtattttgagctgaacaaGTGGTCCTTTGAAACCATTTGCTATGTGATCTATGACAAGCGTTTCGGGCTTCTGCAAGACAGTGTCAGCAAGGAGGGCATGGATTTCATCACCGCAGTGAAAACGATGATGAGCACTTTTGGGACGATGATGGTGACGCCTGTTGAGCTCCACAAAACTCTGAATACCAAGACGTGGAAGGACCACACGGAGGCCTGGGACCGTATTTTTAGCACAGCAAAACATTACATCGACAAGAACCTGCAGAAGCAGTCAAACGGCGAGGCGGACGACTTTCTGTCGGACATCTTCCATAACGGCAACCTCACCAAGAAAGAGCTTTACGCTGCCACAACAGAGCTGCAGGTCGGAGGAGTGGAGACGACGGCTAATAGCATGCTGTGGGTCATTTTCAACCTGTCACGTAACCCCTGCGCCCAAGGCAAACTCCTGAAGGAGATCCAGGACGTGGTGCCTGCTGGCCAAACTCCACGCGCAGAACACATCAAGAACATGCCCTACCTCAAAGCCTGCCTGAAGGAGTCCATGAGagtttcacCGTCCGTGCCGTTCACCAGCCGGACCCTGGACAAAGATACCGTGCTGGGCGATTACACCCTGCCTAAAGGAACCGTCCTAATGCTCAACAGTCAGGCTATCGGTGTAAGCGAGGAGTATTTTGACAATGGGAGGCAGTTCAGACCCGAGCGCTGGCTGGAAGAGAAAAGCTCCATCAACCCTTTTGCTCATGAGCCGTTTGGCGTTGGGAAGCGGATGTGCATCGGCCGGCGTCTCGCTGAGTTACAGATCCAGCTGGGTCTCTGCTGGATTCTGCGTGACTATAAGATTGTGGCAACAGACCTGGAGCCGGTGGACTCACTGCATTCAGGAACGCTGGTGCCCAGTCGAGAGCTTCCAGTGGCTTTTGTTCCACGATGAGAAACCATGTACCAACCTGAACGGATGACTCCATATATCAATGGATCAGACACACGACGAGGCCTTTATAATGCTGCTATAACCTAACCGAATGTATCCGTCTCCCTTCAGATATACCTCATactattattatagttttataataTTTGTAGTAAATATGATTCTTCTATTTATTTCCTTTATGCAAATGACAGAGTTAAGATAAATATTTAAGGTGTTCTTGTAATTGCTGCTACCTATTATTTTACTacagtgcatatatatattttactaaaattgTTCTGTAGAGTTGCTAAATTTTTTTATGCAATACTATTTAGTACTGAAATCGTTCCATGTACAGTATTATGTAaaattctttctctttctctctttatttTGTAATACGAAAAGTGTTTAGAAATGTACATAGATGTCATATGAAATATTATTGTAACTTTCTATTTATATACTTAGTTATAAATATATGTGTCTGAATGAGTGAGTGGTGGAAATGTAGAGAATGTAGAAAATCACTGGATGTTGTTCACCTTTCATTcttaataaaaagtgaaaatgt

Function

symbol description
cyp24a1 Predicted to enable 1-alpha,25-dihydroxyvitamin D3 24-hydroxylase activity; 25-hydroxycholecalciferol-24-hydroxylase activity; and vitamin D 25-hydroxylase activity. Predicted to be involved in fatty acid omega-oxidation; response to vitamin D; and vitamin D catabolic process. Is expressed in liver. Human ortholog(s) of this gene implicated in hypercalcemia. Orthologous to human CYP24A1 (cytochrome P450 family 24 subfamily A member 1).

GO:

id name namespace
GO:0010430 fatty acid omega-oxidation biological_process
GO:0033280 response to vitamin D biological_process
GO:0055114 oxidation-reduction process biological_process
GO:0042369 vitamin D catabolic process biological_process
GO:0008403 25-hydroxycholecalciferol-24-hydroxylase activity molecular_function
GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen molecular_function
GO:0004497 monooxygenase activity molecular_function
GO:0005506 iron ion binding molecular_function
GO:0046872 metal ion binding molecular_function
GO:0016491 oxidoreductase activity molecular_function
GO:0070643 vitamin D 25-hydroxylase activity molecular_function
GO:0020037 heme binding molecular_function
GO:0030342 1-alpha,25-dihydroxyvitamin D3 24-hydroxylase activity molecular_function

KEGG:

id description
ko00100 Steroid biosynthesis
ko04928 Parathyroid hormone synthesis, secretion and action
ko05206 MicroRNAs in cancer
ko00199 Cytochrome P450

ZFIN:

id description
ZDB-GENE-060825-1 Predicted to enable 1-alpha,25-dihydroxyvitamin D3 24-hydroxylase activity; 25-hydroxycholecalciferol-24-hydroxylase activity; and vitamin D 25-hydroxylase activity. Predicted to be involved in fatty acid omega-oxidation; response to vitamin D; and vitamin D catabolic process. Is expressed in liver. Human ortholog(s) of this gene implicated in hypercalcemia. Orthologous to human CYP24A1 (cytochrome P450 family 24 subfamily A member 1).

Ensembl:

ensembl_id ENSDARG00000103277

RNA

RNA id representative length rna type GC content exon number start site end site
TCONS_00064546 True 2118 mRNA 0.47 12 55852274 55864687

Neighbor

gene id symbol gene type direction distance location
XLOC_033239 BX470154.1 coding downstream 24757 55814757 ~ 55827517 (-)
XLOC_033238 LO017956.1 coding downstream 202023 55650119 ~ 55650251 (-)
XLOC_033235 slc12a5a coding downstream 266851 55449300 ~ 55585423 (-)
XLOC_033237 CR847793.1 coding downstream 296878 55555262 ~ 55555396 (-)
XLOC_033236 CR847793.2 coding downstream 305004 55547135 ~ 55547270 (-)
XLOC_033241 eya2 coding upstream 45108 55909795 ~ 55997350 (-)
XLOC_033242 NA coding upstream 144491 56009178 ~ 56038817 (-)
XLOC_033243 NA coding upstream 197034 56061721 ~ 56073926 (-)
XLOC_033244 gcnt7 coding upstream 233284 56097971 ~ 56111829 (-)
XLOC_033245 NA coding upstream 465584 56330271 ~ 56618557 (-)
XLOC_033230 NA non-coding downstream 574111 55274006 ~ 55278163 (-)
XLOC_033246 NA non-coding upstream 522767 56387454 ~ 56389460 (-)
XLOC_033247 CR388191.1 non-coding upstream 674322 56539009 ~ 56539125 (-)

Expression


Co-expression Network

Homologous

species gene id symbol gene type chromosome NCBI id location
grasscarp (Ctenopharyngodon idella) CI01000340_17318768_17326504 CYP24A1 coding CI01000340 null 17318100 ~ 17326544 (-)