XLOC_003482 (comtb)


Basic Information

Item Value
gene id XLOC_003482
gene name comtb
gene type coding
species zebrafish (Danio rerio)
category of species model fish

Chromosome Information

Item Value
chromosome id NC_007122.7
NCBI id CM002895.2
chromosome length 45484837
location 25619892 ~ 25631442 (+)
genome version GRCz11_2017_zebrafish_Genome

Sequence

>TCONS_00006829
GATCCTTGGCCTAGTTTGGATTCGCGTTTTCTGTCAGGGGGTGTTTATTCCCCTAAAAGACCTCCGGTCAGACATTCCTCGCGGCTCAGATCTGCCCAGAGGAGGTTTAACAGAAGGTCCTTAAGAGAAAGAGACATTTCGTAAAAGGCAAAGAAAGATCCTCACTGAAAtaTGTTGGGGGTGTTGCTGTGCTGGTGTTTAGGGGCCTCAGTGCTGTTATACGTCCTGTAC
>TCONS_00006830
GTGTTTATTCCCCTAAAAGACCTCCGGTCAGACATTCCTCGCGGCTCAGATCTGCCCAGAGGAGGTGAGAGAGCGAATTACAGGGTCagctgagagagagagggagcgaGAGAGCACagatgatcagtgtgtgtgtgtgcatttgcgtCCTCGCAGGTTTAACAGAAGGTCCTTAAGAGAAAGAGACATTTCGTAAAAGGCAAAGAAAGATCCTCACTGAAAtaTGTTGGGGGTGTTGCTGTGCTGGTGTTTAGGGGCCTCAGTGCTGTTATACGTCCTGTACTCGTGGCTGATTCCTGCAGCGGTGCAGTTTAATGGCAGTCTGGCGTTACTCTGGCATGATGTCATCGTGGAGCGAGCTTTGGATTCCCTGACCCGATCAACTCGACCACAGCGTCTGCTGAAAGCTGTAAAGCAGCATGCGACTCGAGGCGACCCTCAGAGCGTCATCTCTGCCATTGATCACTTCTGCAGACACCGCGAATGGGCTATGAATGTTGGAGATGAGAAAGGCTGTATCCTGGATTCAGTGGTAAGTGAGCTGAACCCAGAGAAGGTCCTGGAGTTGGGCACATACTGTGGCTACTCTACAGTTCGCATCGCTCGTCTGCTTCCTCCTGGAGCTCGTCTCATTACACTGGAGTTCAACCCAGATTACGCTGTGATTGCTCGACAAGTCATCGCCTGGGCTGGAATTGAAGACAAAGTGCAGCTTGTAGAAGGTGCGTCTGAAGACTGGATCCCACGCATGAAGGAGCACTTTGGAATCGAAACCtttgatttagtttttctggACCACTGGAAAGACCATTACCTTCCTGACACTAAATTAATGGAGGGTTGTGGTCTGCTAAGGAAAGGCACGGTTCTTCTTGCTGATAATGTGATCTGTCCTGGAGTCCCAGACTATCTTGAATATGTGCGCAATAGCCGTTCCTATAAAAGCTGCTATTTTAAATCCCATTTAGAGTACACCAGGGCAGAGGATGGCTTGGAGAAGTCTGTGTTTTTGGGCTAGAGATGTACAGAGATGATTCTTATGCTTAAAaggaggattttttttcttttctgagaGCCAGTGTGaggtttattttaaatgatttattattataagtCCCCTACACTCTTCAAACACTTGGTTGTTTTAAACCAAATTTagataaaatatgaacaaactgtAACAATGGGTTAAAGGCGTAGtaaacccaaaaatttaaatcccATCAGTATTACTTGAACTTCATCTGTTAGAGTTTATTTCTtgtcttgaacacaaaagaagatacttagcAAACATTTGGGAAACTGGTAGACATTGACTTCTGTAgtgtattattaattcattaattttctttttggcttagtccctatattatttaggggtcgccacggcggaatgaatcgccaacctatccagcatatgttttacgcagcggatgccctttcagccgcaacccaacacttggaaacaacaatacactcttgcattcacacacaaacactacggccaactgaaatgccaattgatccagccagggcttgaaccagtgaccttcttgctgtgaggcgattgtgctacccactgcgccaccgtgacgccccttaAATCATTTTTGGTTCCACTTTATTTTTAAGAAGACGATGTTAAAGTGTAACTATCCAGTTAATTGCTGTGTAAAAGTTATTAATAACATGTACCTACTATATGGTTAGGTCCCACTTTACATTAGGAGGCCTTAGCTAACATCTAGTcacactgaaattaatcatttgttacaatgtacttattgtgtaaatacatgtttttacatttatgattgattaaatacgtgcatgtaattacatctgtaattaatttctgcaattacatttgtaattgaccatccttacaccttaacccacccttaaacctacccatgccatcaaacctgtccctaactctacctgtatcccacctcaagacCACCAGAAAAGTTTTGcgatacattatgaacacagtaagtacgttgtatttattcttttatgcAAGCACATATTAGTTGAGGTCACCTGGTATAAAGTAAGATCCatcattttaattgttattactaTAGTAAGTGCATGGAACATGTGTAACTATGTCTCCTTAAATAAAGCATTACAATTGTAAA

Function

symbol description
comtb Predicted to enable catechol O-methyltransferase activity. Predicted to be involved in catecholamine catabolic process; developmental process; and dopamine metabolic process. Predicted to act upstream of or within catecholamine metabolic process; methylation; and neurotransmitter catabolic process. Predicted to be located in extracellular region. Is expressed in several structures, including digestive system; gill; heart; immune system; and nervous system. Human ortholog(s) of this gene implicated in several diseases, including attention deficit hyperactivity disorder; autoimmune disease of skin and connective tissue (multiple); bulimia nervosa; cognitive disorder (multiple); and reproductive organ cancer (multiple). Orthologous to human COMT (catechol-O-methyltransferase).

GO:

id name namespace
GO:0042417 dopamine metabolic process biological_process
GO:0042424 catecholamine catabolic process biological_process
GO:0042135 neurotransmitter catabolic process biological_process
GO:0032502 developmental process biological_process
GO:0032259 methylation biological_process
GO:0006584 catecholamine metabolic process biological_process
GO:0005576 extracellular region cellular_component
GO:0016740 transferase activity molecular_function
GO:0008168 methyltransferase activity molecular_function
GO:0008171 O-methyltransferase activity molecular_function
GO:0046872 metal ion binding molecular_function
GO:0016206 catechol O-methyltransferase activity molecular_function
GO:0102084 L-dopa O-methyltransferase activity molecular_function
GO:0102938 orcinol O-methyltransferase activity molecular_function
GO:0000287 magnesium ion binding molecular_function

KEGG: NA

ZFIN:

id description
ZDB-GENE-040724-164 Predicted to enable catechol O-methyltransferase activity. Predicted to be involved in catecholamine catabolic process; developmental process; and dopamine metabolic process. Predicted to act upstream of or within catecholamine metabolic process; methylation; and neurotransmitter catabolic process. Predicted to be located in extracellular region. Is expressed in several structures, including digestive system; gill; heart; immune system; and nervous system. Human ortholog(s) of this gene implicated in several diseases, including attention deficit hyperactivity disorder; autoimmune disease of skin and connective tissue (multiple); bulimia nervosa; cognitive disorder (multiple); and reproductive organ cancer (multiple). Orthologous to human COMT (catechol-O-methyltransferase).

Ensembl:

ensembl_id ENSDARG00000025679

RNA

RNA id representative length rna type GC content exon number start site end site
TCONS_00006829 False 231 mRNA 0.48 3 25619892 25624972
TCONS_00006830 True 2150 mRNA 0.42 6 25619932 25631442

Neighbor

gene id symbol gene type direction distance location
XLOC_003481 ccdc120 coding upstream 1309 25583950 ~ 25618583 (+)
XLOC_003480 mbd1b coding upstream 43693 25560072 ~ 25576199 (+)
XLOC_003479 cxxc1b coding upstream 69047 25539698 ~ 25550845 (+)
XLOC_003478 tfe3b coding upstream 100055 25504215 ~ 25519837 (+)
XLOC_003477 gnl3l coding upstream 117401 25485774 ~ 25502491 (+)
XLOC_003483 grm6b coding downstream 2599 25634041 ~ 25679721 (+)
XLOC_003484 otud5b coding downstream 49893 25681335 ~ 25689873 (+)
XLOC_003485 mon1bb coding downstream 61953 25693395 ~ 25709311 (+)
XLOC_003486 si:dkey-183j2.10 coding downstream 104036 25735478 ~ 25750060 (+)
XLOC_003487 NA coding downstream 197928 25829370 ~ 25830337 (+)
XLOC_003369 CR854846.2 misc upstream 9496810 16122786 ~ 16123082 (+)
XLOC_003318 CR450764.6 misc upstream 12907896 12711700 ~ 12711996 (+)
XLOC_003317 CR450764.16 misc upstream 12925629 12693967 ~ 12694263 (+)
XLOC_003316 CR450764.11 misc upstream 12934293 12685304 ~ 12685599 (+)
XLOC_003315 CR450764.18 misc upstream 12939864 12679732 ~ 12680028 (+)
XLOC_003467 NA non-coding upstream 353657 25256812 ~ 25266235 (+)
XLOC_003466 NA non-coding upstream 391697 25181857 ~ 25228195 (+)
XLOC_003463 NA non-coding upstream 559794 25059462 ~ 25060098 (+)
XLOC_003447 BX072564.1 non-coding upstream 1038778 24580579 ~ 24581114 (+)
XLOC_003444 AL831791.1 non-coding upstream 1440954 24178823 ~ 24178938 (+)
XLOC_003488 CR318604.1 non-coding downstream 446505 26077947 ~ 26078061 (+)
XLOC_003489 NA non-coding downstream 557075 26188517 ~ 26196145 (+)
XLOC_003490 NA non-coding downstream 594640 26226082 ~ 26234069 (+)
XLOC_003497 NA non-coding downstream 1071515 26702957 ~ 26709080 (+)

Expression


Co-expression Network

Homologous

species gene id symbol gene type chromosome NCBI id location
grasscarp (Ctenopharyngodon idella) CI01000306_03214469_03216852 COMTB coding CI01000306 null 3214469 ~ 3216880 (+)