AMCG00014102 (app)


Basic Information

Item Value
gene id AMCG00014102
gene name app
gene type coding
species bowfin (Amia calva)
category of species ecological fish

Chromosome Information

Item Value
chromosome id CM030128.1
NCBI id CM030128.1
chromosome length 42883965
location 1858678 ~ 1869442 (+)
genome version AmiCal1_2021_bowfin_Genome

Sequence

>AMCG00014102
aggTGCCCACGGACGGCTCGGTGGGCCTGCTGGCGGAGCCCCAGGTGGCGATGTTCTGCGGGAAGCTGAACATGCATGTGAACGTGCAGAGCGGCCGCTGGGAGCCCGACCCCACTGGCACACGCAGCTGCATCGGCACCAAGGAGGGGATCCTGCAGTACTGCCaggaggtgtaCCCTGAGCTCCAGATCACCAATGTGGTCGAGGCCAACCAGCCGGTCAGCATCCAGAACTGGTGCAAGAAGGGCCGTCAGCAGTGCCGCAGCCACCTGCACATCGTGGTGCCCTATCGCTGCCTGGtggGGGAGTTTGTGAGCGACGCCCTACTGGTCCCAGACAAGTGTAAGTTCCTGCACCAGGAGCGCATGGACATGTGCGAGAGCCACCTGCACTGGCACACCGTGGCCAAAGAGTCCTGTGGGGACCGCTCCATGAATCTCCATGACTATGGCATGCTGTTGCCATGTGGGATTGACCGCTTCCGTGGCGTGGAGTTCGTGTGCTGCCCCTCGGAGGCGGAGCGTGACGACAGTGCCCAGCTGGAGGAGGACGACTCAGACGTGTGGTGGGGCGGAGCTGACACGGACTACACCGACAacagtGAGCCCCGGGAGGCGGGTCAAGCCGAGGTGAAGGAGGAAGGTGCCGAGGCAGCCCTGGGGGAGGATGACGAGGatgtggaggaggaagaggaggaggaggaggaggaggaagacgacGAGACGGAGGAGCCGGAGGCCAGCGAGCGCACCACCAGCGTGGCCATGACGACCACGACCACGACCACCACGGAGTCGGTGGAGGAGGTGGTGCGAGaggTGTGCTCAGAGGCGGCGGAGACCGGGCCGTGCCGGGCCATGTTGCCGCGCTGGTTCTTCGACAGTGAGGAGGGCCGCTGCGCTCAGTTCATCTACGGCGGCTGCGGTGGCAACCGCAACAACTTCGACTCCCAGGAGtactgcctgtctgtgtgcgGCAGCGTGTTGCCCACCACCGCCCCCAGCCCCCCCGACGCCGTGGACCGGTATCTGGAGACGCCCGGCGACGAGAACGAACACGCCCACTTCCAGAAGGCCAAGGAGAGCCTGGAGGCCAAGCACCGCGACAGGATGTCAcagGTGATGAGAGAgtgggaggaggcagagagacaggCCAAGAACCTGCCCCGTGCCGACAAGAAGGCCGTCATCCAGCACTTCCAGGAGAAGGTGGAGTCTCTTGAGCAGGAGGCGGCGAGCGAGCGGCAGCAGCTGGTGGAGACGCACATGGCCCGTGTGGAGGCGCTGCTGAACGACCGGCGCCGGCTGGCCCTGGAGAACTACCTCACCGCCCTGCAGGCCGACCCCCCCAAGGTGCTGACCCACCTGCGGGTGATCGAGGAGCGCATGAACCAGAGTCTGGGGCTGCTGTACAAGGTGCCCGGCGTCGCCGACGACATCCAGGAGCAAGTGGACGAGCTGGTGCAGAGGGAGCAGGCGGACGTGTGGGAGCAGGTGGCGTCTCTGCAGAGCGAGGGCAGGGTGAGCTACGGCAACGACGCCCTCATGCCCTCGCTGGCGGACAGCACCGCCCCGCTGGACCTGCTACCCCAGGAGGAGGGCGGCATTGGCCGGGACGGGCTGGGCTACATCCACCCCGGCGGCTTCGGACCCGCCAACACCCAGAACCAGGtggAGCCCATCGATGTGCGTCCCGCCCCTGACAGAGGACTCCCCACCCGGCCTGGCTCAGGTCTGCCGGGGGTGATTGTGGAGGAGGTGCCCGAGTTGAGGATGGAGGCAGAGGAGCGACACAGCACTGGGTACGAGGTGCGCCACCAGAAACTGgtgttCTTCGCGGAGGACGTGGGCTCCAATAAGGGGGCCATCATCGGGCTGATGGTGGGAGGCGTCGTCATTGCGACCGTGATTGTGATCACGCTGGTGATGCTGAGGAAGAAGCAGTACACGTCCATCCATCACGGAGTGGTAGAGgTGGACGCGGCAGTGACTCCAGAGGAACGCCACCTGTCCAAGATGCAGCAGAACGGCTATGAGAACCCCACCTACAAGTTCTTCGAGCAGATGCAGAACTGAGGccccactctccctccctcttcctcctctcctcctcctcctcctcctcctttccctCTCCTATCGTCCCcaggcccctccccctctgACCTCCAGGCTTGCCCCAGTGTCCAGGGCAGTGTGTGTCCAGCACTGACGCACTGAGCACACTGCGGCTCTGTCAGTGTGTCCTCCCGtccgtcagtgtgtcagtcagtcactgtgggtgtctgtctgtgtgtccgtcagtcagtcagtctgagGCACGGCACTCCCCTGTGCTGTGATTGGACCGGATCCGAGAGGCCTGTTCTGATTGGACAAGGGGCCCTTCTCCACAGCAATAGACCactacccccctcccccctgttGCTGGGGAGAGGTGTCTTTGTCCAATCAGCAGGCTTGCAGCAGGGAGGCCACGCCCCCTCGTGCTCCGGTGAGGGGCGGCACGGAGGCGGGCCGCTGACTGGCAGTGAGCCGGTGCCGAGAGCGGCCCACACTGCCCTGGCAGGGTGGCACCGGGGACAGGGAGCAGGCGGGGCTCTCTGCTCGATGCCTGTGCCctactctctctcccctccccttccctcctctcctctctctccctcctatccctccttctttccctcctcctctcctccttttTTCTGGTGACAGCTGCGCTGTGCTTGACCACACACAGGTtcttaatgaaaagaaacaaaaacactcagTAATGTCTTTGatgagctttttattttattattttattgtttctttgtttgtttttccaaaaaaaaaagaaaatagaaaaaaaactaaaacaaaaaaaacaaacctgatTATAAATAATCGAATCACTGAAGAAAGACAGGaagttcaaataaaaaatggaaaaaaaggtgAAAACGGAGGACCGCCAATCCGagctgaatgttttttatttccgtGTGATGTGTCCAGTTGCGGACAGAGGCCAGCTGTTGCTGTGTAGTGCATGACCATAAATACAggacaaaatgttaataatgaaaaaaaaactaaaaaaatggagaaaaaaaaagtgctaatTGCGCGTTTGTTTTCCGTTCCGCTATCTGGCCTCGTCCTTCTCCTGTAGAGACTGTGTATTTTAGCAGGGTTGTAAAGTTAGTACTTCTTTGTGATCACGTGgtttaaaaaacgaaaacaagACGATCTCAGATTCAGAGTCTCCGGTCTGCTGTTTCAGAGACTCCGCTCCGCTCCGCTCATCCGTCTGTTGAGTTCAGGTTTTCGGGggtctgtttatatatatttttgttcgtCCTCCTATGTAGCAGCTCCCCCTGGTGTCCAGAGCTCGCGTCGCGTggccgggggggcgggggttgtGCTGTTCATCGGAGCGGTCGCGTTGGCTTCCTATGCATTCTGAGAGAGTCGTTCTGGATCTCGTTAAGacgtttcattttattttattgtctggTGTTTGACTTTATTCTCCCGTTGTCACCGTGGTGGTGCCCGGGCCCCTGGGCGGAGGAGCCGGCCTCTGTTCCtcgtcatcctcctcctctccgGACAGCTGGACGGACCCCTCATCCCTCGCTCAGCCTCTCTTCCTCTCGCCTCGCAGTCTCCCCTCCTGTCCCATGGGTTGCCGTTGTGCTGTCCTGGCAGTGGGAGCCGCCGGTCGAGTCGGAGGGAGTGGTTAGTGGTGTGGGCGTGGCTTTGTGCCACCGGCTGCTTTTGTGGCGGTGGGGTGGGTGGCAGCAGACGTGTCCGAGCATGTGCAATGGTGTGGGTGTGGCCGGGCCGTGGAGAGTAACGACAGGgtgagagaggcagaggagagtgagagagagacgtgTTATTgtagagagatgagagagaggatGTATGTGTGAGAGACGCACCTCCTTTTCTGAGCAGCCTCCCCAACACCCCCAAGCTTCCCCTCTTAAGTCTTACCCCCCCCATGGCCACAGCCCCTAATTGGCTCCTTCGTTACTTAATTGGCCTGTCGGAATGTGGAATGTAGCAAGACGGCCCCGGCAGCCGGCTCCTGCACTAGCTGTGgcctcctgcccccccaccccccgttaTTAATGTTCAGTCGTGGGAGTGTGTGTCGGGCGGCGCCGGGTCCGAAGGCAATGTTGTGTTTCTCCACCAGATCCCCGTCAGGCGACTGACAGCGCTGCCCAGCTGCAGGAAGACAGGAGGCTTAGAAACAACACAGTCCGGTGGGGCCTCGGACCAGGGCGTCCAGAGCTGCTGACCCGGGCCGGAGAACGGAGTGGGGGGGTCGGGGTCGGGGGTCAGAGTCCGGGACAGGGACAGGGTGCGGAGGATTTGGGCATGGGTCAGTGTGAGGGTGTGTTCAGCAGACGCCTCCTTTAGCTCCGTCAGTGCGTGGCAGTCTCCAGCCCATGTGCGCGTccgagagggacacacacacacacacaggtattcACACACTCGCTTAGTCGCACTCACTCACTTCCTCTCATGTAGTCACACTATTGGCGCACTCTGACACAGTCGGACACGCACCAAGTCGCACTCTTAAACCAAAGCTCTCGAACCGGGTGCGTGTCTCTCCACGCTGGGCCGATCAGAAGCCGGAGCTCTGGCCTGTTGAACTCTGACCCCCTGTGGTGGGCGGGGCAGCCTGGACTGTACCAAAGCCAGCGCAGGCGGGGGTGGTGGAGTGGGGAGAGGGGCGTGGCTTATTTCATccgtgtgtgtcagtgcaggcGACTCTTCTTCTTGCTCTTGTGACGATGCTGTGCTTCGCCACCAGCTCTGGACGGACCGCCCCGCcccgctcgctctctctctccctctcccgcaGTGCGAGTGCGGGCCCGGGGGCCGTGGAGCCGGGGGattctctgtatctctgtgcgACTGTACAAACATTGCTGTGACTGGGAAAGCTTTCTACActgtattacataaataaacttcAAAAAAACAAGGCGGCACTGCGCTCTGGC

Function

symbol description
app Enables several functions, including PTB domain binding activity; protein dimerization activity; and signaling receptor binding activity. Involved in several processes, including defense response to other organism; modulation of chemical synaptic transmission; and positive regulation of macromolecule metabolic process. Acts upstream of or within regulation of gene expression. Located in several cellular components, including cytoplasmic vesicle; dendrite; and nuclear envelope lumen. Part of several cellular components, including amyloid-beta complex; high-density lipoprotein particle; and intermediate-density lipoprotein particle. Colocalizes with several cellular components, including cell body; low-density lipoprotein particle; and very-low-density lipoprotein particle. Implicated in APP-related cerebral amyloid angiopathy; Alzheimer's disease; Alzheimer's disease 1; cognitive disorder; and visual epilepsy. Biomarker of Alzheimer's disease; obesity; and periodontitis.

NR:

description
amyloid-beta A4 protein isoform X1

GO:

id name namespace
GO:0010951 negative regulation of endopeptidase activity biological_process
GO:0016021 integral component of membrane cellular_component
GO:0008201 heparin binding molecular_function
GO:0046914 transition metal ion binding molecular_function
GO:0004867 serine-type endopeptidase inhibitor activity molecular_function

KEGG:

id description
K04520 APP; amyloid beta A4 protein

RNA

RNA id representative length rna type GC content exon number start site end site
AMCG00014102 True 5020 mRNA 0.60 15 1858678 1869442

Neighbor

gene id symbol gene type direction distance location
AMCG00014101 NA coding upstream 25318 1825855 ~ 1833360 (+)
AMCG00014100 NA coding upstream 45380 1799682 ~ 1813298 (+)
AMCG00014095 NA coding upstream 294104 1545327 ~ 1564574 (+)
AMCG00014096 NA coding upstream 313453 1541410 ~ 1545225 (+)
AMCG00014089 NA coding upstream 425070 1412350 ~ 1433608 (+)
AMCG00014103 NA coding downstream 3307 1872749 ~ 1878960 (+)
AMCG00014106 NA coding downstream 51897 1921339 ~ 1925062 (+)
AMCG00014112 NA coding downstream 139160 2008602 ~ 2022266 (+)
AMCG00014113 NA coding downstream 155156 2024598 ~ 2028511 (+)
AMCG00014120 NA coding downstream 213984 2083426 ~ 2113366 (+)
G67789 NA non-coding upstream 16233 1840165 ~ 1842445 (+)
G67792 NA non-coding upstream 36920 1820573 ~ 1821758 (+)
G67699 NA non-coding upstream 582462 1275991 ~ 1276216 (+)
G67698 NA non-coding upstream 608364 1250099 ~ 1250314 (+)
G67690 NA non-coding upstream 835865 981839 ~ 1022813 (+)
G67882 NA non-coding downstream 207861 2077303 ~ 2077602 (+)
G67899 NA non-coding downstream 279007 2148449 ~ 2148654 (+)
G67907 NA non-coding downstream 464049 2333491 ~ 2333944 (+)
G67908 NA non-coding downstream 480687 2350129 ~ 2373305 (+)
G67983 NA non-coding downstream 876802 2746244 ~ 2755484 (+)
AMCG00014104 cyyr1,LOC107751099 other upstream 20553 1835432 ~ 1838125 (+)
AMCG00014099 NA other upstream 361074 1479919 ~ 1497604 (+)
AMCG00014061 NA other upstream 1611676 136864 ~ 247002 (+)
G67577 NA other upstream 1751556 58449 ~ 107122 (+)
G67801 NA other downstream 9649 1879091 ~ 1881041 (+)
AMCG00014111 NA other downstream 30778 1900220 ~ 1902687 (+)
G67896 NA other downstream 257430 2126872 ~ 2130145 (+)
AMCG00014146 NA other downstream 837398 2706840 ~ 2710329 (+)
AMCG00014196 NA other downstream 2258034 4127476 ~ 4131718 (+)

Expression


Co-expression Network

Homologous

species gene id symbol gene type chromosome NCBI id location