XLOC_007282 (med12)


Basic Information

Item Value
gene id XLOC_007282
gene name med12
gene type coding
species zebrafish (Danio rerio)
category of species model fish

Chromosome Information

Item Value
chromosome id NC_007125.7
NCBI id CM002898.2
chromosome length 52660232
location 23593989 ~ 23679139 (+)
genome version GRCz11_2017_zebrafish_Genome

Sequence

>TCONS_00014376
GTGAAGCAGCGGAGCTCTAGCCGCAGCAGTAGCGCTCAGGATCGGCTACACACCGGGCTGACATGCCGCGGGGATGATGGCTGCCTTCGGCGTTCTGAGCTACGAACACAGGCCTCTTAAACGGCCAAGACTCGGTCCTCCGGACGTTTATCCACAGGACCCGAAGCAAAAAGAGGATGAGTTAACCGCATTGAACGTCAAGCAAGGATTTAACAACCAGCCAGCTGTTTCAGGCGATGAACATGGCAGCGCTAAAAATGTCAATTTCAACTCTTCAAAGATCAGCTCAAACTTCAGCAGCATCATTGCAGAGAAGTTACGCTGCAACACTTTTCCAGACACAGGGAAGAGGAAGCCGCAGGTCAACCAGAAGGATAATTTCTGGCTCGTCACAGCGAGGTCACAGAGCTCCATCAATAACTGGTTTACAGACTTGGCCGGGACCAAACCCCTAACTCAGCTCGCTAAAAAGGTTCCCATCTTCAGCAAGAAAGAGGAAGTGTTTGGCTACCTTGCCAAGTACTCTGTGCCAGTGATGCGATCTGCTTGGATGATTAAAATGACATGTGCGTATCACGCTGCCATAACTGAAAACAAGATGAAGAAGAGGCACGTCATCGACCCCTGTATAGAATGGACTCAGATAATTACTAAATACCTGTGGGAACAGCTGCAGAAGGTGGCGGAGTTTTACAGACAGTCTCCCAGCCAAGGCTGCGGGTCTCCTCTGCCTGCTCCTCCTGCCGAGGTGGAAACTGCCATGAAACAGTGGGAGTACAACGAGAAACTGGCCATGTTCATGTTCCAGGATGGTATGTTAGACAGACACGAGTTCCTCACCTGGGTGCTGGAGTGCTTTGAGAAGATTAGACCTGGAGAGGATGAGCTTCTACGTTTGCTTCTGCCACTTCTGTTACAGTACTCTGGGGAGTTTGTGCAGTCAGCATATTTATCTAGACGCTTGGCGTATTTCTGCACACGCCGGCTCAATTTGCTGCTGAGCGATGGCAGTATCGGGCCTGGTCCAGGTGGGCATCAGGCCCATGGCATTTCTGCGCAGCAGGGGAACGCTCTACCCCCAACACCCACATCTCAACCTGCAGGGGGCAACCAGCCACAGACCCCCTTCACGGACTTCTACATCTGCCCTCAGCATAGGCCAGTGGTGTTTGGACTAAGCTGCATGCTACAGAGTATTGTGTTGTGTTGCCCCAGCGCTCTGGTCTGGCACTACTCTCTGACAGATAGTCGTAATAAGACTGGCTCTCCATTAGACCTCTTGCCAATCGCCCCCTCTAATCTCCCTATGCCAGGGGGCAACAGCACCTTTAACCAACAGGTTCGGGCAAAGGTCCGGGAGATTGAAGAGCAGATTAAAGAGAGAGGGCAGGCCGTGGAATTTCGCTGGTCCTTTGACAAGTGTCAGGAGACAACAGCAGGTTTCACCATTAGCCGGGTTTTGCATACATTGGAGGTTTTGGATAACCACAGCTTTGAGAAGTCTGACTTCAGCAACTCTTTGGATTCTCTATACAATCGGATCTTTGGCTCAGGACAAAGCAAAGATGGGCATGAGATGAGTCCAGACGATGATGCAGTGGTCACCCTGCTGTGTGAGTGGGCTGTTTCTTGTAAAAGGTCAGGGCCACATAGAGCCATGGTGGTGGCCAAACTCCTGGAGAAAAGGCAGACTGAGATTGAAGCAGAGagGTGCGGCGAGTCAGAAGTTGTAGATGAGAAAGGCTCTGTGTCCTCAGGGTCTCTGTCTGCTGCCACACTCCCTGTCTTTCAGGATGTCCTGCTGCAGTTTCTGGACACACAGGCCCCTGTGCTCACTGAGCCTGGGAACGAGAGTGAGCGAGTGGAGTTCTCTAACCTTGTGCTCCTGTTCTACGAGCTCATCCGTCATGATGTCTTCTCACACAACATCTACATGTGCACCCTTATATCCCGTGGGGACCTGGCCTCCAACTCTCATCTGCCCCGCCCTCGTTCCCCCAGCGATGAGCCCTCTGATGAGTCAGAGCGCAAGGACCAGGATGCAGGAAGTAGTGTTAAAATCGAGGATACTGGTATGTCCGAGTCGATGGAGATAGATCACAACTCAAGCGCTAACTTTGATGAGATGTTTTCTCCTCCAATGCACTGTGAGTCGAAGGGAAGCCCTTCTCCAGAGAAACAAGCCCAAGAGCAGGAGAGCAAAAGCACTGCCAAGGATAAGGGCATGGACCCAGCCTTCCCTTTGGTTTATGAACAGCCCCGCCACATACAGTACGCCACCCACTTCCCCATTCCTCAGGAGGAGAGTGCAAGTCATGAGTGTAACCAGCGTCTAGTGGTTCTCTATGGAGTCGGCAAGCAGCGAGATGAAGCTCGCCACGCCATCAAGAAGATCACCAAAGACATCCTGAAGGTTCTCAACCGCAAGAGTACAGCAGAGACAGGAGGTGAGGAAGGCCAGAAGAGGAAGAGGAGCAAACCTGAGGCCTTCCCCACTGCTGAAGATATTTTCTCTAAATTCCAGCACCTCTCACACTTTGACCAGCACCAGGTCACCTCACAGGTGTCCAGGAATGTTCTGGAGCAAATCACCAGCTTTGCCTTAGGGATGTCCTATCACCTCCCACTGGTCCAACACATCCAGTTCATCTTTGACCTCATGGAGTACTCTCTTAATATAAGTGGCCTCATTGACTTTGCTATACAGCTGCTGAATGAATTGAGTCTGGTGGAAGCAGAACTCCTGCTTAAGTCCTCCAACCTGGCGGGCAGTTACACTACAGGCCTCTGTTTGTGTATCGTGGCTGTTCTGCGGAGATACCACTCCTGCCTCATCCTCAACCCTGACCAGACCGCACAGGTCTTTGACGGGTTGCGGATTGTAGTCAAGTCTGGTGTGAATCCTGCAGACTGTTCCTCAGCAGAACGCTGTATCCTAGCCTATCTCTACGACCTCTATACCTCCTGCAGTCACCTAAAGAGCAAGTTTGGAGAGATTTTCAGTGAGTTCTGCTCAAAGGTGAAGAATTCCATCTATTATAACATCGACCCGTCAGACTCCAACATGCTGTGGGATCAGATGTTTATGATCGATGCCATCACTAATCCTACCGCACACAACCTCAACCACTCCATGTTGGGAAAGATCACCAATGAACTCAATGACAGCCCGGCTAACCGCTACAGCTTTGTGTGTAATGTGCTCATGGATGTTTGCGTTGACCATCGAGATCCTGAGAGgGTGAATGATATTGGTATCCTGTGTGCGGAGCTGACAGCATACTGTCGCTCTCTAAGTGCTGAGTGGTTGGGTGTGCTCAAGGCCCTCTGCTGCTCTTCTAACAACGGCAACTGTGGCTTCAACGATCTGCTCTGCAATGTTGACGTGAGCGATCTATCTTTCCACGACTCTCTAGCAACATTCGTTGCCATCTTAATAGCTCGGCAGTGTTTGTTGCTGGAAGATCTGGTGCGCTGTGTTGCCATCCCATCCCTCCTGAATGCAGcCTGTAGTGAACAGGATTCTGAACCTGGAGCCAGACTGACATGTAGGATCCTGCTTCATCTGTTCAGAACCCCACAGCGCAACCCCTGTCCCCAGGATGGCACTAAATCAGACAAATCCATAGTGGGGATCAGGTCGTCCTGCGACCGACATCTGCTGGCTGCTTCACAGAACAGCATCGTGGTGGGAGCCGTTTTTGCTGTATTAAAAGCTGTGTTCATGCTGGGAGATGCTGAGCTGAAAGGCTCAGGCTTTTCCCATCCTGCTGGTCTGGATGATATTGGAGAGGATGACATGGGCTCTAAAAAATCTGGAGGACGTAATGTCTCTATTGAAACAGCCAGTCTGGTGGTTTACGCCAAGTATGTGCTGAAGAGCATCTGCCACCAGGAATGGGTTGGCGAGCGCTGTCTGAAGTCTCTGTCAGAAGACAGCAGTGCACTGCAGGATCCAGTGCTGGTCAACATCCAGGCTCAGCGCTTGCTGCAGCTCATCTGTTACCCACACCGACAGCTGGACAGTGAAGAGGGTGACAATCCACAGAGACAGCGCATCAAACGCATCCTGCAGAACATGGACCAGTGGACCATGAGACAGTCCTCTCTTGAGCTACAACTCATGATCAAGCAAAGCTCAAATAATGAGCTGTATTCTCTTCTGGAGAACATAGCCAAGGCCACTATTGAGGTTTTCCAGAAGTCTGCAGAGATGAACTCTAGTAACCCCTCCTGGAATGGCTCTGCTGTCTCGGGTAGCTCAGTCTCCAATAGCAACAGTGCCAGCAAACTCAAACCTGTGCTAAGTTCCTCTGAGCGTTCAGGTGTCTGGTTAGTTGCCCCTCTAATTGGTAAGCTGCCCACCTCAGTGCAGGGGCACGTGCTCAAGGCTGCAGGCGAGGAGCTGGAGAAGGGACAGCATCTGGGACCCTCTTCACGAAAAGAAAGAGATCGACAGAAGCAAAAAAGCATGTCTCTCCTGAGCCAGCAGCCCTTCCTGTCACTGGTTCTGACATGTCTCAAAGGGCAAGACGAGCAGAGAGAGGGTCTCTTGACGTCCCTCTACAGCCAAGTCCAGCAGATTGTGACTAACTGGCGAGAGGACCAGTACCAGGACGACTGCAAGGCTAAGCAGATGATGCACGAGGCCTTGAAGCTGCGACTCAATCTGGTGGGTGGGATGTTTGACACTGTACAGCGTAGCACTCAGCAGACAACAGAGTGGGCAGTGCTTCTGCTGGACATCATCAGCAGTGGCACAGTGGACATGCAGTCTAACAATGAGCTCTTCACTACGGTTTTAGACATGCTGAGCGTGTTGATTAACGGGACTCTGGCGGCTGACATGTCCAGCATATCTCAGGGCAGCATGGAGGAGAATAAGAGAGCTTACATGAACCTGGTCAAGAAGCTCAGGAAAGAACTTGGTGACCGACAATCCGAGAGCTTGGAGAAAGTGCGTCAGTTGCTGCCTCTGCCCAAGCAGACGCGTGATGTCATCACCTGTGAGCCCCAGGGGTCACTCATTGACACAAAGGGCAACAAAATTGCTGGATTTGAAAAAGAGGGTCTTCAGGTATCAACTAAGCAGAAGATTTCTCCATGGGATGTGTTTGAGGGACTAAAGCACTCTGCTCCGCTCTCCTGGGGCTGGTTCGGAACCATACGGGTCGACCGCAAAGTCACTAAGTTTGAAGAGCAGCAGCGGCTCCTGCTTTACCACACACACATCAAGCCCAAGCAACGCAGTTACTACCTGGCGCCCCTCAACCTGCCCCAAGAAGAAGAGGAACCACTCACTCCTGTGCCTCCCGAGCCAGACAAGAAGCTGGACACAGCGAAGGTGGAGAAAAGCGTCTCCAATGTCCCgactaagaaaaagaaaaagaaacctgCATCGACGGTTAAACAAGAGGACTACAAGCCACACAACACAGTCATGCAGTACGCTCCAGGCATGACCCCTGATCTCCCACTGAGCATGGGACAAACAAACATGTCATATCGAATGGGCTACCAAGCTCCAATGAACATGTATGCCCAGAACCAGCCTTTACCACCAGGAGGTCCTGGTTTGGAGCCACCTTTTCGTCCTAGGGTTCCTATGAATAAAATGCCTCCACGTCCCAACTACACTATGCCTAATATGCAGACCGCTGGCATGGGCAACCTAATGGGAATGGAGAAGCAGTACCAGATGAACTATAAACCCATGCCCAACATGGCTCAGGGGCAGATGCTCCGTCATCAGCTACAGGGTCATAATCATTTAATTGGACAGCAGATTAGACAAGTGACACCTAATCCACAGTATTCATCAATGCAGCCAGCACAGAATATACCCCAGGGCTACACCTCCTACGGCTCACACATGGGGATGCAGCCACACCCCTCTCAGACCCCTGGAATGGTTCCCAATTCATATGGAAACCAGGGCTTTCAGACAGGACATCCTGCCACTAACCCAACTATGGTGGACTCAATAAGGCAGATGCAGCAGAGACCTGGCTACGTCCATCAGCAGGCTCCTGCGGCATATGGGCACACAATCCAGAGCACACAAAGGTTTCCGCATCAATCCATGCAGCAGACACCCATGATGCACGGCTTGGCTCAAAGTCACTTGGGAGTGCAGGGCATCCACCCAAACATGAGGCCCAATCAGATGAtggagcagcagcagcaacaacaacaacaacaacagcaacagcagcaacaacaacaacaacaacaggtccaccagcagcagcagcacatcCGACAGGGTCCAGTTTTTAGACCACAGCAGCAACAGCAGGTTCAGCAGCAAGTGCAACAGCAGGTCCAGCAGCAGCAGGTCCAACAGCAGCAGGTCCAGCAACAGGTTCAGCCTCAGCAAGTTCAACAGCAGCAggttcagcagcagcagcagcaggtgtCTGCAGCTCAGCCTCCCGCTCAGGCCCTGGGCATGCAGGCTCTGCCCCCGCAACAGCCCATGTTCCAGCGGCAAGGCATGCAGCAaacccagcagcagcagcagaccgCAGCACTGGTCAGGCAACTCCAGCAGCAGCTCTCCAGTACTCAACCTGCACAGAACAACAGCTCCTATTACTGAGTGTTTGAATGCATTTCATCAATGGTAAagaatagttttgttttgtttttgtcagtgTAGCAGAAAATCTGCTCATGTGGACCTTTCTGAGAGAAGAGGAACTCTGCGCCCTGTAACTGAAGTAGAGTCAAACTATGTTTTTCAGACATGTCTCTGAAAATCATACTGGCGTTGTTCTGTGAAACACTGAGGTGAACAATGGAAGAGTTTATGTAAAAAGAAGTACAGGAAATTATAAGAATAttgcaacttttttattttatttcaatttgtaCAATTTTTCAGTTTGGTGTatttctcattaaaaaaaatcatgtcaaGTT
>TCONS_00014377
CCCAACTACACTATGCCTAATATGCAGACCGCTGGCATGGGCAACCTAATGGGAATGGAGAAGCAGTACCAGATGAACTATAAACCCATGCCCAACATGGCTCAGGGGCAGATGCTCCGTCATCAGCTACAGGGTCATAATCATTTAATTGGACAGCAGATTAGACAAGTGACACCTAATCCACAGTATTCATCAATGCAGCCAGCACAGAATATACCCCAGGGCTACACCTCCTACGGCTCACACATGGGGATGCAGCCACACCCCTCTCAGACCCCTGGAATGGTTCCCAATTCATATGGAAACCAGGGCTTTCAGACAGGACATCCTGCCACTAACCCAACTATGGTGGACTCAATAAGGCAGATGCAGCAGAGACCTGGCTACGTCCATCAGCAGGCTCCTGCGGCATATGGGCACACAATCCAGAGCACACAAAGGTTTCCGCATCAATCCATGCAGCAGACACCCATGATGCACGGCTTGGCTCAAAGTCACTTGGGAGTGCAGGGCATCCACCCAAACATGAGGCCCAATCAGATGAtggagcagcagcagcaacaacaacaacaacaacagcaacagcagcaacaacaacaacaacaacaggtccaccagcagcagcagcacatcCGACAGGGTCCAGTTTTTAGACCACAGCAGCAACAGCAGGTTCAGCAGCAAGTGCAACAGCAGGTCCAGCAGCAGCAGGTCCAACAGCAGCAGaccgCAGCACTGGTCAGGCAACTCCAGCAGCAGCTCTCCAGTACTCAACCTGCACAGAACAACAGCTCCTATTACTGAGTGTTTGAATGCATTTCATCA

Function

symbol description
med12 Enables DNA-binding transcription factor activity and promoter-enhancer loop anchoring activity. Acts upstream of or within several processes, including animal organ development; embryonic pectoral fin morphogenesis; and iridophore differentiation. Predicted to be located in nucleus. Predicted to be part of mediator complex. Is expressed in several structures, including brain; head; immature eye; intermediate cell mass of mesoderm; and liver. Human ortholog(s) of this gene implicated in FG syndrome; leiomyosarcoma; major depressive disorder; phobic disorder; and syndromic X-linked intellectual disorder Lujan-Fryns-type. Orthologous to several human genes including MED12 (mediator complex subunit 12).

GO:

id name namespace
GO:0007492 endoderm development biological_process
GO:0043583 ear development biological_process
GO:0007507 heart development biological_process
GO:0006357 regulation of transcription by RNA polymerase II biological_process
GO:0021591 ventricular system development biological_process
GO:0050935 iridophore differentiation biological_process
GO:0030182 neuron differentiation biological_process
GO:0007275 multicellular organism development biological_process
GO:0001822 kidney development biological_process
GO:0021654 rhombomere boundary formation biological_process
GO:0035118 embryonic pectoral fin morphogenesis biological_process
GO:0045893 positive regulation of transcription, DNA-templated biological_process
GO:0014032 neural crest cell development biological_process
GO:0021954 central nervous system neuron development biological_process
GO:0021982 pineal gland development biological_process
GO:0071733 transcriptional activation by promoter-enhancer looping biological_process
GO:0021986 habenula development biological_process
GO:0030900 forebrain development biological_process
GO:0030901 midbrain development biological_process
GO:0048702 embryonic neurocranium morphogenesis biological_process
GO:0048703 embryonic viscerocranium morphogenesis biological_process
GO:0002761 regulation of myeloid leukocyte differentiation biological_process
GO:0005634 nucleus cellular_component
GO:0016592 mediator complex cellular_component
GO:0003700 DNA-binding transcription factor activity molecular_function
GO:0003712 transcription coregulator activity molecular_function
GO:0003713 transcription coactivator activity molecular_function
GO:0008013 beta-catenin binding molecular_function

KEGG:

id description
ko04919 Thyroid hormone signaling pathway
ko03021 Transcription machinery

ZFIN:

id description
ZDB-GENE-060125-1 Enables DNA-binding transcription factor activity and promoter-enhancer loop anchoring activity. Acts upstream of or within several processes, including animal organ development; embryonic pectoral fin morphogenesis; and iridophore differentiation. Predicted to be located in nucleus. Predicted to be part of mediator complex. Is expressed in several structures, including brain; head; immature eye; intermediate cell mass of mesoderm; and liver. Human ortholog(s) of this gene implicated in FG syndrome; leiomyosarcoma; major depressive disorder; phobic disorder; and syndromic X-linked intellectual disorder Lujan-Fryns-type. Orthologous to several human genes including MED12 (mediator complex subunit 12).

Ensembl:

ensembl_id ENSDARG00000103953

RNA

RNA id representative length rna type GC content exon number start site end site
TCONS_00014376 False 6924 mRNA 0.51 44 23593989 23679139
TCONS_00014377 True 825 mRNA 0.52 7 23668730 23678837

Neighbor

gene id symbol gene type direction distance location
XLOC_007281 si:ch211-221f10.2 coding upstream 2311 23518110 ~ 23591678 (+)
XLOC_007280 enox2 coding upstream 114412 23076127 ~ 23479577 (+)
XLOC_007279 NA coding upstream 634769 22841157 ~ 22959220 (+)
XLOC_007278 BX005043.2 coding upstream 781992 22807498 ~ 22811997 (+)
XLOC_007277 gfra4b coding upstream 885212 22591624 ~ 22708777 (+)
XLOC_007283 hspa4b coding downstream 8539 23687678 ~ 23708159 (+)
XLOC_007284 gnpda1 coding downstream 29995 23709134 ~ 23715349 (+)
XLOC_007285 ndfip1 coding downstream 38026 23717165 ~ 23726768 (+)
XLOC_007286 kctd16a coding downstream 132669 23811808 ~ 23812725 (+)
XLOC_007287 sh3rf2 coding downstream 194923 23874062 ~ 23970173 (+)
XLOC_007268 NA non-coding upstream 1453776 22129096 ~ 22140213 (+)
XLOC_007259 NA non-coding upstream 1816153 21777557 ~ 21777836 (+)
XLOC_007255 ndufs8b non-coding upstream 1915072 21671107 ~ 21678917 (+)
XLOC_007293 NA non-coding downstream 551772 24230911 ~ 24234703 (+)
XLOC_007298 BX005228.1 non-coding downstream 678261 24357400 ~ 24357517 (+)
XLOC_007300 NA non-coding downstream 1197963 24877102 ~ 24878581 (+)
XLOC_007302 AL645792.1 non-coding downstream 1364671 25043810 ~ 25046769 (+)
XLOC_007303 NA non-coding downstream 1373570 25052709 ~ 25055796 (+)

Expression


Co-expression Network