XLOC_008249 (mre11a)


Basic Information

Item Value
gene id XLOC_008249
gene name mre11a
gene type coding
species zebrafish (Danio rerio)
category of species model fish

Chromosome Information

Item Value
chromosome id NC_007126.7
NCBI id CM002899.2
chromosome length 48040578
location 2856696 ~ 2890101 (+)
genome version GRCz11_2017_zebrafish_Genome

Sequence

>TCONS_00016624
gtttttattattcctacttttatttttgtttaaaaaacattttaatcactgtgtaaaacatttgctggataagttggcggttcattccgctgtggcaacccctgatgaataaagggactaagtcgaaggaaaataaatgaatgaatttctcatTCAGTTTTTTAAAGAACTTGTGTTTAACTAAAAAcgtagaaatattaaataaatataataaaaaataaaacaacttctCACTATTACAggtcaaacataataataatatacaaaatatagctaaataaaatgctaaatctaAACACTGATCTTTCAGTATGCATCTTTCCCACGGTGTTTCTGTCTGCAACCCTATAATGATGAGTAATACTGCactcatataaaaaatatgaccataaacattcattcattttcttttcggctatgtctctttattaacccggggtcgccacagcggcatgaaccgccaacttatccagcacgtttttacgcagcggattcccttccagccgcaacccatctctgggaaatgaccATAAACAATGTAATGTTATTTTATGACGATAGAGCATGATATCAAACGACACAGCCCTACTTTATATCGATGCAACGTTAACATTAAATCATAAATAGTTCCAAACGACGTAAATTAAAACGATCCTCCCGTGTAAAGTAGTAAATCCGTGCATGTAAAGTAATTATTTGTAAATCACTTACAGAAAACAGCAATGACCAACCGTCTTCACGTTGAACTCACAAAATGTGCAAGTGACGCTGGGAAGTGTAGTTTTTTGCGCAATCAATTGCGCAGTCAGTTCGCTTTCATAAAATACATTTCCCAGAATTCTAAGGAAACAAACCTTCCCGCGACTTCCGACAGTGGGCGGAGATTGTGTACATGTGAACTCCTGTGTCAGTCTAAGGAGCTTTCTTGCTTTTCATAGCACGACCGTTTTTAGTATCTGCAGTCTCCTAGTATGGCATCAGCTGGAAGCACCGTtgACGATGAGGACACGTTCAAGATCCTCATTGCTACTGACATTCATCTGGGATATCTAGAGAAAGATGCCATTAGAGGGAACGACACGTTTGTGACCTTCGACGAGATTATGAAACAAGCTATGCAAAATGAGGTTGACTTTGTTTTGCTGGGTGGGGATCTGTTCCATGACAATAAACCGTCCCGCAAGACCATGCACAGTTGTATGGAGGTGATGAGAAAGTACTGCATGGGGGACCGTCCAATCATCTTTGAAATCATCAGCGATCAGGCTGTCAATTTCAGCCACAGCAGGTTTCCATGGGTGAACTACCTGGATGATAATCTCAACATTTCCATCCCTATCTTCAGTGTGCATGGCAACCATGATGACCCAACTGGGTCTGACGGGCTGTGCGCAGTAGACTTGTTGAGTTGTGCTGGTTTGGTGAATCATTTCGGCCGCAGTCGTTCTGTGGAGAAAGTTGAGATCAGTCCTGTTCTTCTGCAGAAAGGAGACACCAGGATTGCACTCTATGGCCTGGGTTCGATTCCGGATGAGAGACTCTACCGGATGTTCGTCAATAACCAGGTGACCATGCTTCGGCCCCGAGAGGATGAAGACGGCTGGTTCAACCTGTTTGTCATCCATCAAAACAGAAGTAAGCACGGAGCGACTAACTACATCCCAGAACAGTTTTTGGATGATTTCCTGGATTTGGTGGTGTGGGGTCACGAGCATGAGTGTAAAATCGCTCCGGTCCGTAATGAACAGCAGCTCTTCTACGTCACACAGCCTGGCAGCTCCGTCATCACATCACTGTCACCAGGAGAAGCTGTGAAAAAGCACATTGGGTTATTGAGGGTGAAAGGTAAAAAGATGAATCTCCAGAAAATTCCTCTACAGACCGTCAGGCAGTTCTTCATTCAGGATGTGGTACTTTCGGATTACCCGGAGCTTTTCAGCCCAGAGCAACCCAACACCATGCTCAAAGTCCAGGCGTTCTGTCAGGAGAagGTTGAAGAGATGCTGGaggaagcagagagagagagacttggaAATCCCCAAATCCCAGAGAAACCTCTAATTAGACTGCGAgtaGATTATAGTGGGGGTTTTGAAGTCTTTAACACTATGCGCTTTAGTCAGAAGTTTGTAGATAAAGTTGCAAACCCCAAAGACATTTTGCATTTCGTCAGACACAGAGAGACCAAAGGCAACATTAAAGATGAAGATGTGGATTTTGAAGCACTTTTCTCTCGTCCCACTTCTGAGGTCTTACAGCTGAGAGTGGAAGATCTTGTGAAGGAGTACTTCCAGACAGCTGAAAAGAATGTGCAGTTGTCTCTGCTGACAGAGCAAGGCATGGGAAAGGCAGTACAAGAGTTTGTGGATAAGGAAGAGAGAGATGCAATTGAAGAACTGATAAACTACCAGCTGGAGAAAACCCAGCGCTACCTCAGAGAGCGACGGGTGGACGCCACAGAGGAGAAGATAGATGAGGAGATTCGACAGTTTCGAGATTCTAAGAGAAACACAGCAGAAGAGGACGAGGAAGTACAAGAGGCTATAATTCGTGCAAAAGCTCATCGGGATCGTGGCGAAACCGCGAGAGACGATGACCTCGGCCTGTCAGATGACCCAGCTGACATTGCCATGGAATCCGATGAAGAGCCCTCGTCTGCTCCTCCAGTCCGTGGAAGGGGGCGGGGCTCCAGAGGAGGACGAGATCCATGCGCCAGTAAAAGAGGAAGAGCGAGAGGTGCTGCCTCTAGATCAGGACGGGGCGGACGTGGACGTGGATCTCTCTCAAGTCCAGTAAAAACCAAGTCAATAATGGATGTGTTTCAGGATGTAAGCCAGAGGTCCACTCGTGGAAAAACACCAAAGTCGTATGCTGAAGAGATCACCATCGAGGACAGCGACTCTGATGAGGATGTTTCGTTTTTAAAAAGTTCCAGGACAAAACAAAAGCTGCCTTCATTAAGTGACAGTAAGAGGGCGTCCCAGAGCCAGTCTTTAAAAGGAGTGTGCATTGATGAAGACAGCGGTGAGGATGAGTTTGATCCATTCAAGGGCTCAAGAAAACAGCGCAGATGAGGACGGACTTCCAGCTGCTTATCTACTTTTTCTTAATGAAAATTTAATAAAACcgatttttctttttccttttagtCTACAAGAATCTTTGCAGCGATTTGAGTAGGTTCAAGGTTCAAATCCCTAAAGTTGCTTTAAAGTCATTGTTGAGTGATGTACATTGAAAACTGATgtcttttaaactatttttttaggATTTATTTGATCATTATTACTGTTCATGTCTGTTTTTAAGTCATAAAAGCGATGAACCTGTCACTTTTCTTCTCATGTGTTTATTCATAGAACATTGCAGGTGGCAATTTATGGAAAGGTATGTGtatgaaagtttgatttatgaagTGTTATGTGTTATGTGATAGCAAAatactgcatgtgtgtttgtttctcaacaaatgtatttttattgcacAGTACTGCAATAttaacactcaccggccactttattaggtacacctcactagtgctgggttggacccccttttgcctttagagctGCCTttatccttcatggcagagattcaacaaggcactggaaatattcctcagagattttgctccatattgacatgatagcatcacgcagttgctgcacatccatgatgtgaatctctcattccaccacatcccaaaggtgctcagttggattgagatctgctgactgtggaggccatttgaatacagtgaactcattgtcatgaccTTGTCATGTTCtagaaaacagtctgagatgattcgcgctttatgacgtggtgcgttatcctgctggaagtagcagaCACAAGATGAGACACTgctcataaaggaatggacatggtcagcaacaatacttagttggtactaatggacccaaagtgtgccaagaaaacatcccccataccattacaccacaaccagcctgaactgcttatacaaagcaggatggatccatgctttcatgttgttgatgccaaattttgacccgaccatctgaatgtggcagcagaaatctaGACTTAAcagatcaggcaacgtttctccaatcttctattgtccagttttggtgagcctgtgtgaattgtagcctcagtttcctgttcttagctgacaggagcagcACCCGGTGTGATACACacattttggtttatttaatcCTAAAAGGAAAAGCCATAGTAACAGTGAAGACAGGAAACTGCAGTCCAAAGAAGcagtacattgcatttatttatataaggcAAAGTAGGAACTTTAGAGTTGTCGATTCAGAATGAAGATTACAGTACACACAgtataacaaaacaacaacaacaaaaactgtaCAATTTATAATACCGACCCCTTTATACACAGTATCTGGATGATACAATCAAACTCATGACTTGTACGAATGGTTTACCAGTCGGTAAACTTAGATTTGAGAAGCTAACTTCACGAGGAGTTAACTTTTTAATCAGATCCAACGACCAGAAAGTACTTTCAGTATAGCTATTGCTTTACTATTTCTAGAgatttttatttccattaaaagtcccatgaaatgaacataaaagttttagatgttagcatcagtatggatatttataagctagtgtgctcccaaacagtaacaaaattcacatttagggGATATAAACACCCAAAGTTTGCAGTtcgtcacttccgcctaaatggatcttGGATTTTTATGATGTCATACTTCAGCTTCTCATCAAATCTCCTGACCAGTCGAATGCTCTCaggtgtctgacatgccccgcccgcTCATTATCTGTTCATTTGATGttcttgagctcaaccactcccactgttataaaatgaaacgtcattggctgtttttttaaagggggcgGGGCTACTCTGTCCCAGCCTCTCTCCACccttcagttgagattacatcacaAATCAAGTTTATAaacaaatgcacatttcaaagcacttaagTAGACCTTTAAAATGTGTGACTGCGCTTCCAATgcaaacacattcatacactttAAACTGCGACTTGTTTTTCCACTACACATGTCCGTTGGTAAGCTCACGCTCCCAAACTCCCACATGACTTGTGTCATTTCAGCACATTTTTCAGAGCTGTTGAAGTGGAACGTAGAAGGGAAACCGAGATATCTGGAGGCACAAACACACGCAAAGAGAAAGTGTTTgagggatgatgatgatgattgagCTTGTCCACCTTGTTTCATCCACTGTCCAGTCTGTTTTTGGGCTTTACAGACTGGGtcatctcttcttcttcttctttttgttcTTCTTCTTGTTCCCGTCCACAGCTTCACTCCTTCTTTTTCTTCTGTCCGTTGACGATGATCTCCAGGACGTGTGTGAGGTCCATCATCTTAGTGAGCATCTCCATGATGTCTGGATGCTCTTTAGCTCCTGTGATGAACTCCTCAAGCGTCAGCTCACCTGAAATAACATTTACACAGATTCTGGGTTAAGCACCTtactatgtttatgtttatatatatatataaaatataattcatatatatatatgtgtgtgtgtgtgtgtagatatgcatatgtatatgtgtatgtatatatatatatatatatatatatatatatgtatatatatatgtgtgtgtgtatgtatatatatgtatatgtataaatgtgtatatgtgtgtgtgtatatatatatatatatgtgtgtgtgtgtgtatatatgtatatgtgtatgtatatatatatatatgtatatgtgtgtatatatgtatatgtgtatatatatatgtatatgtatgtgtgtgtgtatgtgtgtgtgtatatatgtgtgtgtgtgtgtatgtatgtatatatatatatatatatatgtatatatatgtatgtatatatatgtatatatatgtatgtatata
>TCONS_00016625
GCGACTTCCGACAGTGGGCGGAGATTGTGTACATGTGAACTCCTGTGTCAGTCTAAGGAGCTTTCTTGCTTTTCATAGCACGACCGTTTTTAGTATCTGCAGTCTCCTAGTATGGCATCAGCTGGAAGCACCGTtgACGATGAGGACACGTTCAAGATCCTCATTGCTACTGACATTCATCTGGGATATCTAGAGAAAGATGCCATTAGAGGGAACGACACGTTTGTGACCTTCGACGAGATTATGAAACAAGCTATGCAAAATGAGGTTGACTTTGTTTTGCTGGGTGGGGATCTGTTCCATGACAATAAACCGTCCCGCAAGACCATGCACAGTTGTATGGAGGTGATGAGAAAGTACTGCATGGGGGACCGTCCAATCATCTTTGAAATCATCAGCGATCAGGCTGTCAATTTCAGCCACAGCAGGTTTCCATGGGTGAACTACCTGGATGATAATCTCAACATTTCCATCCCTATCTTCAGTGTGCATGGCAACCATGATGACCCAACTGGGTCTGACGGGCTGTGCGCAGTAGACTTGTTGAGTTGTGCTGGTTTGGTGAATCATTTCGGCCGCAGTCGTTCTGTGGAGAAAGTTGAGATCAGTCCTGTTCTTCTGCAGAAAGGAGACACCAGGATTGCACTCTATGGCCTGGGTTCGATTCCGGATGAGAGACTCTACCGGATGTTCGTCAATAACCAGGTGACCATGCTTCGGCCCCGAGAGGATGAAGACGGCTGGTTCAACCTGTTTGTCATCCATCAAAACAGAAGTAAGCACGGAGCGACTAACTACATCCCAGAACAGTTTTTGGATGATTTCCTGGATTTGGTGGTGTGGGGTCACGAGCATGAGTGTAAAATCGCTCCGGTCCGTAATGAACAGCAGCTCTTCTACGTCACACAGCCTGGCAGCTCCGTCATCACATCACTGTCACCAGGAGAAGCTGTGAAAAAGCACATTGGGTTATTGAGGGTGAAAGGTAAAAAGATGAATCTCCAGAAAATTCCTCTACAGACCGTCAGGCAGTTCTTCATTCAGGATGTGGTACTTTCGGATTACCCGGAGCTTTTCAGCCCAGAGCAACCCAACACCATGCTCAAAGTCCAGGCGTTCTGTCAGGAGAagGTTGAAGAGATGCTGGaggaagcagagagagagagacttggaAATCCCCAAATCCCAGAGAAACCTCTAATTAGACTGCGAgtaGATTATAGTGGGGGTTTTGAAGTCTTTAACACTATGCGCTTTAGTCAGAAGTTTGTAGATAAAGTTGCAAACCCCAAAGACATTTTGCATTTCGTCAGACACAGAGAGACCAAAGGCAACATTAAAGATGAAGATGTGGATTTTGAAGCACTTTTCTCTCGTCCCACTTCTGAGGTCTTACAGCTGAGAGTGGAAGATCTTGTGAAGGAGTACTTCCAGACAGCTGAAAAGAATGTGCAGTTGTCTCTGCTGACAGAGCAAGGCATGGGAAAGGCAGTACAAGAGTTTGTGGATAAGGAAGAGAGAGATGCAATTGAAGAACTGATAAACTACCAGCTGGAGAAAACCCAGCGCTACCTCAGAGAGCGACGGGTGGACGCCACAGAGGAGAAGATAGATGAGGAGATTCGACAGTTTCGAGATTCTAAGAGAAACACAGCAGAAGAGGACGAGGAAGTACAAGAGGCTATAATTCGTGCAAAAGCTCATCGGGATCGTGGCGAAACCGCGAGAGACGATGACCTCGGCCTGTCAGATGACCCAGCTGACATTGCCATGGAATCCGATGAAGAGCCCTCGTCTGCTCCTCCAGTCCGTGGAAGGGGGCGGGGCTCCAGAGGAGGACGAGATCCATGCGCCAGTAAAAGAGGAAGAGCGAGAGGTGCTGCCTCTAGATCAGGACGGGGCGGACGTGGACGTGGATCTCTCTCAAGTCCAGTAAAAACCAAGTCAATAATGGATGGCTGCCTTCATTAAGTGACAGTAAGAGGGCGTCCCAGAGCCAGTCTTTAAAAGGAGTGTGCATTGATGAAGACAGCGGTGAGGATGAGTTTGATCCATTCAAGGGCTCAAGAAAACAGCGCAGATGAGGACGGACTTCCAGCTGCTTATCTACTTTTTCTTAATGAAAATTTAATAAAACcgatttttctttttcctttt
>TCONS_00018869
ACAATAGGCTGCCTTCATTAAGTGACAGTAAGAGGGCGTCCCAGAGCCAGTCTTTAAAAGGAGTGTGCATTGATGAAGACAGCGGTGAGGATGAGTTTGATCCATTCAAGGGCTCAAGAAAACAGCGCAGATGAGGACGGACTTCCAGCTGCTTATCTACTTTTTCTTAATGAAAATTTAATAAAACcgatttttctttttccttttagtCTACAAGAATCTTTGCAGCGATTTGAGTAGGTTCAAGGTTCAAATCCCTAAAGTTGCTTTAAAGTCATTGTTGAGTGATGTACATTGAAAACTGATgtcttttaaactatttttttaggATTTATTTGATCATTATTACTGTTCATGTCTGTTTTTAAGTCATAAAAGCGATGAACCTGTCA

Function

symbol description
mre11a Predicted to enable single-stranded DNA endodeoxyribonuclease activity. Predicted to be involved in mitotic DNA damage checkpoint signaling and nucleic acid metabolic process. Predicted to act upstream of or within double-strand break repair and meiotic cell cycle. Predicted to be located in nucleus. Predicted to be part of Mre11 complex. Predicted to be active in site of double-strand break. Is expressed in alar plate midbrain region; digestive system; eye; immature eye; and midbrain. Human ortholog(s) of this gene implicated in breast carcinoma; endometrial cancer; stomach carcinoma; and urinary bladder cancer. Orthologous to human MRE11 (MRE11 homolog, double strand break repair nuclease).

GO:

id name namespace
GO:0006302 double-strand break repair biological_process
GO:0006303 double-strand break repair via nonhomologous end joining biological_process
GO:0042138 meiotic DNA double-strand break formation biological_process
GO:0006974 cellular response to DNA damage stimulus biological_process
GO:0031573 intra-S DNA damage checkpoint biological_process
GO:0007095 mitotic G2 DNA damage checkpoint biological_process
GO:0051321 meiotic cell cycle biological_process
GO:0000723 telomere maintenance biological_process
GO:0000724 double-strand break repair via homologous recombination biological_process
GO:0006281 DNA repair biological_process
GO:0097552 mitochondrial double-strand break repair via homologous recombination biological_process
GO:0035861 site of double-strand break cellular_component
GO:0005634 nucleus cellular_component
GO:0030870 Mre11 complex cellular_component
GO:0008408 3'-5' exonuclease activity molecular_function
GO:0000014 single-stranded DNA endodeoxyribonuclease activity molecular_function
GO:0030145 manganese ion binding molecular_function
GO:0004518 nuclease activity molecular_function
GO:0004519 endonuclease activity molecular_function
GO:0004527 exonuclease activity molecular_function
GO:0016787 hydrolase activity molecular_function

KEGG: NA

ZFIN:

id description
ZDB-GENE-040426-2638 Predicted to enable single-stranded DNA endodeoxyribonuclease activity. Predicted to be involved in mitotic DNA damage checkpoint signaling and nucleic acid metabolic process. Predicted to act upstream of or within double-strand break repair and meiotic cell cycle. Predicted to be located in nucleus. Predicted to be part of Mre11 complex. Predicted to be active in site of double-strand break. Is expressed in alar plate midbrain region; digestive system; eye; immature eye; and midbrain. Human ortholog(s) of this gene implicated in breast carcinoma; endometrial cancer; stomach carcinoma; and urinary bladder cancer. Orthologous to human MRE11 (MRE11 homolog, double strand break repair nuclease).

Ensembl:

ensembl_id ENSDARG00000105014

RNA

RNA id representative length rna type GC content exon number start site end site
TCONS_00016624 False 5935 mRNA 0.41 20 2856696 2890101
TCONS_00016625 False 2157 mRNA 0.48 18 2857556 2887313
TCONS_00018869 True 392 lncRNA 0.36 2 2886700 2887498

Neighbor

gene id symbol gene type direction distance location
XLOC_008248 NA coding upstream 1067 2844812 ~ 2855629 (+)
XLOC_008247 NA coding upstream 40982 2814070 ~ 2815714 (+)
XLOC_008246 CR382327.3 coding upstream 170990 2685055 ~ 2685706 (+)
XLOC_008245 CR382327.2 coding upstream 182106 2673935 ~ 2674590 (+)
XLOC_008244 SH2B2 coding upstream 278557 2559875 ~ 2578139 (+)
XLOC_008251 NA coding downstream 98690 2988791 ~ 2989951 (+)
XLOC_008252 rcbtb2 coding downstream 235035 3125136 ~ 3162586 (+)
XLOC_008253 CABZ01053592.1 coding downstream 279873 3169974 ~ 3201297 (+)
XLOC_008254 NA coding downstream 329033 3219134 ~ 3223448 (+)
XLOC_008255 NA coding downstream 347494 3237595 ~ 3239957 (+)
XLOC_008463 BX663520.1 misc downstream 18362090 21252191 ~ 21252282 (+)
XLOC_008239 CU695208.1 non-coding upstream 498071 2358511 ~ 2358625 (+)
XLOC_008258 NA non-coding downstream 492713 3382814 ~ 3383114 (+)
XLOC_008259 FO704837.1 non-coding downstream 616208 3506309 ~ 3506423 (+)

Expression


Co-expression Network