XLOC_008305 (sirt2)


Basic Information

Item Value
gene id XLOC_008305
gene name sirt2
gene type coding
species zebrafish (Danio rerio)
category of species model fish

Chromosome Information

Item Value
chromosome id NC_007126.7
NCBI id CM002899.2
chromosome length 48040578
location 6786757 ~ 6807963 (+)
genome version GRCz11_2017_zebrafish_Genome

Sequence

>TCONS_00016684
CCACTTATCAGCATGAGCCGCCCAAAGAAATATCAGCGACTCACAAGAGCTATCGTCCCTTTAATAAAACAGTGGTGCCATCTCAACTTCAAGTGTTTCTTTTGGTATTTTTAGCTGGCTTATAGTTTTAAAGAGGGTAGATGTCTGAAGAGGTTTCTAAAAGGGAAGAAGAGGAGGCTGACACACCAGGTCTCGagggtcagtcagatgatAGCAGTGACGAGGGTGACGCTTCAGGAGATACTGAGATGGATTTTTTGCGCAGTCTTTTCTCGCGAACACTTGGCCTTAGTCCTGGAGATAAAGTCTTGGATGAGTTAACCCTGGACTCAGTTGCTCGCTACATACTGAGTGGCAAATGTAAGAACATTATCTGTATGGTTGGAGCTGGGATATCTACATCTGCAGGAATCCCAGATTTCCGCTCTCCTGGCACGGGCTTATATGCAAATCTGCAGAAGTACAACCTGCCTTACCCAGAGGCCATCTTTCAGATAGACTATTTCAAGAAACATCCGGAGCCCTTCTTTGCTCTGGCCAGAGAACTGTACCCAGGACAGTTTAAGCCCACAGTGTGCCACTATTTCATAAAGATGCTGAAAGACAAAGGCTTACTGAGGCGCTGTTATTCTCAAaatattgATACTCTAGAAAGGGTTGCAGGACTGGAAGGGGAGGACCTGATTGAAGCTCATGGTACATTTCACACATCTCACTGTGTGAGCTTCCTCTGTCGTAAAGAGTACAGCATGGACTGGATGAAAAATCAAATTTTCTCTGAAGAAATTCCTAAGTGCGATTCCTGTGGAAGCCTCGTAAAACCCGATATTGTGTTTTTTGGGGAAAGTCTGCCTTCCCGATTTTTCACTTCAATGAAAGCGGACTTTCCTCAATGTGACCTTCTGATCATAATGGGGACATCTTTGCAGGTTCAGCCATTTGCATCTCTAGTGAGCAGAGTCTCAAACCGCTGTCCACGATTGCTGATCAATATGGAGAAAACTGGACAGtctGAATTTGGCATGGGGCTATTCAGTTTTGGAGGCGGAATGGATTTTGATTCAGATAAGGCCTACAGAGATGTGGCTCATCTGAGCACCTGTGACGATGGCTGCATGACTCTCGCTGAACTGCTGGGCTGGAAAAAAGAGCTGGAGGAGATGGTGAAGCGTGAACATGCTTTGATTGACAGCAAAGATGCCAAAAAGACTGACAAAGAAGCCAGTCAGAGCTCCAAAAGTGCTGTGGCGGAGGCAGAGAAGACTGACAAAACAGAATAACCATTCAGAGCCTGCAGAGGGTGAACATGACATCTAAAGTAGTTTCACTACACTCTGGCCTGCTCCGGTTTACTGTCGACCTCTGTTCCTTTGAGCTCTTGTATCTCTCACCTGCCTATAATAACAATATAGAGAACGTAGAAATAGTGCAGAAACCTCAAAGGGGACAGAAACAGCACGAGCGAAAGACAGCAAACACTGTAGTTGAGAGGTGGTGTTCTGCTTGGGGGACGGCTCTTATGAAATAACATAACGCTTTAAATATaaagtttgaaatattatttacattacatttaaatgtatcaTATGAGGTATCAGGGTTAAATGtgtctgaaagaaaaaaattggAATGACATACAAGCGAACAtggctgttattttttttttatgacaccaTGTGTGACAAGCAACTAAAACAATTGAACTACATTCTCATTACTGTAATTTCTTTGtgaattgtaacatttttaaacacgAGTAAATTGAATGCAATTAAATTAATAgtaaactatattaaaaaaaatactacattttaaaatttccagaaatgtacaaaataaaataccgtaaatattttacaattaacaTTCCAAAGTAATCAAAATTACATTTCTTTGTGTTCTTACAATTAGATTTAATTAGAAAAGTCTACTCTGCTAAATTCTTACAAGGTTTCATGAGATTAACCTTGATGATGCTTGTTAACATGATTCCTTTCTTTGTgcaatcatttatatattttagtataatgtcatttttttaaggTGTAACTAATGgatgtttattttaatggaaaaaaggtaacactttattttgagggtccatttgagtgttagtagactATCTCAttattatctgttgatactgaCATTTAAcagtcattcaacagacatttaactgactaaaagaaactttgcaagtacatgtcaacttacactaaccctaacctacagtctacttataatctaatgagaattagttggcatgtagatgcaatgtaacttaaattcaacaaacggaccattaaGATAAAGTGTAACCGAAAAAATAATAGCATCTGGATTATATGAACTATTCTAATACATTTTGCTGTGTATTCTTTCTCTATTGCTTATCTTTGGTTTGGAATGTTTCAGCCCATGTTTCAAATGTGTAAGAGGAAGTTGGCCCAGGAGTGTTTTACAACATTACTACGATATCTGATGAAGTCTAATGCAACCCTATTTGAGGAAACAAAAGTGAGAGACAAAACTTGTATGCATGCCTGTGGTGTAACATTGTTATAAGGcattaaaatggttattaaaata

Function

symbol description
sirt2 Predicted to enable NAD+ binding activity; NAD-dependent histone deacetylase activity (H4-K16 specific); and tubulin deacetylase activity. Acts upstream of or within cilium assembly; hemopoiesis; and negative regulation of angiogenesis. Predicted to be located in several cellular components, including Schmidt-Lanterman incisure; main axon; and microtubule cytoskeleton. Predicted to be active in nucleus. Is expressed in liver and retina. Orthologous to human SIRT2 (sirtuin 2).

GO:

id name namespace
GO:0051726 regulation of cell cycle biological_process
GO:0061428 negative regulation of transcription from RNA polymerase II promoter in response to hypoxia biological_process
GO:0061433 cellular response to caloric restriction biological_process
GO:0042177 negative regulation of protein catabolic process biological_process
GO:0000122 negative regulation of transcription by RNA polymerase II biological_process
GO:2000777 positive regulation of proteasomal ubiquitin-dependent protein catabolic process involved in cellular response to hypoxia biological_process
GO:0043388 positive regulation of DNA binding biological_process
GO:0016525 negative regulation of angiogenesis biological_process
GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process biological_process
GO:0006476 protein deacetylation biological_process
GO:0008285 negative regulation of cell population proliferation biological_process
GO:0010507 negative regulation of autophagy biological_process
GO:0034599 cellular response to oxidative stress biological_process
GO:0060271 cilium assembly biological_process
GO:1900119 positive regulation of execution phase of apoptosis biological_process
GO:0045944 positive regulation of transcription by RNA polymerase II biological_process
GO:0070446 negative regulation of oligodendrocyte progenitor proliferation biological_process
GO:2000378 negative regulation of reactive oxygen species metabolic process biological_process
GO:0048471 perinuclear region of cytoplasm cellular_component
GO:0072686 mitotic spindle cellular_component
GO:0072687 meiotic spindle cellular_component
GO:0005813 centrosome cellular_component
GO:0005814 centriole cellular_component
GO:0005829 cytosol cellular_component
GO:0097386 glial cell projection cellular_component
GO:0030496 midbody cellular_component
GO:0044224 juxtaparanode region of axon cellular_component
GO:0033270 paranode region of axon cellular_component
GO:0005634 nucleus cellular_component
GO:0033010 paranodal junction cellular_component
GO:0043204 perikaryon cellular_component
GO:0005694 chromosome cellular_component
GO:0043209 myelin sheath cellular_component
GO:0043220 Schmidt-Lanterman incisure cellular_component
GO:0005737 cytoplasm cellular_component
GO:0008134 transcription factor binding molecular_function
GO:0034979 NAD-dependent protein deacetylase activity molecular_function
GO:0016740 transferase activity molecular_function
GO:0046872 metal ion binding molecular_function
GO:0017136 NAD-dependent histone deacetylase activity molecular_function
GO:0008270 zinc ion binding molecular_function
GO:0046970 NAD-dependent histone deacetylase activity (H4-K16 specific) molecular_function
GO:0070403 NAD+ binding molecular_function
GO:0042903 tubulin deacetylase activity molecular_function

KEGG:

id description
ko00760 Nicotinate and nicotinamide metabolism
ko03036 Chromosome and associated proteins

ZFIN:

id description
ZDB-GENE-030131-1028 Predicted to enable NAD+ binding activity; NAD-dependent histone deacetylase activity (H4-K16 specific); and tubulin deacetylase activity. Acts upstream of or within cilium assembly; hemopoiesis; and negative regulation of angiogenesis. Predicted to be located in several cellular components, including Schmidt-Lanterman incisure; main axon; and microtubule cytoskeleton. Predicted to be active in nucleus. Is expressed in liver and retina. Orthologous to human SIRT2 (sirtuin 2).

Ensembl:

ensembl_id ENSDARG00000011488

RNA

RNA id representative length rna type GC content exon number start site end site
TCONS_00016684 True 2589 mRNA 0.39 16 6786757 6807963

Neighbor

gene id symbol gene type direction distance location
XLOC_008304 NA coding upstream 702 6785649 ~ 6786055 (+)
XLOC_008303 si:ch1073-228b5.2 coding upstream 1792 6773876 ~ 6784965 (+)
XLOC_008302 CU694757.1 coding upstream 14637 6770586 ~ 6772120 (+)
XLOC_008301 CU633984.1 coding upstream 59675 6678521 ~ 6727082 (+)
XLOC_008300 nop53 coding upstream 120454 6652396 ~ 6666303 (+)
XLOC_008306 NA coding downstream 59313 6867276 ~ 6875548 (+)
XLOC_008307 foxl2a coding downstream 246791 7054754 ~ 7058214 (+)
XLOC_008308 pik3cb coding downstream 256856 7064819 ~ 7161877 (+)
XLOC_008309 her8.2 coding downstream 368219 7176182 ~ 7178865 (+)
XLOC_008310 her13 coding downstream 379265 7187228 ~ 7190183 (+)
XLOC_008463 BX663520.1 misc downstream 14444228 21252191 ~ 21252282 (+)
XLOC_008299 CU655863.1 non-coding upstream 227572 6559050 ~ 6559185 (+)
XLOC_008297 NA non-coding upstream 626254 6159009 ~ 6160503 (+)
XLOC_008311 NA non-coding downstream 926526 7734489 ~ 7737531 (+)
XLOC_008312 CR589941.1 non-coding downstream 997816 7805779 ~ 7805920 (+)
XLOC_008317 CR293508.2 non-coding downstream 1874859 8682822 ~ 8682937 (+)
XLOC_008318 CR293508.3 non-coding downstream 1923789 8731752 ~ 8731866 (+)

Expression


Co-expression Network

Homologous

species gene id symbol gene type chromosome NCBI id location
grasscarp (Ctenopharyngodon idella) CI01000092_03532136_03542761 SIRT2 coding CI01000092 null 3532136 ~ 3542883 (+)